Materials Today Physics
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2022
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IF 11.021
Chaosheng Zhang,Xiwei Lan,Qing Liu,Le Yu,Yaqian Li,Xianluo Hu
LiMn 2 O 4 -based lithium-ion batteries (LIBs) have attracted considerable attention due to their cost advantage, but industrial use has been hindered by severe capacity deterioration during cycling with LiPF 6 -based carbonate electrolytes, especially under high-temperature (55 °C) cycling conditions. Herein, a bifunctional, Janus-faced, inorganic-organic hybrid separator is demonstrated to ensure long-term cycling reversibility of LiMn 2 O 4 ||graphite LIBs. The monolithic all-nanomat separator is constructed by a bottom layer of poly ( m -phenylene isophthalamide) nanofibers by electrospinning and a top layer of interpenetrating hydroxyapatite/bacterial cellulose fibers . Benefiting from such a unique Janus configuration, the as-formed separator exhibits synergistic coupling in functions, simultaneously scavenging trace acid and mitigating the dissolution/deposition of Mn 2+ ions in batteries. Consequently, the cells with the Janus separator achieve enhanced capacity retention compared with traditional cells with the commercial polyolefin separator over 100 cycles at 55 °C. Furthermore, bulk structure and surface chemistry characterizations confirm that irreversible structural change in the LiMn 2 O 4 cathode could be avoided, and the amount of manganese on the graphite anode from the cycled cells with the Janus separator is suppressed. This work demonstrates that a composite Janus all-nanomat separator offers an unexpected route towards highly durable LiMn 2 O 4 -based LIBs.
研究领域:
材料科学
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电化学
✓ 已验证
DOI
高影响因子
Biomaterials Science
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2025
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IF 5.7
Yuhang Miao,Kaizhen Wang,Xin Liu,Xin Wang,Yanwei Hu,Zhenwei Yuan,Dawei Deng
Chemotherapy and surgery, though effective in cancer treatment, trigger the release of nucleic acid-containing pro-inflammatory compounds from damaged tumor cells, known as nucleic acid-associated damage-associated molecular patterns (NA-DAMPs). This inflammation promotes tumor metastasis, and currently, no effective treatment exists for this treatment-induced inflammation and subsequent tumor metastasis. To address this challenge, we developed a biomimetic liposome complex (Lipo-Rh2) incorporating a hybrid structure of liposomes and dendritic polymers, mimicking cell membrane morphology. Lipo-Rh2 leverages the multivalent surface properties of dendritic polymers to clear cell-free nucleic acids while serving as both a structural stabilizer and targeting ligand via embedded ginsenoside Rh2. Experimental data show that Lipo-Rh2 effectively reduces free nucleic acids in mouse serum through charge interactions, downregulates Toll-like receptor expression, decreases inflammatory cytokine secretion, and inhibits both primary tumor growth and metastasis. Compared to the current nucleic acid scavenger PAMAM-G3, Lipo-Rh2 demonstrates stronger antitumor effects, lower toxicity, and enhanced targeting capabilities. This biomimetic liposome-based nucleic acid scavenger represents a novel approach to nucleic acid clearance, expanding the framework for designing effective therapeutic agents.
研究领域:
药理学
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肿瘤学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
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IF 10.7
Xinlin Jiang,Zipeng Wu,Xiaoru Tan,Yichen Lin,Hui Xing,Yinglin Xuan,Dong Ma,Xin Cui
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity. By leveraging the molecular motility of the polyrotaxane structure, featuring β-cyclodextrin (β-CD) shuttles along the F-127 axis, we significantly improved the molecular recognition between DT and UA for enhanced UA absorption efficiency. In vitro experiments confirmed that HPR/DT MS rapidly reduced UA levels compared to control groups. Using a type 2 diabetic wound model, HPR/DT MS treatment effectively reduced UA levels, suppressed COX-2 expression, and transformed the immune microenvironment from a pro-inflammatory to a regenerative state in vivo . This was accompanied by enhanced M2 macrophage polarization, angiogenesis, and improved blood perfusion, resulting in accelerated wound healing. Overall, these findings highlight HPR/DT MS as a promising therapeutic strategy for hyperuricemia-related diabetic wounds, targeting the core pathological factors to improve wound repair.
研究领域:
药学
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生物医学工程
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伤口愈合
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糖尿病研究
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炎症
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2025
·
IF 9.6
Shuangfeng Ge,Xing-Huo Wang,Juntao Fan,Haofei Liu,Youtao Xin,Xiaohui Li,Yunjian Yu,Ying-Wei Yang,Hui Gao
Sepsis is an underappreciated yet severe threat to human life, marked by organ dysfunction and high mortality resulting from disordered inflammatory responses to blood infection. Unfortunately, no specific drugs are available for effective sepsis treatment. As a pivotal biomarker for sepsis, lactate levels are closely related to vascular permeability and sepsis-associated mortality. Herein, a dual-pipeline lactate removal strategy is reported from circulating blood to ameliorate vascular permeability and lipopolysaccharide (LPS)-induced sepsis. This is achieved by formulating lactate oxidase (LOX)-encapsulated hollow manganese dioxide (HMnO 2 ) nanohybrids (LOX@HMnO 2 -P[5]A) bearing pillar[5]arene (P[5]A) macrocycle with excellent host-guest properties. The highly biocompatible nanohybrids enable direct lactate consumption through LOX catalytic degradation and block lactate production by P[5]A-mediated LPS trapping, allowing for dual-pipeline lactate removal to maximize the reversal of lactate-mediated vascular hyperpermeability. Besides, HMnO 2 cores decompose hydrogen peroxide produced from lactate oxidation into oxygen, further contributing to lactate consumption and mitigating the hypoxic inflammatory environment. In vivo investigations demonstrate that intravenous administration of LOX@HMnO 2 -P[5]A nanohybrids with extended blood circulation can effectively ameliorate endothelial barrier dysfunction, inflammatory responses, and multiple organ injury, ultimately improving survival outcomes in LPS-induced sepsis. Taken together, this dual-pipeline lactate removal strategy offers a promising approach for efficient sepsis treatment.
研究领域:
医学
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药理学
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纳米技术
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免疫学
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重症监护
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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