INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Xinming Li,Juan Zhang,Peng Liu
More precise drug release is expected by conjugating the drug structural units in the polyprodrugs with dynamic covalent bonds responding to different stimuli. Here, amphiphilic acid/hypoxia co-triggered degradable diblock polyprodrug was designed via a facile one-pot method with drug content of 78.6% (1.22 mmol/g) and relatively molecular weight of 2.08 × 10 4 , by condensation polymerization of acid-sensitive dimer of doxorubicin (D-DOX ADH ) with 2-iminothiolane, in presence of PEGylated D-DOX ADH as end capping reagent for the PEGylation. Polyprodrug nanoparticles were easily obtained with mean hydrodynamic diameter of 177.6 ± 8.9 nm via self-assembly, which showed excellent acid/hypoxia co-triggered degradation and drug release performance. The ideal tumor selective cytotoxicity and enhanced antitumor efficacy were revealed with the in vitro cellular experiments. Such features make the proposed amphiphilic acid/hypoxia co-triggered degradable diblock polyprodrug a promising candidate for tumor chemotherapy.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Lirui Ren,Jianing Zhao,Wenjing Li,Qingjie Li,Daqi Zhang,Wensheng Fang,Dongdong Yan,Yuan Li,Qiuxia Wang,Xi Jin,Aocheng Cao
An accurate controlled-release strategy of pesticides is considered desirable in sustainable agriculture. A site-specific nanorelease system of dazomet (DZ) was proposed by employing the zeolitic imidazolate framework-8 composite (DZ@ZIF-8) by a one-pot method. The synthetic parameters of DZ@ZIF-8 were optimized, and the loading content of DZ was maximized. ZIF-8 endowed DZ with a pH-sensitive behavior. The collapse of the DZ@ZIF-8 structure and the site-specific release of DZ were triggered by acidic substances produced by Botrytis cinerea. In vitro and pot experiments showed that the fungicidal activity of DZ@ZIF-8 was about 36.3 and 42.7% higher than that of DZ, respectively. DZ is conventionally used before a crop is planted because of its volatility and toxicity. However, DZ@ZIF-8 could avoid phytotoxicity of DZ to plants, which made the application of DZ possible during plant growth. Moreover, the acute toxicity to zebrafish changed from high to moderate levels. This study highlights a potential strategy that improves DZ effective utilization and reduces side effects.
研究领域:
农业科学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Na Liang,Wei Zhao,Siyi Li,Xiaoxin Li,Zhenrong Liu,Kun Jiang,Shaoping Sun
In this study, an amphiphilic polymer (Bio-HA(TPE-CN)-mPEG) was designed and synthesized, which was fabricated by introducing hydrophobic aggregation-induced emission (AIE) fluorophore, acid-labile imine bond, methoxy poly (ethylene glycol) (mPEG) and tumor targeting ligand biotin to the backbone of hyaluronic acid. The polymer could self-assemble into micelles and solubilize hydrophobic anticancer drugs. In vitro drug release study indicated that the micelles could disassemble rapidly under acidic environment. The involvement of biotin and HA could enhance the cellular uptake of micelles by tumor cells. Modification of micelles by mPEG could minimize non-specific protein adsorption. Fluorescence studies indicated that the micelles exhibited excellent AIE features and emitted intense long-wavelength fluorescence. More excitingly, the micelles were red emissive in the normal physiological environment, but switched to blue fluorescence in the acidic tumor environment, which could be further applied for real-time monitoring and quantification of the drug release. The in vivo antitumor efficacy study demonstrated the superior antitumor activity of the PTX-loaded micelles. The Bio-HA(TPE-CN)-mPEG micelles were promising drug carriers for chemotherapy and bioimaging.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Xiaomeng Yuan,Xiaoying Liu,Hongjie Li,Shan Peng,Haiqin Huang,Zhe Yu,Limei Chen,Xinlu Liu,Jingkun Bai
Increasing the penetration and accumulation of antitumor drugs at the tumor site are crucial in chemotherapy. Smaller drug-loaded nanoparticles (NPs) typically exhibit increased tumor penetration and more effective permeation through the nuclear membrane, whereas larger drug-loaded NPs show extended retention at the tumor site. In addition, cancer stem cells (CSCs) have unlimited proliferative potential and are crucial for the onset, progression, and metastasis of cancer. Therefore, a drug-loaded amphiphilic peptide, DDP- and ATRA-loaded Pep1 (DA/Pep1), is designed that self-assembles into spherical NPs upon the encapsulation of cis -diamminedichloroplatinum (DDP) and all- trans retinoic acid (ATRA). In an acidic environment, DA/Pep1 transforms into aggregates containing sheet-like structures, which significantly increases drug accumulation at the tumor site, thereby increasing antitumor effects and inhibiting metastasis. Moreover, although DDP treatment can increase the number of CSCs present, ATRA can induce the differentiation of CSCs in breast cancer to increase the therapeutic effect of DDP. In conclusion, this peptide nanodelivery system that transforms in response to the acidic tumor microenvironment is an extremely promising nanoplatform that suggests a new idea for the combined treatment of tumors.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Miao Wang,Lifo Ruan,Tianyu Zheng,Dongqing Wang,Mengxue Zhou,Huiru Lu,Jimin Gao,Jun Chen,Yi Hu
Photothermal therapy emerges as a promising approach in antitumor treatment. A major challenge for conventional photothermal therapy is its unselective hyperthermia distribution within tumor tissues, which leads to detrimental effects on surrounding healthy tissues and compromised therapeutic effectiveness. In this study, a targeted photothermal delivery nanoplatform (P-D-CS-CNTs) was facilely fabricated by decoration of an acidity-labile polyethylene glycol (PEG) derivative onto chitosan nanoparticles encapsulating single-walled carbon nanotubes. P-D-CS-CNTs displayed a good stability in serum at normal physiological pH and convertibility of surface charges upon exposure to tumoral acidic pH, which was attributed to the acidity-triggered dePEGylation. The confocal laser scanning microscopic observations suggested that such surface-convertibility of nanoparticles facilitated tumor cell uptake, endo/lyososomal escape, and enhanced mitochondrial targeting. Furthermore, upon irradiation with an 808 nm laser, P-D-CS-CNTs could sabotage mitochondria with mild hyperthermia, which further induced the ROS burst from damaged mitochondria. The overdosed ROS ultimately resulted in mitochondrial damage and cell death. These findings indicate that the surface-convertible nanoplatform is promising for improved photothermal anticancer therapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Xinming Li,Peng Liu
Acid-triggered degradable polyprodrug P(DOX-AH) was designed for long-acting drug delivery with minimal leakage and enhanced antitumor efficacy. By facile polymerization of doxorubicin (DOX) and N-(tert-butoxycarbonyl)acryloylhydrazine (Boc-AH), P(DOX-AH) with drug as unique repeating unit was obtained, possessing an ultrahigh drug content. It was stable in the neutral media but could degrade completely into DOX-AH in the acidic media without any other by-product. The cleavage of the hydrazone linkage between the DOX-AH repeating units was revealed by the LC-MS/MS analysis. Furthermore, a slow solubility-controlled drug release performance was achieved in the acidic media because of the low solubility of the released DOX-AH. Even with the slow DOX-AH releasing, the enhanced antitumor efficacy was obtained than free DOX in the in vitro cellular experiments. These features demonstrated the promising potential of the proposed polyprodrug for long-acting drug delivery in future tumor chemotherapy.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Meng Gao,Weibing Zhang,Binchang Wu,Yining Dai,Chengdong Peng,Yuexiao Pan
Mn 4+ -doped red fluoride phosphors generally exhibit irregular bulks, thus, it is promising and challenging to regulate the morphology via a facile green synthesis approach for their desired application. In this study, the morphology evolution of a phosphor K 2 NaInF 6 :Mn 4+ (KNIF:Mn) from irregular polyhedrons to uniformly micro-cubic crystals about 2–3 μm has been achieved via acetate (CH 3 CH 2 COO-, Ac-)-triggered strategy while maintaining the high phase purity and photoluminescence (PL) efficiency. The modified KNIF:Mn micro-cubic crystals demonstrate higher moisture resistance and thermal stability compared to the unmodified counterpart. The obtained KNIF:Mn particles with regular morphology show superior performance in latent fingerprint visualization (LFV) as well as “warm” white light-emitting diodes (WLEDs). The phosphor mass required for fabrication of WLEDs with a correlated color temperature (CCT) of about 3900 K is deceased to half due to the optimized morphology, which indicates the potential on large-scale commercial applications.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Huanle Chen,Runan Zhao,Junjie Hu,Zixiang Wei,David Julian McClements,Shilin Liu,Bin Li,Yan Li
Chitosan is a polysaccharide widely used as a structuring agent in foods and other materials because of its positive charge (amino groups). At present, however, it is difficult to form and stabilize emulsions using chitosan due to its high hydrophilicity. In this study, oil-in-water emulsions were prepared using a one-pot green-chemistry method. The chitosan and aldehyde molecules were in situ interfacially conjugated during homogenization, which promoted the adsorption of chitosan onto the oil droplet surfaces where they created a protective coating. The universality of this method was verified by using chitosan with different molecular weights and four kinds of natural aldehydes [cinnamaldehyde (CA), citral (CT), citronella (CN), and vanillin (VL)]. Chitosan with higher molecular weight facilitated the formation of emulsions. By harnessing the dynamic covalent nature of imine bonds, chitosan emulsions with an imine link display dynamic behavior with acid-catalyzed hydrolysis. The aldehyde structure could control the pH point of trigger for breakdown of emulsions, which was 1.0, 3.0, 4.0, and 4.0 for CA emulsion, CT emulsion, CN emulsion, and VL emulsion, respectively. At pH 6.5, aldehyde helped to decrease the interfacial tension of chitosan to about 10 mN/m, while this value would increase if the pH decreased by adding acid during the measurement. Chemical kinetics studies indicated that the hydrophobicity and conjugation effect of the aldehyde together determined the trigger points and properties of the emulsion. Finally, we used the optimized emulsions to encapsulate and control the release of curcumin. The gastric release behavior of the curcumin depended on aldehyde structure: VL > CN > CT ≈ CA. Hence, a tailor-made trigger release emulsion system can be achieved by rational selection and design of aldehyde structure to control hydrophobicity and conjugation effect of aldehydes.
研究领域:
食品科学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Liangxi Zhu,Zixiu Shen,Xiaoyang Liu,Runqun Tang,Ziyi Zhang,Furong Zhao,Jue Wang,Wenjun Zhan,Lei Zhou,Gaolin Liang,Rui Wang
Using anticancer drug-encapsulated nanocarriers to actively target tumors is a promising chemotherapy strategy. Nevertheless, premature release of the drugs in tumor microenvironment (TME) or low tumor targeting efficiency of the nanocarriers significantly reduces its therapeutic efficiency. Herein, we propose a release-and-trapping strategy that significantly enhances the chemotherapeutic efficiency of an anticancer drug camptothecin. TME acid triggers the release of its prodrug from the nanocarrier and thereafter phosphatase instructs the prodrug to form hydrogel to trap the nanocarrier on cancer cell membrane. As trapped nanocarrier facilitates cell uptake of the prodrug and its intracellular carboxylesterase-mediated hydrolysis to release camptothecin. In vitro studies showed that the prodrug release from nanocarrier was maximized at pH 6.5. In tumor-bearing mice, our release-and-trapping strategy significantly prolonged the retention of the nanocarrier in tumor and significantly enhanced the anticancer efficacy of camptothecin. We propose that our release-and-trapping strategy be applied for more efficient cancer treatment in the future.
研究领域:
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Chongzhi Wang,YiKai Tang,Cheng Li,Wei Wu,Xiqun Jiang
Nanomedicines whose size can be varied on demand may synchronously achieve excellent tumor accumulation and penetration. In this study, by taking advantage of the pH sensitivity of a boronate ester, we synthesized acid-triggered size-reducing polymer nanoparticles (named PCD) by cross-linking β-cyclodextrin-cored multiarm polymers through the boronate ester. In PCD, the antitumor agent doxorubicin was loaded via the pH-sensitive hydrazone linkage. The in vitro and in vivo properties of PCD were investigated using a non-responsive nanoparticle (named UCD) as a reference. In the neutral condition of the bloodstream, PCD was stable and exhibited a suitable size for long circulation time. Upon entering tumors, PCD decomposed into stable and smaller multiarm polymers, which could deeply penetrate tumors. The high tumor accumulation and penetration of PCD offered significantly better anti-tumor efficacy than UCD.
研究领域:
生物医学工程
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Ruijuan Zhang,Qian Ma,Gaofei Hu,Leyu Wang
The real-time tracking and efficacy evaluation of therapeutic nanoplatforms especially in deep-tissues is of great importance but faces challenges. Meanwhile, chemodynamic therapy (CDT), relying on Fenton reaction by converting H2O2 into toxic hydroxyl radicals (•OH), has drawn wide interests in the fabrication of nanozymes for tumor therapy, while endogenous H2O2 is usually insufficient for effective CDT. Here, we report the pH-responsive multifunctional nanoplatforms consisting of copper peroxide (CP) nanoparticles, paclitaxel (PTX) and perfluoro-15-crown-5-ether (PFCE), for 19F magnetic resonance imaging guided and enhanced chemo–chemodynamic synergetic therapy with self-supplied H2O2 stemmed from the decomposition of CP nanoparticles under acid conditions in tumor. The decomposition of CP nanoparticles further promotes the release of PTX for enhanced chemotherapy. Both in vitro and in vivo results indicate that the efficient generation of •OH and drug release effectively inhibits tumor growth. Furthermore, 19F MRI signal can clearly track the fate of nanoplatforms in tumor and guide tumor treatment. This work provides a promising strategy for the rational design and construction of multifunctional nanoplatforms for imaging-guided synergistic therapy of deep seated tumor.
研究领域:
肿瘤学
·
生物医学工程
·
影像医学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2018
·Vol. 106
·期 11
·2955-2962
·
IF 3.231
Jinze Wang,Lin Liu,Liping Yin,Li Chen
To enhance anticancer efficacy and decrease side effects, the synergistic multi-agent therapy has now increasingly gotten great attention. Herein, the flexible polycaprolactone had been modified by histidine and formed assembles with PEGylated metallo-porphyrin via metal-coordinated supramolecular interaction. This supramolecular assembles showed excellent acid sensitivity. At neutral environment, the hydrophobic anticancer drug could be effectively co-encapsulated with photosensitizer Fe-TPP to improve the water solubility. While at the intracellular microenvironment, the changed acid environment would trigger the drug and Fe-TPP release due to the reduction of metal-coordinated interaction between histidine and metallo-porphyrin leading to the disintegration of assembles. The in vivo anticancer experiments toward HeLa and MCF-7 cells disclosed that this co-delivery system of anticancer drug and photosensitizer showed enhanced anticancer efficacy, implying that the synergistic chemo-photodynamic therapy could improve cellular proliferation inhibition. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2955–2962, 2018.
研究领域:
生物材料
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）