CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2013
·Vol. 92
·期 5
·851-860
·
IF 1.003
Zhenhua Pan,Qizhou Cai,Qiang Luo,Xinwei Li
The mechanism and kinetics of synergetic effect in TiO 2 /O 3 /UV process on H-acid degradation were investigated. The experimental results showed that H-acid removal rate of TiO 2 /O 3 /UV process was the highest among TiO 2 /UV, O 3 /UV and TiO 2 /O 3 /UV processes. The investigation of reactions with suitable active species scavengers confirmed that H-acid was mainly oxidised by ozone and holes on TiO 2 in the TiO 2 /O 3 /UV process. The recombination between holes and electrons in TiO 2 reduced in the presence of ozone, as indicated by fluorescence emission spectra. Moreover, the intermediates generated during H-acid oxidation in various processes were analysed by LC/MSD trap. It is proposed that H-acid was oxidised to polyhydroxy aromatics, benzene carboxylic acids and quinoids in the first step. Then, saturated aliphatics carboxylic acids were formed and mineralised to inorganic compounds through the Photo-Kolbe reaction. Finally, a kinetic study on TiO 2 /UV, O 3 /UV and TiO 2 /O 3 /UV processes was conducted and it was confirmed that both ozonation and photocatalytic activity were improved in TiO 2 /O 3 /UV process because of the synergetic effect.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Zhao Xinyue,Shan Pengfei,Liu Haiwei,Li Daai,Cai Peihan,Li Zhongyu,Li Zhihui
A synthetic route to prepare a poly(ethylene glycol) with a single cinnamaldehyde acetal unit in the polymer chain, was successfully established using a newly synthesized cinnamaldehyde acetal diethylene glycol (CADEG) as initiator. This HO-PEG(ca)-OH is non-toxic and would be degraded into a cinnamaldehyde and two PEG diols in acid environment. A whole polyethylene glycol based hydrogel was easily fabricated by thiol-ene “click” reaction in alkalescence aqueous solution using acrylate-PEG(ca)-acrylate and 4-arm PEG-SH as raw materials at room temperature. The gel time was dependent on the pH of the solution and its alkalinity can promote gel. The hydrogel can be degradable in acidic conditions and the stronger the acidity, the faster the degradation. This HO-PEG(ca)-OH also can be used in synthesis of cinnamaldehyde containing PEG derivatives, block copolymers or other acid degradable materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Science China-Chemistry
·
2025
·
IF 9.7
Zeng Si-Min,Zheng Di-Wei,Pan Ting,Ding Xing-Lan,Zhang Yun,Yang Chi-Hui,Cheng Si-Xue,Zhang Xian-Zheng
Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum ( P. polycephalum ) extends continuously to form a protoplasmic microtubular network structure, directly connecting food sources. Computational simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucose-catalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid (UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase (UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.
研究领域:
生物医学工程
·
材料科学
·
计算生物学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Chenghong Qiang,Nan Li,Shixiang Zuo,Zhimin Guo,Wei Zhan,Zhengping Li,Jiangquan Ma
Seeking active and low-cost cocatalysts is a vital task for solving the sluggish kinetics of photocatalysis process in environmental management. Herein, we report a novel and high-efficiency crystallized RuTe 2 cocatalyst, and loaded it onto black TiO 2 to form photocatalytic heterostructure (denoted as RuTe 2 /B-TiO 2 ) for diclofenac (DCF) degradation. To the best of our knowledge, the RuTe 2 as a cocatalyst for photocatalysis based on swift electron capture has not been documented yet. The degradation efficiency of DCF over 0.5% RuTe 2 /B-TiO 2 reached 95.2% for 120 min, which is 1.2 times higher than that of pure B-TiO 2 . In addition, the effects of different calcination temperatures, catalyst amounts, DCF concentrations and solution pH of the as-prepared catalysts were also investigated in depth. Spectroscopy/electrochemistry showed that 0.5% RuTe 2 /B-TiO 2 exhibited a narrower band gap, more active sites and better electrical conductivity than pure B-TiO 2 . Experiments with trapping agents have shown that O 2 – was the main active substance under irradiation. Furthermore, intermediates for the photodegradation of DCF were detected by liquid chromatography mass system (LC-MS) and density functional theory (DFT) calculations. Finally, the degradation pathway was rationalized and a possible photocatalytic mechanism for 0.5% RuTe 2 /B-TiO 2 was proposed.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 3
·687
·
IF 3.267
Wan-Xia Wu,Zi Liu
A series of new hyperbranched aliphatic poly(β-thioether ester)s were prepared by the enzymatic ring-opening polycondensation of 1,4-oxathiepan-7-one (OTO) and AB2/ABB’ comonomer with acid-labile β-thiopropionate groups. Two kinds of comonomers, methyl 3-((3-hydroxy-2-(hydroxymethyl)propyl)thio)propanoate (HHTP) and methyl 3-((2,3-dihydroxypropyl)thio)propanoate (DHTP), with different primary alcohols and secondary alcohols, were synthesized by thiol–ene click chemistry and thiol-ene Michael addition, respectively. Immobilized lipase B fromCandida antarctica(CALB), Novozym 435, was used as the catalyst. The random copolymers were characterized by1H-NMR,13C-NMR, GPC, TGA, and DSC. All branched copolyesters had high molecular weights over 15,000 Da with narrow polydispersities in the range of 1.75–2.01 and were amorphous polymers. Their degradation properties under acidic conditions were also studied in vitro. The polymeric nanoparticles of hyperbranched poly(β-thioether ester)s were successfully obtained and showed good oxidation-responsive properties, indicating their potential for biomedical applications.Keywords:Novozym 435;poly(β-thioether ester);hyperbranched;acid degradation;oxidation response
研究领域:
高分子化学
·
生物材料
·
酶催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Xiqian Tan,Anqi Sun,Shuaibo Gao,Fangchao Cui,Dangfeng Wang,Xuepeng Li,Jianrong Li
Hyperuricemia, a metabolic disease characterized by elevated uric acid (UA) levels due to abnormal purine metabolism, may benefit from a multi-target therapeutic approach using lactic acid bacteria (LAB). In this study, 49 strains of LAB were screened from plant and animal samples, with the top 10 strains selected via principal component analysis (PCA) based on their lipid-lowering, glucose-lowering, and obesity-inhibiting abilities to improve energy metabolism. After evaluating the hemolytic, DNase-, gelatin-, and amine-producing abilities of these strains, one strain X1 was elected for its high UA lowering ability based on the in vitro xanthine oxidase (XO) inhibition and in vivo (zebrafish model) XO reduction assay. X1 was then identified, its probiotic characteristics were investigated, and its potential anti-hyperuricemia mechanism was explored. The results showed X1 was Weissella cibaria with probiotic potential, and exhibited an in vitro XO inhibitory capacity of 57.77 ± 10.34% and reduced UA levels and XO activities by 47.30 ± 1.33% and 41.29 ± 5.26%, respectively, in a hyperuricemia zebrafish model. The anti-hyperuricemia mechanism of X1 may involve the degradation of inosine (45.26%) and guanosine (99.23%), along with the regulation of Organic anion transporter 1 (OAT1), UOX (urate oxidase), Hepatocyte nuclear factor 4 alpha (HNF4A), and Hypoxanthine-guanine phosphoribosyltransferase (HPRT) expression levels. These findings indicated that X1 has potential as a probiotic for treating hyperuricemia.
研究领域:
微生物学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Wenjing Huang,Qiuyan Liu,Xiaoxue Fu,Yida Wu,Zihao Qi,Guofu Lu,Jingming Ning
Ripening refers to the process of chemical change during the refinement of Keemun black tea (KBT) and is crucial in the formation of Keemun Congou black tea’s quality. In this study, the aroma composition of KBT during the ripening was analyzed. Sensomics indicated that ripening strengthened the coconut and fatty aroma of KBT and contributed to the decrease of green aroma substances, resulting in a shift of the overall aroma type of KBT to an integrated aroma profile, which was consistent with sensory evaluation. Changes in fatty acid content and the results of in vitro addition simulation tests confirmed that heat causes highly degradation of fatty acids into fatty aroma volatiles, which is a key driver of the formation of “Keemun aroma” quality. This study revealed the mechanism behind the formation of KBT’s integrated “Keemun aroma” quality and the mode of thermal degradation of major fatty acids.
研究领域:
食品科学
·
茶叶化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
·
2020
·
IF 7.539
Jun Cheng,Junjie Hua,Ting Kang,Bo Meng,Liangchen Yue,Haiquan Dong,Hui Li,Junhu Zhou
Serious inhibition of methane production in an anaerobic digestion (AD) system can be caused by propionic acid, which is derived from lactic acid degradation. Nanoscale zero-valent iron (nZVI) was used in this study to improve conversion of propionic acid into acetic acid, thereby promoting methane production. The methane yield was markedly enhanced when nZVI concentration increased from 0 to 2 g/L; however, it decreased when nZVI concentration further increased to 8 g/L. At an nZVI concentration of 2 g/L, the methane yield increased by 37% from 398.5 to 546.4 mL CH 4 /g TVS. The abundance of Candidatus Cloacamonas in the bacterial community increased from 2.17% to 3.78%, which facilitated conversion of propionic acid into acetic acid. Meanwhile, the abundances of Methanomassiliicoccus and Methanosarcina in archaeal community increased, which was beneficial to methane production. Cyclic voltammetry showed that the electron transfer coefficient in the AD system increased from 0.029 to 0.034 s −1 .
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Microorganisms
·
2025
·Vol. 13
·期 4
·798
·
IF 4.2
Xiaoyu Cao,Yu Zhang,Qianqian Xu,Hai Yan
Hyperuricemia is a metabolic disorder owing to the underexcretion and/or overproduction of uric acid (UA). Recent studies have shown that probiotics have many potential applications as functional foods to ameliorate hyperuricemia. In this study, we have successfully isolatedBacillus paranthracisYC03 with urate-lowering potential from Jiangshui. The in vitro results indicated that YC03 exhibited strong biodegradation capacities toward UA and its precursors (inosine and guanosine). Meanwhile, the cell-free extracts of YC03 were also found to catalyze and remove inosine and guanosine. To further explore the application potential of this strain in developing functional foods, we evaluated its probiotic properties through in vitro assays and whole genome analysis.B.paranthracisYC03 has excellent abilities, with tolerance to acid and bile salt and good adhesion. In addition, hemolytic assays, along with antibiotic resistance and biogenic amine production tests, have also preliminarily confirmed the safety of using YC03 in food. We have also annotated the key enzyme genes, includingauaG,hpt,rih,punAanddeoD, which are involved in the biodegradation of UA and nucleosides. The results of nucleoside biodegradation product detection will be valuable for exploring the metabolic pathway for biodegrading nucleosides with YC03. These findings provide meaningful insights for the development of functional foods to improve hyperuricemia usingB.paranthracisYC03.
研究领域:
微生物学
·
营养学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
·
2021
·Vol. 26
·期 6
·910-922
·
IF 2.836
Chen Yi,Zhao Min,Hu Liyong,Wang Zeyu,Hrynsphan Dzmitry,Chen Jun
Acrylic acid has been widely used in various industrial applications but is harmful to human health and the environment. A novel and efficient degrading acrylic acid bacterium was isolated and identified as Bacillus aryabhattai CY. In this study, batch experiments were conducted to evaluate the biodegradation of acrylic acid by B. aryabhattai CY, which were immobilized in calcium-alginate beads under different conditions. The components of the alginate beads were optimized by the response surface method, and the degradation performance of the immobilized cells was determined. Relative to the free cells, experiment results showed that the immobilized cells can achieve complete degradation of 100 mg/L acrylic acid in 24 h under the optimal conditions of SA 6% (w/v), CaCl 2 1% (w/v), and immobilization time of 6 h. According to Haldane’s model, the maximum specific growth rate ( μ max ) of the free cells and immobilized cells were 0.165/h and 0.210/h, respectively. Experiment data revealed that acrylic acid showed an inhibitory effect on biodegradation by B. aryabhattai CY, especially at concentration higher than 100 mg/L. Furthermore, the reusability of the immobilized cells revealed that the acrylic acid removal rate was above 93.70% within the eight cycles. The immobilized cells also showed higher removal efficiencies in wider ranges of temperature (20°C–60°C) and pH (5.0–10.0) than the free cells. Moreover, the possible degradation intermediates were proposed during the biodegradation of acrylic acid by GC-MS analysis. Results indicated that immobilized beads might have a potential environmental implication in the purification of practical acrylic acid wastewater.
研究领域:
环境生物学
·
微生物学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2020
·
IF 6.551
Haoran Song,Yuwei Wang,Zheng Ling,Daoyuan Zu,Zhuo Li,Yongming Shen,Changping Li
In-situ construction of heterojunction photocatalyst on two-dimensional (2D) Ti 3 C 2 MXene substrate has been proved to be a feasible method to enhance the photocatalytic degradation of organic pollutants. However, the limited interlayer spacing of 2D Ti 3 C 2 hinders the in-situ growth of TiO 2 photocatalyst. Herein, the intercalation strategy was developed in deep eutectic solvents (DESs) method to achieve interlayer expansion of Ti 3 C 2 and improve Ti 3 C 2 -derived photocatalyst performance. Because of the intercalation of choline cations, the DESs method synthesized Ti 3 C 2 (Ti 3 C 2 -DES) had the larger c -lattice parameter than that of traditional HF method synthesized Ti 3 C 2 (Ti 3 C 2 -HF). The interlayer space of Ti 3 C 2 -DES could be intercalated with more water molecule for oxidization of the Ti atoms, which remarkably promoted the in-situ growth of TiO 2 crystals. The formed heterojunction between (001) and (101) facets enhanced carriers separation. The Ti 3 C 2 substrate with excellent conductivity further promoted carriers transfer. As a result, Ti 3 C 2 /TiO 2 photocatalyst exhibited superior perfluorooctanoic acid (PFOA) removal performance (almost 100% removal efficiency and 49% defluorination efficiency within 16 h) compared with the traditional Ti 3 C 2 -HF/TiO 2 (22% removal efficiency and 12% defluorination efficiency within 16 h). This study provides a feasible strategy for enhancing photocatalytic degradation of PFOA by Ti 3 C 2 MXene-derived heterojunction photocatalyst.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-23
·
IF 10.6
Zhao Pei,Hu Hua-Zhong,Chen Xiao-Tong,Jiang Qi-Yun,Yu Xue-Zhao,Cen Xiao-Lin,Lin Shi-Qing,Mai Sui-qing,Pang Wei-lin,Chen Jin-Xiang,Zhang Qun
Background Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts of the body, which leads to a deterioration of the local microenvironment. This degradation is marked by elevated levels of uric acid (UA), increased reactive oxygen species (ROS) production, hypoxic conditions, an upsurge in pro-inflammatory mediators, and mitochondrial dysfunction. Results In this study, we developed a multifunctional nanoparticle of polydopamine-platinum (PDA@Pt) to combat acute gout by leveraging mild hyperthermia to synergistically enhance UA degradation and anti-inflammatory effect. Herein, PDA acts as a foundational template that facilitates the growth of a Pt shell on the surface of its nanospheres, leading to the formation of the PDA@Pt nanomedicine. Within this therapeutic agent, the Pt nanoparticle catalyzes the decomposition of UA and actively breaks down endogenous hydrogen peroxide (H 2 O 2 ) to produce O 2 , which helps to alleviate hypoxic conditions. Concurrently, the PDA component possesses exceptional capacity for ROS scavenging. Most significantly, Both PDA and Pt shell exhibit absorption in the Near-Infrared-II (NIR-II) region, which not only endow PDA@Pt with superior photothermal conversion efficiency for effective photothermal therapy (PTT) but also substantially enhances the nanomedicine’s capacity for UA degradation, O 2 production and ROS scavenging enzymatic activities. This photothermally-enhanced approach effectively facilitates the repair of mitochondrial damage and downregulates the NF-κB signaling pathway to inhibit the expression of pro-inflammatory cytokines. Conclusions The multifunctional nanomedicine PDA@Pt exhibits exceptional efficacy in UA reduction and anti-inflammatory effects, presenting a promising potential therapeutic strategy for the management of acute gout. Graphical Abstract
研究领域:
生物医学工程
·
药物化学
·
炎症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）