Gels
·
2022
·Vol. 8
·期 12
·819
·
IF 4.432
Pengfei Cui,Luping Ma,Pengju Jiang,Cheng Wang,Jianhao Wang
Currently, nucleic acid preparations have gained much attention due to their unique working principle and application value. However, as macromolecular drugs, nucleic acid preparations have complex construction and poor stability. The current methods to promote stability face problems such as high cost and inconvenient operatios. In this study, the hydrophilic pharmaceutical excipient PEG was used to gelate nucleic acid preparations to avoid the random movements of liquid particles. The results showed that PEG gelation significantly improved the stability of PEI25K−based and liposome−based nucleic acid preparations, compared with nucleic acid preparations without PEG gelation. After being stored at 4 °C for 3 days, non−PEG gelled nucleic acid preparations almost lost transfection activity, while PEGylated preparations still maintained high transfection efficiency. Fluorescence experiments showed that this effect was caused by inhibiting particle aggregation. The method described in this study was simple and effective, and the materials used had good biocompatibility. It is believed that this study will contribute to the better development of gene therapy drugs.Keywords:nucleic acid preparation;PEG gelation;stability
研究领域:
药剂学
·
分子生物学
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DOI
PubMed
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 21
·3931
·
IF 3.06
Yuxiang Wang,Zeyu Kao,Ting Zhang,Yujun Zhang,Lili Qin,Zhihua Zhang,Bin Zhou,Guangming Wu,Jun Shen,Ai Du
The trans-resveratrol (RSV)-loaded silica aerogel (RLSA) was prepared by the sol-gel method, adding the drug during the aging process, solvent replacement and freeze drying. A series of characterizations showed that RSV stays in the silica aerogel in two ways. First, RSV precipitates due to minimal solubility in water during the solvent replacement process. After freeze drying, the solvent evaporates and the RSV recrystallizes. It can be seen from scanning electron microscope (SEM) and transmission electron microscope (TEM) images that the recrystallized RSV with micron-sized long rod-shaped is integrated with the dense silica network skeleton. Second, from small-angle X-ray scattering (SAXS) results, a portion of the RSV molecules is not crystallized and the size is extremely small. This can be attached to the primary and secondary particles of silica to enhance its network structure and inhibit shrinkage, which is why the volume and pore size of RLSA is larger. In addition, the diffusion of RSV in silica alcogel was studied by a one-dimensional model. The apparent diffusion coefficients of inward diffusion, outward diffusion and internal diffusion were calculated by fitting the time- and position-dependent concentration data. It was found that the outward diffusion coefficient (5.25 × 10−10m2/s) is larger than the inward (2.93 × 10−10m2/s), which is probably due to the interface effect. The diffusion coefficients obtained for different concentrations in the same process (inward diffusion) are found to be different. This suggests that the apparent diffusion coefficient obtained is affected by molecular adsorption.Keywords:RLSA;one-dimension diffusion;alcogel;adsorption/desorption;Silica Aerogel
研究领域:
药学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2023
·
IF 4.6
Yongchuan Wu,Wenqian Xing,Jing Wen,Zhonglian Wu,Ya Zhang,Hechuan Zhang,Haidi Wu,Hang Yao,Huaiguo Xue,Jiefeng Gao
Polymeric organohydrogels as emerging soft materials have attracted tremendous interests because of their promising applications in wearable electronics, soft robotics and so on. However, it remains great challenges for the organohydrogels to achieve simultaneously high strength , toughness, stretchability, transparence, biocompatibility and temperature tolerance. Here we report a facile one-step mixed solvent-exchange strategy to prepare high performance organohydrogels (or organogels) by regulating macromolecular noncovalent interaction. The obtained poly(vinyl alcohol) gels have highly dense and homogenous structures comprising abundant hydrogen bonds , entanglements and crystalline domains, originating from the strong interaction of polymer-polymer and polymer-solvent-polymer. Theses gels exhibit excellent mechanical properties with a strength (up to 8.39 ± 0.51 MPa), fracture strain (up to 1127 ± 123%), toughness (52.63 ± 1.98 MJ/m 3 ) and fracture energy (up to 16.34 ± 5.6 kJ m −2 ), anti-freezing (−65 °C), long-term tolerance (95% of retention coefficient for 14 d), thermal stability (110 °C), transparence (over 90%) and biocompatibility.
研究领域:
材料科学
·
软物质物理
·
生物医学工程
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 25
·10621-10627
·
IF 3.288
Xue Xiong,Meiling Qi
This work presents a novel column fabrication approach for capillary gas chromatography (CGC) through the condensation reaction of a hydroxyl-terminated polymer with a cross-linker inside a capillary column. In this work, polypropylene glycol (PPG 4000) and tris[3-(trimethoxysilyl)propyl]isocyanurate (ICS) were employed to fabricate the PPG-gel capillary column for GC analyses. Inside the column, a 3D cross-linked organogel network forms on the capillary inner surface by condensation of PPG 4000 with ICS under the given mild conditions. As a result, the PPG-gel column exhibited moderate polarity and showed distinctly advantageous resolving performance and inertness for carboxylic acids over the PPG column by the conventional static coating method. Also, it achieved high-resolution separations of the isomer mixtures of alkanes, alkylbenzenes and halobenzenes. Moreover, the PPG-gel column exhibited dramatically improved solvent stability because of its cross-linked organogel network. The organogel column displayed excellent column repeatability and reproducibility with the RSD% values in the range of 0.01–0.04% for run-to-run, 0.71–0.84% for day-to-day and 2.4–3.1% for column-to-column. The proposed organogel approach is facile and applicable to other analogous materials and has a promising future for wide applications.
研究领域:
分析化学
·
材料科学
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产品关联
DOI
高影响因子
Green Energy & Environment
·
2021
·
IF 8.207
Yifei Wang,Wending Pan,Kee Wah Leong,Shijing Luo,Xiaolong Zhao,Dennis Y.C. Leung
Hydrogel electrolyte is especially suitable for solid-state Al-air batteries targeted for various portable applications, which may, however, lead to continuous Al corrosion during battery standby. To tackle this issue, an ethanol gel electrolyte is developed for Al-air battery for the first time in this work, by using KOH as solute and polyethylene oxide as gelling agent. The ethanol gel is found to effectively inhibit Al corrosion compared with the water gel counterpart, leading to stable Al storage. When assembled into an Al-air battery, the ethanol gel electrolyte achieves a much improved discharge lifetime and specific capacity, which are 5.3 and 4.1 times of the water gel electrolyte at 0.1 mA cm −2 , respectively. By studying the gel properties, it is found that a lower ethanol purity can improve the battery power output, but at the price of decreased discharge efficiency. On the contrary, a higher polymer concentration will decrease the power output, but can bring extra benefit to the discharge efficiency. As for the gel thickness, a moderate value of 1 mm is preferred to balance the power output and energy efficiency. Finally, to cater the increasing market of flexible electronics, a flexible Al-air battery is developed by impregnating the ethanol gel into a paper substrate, which can function normally even under serious deformation or damage.
研究领域:
材料科学
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电化学
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Zhangfeng Wu,Chuanluan Guo,Juguo Dai,Zhenwu Lu,Conghui Yuan,Birong Zeng,Yiting Xu,Lizong Dai
In order to overcome the structural drawbacks of layered electrodes in flexible supercapacitors , the construction of an electrode frame with high adaptability for the loading of different active materials makes the production of flexible supercapacitors simpler and more accurate. Herein, a novel loader type flexible supercapacitor with three-dimensional hybrid structure is built. In our design, the acetylene black and active material are enriched in the polyvinyl alcohol matrix, and the three-dimensional conductive network that can load different active material is formed. The active material can be selected on demand. The basic electrode (also a loader) formed by polyvinyl alcohol and acetylene black is an electronic conductor (∼1 Scm −1 ) with good electrochemical and mechanical performance. By loading active materials in this basic electrode, more powerful flexible electrodes can be built easily and accurately with the same steps according to the designed proportion. Electrodes constructed according to this method deliver nonnegligible surface capacity (e.g. 1.1 Fcm −2 in surface capacitance, polyaniline/carbon nanotube composite as active materials) with good response, rate performance, excellent durability (10000 times of charge-discharge), and good foldability (1000 times of folding). This pattern of carrier type electrodes provides a simple and universal strategy for manufacturing flexible supercapacitors.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiaohong Liang,Guangming Liu
Aqueous poly(vinyl alcohol) (PVA) gel electrolyte-based quasi-solid-state electrical double-layer capacitors (QSEDLCs) have been extensively investigated in the past ten years, but challenges remain to fabricate the PVA gel electrolyte possessing both superior mechanical and outstanding electrochemical performances. Herein, we develop a strategy to address this issue by a rational design of PVA gel electrolytes, based on a combination of the freeze–thaw (FT) method and sodium perchlorate (NaClO4)-based water-in-salt (WIS) electrolyte. Our study demonstrates that either the FT method or the NaClO4-based WIS electrolyte can improve both the mechanical performance of the PVA gel electrolyte by increasing the crystallization of PVA chains and the electrochemical performance of the PVA gel electrolyte-based QSEDLC by different mechanisms. In comparison with the conventional solvent evaporation method, this work provides an effective strategy to concurrently improve both the mechanical and electrochemical performances of aqueous QSEDLCs.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2011
·
IF 2.925
Li Zhou,Benzhao He,Faai Zhang
In this paper, a facile one-pot strategy for scalable synthesis of robust magnetic poly(vinyl alcohol) (mPVA) gel beads is developed. Through dropwise addition of mixed aqueous solution of iron salts and PVA solution into alkaline (e.g., ammonia, NaOH, and KOH) solution, mPVA gel beads with uniform size and excellent superparamagnetic property can be fabricated based on the simultaneous formation of magnetic iron oxide nanoparticles (MIONs) and cross-link of PVA chains. Moreover, this approach can be extended to prepare dual- or multiresponsive gel beads through simply adding functional fillers into PVA solution (e.g., mPVA-PNIPAM gel beads that possess both magnetic and temperature responsibilities can be readily prepared by adding temperature responsive poly(N-isopropylacrylamide) (PNIPAM) into PVA solution). It is found that that the obtained mPVA gel beads exhibit high drug loading level (e.g., above 70%) after the treatment of freezing-thawing. Drug release experiments reveal that the drug release rate and amount of the mPVA gel beads can be tuned by operating the external magnetic field and adjusting the concentration of iron oxide nanoparticles and temperature (for mPVA-PNIPAM gel beads). The present work is of interest for opening up enormous opportunities to make full use of magnetic gel beads in drug delivery and other applications, because of their facile availability, cost-effective productivity, and tunable drug release performance.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Zeying Liu,Lingze Zhang,Peng Xiao,Lingfeng Liu,Peng Tang,Ya Wang,Shihong Shen,Jiajun Liu,Zhenhai Gan,Daocheng Wu
To improve the recycling efficiency of magnetic recycling system, magnetothermally responsive composite submicron particles (CFMNs@PEG CSPs) were designed and prepared for recyclable catalytic applications, in which poly(ethylene glycol) gel was used as the shell and clusters of cobalt ferrite magnetic nanoparticles as the core. A novel strategy for recycling both loadings and carriers was proposed based on loadings immobilized CFMNs@PEG CSPs via magnetic separation at first and then magnetothermally responsive release. The morphology and core–shell structure were observed by transmission electron microscope . The physicochemical characteristics were investigated by Fourier transform infrared, 1 H NMR, Magnetic property measurement system, thermogravimetric analysis and X-ray photoelectron spectroscopy. The size of CFMNs@PEG CSPs was 285.1 ± 7.6 nm (the core was 160.0 ± 13.2 nm and PEG gel shell was 62.6 nm). The shell thickness of CFMNs@PEG CSPs shrunk from 62.6 nm to 35.5 nm when the temperature changed from 25 °C to 50 °C, and more than 95% of the loadings were released in 30 min by magnetothermally responsive release. Combing magnetic separation and magnetothermally responsive release, CFMNs@PEG CSPs were recycled over 42 times for horseradish peroxidase catalysis (horseradish peroxidase was re-immobilized for six times and reused seven times for each re-immobilization) and 25 times for gold nanoparticles catalysis (reactivated gold nanoparticles were re-immobilized for five times and reused five times for each re-immobilization) without significant catalytic activity loss, indicating their extensive potential in recyclable catalytic applications and other applications.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2023
·
IF 8.7
Yanhua Xie,Zifan Wu,Xuewen Xie,Shun Fu,Shujie Liu,Shimeng Mou,Xiangjun Pei
The stacking of phosphogypsum has caused considerable phosphorus pollution in water bodies near phosphogypsum yards through surface runoff and underground infiltration. The phosphate oxygen isotope (δ 18 O p ) tracing method has served as a valuable tool for tracing phosphorus pollution in water. However, the existing δ 18 O p enrichment and purification methods are complex, costly, and inefficient for phosphate recovery, particularly for phosphogypsum leachate with complex compositions. Herein, a simplified and optimized pretreatment method for δ 18 O p measurement in phosphogypsum leachate was developed. Zirconium/polyvinyl alcohol (Zr/PVA) gel beads showed good selectivity for phosphate enrichment from water at different initial phosphate concentrations with appropriate Zr/PVA dosage. The optimal enrichment pH value was <7, and the concentrated phosphate on the Zr/PVA gel beads could be effectively eluted in an alkaline environment . Compared with the traditional Fe or Mg coprecipitation enrichment methods, impurities in the solution showed no obvious adverse effects on the phosphate enrichment process. Further, the phosphate solution eluted from the Zr/PVA gel beads was purified by a simple adjustment of the pH instead of cation exchange in the traditional purification process. Magnesium ions in the solution could be completely removed when the pH ranged from 3.17 to 6.15, and the phosphate recovery rate could reach 98.66% when the eluent pH was 5.02. Fourier-transform infrared spectroscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy revealed that similar to traditional pretreatment method, the proposed method can obtain high-purity Ag 3 PO 4 solids for δ 18 O P measurement and no isotope fractionation of δ 18 O P was observed. Therefore, this study provides a promising and reliable pretreatment method for δ 18 O P measurement, especially in complex phosphogypsum leachate.
研究领域:
环境科学
·
同位素地球化学
✓ 已验证
DOI
PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 10
·783
·
IF 5.3
Jiefeng Yan,Zhenxing Fang,Jinxing Hu,Yangming Sun,Xinyi Huang,Guannan Zhou,Lu Li,Rui Wang,Yan Chen
Oxygen-deficient tungsten oxide W18O49was synthesized through lattice oxygen escaping at high temperature in N2atmosphere. The temperature and inert atmosphere were critical conditions to initiate the lattice oxygen escaping to obtain W18O49. The large amount of oxygen vacancies supports its performance in photothermal conversion. The synthesized tungsten oxides were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and ultraviolet-visible absorption spectroscopy (UV-Vis). The composite gel was fabricated by the insertion of oxygen-deficient tungsten oxide into PVA-based gel, which was cross-linked by glutaraldehyde. The PVA-based gel ensures a matched water supply speed with that of the evaporation rate due to its hydrophilic nature. The result of the solar steam generation shows that the W18O49-PVA gel (steam generation rate 2.65 kg m−2h−1) was faster than that of the pure PVA gel.
研究领域:
材料科学
·
物理化学
·
能源工程
·
纳米材料
·
光热治疗
·
环境功能材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Hao Liu,Shunzhe Zhang,Zhaopao Ma,Haochang Chen,Feihong Chen,Kaifeng Wang,Chongyin Zhang,Hua Li
Structural electrolytes with both mechanical and electrochemical properties are of great significance in structural energy storage devices. In this paper, we succeeded to synthesize a novel epoxy resin/hydrogel bicontinuous phase structure electrolyte for the first time by the ingenious design of the hydrophobic curing agent and the substitution of hydrogel for water, and filled the application of bicontinuous electrolyte in aqueous electrochemical energy storage system. The fine structure composition of electrolyte was divided and analyzed in detail by X-ray micro-CT technology. The epoxy resin phase is composed of a reasonable distribution of skeleton structures of various sizes, the largest of which is able to support heavy weights. And a large number of tiny skeletons are distributed to connect the skeletons of different sizes, which improves the three-dimensional interconnection of the epoxy resin phase and makes it excellent mechanical properties (Tensile strength 11.91 Mpa). The large size PVA gel phase constitutes the main pathway for conducting ions. Furthermore, the large-diameter gel phases are coupled in three dimensions with a huge number of micro-diameter gel phases, increasing the number of micro-ion transport channels and decreasing the distance of ion transport with good ionic conductivity (0.15 mS cm −1 ). Using carbon cloth coated in slurry as the electrode, an integrated structural energy storage bearing device was created in situ using layer brush technology, which exhibited exceptional electrochemical performance during in-situ variable load tests. We have successfully solved the construction of aqueous bicontinuous phase structure electrolyte, which made the application of various water chemistry systems in structural energy storage possible.
研究领域:
材料科学
·
电化学
·
能源存储
·
复合材料
·
机械工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）