ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Yujuan Xu,Wu Lei,Juan Su,Jinjin Hu,Xiaodan Yu,Tong Zhou,Yun Yang,Daniel Mandler,Qingli Hao
A fast, ultrasensitive electrochemical sensing platform based on graphitic carbon nitride-electrochemically deposited-poly(3,4-ethylenedioxythiophene) (g-C 3 N 4 -E-PEDOT) composite was constructed by in-situ electropolymerization and applied for the quantitative determination of acetaminophen (AP). E-PEDOT was introduced as the conducting matrix for developing g-C 3 N 4 composite to complement the poor conductivity disadvantage of g-C 3 N 4 . The strong affinity and synergetic effect between g-C 3 N 4 and E-PEDOT, which were analyzed by PM6 computational calculation, highly improved the electron transfer property and remarkably enhanced the electrochemical catalytic activity of the composite. The g-C 3 N 4 -E-PEDOT modified glassy carbon electrode (GCE) demonstrated better electrocatalytic activity towards the oxidation of AP than bare, g-C 3 N 4 and E-PEDOT modified ones. Under the optimized conditions, the oxidation peak currents at the g-C 3 N 4 -E-PEDOT/GCE increased linearly in the concentration range of AP from 0.01 to 2 μM and 2–100 μM, and an ultra-low limit of detection (LOD) of 34.28 nM was obtained (S/N = 3). In addition, the g-C 3 N 4 -E-PEDOT/GCE was successfully applied for the AP determination in the clinical human serum, and also exhibited excellent selectivity, reproducibility and stability. Except the novel AP determination approach, moreover, this work provided a new electrochemical application angle of graphitic carbon nitride theoretically as well as experimentally.
研究领域:
分析化学
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材料科学
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医学检测
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产品关联
DOI
高影响因子
Advanced Materials Technologies
·
2022
·Vol. 7
·期 10
·2200103
·
IF 8.856
Ying Fang,Na Qiao,Heli Deng,Meng Ren,Yufan Zhang,Desuo Zhang,Hong Lin,Yuyue Chen,Ken Tye Yong,Jiaqing Xiong
Transdermal drug delivery system (TDDS) is effective in alleviating patient's pain and reduces frequent administration. Realizing tunable drug release on fibers/fabrics is important for constructing TDDS platform with good skin affinity and long-term comfortability. Herein, a conductive fiber consisting of polyvinyl pyrrolidone/sodium alginate/ acetaminophen/poly(3,4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) (PVP/SA/AAP/PEDOT: PSS, PSAP) is fabricated by core-shell microfluidic spinning technology for the controllable release of AAP, a typical pain reliever. Incorporation of conductive fillers endows fibers with microcracks that are responsive to electrical stimulation for promoting drug diffusion and release. The release rate of AAP in simulated body fluid can be improved from 70.81% to 92.07% under electric stimulation, demonstrating a regulable release process enabled by tunable fiber conductivity and applied voltage (0–1.5 V). The drug release kinetic model reveals Fickian diffusion dominates the release process of AAP that generates local concentration difference in the microcracked PSAP fiber with electrical stimulation. This work proposes an accurate fabrication strategy of fibers-based TDDS that is promising for wearable biomedical electronics and self-powered on-demand drug delivery systems.
研究领域:
生物医学工程
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材料科学
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药学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 8
·1-8
·
IF 5.705
Song Xinjian,Fu Ju,Wang Juan,Li Chunya,Liu Zhihong
Graphene nanosheets (GSs) were prepared via liquid-phase non-covalent exfoliation of graphite powder in N , N -dimethylformamide under the assistance of copper(II) meso-tetra(4-carboxyphenyl)porphyrin tetrasodium salt Na 4 (CuTCPP). A glassy carbon electrode (GCE) was modified with a film of such GSs which, due to the good electrical conductivity of graphene and the electrocatalytic properties of Na 4 (CuTCPP), is capable of simultaneous determination of acetaminophen (AC) and dopamine (DA). The peak currents, best measured at voltage of 0.2 V (for DA) and 0.4 V (for AC; both vs. SCE), increase linearly in the 0.0024–3.6 μM and 0.004–7.6 μM concentration ranges, respectively. The detection limits are 0.8 nM for DA and 0.7 nM for AC. The sensor was successfully applied to the simultaneous determination of AC and DA in pharmaceutical preparations and spiked human serum. The results were in good agreement with those obtained for the same samples by HPLC.
Graphene nanosheets were prepared via a facile liquid-phase exfoliation of graphite with the assistance of copper(II) meso-tetra(4-carboxyphenyl)porphyrin tetrasodium salt. A graphene nanosheet-film modified glassy carbon electrode was fabricated to determine acetaminophen and dopamine through a simple and effective strategy.
研究领域:
分析化学
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电化学
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药物分析
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2015
·
IF 4.097
Fen-Ying Kong,Sai-Xi Gu,Jing-Yi Wang,Hai-Lin Fang,Wei Wang
We demonstrate herein a newly developed electrochemical sensor base on the reduced graphene oxide–titanium nitride (RGO–TiN) nanohybrid . The nanohybrid was prepared by mixing the TiN nanoparticles and GO dispersion and then treating with glucose and Zn foils. The morphologies and microstructures of the as-prepared nanohybrid were characterized by UV–vis absorption spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy and Raman spectroscopy. The as-prepared RGO–TiN nanohybrid exhibited excellent electrocatalytic activity toward the simultaneous detection of acetaminophen (ACOP) and 4-aminophenol (4-AP). As a result, the linear detection ranges were 0.06–660 μM for ACOP and 0.05–520 μM for 4-AP, respectively, with the low detection limits of 0.02 μM for ACOP and 0.013 μM for 4-AP. Based on the excellent performance, it was demonstrated that the prepared RGO–TiN nanohybrid was a promising candidate for advanced electrode material in electrochemical sensing field and the as-prepared RGO–TiN nanohybrid may find more applications for the detection of various analytes.
研究领域:
材料科学
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分析化学
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产品关联
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
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2022
·Vol. 51
·期 9
·5310-5321
·
IF 2.047
Shen Yuli,Yang Juan,Zhang Yuanyuan,Zeng Ting,Wan Qijin
Efficient sensing materials are required to achieve sensitive, selective, and reproductive detection of different targets by means of electrochemical approaches. In this study, a sensing material of a Ni-doped ZnO/graphene nanoplatelet (Ni-ZnO/GNP) composite is constructed through a simple hydrothermal method and further utilized for electrochemical determination of frequently used drugs, acetaminophen and estradiol. The characterization of this Ni-ZnO/GNP hybrid using scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray photoelectron spectroscopy (XPS), x-ray powder diffraction (XRD), Raman spectroscopy, and electrochemical techniques reveals that in this composite the highly conductive GNP provides abundant active sites for the growth of Ni-ZnO, while the introduction of Ni-ZnO weakens the accumulation of the GNP. In comparison to either Ni-ZnO or the GNP, the Ni-ZnO/GNP composite exhibits a much larger electrochemically active area and enhanced catalytic activity. In this regard, the electrochemical response of both acetaminophen and estradiol is improved, resulting in their sensitive and reproductive determination with detection limits of as low as 0.0072 and 0.00056 µM, respectively. This study offers a new approach to design high-performance sensing materials as well as to explore their applications for the determination of trace-leveled drugs. Graphical Abstract
研究领域:
材料科学
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分析化学
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药物分析
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DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2021
·
IF 6.291
Yimin Zhang,Jingkun Lou,Leliang Wu,Minghua Nie,Caixia Yan,Mingjun Ding,Peng Wang,Hua Zhang
Homogeneous Cu 2+ -mediated activation of H 2 O 2 has been widely applied for the removal of organic contaminants, but fairly high dosage of Cu 2+ is generally required and may cause secondary pollution. In the present study, minute Cu 2+ (2.5 μM) catalyzed H 2 O 2 exhibited excellent efficiency in degradation of organic pollutants with the assistant of naturally occurring level HCO 3 − (1 mM). In a typical case, acetaminophen (ACE) was completely eliminated within 10 min which followed the pseudo-first-order kinetics. Singlet oxygen and superoxide radical rather than traditionally identified hydroxyl radical were the predominant reactive oxygen species (ROS) responsible for ACE degradation. Meanwhile, Cu 3+ was deduced through Cu + and p -hydroxybenzoic acid formation analysis. CuCO 3 (aq) was the main complex with high reactivity for the activation of H 2 O 2 to form ROS and Cu 3+ . The removal efficiency of ACE depended on the operating parameters, such as Cu 2+ , HCO 3 − and H 2 O 2 dosage, solution initial pH. The presence of Cl − , HPO 4 2− , humic acid were found to retard ACE removal while other anions such as SO 4 2− and NO 3 − had no obvious effect. ACE exhibited lower degradation efficiency in real water matrices than that in ultra-pure water. Nevertheless, 58–100% of ACE was removed from domestic wastewater, lake water and tap water within 60 min. Moreover, eight intermediate products were identified and the possible degradation pathways of ACE were proposed. Additionally, other typical organic pollutants including bisphenol A, norfloxacin, lomefloxacin hydrochloride and sulfadiazine, exhibited great removal efficiency in the Cu 2+ /H 2 O 2 /HCO 3 − system.
研究领域:
环境科学
·
化学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2024
·
IF 4
Hao Gao,Xiaoping Xing,Yuting Chu,Yong Dai,Hui Zhang
The objective of this study is to synthesize and characterize two types of organic montmorillonites, namely H-Mt and O-Mt, through the modification of sodium montmorillonite (Na-Mt) using quaternary ammonium salt surfactants, specifically hexadecyl dimethyl benzyl ammonium chloride (HDBAC) and octadecyl dimethyl benzyl ammonium chloride (ODBAC). And the application of H-Mt and O-Mt as acetaminophen (PCT), an adsorbent for an emerging pharmaceutical contaminant, in wastewater treatment was investigated. The Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometer (XRD) results demonstrated the successful intercalation of both modifiers into Na-Mt. The intermittent adsorption experiments demonstrated that the optimal dosages of H-Mt and O-Mt modifiers were 1.6 CEC and 1.0 CEC (CEC is the cation exchange capacity of Na-Mt), respectively. The saturated adsorption capacities of PCT reached 25.9087 mg/g (H-Mt) and 14.7313 mg/g (O-Mt) at pH 5, respectively, while the original Na-Mt exhibited a significantly lower adsorption capacity of only 0.7668 mg/g. Additionally, it was observed that the adsorption capacity of O-Mt on PCT was inferior to that of H-Mt, suggesting that the longer alkyl hydrocarbon chain has a larger steric hindrance during the adsorption process, which prevents PCT from entering the adsorption site in the organic montmorillonite. The adsorption of PCT by two types of organic Mt was more accurately described by the pseudo-second-order kinetic model and the Freundlich adsorption isotherm equation. The negative Δ G° values and negative Δ H° values determined by the thermodynamic parameters study confirmed that the adsorption of PCT on H-Mt and O-Mt was a spontaneous exothermic process. The present study validated the potential of Na-Mt functionalized with HDBAC and ODBAC as a highly effective adsorbent for emerging pharmaceutical contaminant.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
Analytical Methods
·
2022
·Vol. 14
·期 45
·4730-4738
·
IF 3.532
Chao Chen,Chenxi Wang,Pengcheng Zhao,Jin Zhang,Yongjun Hu,Junjie Fei
A novel facile, quick, and temperature-controlled sensor was constructed based on a polystyrene-poly-N,N-diethyl acrylamide-polystyrene (PS-PDEAM)/carboxylated multi-walled carbon nanotube (MWCNT) composite modified glass carbon electrode. The sensor achieves acetaminophen (AP) reversibility through better temperature sensitivity. PS-PDEAM shrinks when the temperature exceeds its lower critical temperature (LCST). When AP molecules pass through the modified interface, the electron transfer rate is accelerated, and the sensor is turned on. In the off state, the electrochemical response of AP cannot be detected. Under ideal experimental conditions, for composite modified films, there is a wide detection range of AP between 1.5–85.1 μM and 85.1–235.1 μM, and the limit of detection of acetaminophen is as low as 0.57 μM (S/N = 3). This method has been successfully applied to the determination of AP in tablets, and shows high stability, good reproducibility and excellent anti-interference ability. The on-off sensor opens up a wide range of possibilities for the use of temperature-sensitive polymers in electro-catalysis, sensors, and environmental pollutant monitoring.
研究领域:
分析化学
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材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Chen-Guang Xia,Hao-Jie Lv,Yue-Feng Liu,Zhen-Long Zhang
Recently, perovskite solar cells (PSCs) based on quasi-two-dimensional (quasi-2D) perovskites have drawn more attention due to their excellent stability, although their efficiencies are still lower than those of 3D ones. Here we applied post-treatment of 2D perovskite GAMA5Pb5I16 (GA = guanidinium, MA = methylammonium) films with acetaminophen (AMP) to improve their performance. The efficiency of the solar cells with 2 mg/mL AMP post-treatment increased to 18.01% from 16.72% for those without post-treatment. The efficiency improvement results from the enlarged grain size, reduced trap state density, and better energy level matching after AMP post-treatment. In addition, the stability of the solar cells is improved. The solar cells with AMP post-treatment maintain 91% of the original power conversion efficiency value after aging for 30 days in the atmosphere. This work opens a new approach for the efficiency and stability enhancement of quasi-2D PSCs.
研究领域:
材料科学
·
能源技术
·
化学工程
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Izaz Ali Shah,Sharafat Ali,Zhe Yang,Ihsanullah Ihsanullah,Haiou Huang
Thin-film composite (TFC) nanofiltration (NF) and reverse osmosis (RO) membranes have been widely used to remove pharmaceutically active compounds (PhACs) from water and wastewater. However, limited information is available to present the rejection of neutral PhACs under complex water matrices. In this study, we used acetaminophen (AAP) as a representative neutral pollutant to study the effects of feedwater matrices on the rejection of neutral PhACs by NF and RO membranes. The results showed that the permeation of solutes and water through NF and RO membranes followed the classical solution-diffusion model. The corresponding permeability coefficients of AAP for the RO membrane showed good consistency, with average values ranging between (6.19–7.56) × 10 −6 μm s −1 in fresh and brackish feedwater. Meanwhile, the NF membrane exhibited stable AAP and NaCl fluxes as the applied pressure increased from 4.8 to 7.6 bar, suggesting an insignificant influence of convection on solute transport . In addition, a 10-fold increase in NaCl concentration reduced the average AAP permeability coefficient of the NF membrane by 57% (i.e. from 2.8 × 10 −5 m s −1 to 1.2 × 10 −5 m s −1 ), highlighting the relevance of co-existing ions to AAP transport. Furthermore, organic fouling resulted in enhanced AAP rejection by both NF and RO membranes at neutral pH level and medium applied pressure (i.e. 5.8 bar). Overall, this study provided important insights into the separation mechanism of TFC membranes for neutral PhACs, as well as the complex effects of the water matrix on the solute permeation processes.
研究领域:
环境科学
·
膜技术
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Dongqin He,Dongli Wang,Hongwei Luo,Yifeng Zeng,Ganning Zeng,Jun Li,Xiangliang Pan
The most important factor that restricts the decomposition of H 2 O 2 in the Fe 3+ /H 2 O 2 reaction is the slow cycling efficiency of reducing Fe 3+ to Fe 2+ . In this study, the addition of tungsten disulfide (WS 2 ) as a co-catalyst achieved a rapid cycling of the reaction rate-limiting step and a significant enhancement of H 2 O 2 decomposition, which resulted in the effective degradation of acetaminophen (APAP). Results show that 99.6% of APAP (5 mg L −1 ) could be degraded by H 2 O 2 /Fe 3+ /WS 2 system within 2.5 min. The conversion of Fe 3+ to Fe 2+ occurred mainly on the surface of WS 2 due to the redox reaction of the exposed W 4+ active sites with Fe 3+ after the unsaturated S atoms were bound to protons. Electron paramagnetic resonance (EPR) and radical quenching experiments evaluated the contribution of hydroxyl radical (•OH) and superoxide radical (O 2 • − ) in the degradation of pollutants. WS 2 showed good recoverability after four cycles of the reaction. This study provides a new perspective to improve the efficiency of Fe 3+ /H 2 O 2 and provides a reference for the involvement of transition metal sulfides in advanced oxidation processes (AOPs).
研究领域:
环境科学
·
催化化学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Shufang Ren,Runyan Feng,Shounian Cheng,Liqiu Huang,Qingtao Wang,Zhixiang Zheng
In this work, an ultrasensitive electrochemical sensor towards quantitative detection of acetaminophen (AP) based on hybrid of metallic 1 T and semiconductive 2H phase molybdenum disulfide (1 T/2H MoS 2 ) anchored on rGO sensing platform was constructed. The XRD, FESEM, FETEM and XPS analysis indicates that nanoflowers 1 T/2H MoS 2 with walnut-like fold structure were in-situ loaded onto the surface of rGO nanosheets by the hydrothermal approach. The formation of stabilized 1 T MoS 2 is associated with the influence of GO. The electrochemical tests of CV, EIS and DPV show that the hybrid composite MoS 2 /rGO remarkably promoted the detecting performance owing to the increased conductivity of 1 T MoS 2 that can facilitate charge transfer kinetics, the great active sites on both basal and edge of planes of 1 T/2H MoS 2 and the synergic effect of 1 T/2H MoS 2 and rGO. After the test condition optimization, MoS 2 /rGO/GCE sensor has great electrocatalytic activity towards AP with wide linear range of 0.005–300 μM and low limit of detection of 1.7 nM (S/N = 3). Furthermore, the sensor shows excellent stability, repeatability, reproducibility and anti-interference performance. All results proved that the GO-assisted hydrothermal prepared hybrid 1 T/2H MoS 2 /rGO is promising material for electrochemical analysis.
研究领域:
分析化学
·
材料科学
·
药物分析
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DOI
高影响因子
危险品化学品经营许可证（带存储）