INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Hesheng Wang,Linna Wang,Silong Jia,Qiyuan Feng,Limin Guo,Shaoying Zhang,Youwei Yu
Conventional petroleum-based food packaging faces sustainability challenges due to limited water resistance and mechanical strength. To address this, we developed an octenyl succinic anhydride (OSA)-modified gelatin film crosslinked with vanillin (OGV), enhancing its potential for food packaging applications. Infrared and X-ray spectroscopy confirmed the successful modification of gelatin and forming a Schiff base structure with vanillin. Thermal analysis showed that the modification and crosslinking enhanced the film's thermal stability. The results demonstrated that OSA modification and vanillin crosslinking significantly enhanced the mechanical strength of OGV films, increasing tensile strength from 19.50 MPa to 43.04 MPa. Additionally, OGV films exhibited excellent water vapor barrier properties, with the water contact angle increasing from 76.6° to 91.1°, along with superior UV-blocking capacity and notable antimicrobial activity against E. coli and S. aureus . Furthermore, applying OGV films to fresh-cut green peppers effectively reduced weight loss (by 9.23 % after 10 days), preserved chlorophyll and ascorbic acid content, and inhibited lipid peroxidation, thereby extending shelf life. These findings highlight the potential of this bio-based film as an effective and sustainable alternative for food packaging applications.
研究领域:
食品科学
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材料科学
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DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 53
·34548-34556
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IF 4.036
Youdan Duan,Haiming Cheng
In the extraction of collagens from mammalian tissues, the free pepsin used in the acid–pepsin extraction system is hard to recycle, and there is a risk of enzyme protein contamination in the extracted collagen products, which limits their applications. To solve this problem, an immobilized pepsin was successfully prepared via the covalent crosslinking of glutaraldehyde using a 3-aminopropyltriethoxysilane (APTES) surface modified silica clay as the support. The immobilized pepsin was applied for the extraction of collagen from bovine hide. The optimal immobilization process involves incubating pepsin with an initial concentration of 35 mg mL−1 and glutaraldehyde with 5% activated APTES modified silica clay at 25 °C for 60 min, by which the loading amount of pepsin was 220 mg g−1 and the activity of the immobilized pepsin was 4.2 U mg−1. The collagen extracted using acetic acid and the immobilized pepsin method retained its complete triple helix structure. This research thus details an effective separation method using pepsin for extraction of collagen via an acetic acid–enzyme method, where the extracted collagen may be a candidate for use in biomaterial applications.
研究领域:
生物化学
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材料科学
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食品科学
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DOI
PubMed
高影响因子
Microbial Cell Factories
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2023
·Vol. 22
·期 1
·1-14
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IF 6.4
Xu Lili,Qin Yimin,Song Yufeng,Tang Aixing,Liu Youyan
Background Existing methods for alkene epoxidation are based on lipase-catalysed perhydrolysis. However, the inactivation of the expensive lipase enzyme is problematic for enzymatic epoxidation at large scales due to the use of hydrogen peroxide and peracids at high concentrations in the reaction. The immobilisation of whole cells appears to be a promising approach to alleviate this problem.Results A green oxidation system containing hydrogen peroxide, Na3C6H5O7, an acyl donor, and glutaraldehyde (GA)-crosslinked cells of Rhizopus oryzae was developed for the epoxidation of alkenes. GA-crosslinked cells of Rhizopus oryzae were adopted as a biocatalyst into the epoxidation system. A variety of alkenes were oxidised with this system, with a 56–95% analytical yield of the corresponding epoxides. The catalytic performance of the crosslinked treated cells was substantially improved compared to that of the untreated cells and the initial reaction rate increased from 126.71 to 234.72 mmol/L/h, retaining 83% yields even after four batches of reactions. The addition of 3.5 mmol Na3C6H5O7 not only acts as an acid-trapping reagent to eliminate the negative effect of the carboxylic acid on the alkene oxide but also forms a saturated salt solution with the aqueous phase, affecting the concentration of H2O2 in the three phases and thus the epoxidation reaction. Organic solvents with a logP value > 0.68 were good at producing hydroxy peracids; however, this method is only suitable for oxidation in a two-liquid phase.Conclusion sCompared with other lipase biocatalysts, the GA-crosslinked whole-cell biocatalyst is inexpensive, readily available, and highly stable. Therefore, it can be considered promising for industrial applications.
研究领域:
生物化学
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酶工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Dichu Lin,Mei Shi,Xixi Wei,Bingxin Liu,Jiangfei Cao,Changsheng Peng
In this study, the capsules were prepared via the one-step titration-gel method by injecting spherical droplets of polyvinyl alcohol (PVA), sodium alginate (SA) and graphene oxide (GO) gelled mixture into the bath with calcium chloride (CaCl 2 ) and oversaturated boric acid (H 3 BO 3 ) solutions. The prepared capsules were then further modified with glutaraldehyde (GA). The formation mechanism of the prepared capsules was investigated. The morphology of the prepared capsules exhibited distinct micro-porous “3D honeycomb” pattern and hierarchical pore sizes distribution . It was also observed that GA not only acted as a co-cross-linked reagent in the fabricating process to increase the specific surface area of the capsules, but also offered exceptional tolerance property to work under a wide pH range (i.e. 2–12). The PVA-SA-GO capsules performed comparatively much better than PVA-SA capsules and they improved the adsorption capacity by up to 21.94%. Their adsorptive performance well followed the Langmuir isotherm. Moreover, the pH of the MB solution was evidently declined after adsorption, demonstrating the electrostatic attraction or ion-exchange might be the governing removal mechanism of methylene blue (MB) dye by the capsules. Importantly, the prepared capsules could be regenerated by simply washing with water and reused for at least 6 consecutive treatment cycles.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2015
·
IF 2.858
Qin Zou,Junfeng Li,Yubao Li
Chitosan microspheres with diameter of 14.3–48.5 μm were prepared by emulsion method and using natural vanillin as cross-linking agent. The surface morphology and microstructure of the microspheres were characterized by scanning electron microscopy, X-ray diffraction and Fourier-transform infrared spectroscopy, etc. The hollow microspheres showed a well-defined spherical shape with median diameter of 30.3 μm and possessed a uniform surface with micro-wrinkles, which is in favor of the drug release. Interpenetrating network cross-linking mechanism might result from the Schiff base reaction and the acetalization of hydroxyl and carbonyl between chitosan and vanillin. Berberine, as a model drug, was loaded in the microspheres and released in a sustainable manner. The drug loading ratio could change from 9.16% to 29.70% corresponding to the entrapment efficiency of 91.61% to 74.25%. In vitro cell culture study using MG63 cells and in vivo implantation clearly showed that the microspheres could provide favorable cell attachment and biocompatibility. The results confirm that the drug-loaded vanillin-crosslinked chitosan microspheres could be a worthy candidate either as carriers of drugs and cells, or as therapeutic matrix for bone repair and regeneration.
研究领域:
生物材料学
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药物递送系统
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组织工程学
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2014
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IF 4.331
Bo Li,Lijian Ma,Yin Tian,Xiaodan Yang,Juan Li,Chiyao Bai,Xiaoyu Yang,Shuang Zhang,Shoujian Li,Yongdong Jin
We proposed a new approach for preparing an efficient uranium-selective solid phase extractant (HTC-btg) by choosing bayberry tannin as the main building block and especially glyoxal as crosslinking agent via a simple, economic, and green one-pot hydrothermal synthesis. The results of characterization and analysis show that after addition of glyoxal into only bayberry tannin-based hydrothermal reaction system, the as-synthesized HTC-btg displayed higher thermal stability, larger specific surface area and more than doubled surface phenolic hydroxyl groups. The sorption behavior of the sorbents toward uranium under various conditions was investigated in detail and the results indicated that the process is fast, endothermic, spontaneous, and pseudo-second-order chemisorption. The U(VI) sorption capacity reached up to 307.3 mg g −1 under the current experimental conditions. The selective sorption in a specially designed multi-ion solution containing 12 co-existing cations over the range of pH 1.0–4.5 shown that the amount of uranium sorbed accounts for about 53% of the total sorption amount at pH 4.5 and distinctively about 85%, unreported so far to our knowledge, at pH 2.0. Finally, a possible mechanism involving interaction between uranyl ions and phenolic hydroxyl groups on HTC-btg was proposed.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
RSC Advances
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2021
·Vol. 11
·期 62
·38982-38989
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IF 3.361
Zang Chuanfeng,Han Xiangye,Dong Erying,Shen Feiyu,Yan Tingting,Wang Runyue,Zhang GuangyuYu
A new type of nanofiber membrane was prepared by mixed electrospinning of cellulose diacetate and amino-terminated hyperbranched polymer (HBP-NH2), and glutaraldehyde (GA) crosslinking was used to improve its water resistance and shape retention. pH, adsorption time, and initial solution concentration on Cu(II) and Cr(VI) ions were studied. Results showed that the prepared GA-CDA/HBP-NH2 nanofiber had good spinning uniformity, hydrophilicity, and adsorption effect on Cu(II) and Cr(VI) ions compared with the pure CDA nanofiber. The maximum adsorption capacity of GA-CDA/HBP-NH2 for Cu(II) and Cr(VI) was 50.2 and 176.6 mg g−1, respectively.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 105
·60460-60466
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IF 3.708
Shuxian Huang,Zuoyi Xiao,Shangru Zhai,Bin Zhai,Feng Zhang,Qingda An
To enhance the stability of a catalyst that uses alginate as a carrier, Ag nanoparticle-loaded glutaraldehyde-crosslinked calcium alginate (Ag/CA@GTA) hydrogel beads were prepared. The Ag/CA@GTA hydrogel beads were characterized by UV-visible spectroscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, transmission electron microscopy and X-ray photoelectron spectroscopy analyses. Given that the mechanical strength of the support was remarkably enhanced by crosslinking alginate with GTA, the resulting Ag/CA@GTA beads exhibited high stability and durable activity, with more than 97% conversion within 10 successive cycles, for the catalytic reduction of 4-nitrophenol to 4-aminophenol by NaBH4 in aqueous solution. These Ag/CA@GTA hydrogel beads were expected to have potential as a highly efficient, cost-effective and eco-friendly heterogeneous catalyst for industrial applications.
研究领域:
材料科学
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催化化学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 29
·5818-5828
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IF 6.331
Yifan Zhang,Xiaojie Li,Guanghang Bai,Wei Wei,Xiaoya Liu
Bioadhesives crosslinked with dynamic bonds exhibit shear-thinning, self-healing, and on-demand detachment properties, but generally show a weak bonding performance due to their poor bulk strength. Obtaining a strong bioadhesive with reversible crosslinking remains a challenge. To address this issue, herein we engineered a dynamic thiol–aldehyde crosslinked solvent-free adhesive based on hyperbranched polymer. The adhesive was obtained by directly mixing a liquid hyperbranched polymer with thiol end groups (HBPTE) and benzaldehyde-terminated polyethylene glycol (PEGCHO) without any additional catalyst or solvent. The solvent-free strategy yielded a dense crosslinking structure with many aldehyde groups, so this HBPTE–PEGCHO adhesive can strongly bond to tissue and various non-biological substrates. In addition, the HBPTE–PEGCHO adhesive has self-healing and thermo-reversible bonding properties due to the dynamic thiol–aldehyde crosslinking matrix. In vivo wound healing experiments show that this HBPTE–PEGCHO adhesive is tissue-benign, suggesting it can be applied in clinical practice. Combining the hyperbranched polymer-based solvent-free strategy and dynamic thiol–aldehyde crosslinking chemistry provides a simple but effective way to engineer a multifunctional bioadhesive with the desired bonding performance.
研究领域:
材料科学
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生物医学工程
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组织工程
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Shanshan Chen,Li-Ming Zhang
Pickering emulsion stabilized by colloidal particles is attracting increasing attention in recent years, and emulsions using food-grade or biocompatible particle stabilizers will be less restrained in biomedical applications. In this work, we demonstrated that the casein nanogels (CSNs) prepared by crosslinking casein, a natural protein with good biocompatibility, with glutaraldehyde could be used as effective stabilizers for Pickering high internal phase emulsions (HIPEs) without any other additives. The CSNs had an average diameter of 179 nm and a zeta potential of -16.4 mV at pH 7 with spherical morphologies. Emulsions were fabricated using CSNs as stabilizers under various conditions with three main variables including CSN concentration, pH and ionic strength , and characterized by fluorescence microscopy , photography and rheological measurement. It was found that CSNs could effectively adsorb on oil-water interface when their surface potential was close to neutrality under certain pH and ionic strength conditions and thereby assist in forming stable oil-in-water (O/W) Pickering HIPEs, even at a low CSN concentration of 0.5 wt%. To exploit the potential of these Pickering HIPEs in drug delivery, indomethacin (IDM) as a hydrophobic drug model was encapsulated into the oil phase. In vitro release experiment showed that the release behavior of IDM could be tuned by manipulating the CSN concentration. Overall, this work demonstrated that the casein nanogels could efficiently stabilize HIPEs and these HIPEs have a potential application in drug delivery system.
研究领域:
食品科学
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生物医学工程
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胶体化学
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产品关联
DOI
高影响因子
KEY ENGINEERING MATERIALS
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2017
·
IF 0
Fang Yu Zhan,Kun Yan Wang,Miao Miao Niu
Glutaraldehyde cross-linked silk sericin films were successfully prepared. FTIR was applied to characterize the chemical structure of films. Compared to pure silk sericin, cross-linked silk sericin film with 3% glutaraldehyde was found a new peak at 1620 cm-1 and the peak intensity of cross-linked film decreased markedly, which indicating cross-linking reaction has been occurred. Thermal and swelling behavior of cross-linked films was investigated. The cross-linking reaction increased the thermal decomposition temperature. The swelling ratio of glutaraldehyde cross-linked silk sericin films went up with increasing glutaralehyde loading to 3wt%.
研究领域:
生物材料学
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生物化学
✓ 已验证
DOI
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Fan Zhang,Meng-hang Gao,Chao-qun Wu,Jing-hui Yang,Nan Zhang,Yong Wang
In today’s electric power systems, biodegradable and environmentally benign dielectric materials with outstanding dielectric capabilities are essential. Here, a hybrid filler MXene@PDA (M@P) was acquired by coating MXene with polydopamine (PDA), and then it was added into cellulose matrix to manufacture regenerated cellulose/M@P (RC/M@P) composite films. Finally, a crosslinking strategy with glutaraldehyde (GA) assistance was developed to further modify the RC/M@P composite films. The crosslinked composite films (CRC/M@P) had a denser structure with fewer defects, considerably decreased dielectric loss, and significantly strengthened breakdown strength. The highest energy storage density of 3.37 J/cm 3 was obtained for CRC/M@P-1 composite film with only 1 wt% M@P at 361.07 MV/m, achieving significant enhancement compared with the original CRC film. Moreover, crosslinking also contributed to the CRC/M@P for achieving better mechanical properties. The excellent comprehensive performances endow CRC/M@P composite films with promising application for the next-generation dielectric capacitors.
研究领域:
材料科学
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环境科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）