LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Tianqi Cui,Yuxue Sun,Yue Wu,Jiarong Wang,Yangyue Ding,Jianjun Cheng,Mingruo Guo
Novel gelatin/dialdehyde starch (GDS) hydrogels based on gelatin were prepared using dialdehyde starch as a macromolecular crosslinking agent. Fourier transform infrared spectroscopy , Raman spectroscopy , and X-ray diffraction showed that the dynamic hydrogel network was formed by covalent imine bonds and hydrogen bonds between dialdehyde starch and gelatin. The synergistic physical and chemical cross-linking endowed the hydrogels with excellent mechanical properties (maximum compressive stress was 0.55 MPa), fatigue resistance (they maintained their shape after ten compression cycles), toughness (54.6 kN/m 2 ), and self-recoverability of the polymeric network. In the rheological tests, all the storage modulus were higher than loss modulus, indicating that they are elastic gels and not viscous sols. The polymer network of GDS hydrogels could recover rapidly when subjected to oscillating shear strain. In addition, with increasing dialdehyde starch concentration, the hydrogels had higher swelling stability and a denser microstructure. Given these excellent properties, the hydrogels have potential application prospects as cell culture scaffolds and carriers of bioactive substance.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2016
·
IF 4.712
Shiju Wu,Cuicui Cai,Jing Cheng,Min Cheng,Hongbin Zhou,Jiali Deng
In order to highly enrich two liver cancer biomarkers (hexanal and 2-butanone) in human blood, in this study, natural nontoxic polydopamine/dialdehyde starch/chitosan (PD/DAS/CHI) coating material was synthesized and immobilized on the inner wall of polytetrafluoro-ethlyene (PTFE) tube. It was used to develop the method based on in-tube solid-phase microextraction (IT-SPME) with in-situ derivatization (ISD) coupled to high performance liquid chromatography for the determination of the above mentioned two liver cancer biomarkers in human blood. The simple, rapid and sensitive IT-SPME-ISD method can be finished within 11 min. Under optimum conditions, the limits of detection (LODs) were 1.4 and 1.6 nmol L −1 for hexanal and 2-butanone, respectively. The relative recoveries from real human blood samples were in the range from 70% to 91% with the intra- and inter-day precisions less than 7.2%. Furthermore, this method was successfully applied for the analysis of hexanal and 2-butanone in blood samples from healthy people with 0.42 ± 0.05 and 0.34 ± 0.04 μmol L −1 , while liver cancer patients with 1.90 ± 0.07 μmol L −1 and 0.91 ± 0.07 μmol L −1 , respectively. The t -test's results showed there is a statistically significant difference between the data from healthy persons and liver cancer patients. Hence, the developed method might be applied in the screening of suspected liver cancer patients.
研究领域:
分析化学
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医学
·
生物化学
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DOI
PubMed
高影响因子
Food Bioscience
·
2021
·
IF 4.24
Pengkai Wang,Yao Wang,Pengzhi Hong,Chunxia Zhou
In this study, 2,3-dialdehyde starch crystal was used as a novel and low-toxicity bio-crosslinker to design composite gelatin-based films with both superior mechanical and barrier properties. The starch crystal containing aldehyde group was fabricated via periodate oxidation as an efficient cross-linker to reinforce the gelatin-based bio-composite films. X-ray photoelectron spectroscopy (XPS) and 1 Hydrogen nuclear magnetic resonance ( 1 H-NMR) revealed that di-aldehyde starch crystal (Di-SC) could react and covalently cross-link with the amine group of gelatin molecules via C=N chemical bond. The tensile strength of gelatin film containing 10% di-aldehyde starch crystal (G/Di-SC-10%) exhibited a tensile strength of 70.8 MPa, which was 967% higher than that of neat gelatin film (6.7 MPa). Additionally, the hydrophobic properties, thermal stability and surface morphology of G/Di-SC-10% were significantly enhanced, and so was its UV-barrier shield efficiency. Our results indicate that the new gelatin/di-aldehyde starch crystal bio-composite film has potential practical applications in the edible film-based packaging industry.
研究领域:
材料科学
·
食品科学
·
生物化学
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DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 5
·1608-1621
·
IF 3.4
Xujian Li,Xumin Chen,Zhixiao Ji,Luqi Pan,Yi Liu,Xiao Yang,Changcan Shi
Rapid hemostasis, biosafety, and adaptability to different bleeding sites are the focus of research on hemostatic materials. In this work, an efficient and simple preparation of aldehyde starch hemostatic microspheres (ASHMs) crosslinked with L-cystine dimethyl ester was developed. Through a series of physicochemical parameters and in vitro and in vivo hemostatic properties measurements, the results showed that under the optimal crosslinking degree, ASHMs had a regular and uniform spherical shape, and it had a liquid suction capacity of up to 880%. At the same time, the aldehyde groups on its surface can increase the adhesion and aggregation of blood cells, thereby enhancing the hemostatic effect, which can be considered as a synergistic effect. More importantly, ASHMs have good biocompatibility and minimal intradermal irritation. Taken together，ASHMs could be used as potential novel hemostatic materials for surgical treatment.
研究领域:
生物材料学
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医学工程
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外科治疗
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Na Wen,Shaoyu Lü,Chunmei Gao,Xiubin Xu,Xiao Bai,Can Wu,Piao Ning,Mingzhu Liu
Both blood stability and glucose responsiveness for carriers are the most important issues in insulin controlled release studies. However, few reports focus on reducing macrophage response performance for drug carriers themselves. Zwitterionic self-assembled micelles mitigated recognition by immune cell has evolved to address this limitation. In this work, novel zwitterionic dialdehyde starch-based micelles, sulfobetaine (SB) as the hydrophilic shell, and 3-aminophenylboronic acid (APBA) as glucose-responsive groups to the dialdehyde starch (DAS) backbones (SB-DAS-APBA) with glucose-responsive behavior were developed. Insulin release from the nanocarriers is sensitive to the different concentration of the glucose, rapidly at the condition of 3 mg/mL of glucose at pH 7.4. Methyl thiazolyl tetrazoliumviability (MTT) assay confirmed that zwitterion micelles were cytobiocompatible and low cytotoxic activity with A549 cells. For comparison, PEGylation micelles, monomethyl ether (mPEG) as the hydrophilic shell, and APBA as glucose-responsive groups to the DAS backbones (mPEG-DAS-APBA), were also synthesized. Confocal laser scanning microscopy (CLSM) and flow cytometry results displayed that PEGylation and zwitterion coating micelles have different recognition processes in contact with macrophages. After 4 h, doxorubicin (Dox) fluorescence of the Dox-loaded mPEG-DAS-APBA micelle groups were mostly located in nuclei. However, SB-DAS-APBA micelle groups were slightly detected in both nuclei and cytosol. In addition, the fluorescence signals of mPEG-DAS-APBA micelles showed enhanced trend than that of SB-DAS-APBA micelles in macrophage cells. These results suggest that, as drug carriers, zwitterionic self-assembled micelles SB-DAS-APBA not only possessed glucose-responsive insulin delivery property, but also reduced macrophage response performance.
研究领域:
药学
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生物材料
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药物递送系统
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Huihui Wang,Aying Wen,Yuhang Du,Shaofeng Yuan,Hang Yu,Weirong Yao
Chemical detergents are extensively used to remove pesticide residues and foodborne pathogens on fresh fruits, but their residues are toxic to humans. To address this issue, a dual-functional starch copolymer, specifically dialdehyde starch-grafted ε-polylysine copolymer (DIA-ε-PL starch), was synthesized utilizing native starch with surfactant properties and the natural antimicrobial cationic peptide ε-polylysine (ε-PL). The effectiveness of DIA-ε-PL starch as a fruit detergent was subsequently evaluated. Raman imaging and HPLC results indicated that the removal efficiency of chlorothalonil (CHT) reached 96.62% under the optimal conditions which involved washing apples with a 1% corn-DIA-0.16-ε-PL solution at 30°C for 15 min. Compared to traditional washing reagents, DIA-ε-PL starch not only exhibited higher CHT removal efficiency without migrating into apple tissues but also demonstrated superior antibacterial effect against S. aureus (94.64%) and E. coli (98.78%). The DIA-ε-PL starch exhibits significant potential as a fruit-specific detergent due to its non-toxicity, economy, sustainability, and eco-friendliness.
研究领域:
食品化学
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高分子科学
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环境科学
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农业技术
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Ying Li,Jin-Hua Wang,Yu Han,Fu-Hao Yue,Xin-An Zeng,Bo-Ru Chen,Man-Qin Zeng,Meng-Wai Woo,Zhong Han
The structural and physicochemical properties changes of corn starch oxidized by sodium periodate under the assistance of pulsed electric fields (PEF) were studied. It was found that dialdehyde starch (DAS) particles produced by PEF-assisted oxidation exhibited shrinkage and pits, and had a larger particle size when compared to the control without PEF. The solubility of the DAS (12 kV/cm PEF- assisted oxidation) improved by 70.2% when compared to the native starch. Increment in the strength of the PEF, led to a decrease in the viscosity of the DAS. In addition, the aldehyde group content of the DAS produced by PEF-assisted oxidation exhibited shrinkage and pits, and had a larger particle size when compared to the control increased by 11.6% when compared with the traditional oxidation method. PEF is an effective method to promote oxidation reaction of starch.
研究领域:
食品科学
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化学工程
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Foods
·
2023
·Vol. 12
·期 20
·3807
·
IF 5.2
Yixi Li,Yulong Qiu,Hongman Hou,Gongliang Zhang,Hongshun Hao,Jingran Bi
In this paper, amino-carboxymethyl chitosan (ACC) was prepared through amino carboxymethylation, which introduces -COOH and -NH2groups to the chitosan (CS) chains. Meanwhile, dialdehyde starch (DAS) was produced by oxidizing corn starch using sodium periodate. To attain the optimal loading and long-time release of ε-polylysine (ε-PL), the ACC/DAS hydrogels were synthesized through the Schiff base reaction between the amino group on ACC and the aldehyde group in DAS. The molecular structure, microcosmic properties, loading capacity, and bacteriostatic properties of the four types of hydrogels containing different mass concentrations of ACC were investigated. The results showed that the dynamic imine bond C=N existed in the ACC/DAS hydrogels, which proved that the hydrogels were formed by the cross-linking of the Schiff base reaction. With the increasing mass concentration of the ACC, the cross-sectional morphology of the hydrogel became smoother, the thermal stability increased, and the swelling behavior was gradually enhanced. The tight network structure improved the ε-PL loading efficiency, with the highest value of 99.2%. Moreover, the loading of ε-PL gave the hydrogel good antibacterial properties. These results indicate that ACC/DAS hydrogel is potential in food preservation.Keywords:hydrogel;amino-carboxymethyl chitosan;dialdehyde starch;antimicrobial peptide;bacterial inhibition
研究领域:
材料科学
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化学工程
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生物技术
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食品科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Guowen Zhou,Xiaoqian Zhang,Zepeng Lei,Haonan Zhou,Xiaohui Wang
Starch-based plastics offer a potential solution to environmental pollution and can reduce the dependence on petroleum-based plastics. However, effectively preparing starch-based plastics with moisture resistance and high strength remains challenging. Herein, dialdehyde starch (DAS) with different degrees of oxidation was first synthesised. The molecular weight and crystallinity of DAS decreased depending on the aldehyde content, as determined through scanning electron microscopy, X-ray diffraction and molecular weight analyses. Subsequently, a sustainable starch plastic (DAS-DA) was prepared via the dynamic imine crosslinking of DAS with diamines. The influence of the degree of oxidation of DAS on the structure and properties of DAS-DA was systematically investigated. No linear relationship was observed between the tensile strength of DAS-DA and the aldehyde content of DAS. When the aldehyde content was 41.1 %, the resulting DAS41-DA exhibited optimal mechanical strength (27.8 MPa), exceeding that of most reported starch-based plastics. In addition, owing to the presence of imine crosslinking networks, DAS41-DA exhibited excellent water and solvent resistance (>60 days), good thermal stability (456 °C–462 °C) and excellent reprocessability and biodegradability. These findings provide a theoretical basis for the preparation of high-performance bioplastics from aldehyde-containing polysaccharides.
研究领域:
材料科学
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环境科学
·
高分子化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Yuhan Wang,Huihuang Ma,Shuni Ying,Jianfei Gao,Xiaodong Zhou
Starch is considered an ideal alternative to petroleum-based plastics. However, the application of thermoplastic starch (TPS), which produced from cassava starch plasticized with glycerol, is limited by its hydrophilic, poor mechanical properties, and inadequate processability. In this study, dialdehyde starch (DAS) is used as crosslinker to modify TPS/poly(vinyl alcohol) (PVA), and DAS crosslinked cassava starch/PVA blends are fabricated by melt mixing method. Studies on the molecular structure of DAS crosslinked cassava starch/PVA blend indicate that the addition of DAS enhances the intermolecular interactions between cassava starch and PVA, resulting in the formation of a dense internal structure. The plasticizing torque and equilibrium torque of crosslinked cassava starch/PVA blends are increased and the tensile strength reaches 3.60 MPa, an improvement of 186% compared with TPS. Additionally, the water contact angle increases from 87.8° to 119.6° after modification. Compared with other crosslinkers, DAS has obvious advantages, making the DAS crosslinked cassava starch/PVA blend a biodegradable material with excellent properties and promising application prospects.
研究领域:
材料科学
·
高分子科学
·
生物降解材料
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yue Xin,Wenshuo Gao,Guang Zeng,Shousen Chen,Jijin Shi,Wenquan Wang,Ke Ma,Baoliu Qu,Jun Fu,Xin He
Conductive hydrogel which belongs to a type of soft materials has recently become promising candidate for flexible electronics application. However, it remains difficult for conductive hydrogel-based strain sensors to achieve the organic unity of large stretchability, high conductivity, self-healing, anti-freezing, anti-drying and transparency. Herein, a multifunctional conductive organohydrogel with all of the above superiorities is prepared by crosslinking polyacrylamide (PAM) with dialdehyde starch (DAS) in glycerol-water binary solvent. Attributing to the synergy of abundant hydrogen bonding and Schiff base interactions caused by introducing glycerol and dialdehyde starch, respectively, the organohydrogel achieved balanced mechanical and electrical properties. Besides, the addition of glycerol promoted the water-locking effects, making the organohydrogel retain the superior mechanical properties and conductivity even at extreme conditions. The resultant organohydrogel strain sensor exhibits desirable sensing performance with high sensitivity (GF = 6.07) over a wide strain range (0–697 %), enabling the accurate monitoring of subtle body motions even at −30 °C. On the basis, a hand gesture monitor system based on the organohydrogel sensors arrays is constructed using machine learning method, achieving a considerable sign language recognition rate of 100 %, and thus providing convenience for communications between the hearing or speaking-impaired and general person.
研究领域:
材料科学
·
柔性电子
·
传感器
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Tianqi Cui,Yue Wu,Chunlei Ni,Yuxue Sun,Jianjun Cheng
A hydrogel carrier was prepared by synergistic cross-linking of dynamic imine bonds and hydrogen bonds between gelatin and dialdehyde starch (DS). The dynamic gelation process and rheological and mechanical properties of hydrogels with different concentrations of DS were studied by dynamic rheology and texture analysis. By changing the content of DS, the gelation kinetics of the hydrogel were adjusted to determine the different gelation times and ensure good injectability. Hydrogels have a stable and firm network structure, and the network can regenerate rapidly after dissociation and collapse. The hydrogel had self-recovery and fatigue resistance, and its hardness, elasticity, deformation capacity, compressive strength and modulus increased with increasing DS content. The hydrogel had good pH-dependent controlled-release ability for curcumin . Injectable hydrogels with biocompatibility, tunable mechanical properties and self-healing properties were used as drug or nutrient delivery carriers for more controlled placement and release.
研究领域:
材料科学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）