WATER RESEARCH
·
2016
·
IF 5.991
Peng Zhang,Weiyu Yao,Songhu Yuan
The release of arsenic (As) from the oxidation of As-rich pyrite is an important source of the high arsenic in groundwater. As a widespread low-molecular-weight organic acid , citrate plays an important role on the cycling of Fe(II)/Fe(III) through complexation in circumneutral subsurface environments, while the influence of citrate on the release of As from the oxidation of As-rich pyrite is poorly understood. In this study, As was loaded onto pyrite particles under anoxic conditions , and its release was investigated in the presence of 0–1 mM citrate at pH 7.4 under oxic conditions . As-loaded pyrite suspension was prepared by the equilibrium of 2.67 μM As(III) in 10 g/L pyrite under anoxic conditions with the decrease in dissolved As(III) concentration to 1 μM. The suspension was subsequently exposed to air for oxygenation. In the absence of citrate, the oxygenation decreased the partitioning of As in the solution because of the re-adsorption of aqueous As by the in situ generated Fe(III) oxyhydroxides. However, with the increase in citrate concentration from 0.1 to 1 mM, the As partitioned in the solution increased from 0.3 to 2.67 μM. In the presence of 1 mM citrate, the As(III) was almost completely oxidized to As(V) during the oxygenation. The mechanisms of citrate-enhanced release of As were mainly attributed to the ligand exchange of citrate with As for pyrite surface sites, the competitive adsorption of citrate with As on Fe(III) oxyhydroxides and pyrite, and the partitioning of As on the newly formed Fe(III) colloids. This finding presents an overlooked mechanism of the release of pyrite-associated As under oxic and circumneutral conditions.
研究领域:
环境科学
·
地球化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Shujie Wang,Yuyue Qin,Yaping Liu,Guoqin Liu,Guiguang Cheng,Thanapop Soteyome
In this study, three types of β -sitosterol-based oleogels ( β -sitosterol + γ -oryzanol oleogels, β -sitosterol + lecithin , oleogels and β -sitosterol + monostearate oleogels), loaded with astaxanthin, were employed as the oil phase to create oleogel-based emulsions (SO, SL, and SM) using high-pressure homogenization. The microstructure revealed that fine-scale crystals were dispersed within the oil phase of the droplets in the β -sitosterol oleogel-based emulsion. The bioaccessibility of astaxanthin was found to be 58.13 %, 51.24 %, 36.57 %, and 45.72 % for SM, SL, SO, and the control group, respectively. Interestingly, the release of fatty acids was positively correlated with the availability of astaxanthin (P = 0.981). Further analysis of FFAs release and kinetics indicated that the structural strength of the oil-phase in the emulsions influenced the degree and rate of lipolysis. Additionally, the micellar fraction analysis suggested that the nature and composition of the oleogelators in SM and SL also impacted lipolysis and the bioaccessibility of astaxanthin. Furthermore, interfacial binding of lipase and isothermal titration calorimetry (ITC) measurements revealed that the oleogel network within the oil phase of the emulsion acted as a physical barrier, hindering the interaction between lipase and lipid. Overall, β-sitosterol oleogel-based emulsions offer a versatile platform for delivering hydrophobic molecules, enhancing the bioavailability of active compounds, and achieving sustained release.
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Yaning Li,Boliang Wang,Zhiwei Han
The preparation and energy release mechanism of highly reactive n-Al/F-polymer metastable intermixed composites are both desirable and challenging. In this study, we employed an optimized electrospray sampling strategy to significantly enhance the reaction activity of aluminum-based MICs, as well as their combustion performance. It is evident that the optimization of the sampling strategy yielded remarkable results. Compared to the physical mixture, MICs-1 exhibited a 7.2-fold and 9.9-fold increase in P max and P max /Δ t , respectively. The combustion rate experienced an 8.5-fold improvement, and the energy release efficiency rose from 52.18 % to 68.11 %. An analysis of the energy evolution mechanism reveals a mitigation of the reactive sintering phenomenon observed in MICs-1. The presence of PVDF facilitates the reactivity of aluminum powders by selectively corroding the alumina shell. The reaction kinetics parameters indicate that MICs-1 demonstrates characteristic three-step reaction behavior and exhibits a lower reaction energy barrier. Furthermore, ReaxFF molecular dynamics simulations demonstrate the adsorption and dissociation of PVDF on the surface of aluminum powders, leading to erosion defects in the alumina crystal structure. These defects, in turn, induce the ignition reaction.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Sicheng Yao,Naiying Chen,Xinxing Sun,Qiuyue Wang,Mingming Li,Yang Chen
Particle size is a key parameter to determine the capacity of nanoparticles to overcome the skin barrier; however, such effect and the possible mechanism remain only partially understood for nanosuspensions. In this work, we examined the skin delivery performance of andrographolide nanosuspensions (AG-NS) ranging in diameter from 250 nm to 1000 nm and analyzed the role of particle size in influencing their ability of skin penetration. The AG-NS with particle sizes of about 250 nm (AG-NS250), 450 nm (AG-NS450), and 1000 nm (AG-NS1000) were successfully prepared by ultrasonic dispersion method and characterized by transmission electron microscopy . The drug release and penetration via the intact and barrier-removed skin were compared by the Franz cell method, and the related mechanisms were probed using laser scanning confocal microscopy (LSCM) via visualization of penetration routes and histopathological study via observation of structural change of the skin. Our finding revealed that drug retention in the skin or its sub-layers was increased with the reduction of particle size, and the drug permeability through the skin also exhibited an obvious dependence on the particle size from 250 nm to 1000 nm. The linear relationship between the in vitro drug release and ex vivo permeation through the intact skin was well established among different preparations and in each preparation, indicating the skin permeation of the drug was mainly determined by the release process. The LSCM indicated that all these nanosuspensions could deliver the drug into the intercellular lipid space, as well as block the hair follicle in the skin, where a similar size dependence was also observed. The histopathological investigation showed that the formulations could make the stratum corneum of the skin loose and swelling without severe irritation. In conclusion, the reduction of particle size of nanosuspension would facilitate topical drug retention mainly via the modulation of drug release.
研究领域:
药剂学
·
皮肤科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Arun K. Kodoth,Vivek M. Ghate,Shaila A. Lewis,Vishalakshi Badalamoole
Pectin-based gel and its nanocomposite with zinc oxide have been compared for their capacity to release Donepezil for the possible use as an implantable drug delivery platform for the treatment of Alzheimer's disease. Adsorption capacities of the samples were determined as a function of pH, temperatures, concentrations of the drug, and the mass of the adsorbent. The nanocomposite exhibited significant adsorption compared to the parent gel. Adsorption data for the nanocomposite system fits well with Langmuir model and followed pseudo-first order kinetics, while that of the parent polymeric system followed pseudo-second-order kinetics. Donepezil adsorbed polymeric samples were prepared and evaluated for tensile strength , swelling index, folding endurance and characterized by FTIR, FESEM, EDS , XRD and TGA techniques. The desorption of zinc oxide was also monitored using the dynamic light scattering technique. The in vitro drug release study indicated desorption of Donepezil to the maximum extent of ~88% and 46% during 5 days period from the nanocomposite and the parent gel respectively. The developed systems showed negligible (<10%) percentage of hemolysis after incubation with sheep erythrocytes. In conclusion, the developed pectin-based nanocomposite can be explored as a potential platform for the development of implantable drug delivery systems for chronic diseases.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2024
·Vol. 25
·期 6
·1-14
·
IF 3.4
Li Xing,Liang Kaili,Dong Yingying,Li Shen,Gao Zhengnan,Wang Qing
In recent years, there has been a significant increase in the prevalence of thyroid diseases, particularly hypothyroidism. In this study, we investigated the impact and mechanisms of Chemical permeation enhancement(CPE) on transdermal permeation of levothyroxine sodium (L-T4) patches.We found that the combination of oleic acid (OA) and Azone (NZ) yielded the best transdermal permeation effect for L-T4.Subsequently, we also investigated the relevant propermeability mechanism.The results demonstrate that the combined application of OA and NZ significantly enhances the transdermal permeation of L-T4 compared to individual applications,it is attributed to two mechanisms: firstly, OA improves drug release by increasing the flowability of the pressure-sensitive adhesive (PSA) matrix; secondly, both OA and NZ act on the stratum corneum, especially facilitating L-T4 permeation through the hair follicle pathway. No skin irritation or cytotoxicity is observed with these final patches, which exhibit a remarkable therapeutic effect on hypothyroidism. this study contributes to the development of transdermal formulations of L-T4. Graphical Abstract
研究领域:
药剂学
·
皮肤科学
·
内分泌学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2018
·
IF 3.466
Qiaoyun Li,Xiaocao Wan,Chao Liu,Liang Fang
The aim of this study was to prepare a drug-in-adhesive patch of nicotine (NIC) and use ion-pair strategy to regulate drug delivery rate. Moreover, the mechanism of how ion-pair strategy regulated drug release was elucidated at molecular level. Formulation factors including pressure sensitive adhesives (PSAs), drug loading and counter ions (C 4 , C 6 , C 8 , C 10 , and C 12 ) were screened. In vitro release experiment and in vitro transdermal experiment were conducted to determine the rate-limiting step in drug delivery process. FT-IR and molecular modeling were used to characterize the interaction between drug and PSA. Thermal analysis and rheology study were conducted to investigate the mobility variation of PSA. The optimized patch prepared with NIC-C 8 had the transdermal profile fairly close to that of the commercial product ( p > 0.05). The release rate constants ( k ) of NIC, NIC-C 4 and NIC-C 10 were 21.1, 14.4 and 32.4, respectively. Different release rates of NIC ion-pair complexes were attributed to the dual effect of ion-pair strategy on drug release. On one hand, ion-pair strategy enhanced the interaction between drug and PSA, which inhibited drug release. On the other hand, using ion-pair strategy improved the mobility of PSA, which facilitated drug release. Drug release behavior was determined by combined effect of two aspects above. These conclusions provided a new idea for us to regulate drug release behavior from patch.
研究领域:
药剂学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Peng Zhou,Xiangzhou Li,Zhi Jiang,Jun Zhou,Liqun Shen
Constructing carrier materials with polysaccharides to enhance the solubility of insoluble active ingredients is a crucial strategy for improving bioavailability. This research constructed pectin-based hesperidin microcapsules (PHM) through self-assembly processes in the deep eutectic solvent , improving the solubility, storage stability, and bioavailability of hesperidin (HES). PHM exhibited high encapsulation efficiency (91.7%) and loading capacity (11.5%), with a small particle size (1.73 μm). The interaction mechanism was clarified through physical characterization and density functional theory (DFT) calculations. The vitro release demonstrated that the release ratio of PHM was only 6.4% in simulated gastric fluid (SGF), but reached 80.9% in simulated intestinal fluid (SIF). The release mechanism of PHM in SGF followed Fickian diffusion, while in SIF followed skeleton dissolution diffusion with a stable rate. Furthermore, the cell cytotoxicity experiments confirmed the remarkable biocompatibility of PHM toward human colon cells, which suggested its potential application in food and pharmaceutical fields.
研究领域:
食品科学
·
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 38
·9246-9259
·
IF 7
Fusheng Zhang,Gongcui Pei,Baihao Huang,Jianchang Xu,Lijuan Zhang
π–π stacking strategies can enhance the stability performance of delivery platforms but are often restricted by incomplete drug release performance, even with the help of crosslinking strategies. Therefore, there has been considerable interest in enhancing the drug release performance by disrupting the π–π stacking region (structural rearrangements). Herein, we synthesized poly(3-(isobutyloxy)-2-oxopropyl benzoate)-b-poly(2-hydroxybutyl methacrylate)-co-poly((ethylene glycol)methylether methacrylate) [PBOOPMA-b-P(HBMA-co-PEGMA), PHB] and revealed the drug release mechanism of PHB-based micelles. The structural rearrangements derived from the crosslinking strategy were revealed to improve the early release performance by 43–55% using micellar dissolutions. Moreover, the esterase-responsive strategy was elucidated to induce reassembly with 77–79% size variation, intensifying the structural rearrangements, which was also synergistic with the crosslinking strategy. Based on the advantages of improving drug release performance, the esterase-responsive strategy was considered a promising candidate for enhancing late release performance. Meanwhile, it is believed that such responsive modulation (crosslinking, esterase-responsive) in the π–π stacking region will become highly promising for subsequent research. Finally, the biosafety of 95.81% at 400 mg L−1 and drug cytotoxicity of IC50 ≈ 2.5 mg L−1 of PHB-EDE@CPT were also validated, confirming the broad application prospects of PHB-based crosslinked micelles.
研究领域:
药剂学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Arabian Journal of Chemistry
·
2015
·
IF 3.725
Shifeng Li,Yanming Shen,Min Xiao,Dongbin Liu,Lihui Fan
Controlled release formulations have been proven to have potential in overcoming the drawbacks of conventional plant growth regulators. Novel controlled-release formulation of β -naphthoxyacetic acid (BNOA) intercalated MgAl-layered double hydroxides (LDHs) was prepared by co-precipitation method. The effects of temperature, pH value, and release medium on BNOA release were studied and the releasing mechanisms were discussed. The results of release show that the increase of temperature induces the increase of BNOA release extent. The release rate and accumulated release amount of BNOA are found to be dependent to the anion in the aqueous solution in the order of CO 3 2− > SO 4 2− > Cl − . Moreover, the pH is the key controlling factor for the BNOA release processes, and with strong acid medium, the release character of BNOA is different from those at pH 7 and 12, which accompanies with fast collapse of LDHs nanolayered structure. The nanohybrid of BNOA intercalated LDHs possessed good controlled release properties and the BNOA release character from the nanohybrid fitted pseudo-second-order model in neutral medium.
研究领域:
材料科学
·
农业科学
·
植物生理学
✓ 已验证
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Xilei Yin,Yuanlong Guo,Wene Zhang,Xinjie shen,Hu Cai,Gu Guo,Xuejun Pan,Haibo Xie
Due to the superior nutrient management and biodegradation properties, the biodegradable slow-release fertilizer shows a greater market prospect and environmental protection significance in the chemical fertilizer industry. In this study, a new kind of full bio-based slow-release fertilizers (B-SRFs) encapsulated by walnut wood-based lignocellulose-grafted with poly(ε-caprolactone) (WWL- g -PCL) in the presence of urea was prepared. Considering the multi-hydroxyl structural feature of walnut wood-based lignocellulose , WWL- g -PCLs were synthesized successfully through the ring-opening graft polymerization reaction (ROP) of walnut wood and ε-caprolactone in DBU/DMSO/CO 2 solvent system without adding additional catalyst. The structural and thermal characteristics of WWL- g -PCLs were thoroughly elucidated by nuclear magnetic resonance (NMR), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimeter (DSC) and thermogravimetric analysis (TGA). The results indicated that the WWL- g -PCLs exhibited favorable thermal properties with adjustable glass transition temperature (T g ) from 20.8 to 29.3 °C compared with walnut wood-based lignocellulose, which was beneficial for melt extrusion and granulation to produce B-SRFs. Scanning electron microscope (SEM), static release in water, and tomato fertilization efficiency experiments were conducted to delve into the slow-release mechanism and assess practical application effects. Subsequently, the outstanding slow-release performance of B-SRFs was observed for cumulative nutrient releases of 48–72% within 5 h in water and agreed with the Korsmeyer-Peppas model, indicating its excellent slow-release property. Furthermore, the formulated B-SRFs demonstrated a substantial increase in tomato cumulative biomass, yield, soil organic matter , and fertilizer utilization. Notably, there was a remarkable 57.8% increase in the cumulative biomass of tomatoes. These findings underscore the potential of walnut wood derivatives in developing effective and environmentally friendly slow-release fertilizers with promising agricultural applications.
研究领域:
材料科学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD ENGINEERING
·
2023
·
IF 5.5
Jinggui Nie,Chao Xue,Yueqi An,Shanbai Xiong,Qilin Huang
This study aimed to investigate the effects and mechanisms of soluble dietary fiber (SDF), temperature and hydrophobicity on the release of fishy compounds from surimi by the preparation of real and simulated systems. The results of gas chromatography-mass spectrometry revealed 15 fishy compounds in silver carp surimi, and adding 2 wt% SDF to surimi was found to inhibit the release of 14 fishy compounds by 2.16–43.49%. The simulated release indicated that SDF matrices with different concentrations inhibited the release of fishy compounds by different mechanisms. The resistance to the release of fishy compounds was attributed to viscosity and chemisorption in 2 and 5 wt% SDF matrices, while chemisorption and entanglement network in 8 and 10 wt% SDF matrices. Moreover, high temperature and hydrophobicity of fishy compounds could promote their release by decreasing interfacial mass transfer resistance and H-bond interaction, respectively. Additionally, adding SDF changed the release pathway of fishy compounds in surimi, and they were released through the first pathway consisting of surimi intraparticle diffusion, SDF boundary layer diffusion and gas-liquid interfacial diffusion, or through the second pathway additionally including chemisorption and desorption. This study provides new insights into controlling the release of fishy odors in surimi products.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）