Frontiers in Pharmacology
·
2023
·
IF 5.6
He Jian,Xu Dengyue,Wang Lu,Yu Xiaohong
Cardiovascular disease has become the primary disease that threatens human health and is considered the leading cause of death. Cardiac remodeling, which is associated with cardiovascular disease, mainly manifests as cardiac hypertrophy, fibrosis, inflammation, and oxidative stress. Farrerol plays an important role in treating conditions such as inflammation, endothelial injury and tumors, and we speculated that Farrerol may also play an important role in mitigating cardiac hypertrophy and remodeling. We established a model of myocardial remodeling using Angiotensin II (Ang II) with concurrent intraperitoneal injection of Farrerol as an intervention. We used cardiac ultrasound, immunohistochemistry, Immunofluorescence, Wheat Germ Agglutinin, Dihydroethidium, Western Blot, qPCR and other methods to detect the role of Farrerol in cardiac remodeling. The results showed that Farrerol inhibited Ang II-induced cardiac hypertrophy; decreased the ratio of heart weight to tibia length in mice; reduced inflammation, fibrosis, and oxidative stress; and reduced the size of cardiomyocytes in vivo. Farrerol inhibited Ang II-induced cardiomyocyte hypertrophy, levels of oxidative stress, and the proliferation and migration of fibroblast in vitro. Our results revealed that Farrerol could inhibit Ang II-induced cardiac remodeling. Farrerol may therefore be a candidate drug for the treatment of myocardial remodeling.
研究领域:
心血管疾病
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-8
·
IF 16.6
Fang Zizheng,Shi Yunpeng,Mu Hongfeng,Lu Runzhi,Wu Jingjun,Xie Tao
Delicate geometries and suitable mechanical properties are essential for device applications of polymer materials. 3D printing offers unprecedented versatility, but the geometries and mechanical properties are typically fixed after printing. Here, we report a 3D photo-printable dynamic covalent network that can undergo two independently controllable bond exchange reactions, allowing reprogramming the geometry and mechanical properties after printing. Specifically, the network is designed to contain hindered urea bonds and pendant hydroxyl groups. The homolytic exchange between hindered urea bonds allows reconfiguring the printed shape without affecting the network topology and mechanical properties. Under different conditions, the hindered urea bonds are transformed into urethane bonds via exchange reactions with hydroxyl groups, which permits tailoring of the mechanical properties. The freedom to reprogram the shape and properties in an on-demand fashion offers the opportunity to produce multiple 3D printed products from one single printing step.
研究领域:
材料科学
·
化学工程
·
高分子科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2024
·
IF 14
Fengli Wei,Jinghao Shen,Jiayin Xie,Zuyang Luo,Luyan Shi,Tayirjan Taylor Isimjan,Xiulin Yang,Jieshan Qiu,Bin Wu
Understanding and manipulating the structural evolution of water oxidation electrocatalysts lays the foundation to finetune their catalytic activity. Herein, we present a synthesis of NiSe 2 -Ce 2 (CO 3 ) 2 O heterostructure and demonstrate the efficacy of interfacial Ce 2 (CO 3 ) 2 O in promoting the formation of catalytically active centers to improve oxygen evolution activity. In-situ Raman spectroscopy shows that incorporation of Ce 2 (CO 3 ) 2 O into NiSe 2 causes a cathodic shift of the Ni 2+ →Ni 3+ transition potential. Operando electrochemical impedance spectroscopy reveals that strong electronic coupling at heterogeneous interface accelerates charge transfer process. Furthermore, density functional theory calculations suggest that actual catalytic active species of NiOOH transformed from NiSe 2 , which is coupled with Ce 2 (CO 3 ) 2 O, can optimize electronic structure and decrease the free energy barriers toward fast oxygen evolution reaction (OER) kinetics. Consequently, the resultant NiSe 2 -Ce 2 (CO 3 ) 2 O electrode exhibits remarkable electrocatalytic performance with low overpotentials (268/304 mV @ 50/100 mA cm −2 ) and excellent stability (50 mA cm −2 for 120 h) in the alkaline electrolyte. This work emphasizes the significance of modulating the dynamic changes in developing efficient electrocatalyst.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2025
·
IF 3.3
Hao Yin,Bingxian Wu,Xueyang Leng,Hong Gao,Jing Yao
Electrolytic water-splitting has the advantages of high efficiency, environmental friendliness, and sustainability. It is becoming a leading approach for producing hydrogen. In order to improve the efficiency of water-splitting, a bifunctional electrocatalyst with high performance is needed. Herein, we present a novel approach to construct a bifunctional electrocatalyst for overall water-splitting by compounding Ni(OH)2 and CoP. This combination induced charge optimization, thereby leading to surface reconstruction. The nanocomposite displayed outstanding catalytic performance, benefiting from its more reactive surface area, improved conductivity and enhanced electrocatalytic activity. The resulting Ni(OH)2/CoP electrocatalyst exhibited excellent catalytic performance, with low overpotentials of 266 mV at 50 mA cm−2 for the OER and 71 mV at −10 mA cm−2 for the HER, and required only 1.54 V to reach 10 mA cm−2 in an overall water-splitting device, overtaking most of the recently reported Co- and Ni-based catalysts. This innovative strategy offers new directions for the design of efficient electrocatalysts.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2021
·
IF 6.024
Peixin Liu,Peng Jing,Xuan Xu,Baocang Liu,Jun Zhang
The electrochemical synthesis of ammonia from N2 under mild conditions is a promising alternative to the energy-consuming Haber–Bosch process. Metal–organic frameworks (MOFs) are promising electrocatalysts for the N2 reduction reaction, but most of them are active for the undesirable and competitive hydrogen evolution reaction. Herein, we developed a facile strategy to grow a Ce-MOF on copper mesh substrate. The Ce-MOF with a self-supporting structure could be directly used as an electrode for the N2 reduction reaction, demonstrating highly efficient electrocatalytic performance with an NH3 yield of 14.83 μg h–1 cm–2 and a Faradaic efficiency of 10.81% at −0.2 V versus a reversible hydrogen electrode. Structural characterizations of Ce-MOF after electrocatalysis revealed that Ce-MOF as precatalyst underwent structural reconstruction at negative potential, forming catalytically active CeO2 with oxygen vacancies embedded in the amorphous Ce-MOF. In addition, the self-supporting structure formed by in situ growth of Ce-MOF on porous and conductive cooper mesh endowed the electrocatalyst with enhanced stability, conductivity, and mass transport. This work demonstrated the structural transformation of Ce-MOF during the electrocatalytic process and provided new insight for the rational design of MOF-based electrocatalysts.
研究领域:
材料科学
·
电化学
·
催化反应
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Jing Hu,Zhanbin Feng,Xiaowei Xu,Weisheng Gao,Nanying Ning,Bing Yu,Liqun Zhang,Ming Tian
The shape memory thermoplastic polyurethane (TPU) generally exhibits a phase-separated structure, in which the hard segments form the hard domains via hydrogen bonds, and plays an important role in shape recovery. However, the physical interaction in the hard domains is always weak, resulting in a permanent deformation and thus decreasing the shape-recovery ability of TPU significantly. In this research, a new type of diol chain extender containing anthracene groups was synthesized, and the photoresponsive anthracene groups were incorporated into the hard segment of TPU. The stability in hard domains and recoverability could be tailored by different UV irradiation times via the photodimerization of anthracene groups, and the shape-recovery ratio and the shape-fixing ratio were still both above 93%, even when the strain reached 270%. More importantly, the shape-free reconfiguration is achieved through the dimerization of anthracene groups under UV irradiation, which achieved free construction of three-dimensional (3D) shapes without templates. Thus, the spontaneous shape change from two-dimensional (2D) to 3D was realized, in combination with melting transition, and the dedimerization of anthracene ensured the recyclability of polyurethane at T = 150 °C. This simple and facile strategy could be used to fabricate the recyclable and photoplasticity shape memory TPU with a high shape-fixing/recovery ratio at large deformation, and it would have a wider range of potential application in stents.
研究领域:
材料科学
·
聚合物化学
·
智能材料
✓ 已验证
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Xiaoqu Wang,Limin Wang,Yongchun Liu,Raj Kumar,Li Liu,Qiulan Huang,Dujuan Huang,You-Jun Fan,Du-Hong Chen,Wei Chen
For large-scale hydrogen production from electrocatalysis of water, the Ni- and/or Fe-based catalysts were commonly used but limited by the ultrahigh overpotential and poor stability at high current density (>500 mA cm−2). Here, the reconstruction of M(OH)x/Fe3O4 (M = Ni, Fe) arrays has been fabricated for boosting the oxygen evolution reaction (OER). The prepared M(OH)x/Fe3O4 grewon iron foam (M(OH)x/Fe3O4/IF) catalysts exhibited low overpotentials of 214 and 311 mV for OER at the current densities of 50 and 500 mA cm−2, respectively, besides the excellent stability up to 70 h of operation at a current density of 10 mA cm−2 in 1 M KOH. The in situ Raman spectra revealed that, the reconstruction of M(OH)x/Fe3O4/IF boosted the OER activity. Theoretical calculation revealed favorable absorption of O2 at Ni site of M(OH)x/Fe3O4/IF during OER. This work highlights the reconstruction structurally definite catalysts for promoting the catalytic activity toward OER and the large-scale electrocatalysis of water.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Carbon Energy
·
2024
·
IF 19.5
Zhi Cai,Mingyuan Xu,Yanhong Li,Xinyan Zhou,Kexin Yin,Lidong Li,Binbin Jia,Lin Guo,Hewei Zhao
The dynamic surface self-reconstruction behavior in local structure correlates with oxygen evolution reaction (OER) performance, which has become an effective strategy for constructing the catalytic active phase. However, it remains a challenge to understand the mechanisms of reconstruction and to accomplish it fast and deeply. Here, we reported a photo-promoted rapid reconstruction (PRR) process on Ag nanoparticle-loaded amorphous Ni-Fe hydroxide nanosheets on carbon cloth for enhanced OER. The photogenerated holes generated by Ag in conjunction with the anodic potential contributed to a thorough reconstruction of the amorphous substrate. The valence state of unsaturated coordinated Fe atoms, which serve as active sites, is significantly increased, while the corresponding crystalline substrate shows little change. The different structural evolutions of amorphous and crystalline substrates during reconstruction lead to diverse pathways of OER. This PRR utilizing loaded noble metal nanoparticles can accelerate the generation of active species in the substrate and increase the electrical conductivity, which provides a new inspiration to develop efficient catalysts via reconstruction strategies.
研究领域:
材料科学
·
电化学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
Research
·
2024
·
IF 8.5
Xi Chen,Xianghong Liu,Mohd Yasir Khan,Zuyao Yan,Dezhou Cao,Shifang Duan,Lingshan Fu,Wei Wang
Colloidal molecules, ordered structures assembled from micro- and nanoparticles, serve as a valuable model for understanding the behavior of real molecules and for constructing materials with tunable properties. In this work, we introduce a universal strategy for assembling colloidal molecules consisting of a central active particle surrounded by several passive particles as ligands. During the assembly process, active particles attract the surrounding passive particles through phoresis and osmosis resulting from the chemical reactions on the surface of the active particles, while passive particles repel each other due to the electric polarization induced by an alternating current (AC) electric field. By carefully selecting particles of varying structures and sizes, we have assembled colloidal molecules of symmetric and asymmetric dimers, trimers, and multimers. Furthermore, the coordination number of these colloidal molecules can be regulated in real time and in situ by tuning the interaction forces between the constituent particles. Brownian dynamics simulations reproduced the formation of the colloidal molecules and validated that the self-assembly arises from chemically induced attraction and electrical dipolar repulsion. This strategy for reconfigurable colloidal assemblies poses the potential for designing adaptive micro-nanomachines.
研究领域:
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemSusChem
·
2024
·
IF 7.5
Rui Yang,Xiaozhong Zheng,Hao Fu,Xinyue Cao,Yangguang Hu,Yiyin Huang
Graphical Cu 7 S 4 /Cu nanoflowers with strong CO 2 adsorption and abundant boundaries were developed by a facile thermal reduction, which underwent in situ dynamic restructuring during ECR to generate highly active S-doped Cu 2 O/Cu hybrid catalyst. Thermodynamic and experimental analysis revealed that the optimized adsorption of the HCOO * intermediate on S−Cu 2 O/Cu was regulated and surface H was suppressed by S-doping. The high activity for CO 2 -to-HCOOH attributed to the strengthen CO 2 adsorption, abundant boundaries at Cu 2 O/Cu interfaces, and the regulation of adsorption energy by S-doping Optimized catalytic properties and reactant adsorption energy played a crucial role in promoting CO 2 electrocatalysis. Herein, Cu 7 S 4 /Cu underwent in situ dynamic restructuring to generate S−Cu 2 O/Cu hybrid catalyst for effective electrochemical CO 2 reduction to formate that outperformed Cu 2 O/Cu and Cu 7 S 4 . Thermodynamic and in situ Raman spectra revealed that the optimized adsorption of the HCOO* intermediate on S−Cu 2 O/Cu was regulated and the H 2 pathway (surface H) was suppressed by S-doping. Meanwhile, Cu 7 S 4 /Cu nanoflowers created abundant boundaries for ECR and strengthened the CO 2 adsorption by inducing Cu. These findings provide a new perspective on synthetic methods for various electrocatalytic reduction processes.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Wenchao Shangguan,Guoqiang Li,Shidi Gui,Xiaodong Zhang,Sugang Meng,Shifu Chen,Yingxuan Li
Separating photoexcited holes in metallic nanostructure to drive H 2 O oxidation reaction to balance the CO 2 photoreduction reaction is highly desirable, but challenging. The bottleneck lies in the sluggish kinetics of both photoexcited hole transfer and H 2 O oxidation. Herein, this work demonstrates that the in situ reconstruction of n -type wide-bandgap AlOOH-supported Au nanoparticle heterogeneous photocatalyst, triggered by thermal and photothermal cooperative effect during photocatalytic reactions, facilitates the efficient CO 2 photoreduction through optimizing the Au 5 d -band holes separation and H 2 O activation. In situ and ex situ characterizations evidence restructuring at interfaces to form an ultrathin γ-Al 2 O 3 nanolayer (≈2 nm thickness), which optimizes the energy band structure and promotes spontaneous transfer of photoexcited Au 5 d -band holes to the valence band of AlOOH, and prolongs the lifetime of electrons available for CO 2 reduction on Au. Furthermore, hydroxyl vacancies generated during restructuring process are demonstrated to promote H 2 O adsorption and lower the energy barrier for O 2 formation, supplying adequate protons for CO 2 protonation reduction and thereby boosting CO 2 photoreduction efficiency. This study offers valuable insights into the underlying mechanisms of utilizing n -type semiconductors to separate photoexcited d -band holes in metal nanoparticles.
研究领域:
材料科学
·
催化化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-10
·
IF 23.4
Yu Mubing,Qin Tingxiao,Gao Gang,Zu Kelei,Zhang Dongming,Chen Nan,Wang Dengke,Hua Yong,Zhang Hong,Zhao Yong-Biao,Zhu Jiaqi
Deep-blue perovskite light-emitting diodes (PeLEDs) based on reduced-dimensional perovskites (RDPs) still face a few challenges including severe trap-assisted nonradiative recombination, sluggish exciton transfer, and undesirable bathochromic shift of the electroluminescence spectra, impeding the realization of high-performance PeLEDs. Herein, an in situ chlorination (isCl) post-treatment strategy was employed to regulate phase reconstruction and renovate multiple defects of RDPs, leading to superior carrier cooling of 0.88 ps, extraordinary exciton binding energy of 122.53 meV, and higher photoluminescence quantum yield of 60.9% for RDP films with deep-blue emission at 450 nm. The phase regulation is accomplished via fluorine-derived hydrogen bonds that suppress the formation of small- n phases. Multiple defects, including halide vacancies (shallow-state defects) and lead-chloride antisite defects (deep-state defects), are renovated via C=O coordination and hydroxy-group-derived hydrogen bonds. Consequently, deep-blue PeLEDs with a record maximum external quantum efficiency of 6.17% and stable electroluminescence at 454 nm were demonstrated, representing the best-performing deep-blue PeLEDs.
研究领域:
材料科学
·
光学工程
·
半导体物理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）