Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 39
·8321-8329
·
IF 6.331
Yaning Dong,Li Liu,Jin Sun,Wan Peng,Xiaohan Dong,Yahui Gu,Zhuangzhuang Ma,Donglin Gan,Pingsheng Liu
Designing a coating material with efficient bactericidal property to cope with bacterial associated infections is highly desirable for metallic implants and devices. Here, we report phosphonate/quaternary ammonium copolymers, p(DEMMP-co-TMAEMA), as the new type of metal anchorable high-efficiency antibacterial coating. Seven p(DEMMP-co-TMAEMA) polymers with varied cationic components were precisely prepared via random radical polymerization. Copolymers were constructed on titanium alloy (TC4) substrates based on strong covalent bonding between the phosphonate group and metallic substrates through a one-step process as evidenced by XPS and water contact angle tests. A robust relationship between the composition of the copolymers and the bactericidal ability endowed to TC4 substrates was established. Results showed that the copolymer, with the pDEMMP content even as low as 6.3%, was able to anchor onto TC4 substrates. With the increase of cationic pTMAEMA content from 4.0 to 93.7% in the coating copolymer, the bactericidal ability endowed to the TC4 substrates was steadily increased from 39.4 to 98.8% for S. aureus and from 70.0 to 99.4% for E. coli after 8 h's of contacting. All p(DEMMP-co-TMAEMA) coating on TC4 substrates showed limited cytotoxicity to C2C12 cells. Notably, the phosphonate/quaternary amine copolymers can be easily constructed on diverse biomedical metals such as titanium (Ti), stainless steel (SS), and Ni/Cr alloys with significantly increased antibacterial performance, demonstrating the potency of the copolymer as the general high-efficiency antibacterial coating for diverse bio-metals.
研究领域:
材料科学
·
生物医学工程
·
聚合物化学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 20
·4169-4177
·
IF 6.331
Xiao Zhang,Li Liu,Wan Peng,Xiaohan Dong,Yahui Gu,Zhuangzhuang Ma,Donglin Gan,Pingsheng Liu
Bacteria associated infection is a critical challenge for metallic implants and devices in biomedical applications. Here, we report phosphonate/zwitterionic/quaternary amine terpolymers as a new type of antifouling and bactericidal coating for metallic substrates. Through reversible-addition fragmentation chain transfer polymerization (RAFT) and quaternization, well-controlled phosphonate/zwitterionic/cationic terpolymers with identical phosphonate segments (repeat units of 15) and varied zwitterionic and cationic components (nSBMA : nTMAEMA = 64 : 0, 54 : 18, 18 : 32, 9 : 52, and 0 : 70) were precisely prepared. The polymers can be coated on TC4 substrates based on the strong coordination between phosphonate groups and metallic substrates, as evidenced by water contact angle and XPS tests. Bactericidal evaluation revealed that the antibacterial efficiency was enhanced with the increase of cationic content in the coating polymers. TC4 substrates coated with the polymer coating with a cationic segment of 70 repeat units were able to kill 97.5 and 94.0% of S. aureus and E. coli, respectively. By virtue of the antifouling ability of the zwitterionic component and the bactericidal ability of the cationic component, the antibacterial efficiency was increased to 99.5% without significant compromising of the cytocompatibility. Meanwhile, the dual functional terpolymers could be easily applied on other metallic substrates, such as titanium, stainless steel, and Ni/Cr alloy, which were able to kill up to 97.9% of S. aureus and 99.9% of E. coli, respectively, endowing the excellent antibacterial properties to general bio-metals. The high-efficiency antibacterial modification strategy demonstrated here may find many applications on metallic implants and devices to combat bacterial associated infections.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 10
·4762-4771
·
IF 3.925
Huijuan Zhang,Li An,Xue Wang,Chao Niu,Xinjuan Hou
A colorless and transparent polyurethane elastomer (PUE) with high mechanical strength, excellent adhesive performance and chemical resistance is highly desirable in applications such as advanced protecting films. It is still challenging to fabricate a PUE with outstanding transparency, high-strength, good chemical resistance and adhesion strength. In this work, a PUE was designed with polytetramethylene ether glycol (PTMEG) as the soft segment and aliphatic isocyanate (m-xylylene diisocyanate, XDI) and 1,6-hexanediol (HDO) as the hard segment. The resulting XDI-PUE showed a remarkable mechanical strength of 21.0 MPa with an elongation at break of 1608%. Owing to the amorphous phase structure and XDI chemical structure, the resulting PUE was highly transparent with ∼90% transparency. Moreover, the elastomer showed good chemical resistance toward organic and inorganic solvents, i.e., toluene and NaOH aqueous solution. After being immersed in toluene and 30% NaOH aqueous solution for 24 h, the mechanical strength of XDI-PUE can maintain 70% and 50% of the original tensile strength with the shape remaining unchanged. It is worth noting that XDI-PUE can adhere strongly to metal substrates like copper and aluminum, and the tensile shear strengths to copper and aluminum were 607 and 343 kPa, respectively. Molecular simulations confirmed the adhesion results and provided the optimized complexes of Cu and Al binding with XDI-PUE. The present study can provide an effective method for fabricating advanced flexible protecting films as well as give molecular insights into the adhesion mechanism of PUE and metals.
研究领域:
材料科学
·
聚合物化学
·
粘附科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）