JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
·
IF 3.218
Zhiwei Qiu,Tao Yang,Rui Gao,Guifen Jie,Wanguo Hou
In this study, a novel Cu-based metal−organic frameworks (Cu-MOFs) composite material was prepared, and used to develop a sensitive and efficient electrochemical ratiometric sensor for dopamine detection. Gold nanoparticles (NPs) and the conductive poly(xanthurenic acid) p(XA) were assembled on the Cu-tetrakis (4-carboxyphenyl) porphyrin (TCPP) surface by electrodeposition and cyclic voltammetry (CV) method, which greatly improved the electrocatalytic performance of the Cu-MOF modified electrode . Two substances (dopamine/DA, paracetamol/PA) with different electrochemical peaks were added to the electrolyte solutions , where DA was the analyte and PA was as a reference. The ratiometric value of differential pulse voltammetry (DPV) oxidation current (I DA /I PA ) linearly increased with the increasing concentration of DA with low detection limit. This electrochemical ratiometric approach based on the metal−organic framework composites is expected to be a valuable strategy for detection of other analytes.
研究领域:
分析化学
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生物传感器
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神经化学
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电分析化学
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纳米材料
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药物分析
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DOI
高影响因子
Nanoscale
·
2018
·Vol. 11
·期 3
·962-967
·
IF 7.233
Zhaohong Su,Xiaolin Xu,Yongbing Cheng,Yueming Tan,Langtao Xiao,Daili Tang,Hongmei Jiang,Xiaoli Qin,Huixian Wang
A porous graphene (PG) bionanocomposite of PG, gold nanoparticles (AuNPs) and anti-indole-3-acetic acid (anti-IAA) antibody for sensitive and label-free amperometric immunoassay of IAA was reported. A PG film was produced by a pre-reduction/electrochemical reduction process on a glassy carbon electrode (GCE) and then a homogeneous AuNPs layer electrodeposition on the PG film. The anti-IAA antibody was immobilized onto the AuNPs through electrostatic adsorption and covalent conjugation. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), elecro-chemical impedance spectroscopy (EIS), ultraviolet visible spectroscopy (UV-vis) and differential pulse voltammetry (DPV) were used to characterize the PG film and the stepwise modification of the immunosensor. The electrochemical immunosensor exhibited a wide linear range from 2 × 10−11 to 2 × 10−8 g mL−1 with a detection limit of 0.016 ng mL−1 (S/N = 3) and showed significant linearity R2 = 0.9970. In addition, the proposed immunosensor showed acceptable selectivity and has been applied to the determination of IAA in the extract samples of several plant seeds with acceptable relative derivation (%) ranging from −5.25% to 4.24% between the immunosensor and high performance liquid chromatography. The proposed chemical pre-reduction and electro-reduction guided protocol can be extended to the preparation of many other functionalized PG nanocomposite films for wide applications.
研究领域:
生物传感
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纳米生物技术
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分析化学
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植物生理学
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电化学
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免疫分析
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DOI
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Analytical Methods
·
2016
·Vol. 8
·期 24
·4926-4933
·
IF 1.915
Dejiang Rao,Qinglin Sheng,Jianbin Zheng
Herein, we report a simple and attractive self-assembly strategy for preparing graphene oxide–multiwalled carbon nanotube–(1-pyrenemethylamine)–gold (GO–MWCNT–PMA–Au) nanocomposites using 1-pyrenemethylamine (PMA) as a coupling agent. The morphology and composition of the nanocomposites were characterized by transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). Further, a non-enzymatic nitrite sensor was fabricated by immobilizing GO–MWCNT–PMA–Au nanocomposites on a glassy carbon electrode (GCE). To obtain the optimal electrochemical experimental conditions, the effects of pH value and the volume of the as-prepared Au nanoparticle suspension were carefully investigated. Its electrochemical sensing properties were studied by cyclic voltammetry and differential pulse voltammetry. The electrochemical investigation showed that the GO–MWCNT–PMA–Au nanocomposites exhibited good catalytic performance for the oxidation of nitrite. The nitrite electrochemical sensor presented a wide linear range from 2.0 × 10−6 to 1.0 × 10−2 mol L−1, a high sensitivity of 483.51 μA mM−1 cm−2 and a low detection limit of 0.67 μmol L−1 at a signal-to-noise ratio of 3 (S/N = 3). It also exhibited good anti-interference capability and stability. This paper provides a self-assembly strategy for preparing nanocomposites which are used to construct improved electrochemical sensors.
研究领域:
分析化学
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纳米生物技术
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电化学传感
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环境监测
·
食品安全
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Huiqiang Wang,Zhanfang Ma
A new strategy for signal amplification was introduced in a label-free amperometric immunoassay platform. Improvements in the signal occurred following the oxidation of glucose by glucose oxidase and catalysis by polythionine of the produced H 2 O 2 from the previous oxidation reaction. In addition, a multifunctional conductive hydrogel, polypyrrole-polythionine-gold with glucose oxidase , was synthesised with a one-pot method using pyrrole and thionine as monomers, ammonium persulfate and HAuCl 4 as co-oxidant agents, and glucose oxidase as the doping agent. Combined with the hydrogel, a label-free amperometric immunoassay for the tumour marker neuron-specific enolase (NSE) was obtained. If operated at 0 V (vs. Ag/AgCl), the sensor exhibited a wide liner range from 100 ng mL −1 to 1 pg mL −1 and ultralow detection limit of 0.65 pg mL −1 (S/N = 3). The presented method was further used for the analysis of human serum samples and showed good consistency with detection results from an electrochemiluminescence immunoassay.
研究领域:
肿瘤学
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免疫学
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生物传感器
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分子诊断
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转化医学
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临床检验医学
·
纳米生物技术
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yunli Peng,Guoquan Wang,Guifeng Li,Yuan Gong,Xi Yang,Xiaotian Tan,Tao Zhu,Chaoyang Gong
Apoptosis detection is significant for understanding fundamental biological processes and is closely associated with numerous diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. However, limited by the intrinsic complexity of physiological environments, achieving highly sensitive detection of apoptotic signals at the single-molecule level remains a major challenge. Here, we propose a label-free single-molecule apoptosis assay based on fiber-optic interferometric imaging. The interference pattern generated by scattered light on the microfiber surface was utilized to resolve localized phase changes, enabling single-particle and single-molecule sensitivity. We found that the dynamic evolution of the interference patterns correlates with the physical heterogeneity among different molecular species, including the surface charge and molecular weight of individual molecules. We achieved single-molecule detection of small proteins down to 5.8 kDa, demonstrating the broad applicability of our method across a wide range of clinically relevant proteins and nucleic acids. After functionalizing the fiber surface with antibodies, the interference patterns exhibited excellent specificity toward the antigen molecules. The dynamic interference pattern was further employed to perform an apoptosis assay at the single-molecule level. Our method enables label-free quantification of biomarkers in complex physiological environments with ultrahigh sensitivity, opening new avenues for fundamental studies of cell-death pathways and early disease diagnosis.
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npj Flexible Electronics
·
2026
·
IF 15.4
Kan Xinyuan,Fan Qian,Guo Wenlan,Sun Chen,Wang Yan,Duan Xuexin,Xue Qiannan
Ocular blood oxygen saturation is critical for detecting vision-threatening and systemic diseases. Existing wearable oxygen sensors are unsuitable for ocular use, and current ocular SpO₂ measurements rely on bulky equipment. This work introduces a flexible plasmonic nano-confinement (PNC) nanowire photodetector, based on a PNC nanowire array consisting of highly aligned and ordered PEDOT:PSS nanowires with embedded gold nanoparticles, for high-sensitivity oxygen saturation sensing. The PNC nanowire array acts as an anode interfacial modification layer, where nanowire-geometry-induced confinement and localized surface plasmon resonance synergistically lower the hole-extraction barrier, suppress interfacial recombination, and enhance photoconversion efficiency. Its flexible and transparent design, combined with a compact backend circuit using wavelet-threshold denoising, enables integration into a smart contact lens for accurate and stable non-invasive ocular oxygen monitoring. In vivo experiments demonstrate that this smart contact lens could provide a simple, non-invasive platform for continuous ocular SpO₂ monitoring, with potential relevance to systemic oxygen-status assessment.
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高影响因子
Cell Communication and Signaling
·
2026
·
IF 11.6
Diao Jiayong,He Qixuan,Liu Quanzhen,Liu Yuxuan,Chen Simiao,Zhang Yuzhe,Gui Houda,Chen Jingyi,wu Dongni,Pang Xinyu,Zhang Qingyue,Wang Ya-nan,Zhang Dongjiao
Background Mitochondria, as crucial organelles in eukaryotic cells, are deeply involved in cellular energy metabolism and biogenesis. Currently, mitochondria have been found to transfer between cells and regulate a range of cellular functions and research has found that mitochondrial transfer has been shown to play an important role in regulating bone homeostasis. Methods Laser confocal imaging was used to confirm the occurrence of mitochondrial transfer between cells. JC-1 staining explains the state of free mitochondria in receptor cells. In order to reveal the relationship between the state and function of free mitochondria, osteogenic induction, Western blotting, flow cytometry, and in vivo experiments were conducted. RNA seq is used to analyze changes in cells. Different inhibitors were used to verify the specific mechanism of action of free mitochondrial transfer. Results Free mitochondrial transfer can improve the function of receptor cells through lysosomal pathway. Free mitochondria are degraded by cathepsin H (Ctsh) in lysosomes and release a large amount of cysteine after entering the receptor cells. In this process, the existence of membrane potential of free mitochondria is not critical. Cysteine, as the most important raw material for glutathione synthesis, can enhance the number and function of mitochondria in receptor cells. Conclusion Our study demonstrates that free mitochondrial transfer promotes bone regeneration by increasing cysteine supply, and provides innovative insights for understanding mitochondrial transfer.
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DOI
PubMed
高影响因子
ChemCatChem
·
2026
·Vol. 18
·期 16
·e71036
·
IF 4.1
Xiang Gao,Longfei Hong,Yuting Jiang,Yixuan Li,Lian-Hua Xu,Qingyu Liu,Huiyan Zhang,Sheng Chu
Polyolefin plastics, such as polyethylene (PE), possess chemically inert and nonpolar C–C backbones, making them difficult to recycle and causing persistent environmental pollution. The lack of green and highly selective upcycling methods has led to severe environmental concerns and resource waste. Photoelectrocatalysis utilizes high-energy photogenerated charge carriers to directionally upgrade plastic-derived small molecules into value-added chemicals. However, current photoelectrocatalytic technologies still face challenges in processing structurally inert bulk polymer plastics. In this study, we report a hydrothermal-photoelectrocatalytic tandem strategy to realize the upcycling of PE and other polyolefin plastics. The acetic acid product obtained from hydrothermal treatment are further converted into ethanol over an Au nanoparticle‑decorated GaN/Si (Au/GaN/Si) photocathode, achieving an optimal performance of a Faradaic efficiency of 57.6%. This tandem strategy also demonstrates excellent generality in the conversion of polypropylene (PP) and polyvinyl chloride (PVC), providing a green route for the upcycling of polyolefin plastics. Graphical Hydrothermal-photoelectrocatalytic tandem upcycling enables the conversion of chemically inert polyolefin plastics into value-added ethanol. The Au/GaN/Si photocathode achieves a Faradaic efficiency of 57.6% for ethanol production, while demonstrating broad applicability to PE, PP, and PVC plastics.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Shuhan Hou,Inseob Noh,Xinlu Shi,Yanbin Wang,Hyung Do Kim,Hideo Ohkita,Biaobing Wang
Flexible superhydrophobic surfaces have been attracting more and more attention due to their foldable property. However, the superhydrophobic structure was easily damaged or destroyed owing to their poor interfacial force between substrate and superhydrophobic coating. Herein, fluorinated silica nanoparticles (F-SiO 2 ) were sprayed onto the wet poly(amide–imide) (PAI) surface, which made F-SiO 2 easily went into PAI substrate to enhance the durability of superhydrophobic surface. The PAI/F-SiO 2 flexible surface exhibited a water contact angle (CA) of beyond 160° and a sliding angle (SA) of as low as 3°, while the tensile strength (34 MPa) was comparable to that of PAI substrate (35.8 MPa). Encouragingly, the superhydrophobicity and hierarchical porous structure of PAI/F-SiO 2 surface were maintained even they were folded by 5000 times or underwent sandpaper abrasion test (500 cm of wear on a 1200 grit sandpaper under 50 g load), while the nanocomposites failed the sandpaper abrasion test when F-SiO 2 were sprayed onto completely dried PAI surface. More importantly, the CA and SA just slightly decreased when PAI/F-SiO 2 surfaces were heated at 300 °C for 24 h due to the unique surface morphology and high thermal stability of PAI, which is one of the highest thermal stabilities for flexible superhydrophobic films. In addition, PAI/F-SiO 2 surfaces maintained superhydrophobic after hot water jet impact, acid–base immersing, UV irradiation , and ultrasonic treatment , indicating the fabricated surfaces could be used for practical application especially under harsh conditions. Furthermore, the superhydrophobic surfaces possessed icephobic properties. It should be noted that PAI/F-SiO 2 surfaces showed such excellent properties, although their fabricating procedure did not undergo any optimization. This wet spraying method was also used to fabricate flexible superhydrophobic surfaces with other polymers as substrates such as poly(acrylic acid) (PAA), thermoplastic polyurethane (TPU), polystyrene (PS), and poly(vinyl alcohol) (PVA). Therefore, the simple strategy provided a general route to prepare flexible superhydrophobic films with high durability.
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DOI
高影响因子
ACS Omega
·
2023
·
IF 4.1
Bolin Wang,Yuxue Yue,Yuliang Li,Lu Yu,Hong Tang,Haifeng Zhang,Feng Feng
Imidazolium-based ionic liquid mixtures with [NO3]− and [AlCl4]− anions were used as oxidizing agents for the dissolution of Au, Pd, and Pt metals under mild conditions. The thermodynamic reduction of [NO3]− to [NO] is catalyzed by [AlCl4]− anions and coupled with the oxidation process of noble metals. The developed ionic liquid system for dissolving Au can reactivate the Au0 formed in the deactivation process of the catalyst in vinyl chloride production. This demonstrates the relevance of the here-presented work for technical noble metal recycling.
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DOI
PubMed
高影响因子
ORGANIC ELECTRONICS
·
2023
·
IF 3.2
Jinyao Zhong,Haitao Xu,Junwei Zhao,Fuhao Gao,Jinxin Zhou,Yongbing Long
Microcavity-based semitransparent organic solar cells (ST-OSCs) have become a hot issue in the research field of green energy harvesting due to their wider potential applications in colored photovoltaic glass, building-integrated photovoltaics, and so on. However, for this kind of ST-OSCs, high photoelectric conversion efficiency (PCE) and high peak transmittance cannot usually be achieved simultaneously. To circumvent the problem, this paper proposes MgF 2 microcavity with a structure of Au/Ag/MgF 2 /Ag for ST-OSCs so that high peak transmittance can be achieved at low cost of PCE. The device structure of ST-OSCs is Glass/ITO/ZnO/PTB7-Th: IEICO-4F/MoO 3 /Au/Ag/MgF 2 /Ag. By combining the high transmittance of MgF 2 microcavities with the low absorption of IEICO-4F in the blue light, a colorful ST-OSCs with high blue light transmittance can be obtained. The IEICO-4F in the active layer shows strong optical absorption in the near-infrared wavelength region, but weak absorption in the visible region. The results demonstrate that the peak transmittance of ST-OSCs reached a high value of 48% at 440 nm and the PCE reached 10.4%. Such a high peak transmittance is achieved while the PCE reduction compared to the control opaque device is about 5%. The PCE loss rate at each peak transmittance is the lowest among the reported values for the similar ST-OSCs devices. By adjusting the thickness of MgF 2 , ST-OSCs with different colors can be obtained, the peak transmittance of which is over 32% and the PCE loss rate is less than 7.25%. This report provides a new approach to solve the trade-off between efficiency and transmittance of ST-OSCs.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Pengcheng Li,Shujuan Dai,Xiaoan Li,Wenhan Sun,Shujie Liu
The leaching rates for gold in the roasting oxidation pretreatment-cyanidation gold leaching process are generally low. An adsorption experiment for quartz baking slag (roasting time of 3 h, roasting temperature of 650℃) and gold cyanide solution was carried out under different stirring time conditions. It is found that after high temperature activation of the quartz surface, gold cyanide can be adsorbed. When the stirring time reaches 50 min, the adsorption rate is 6.08%, and the unit adsorption amount is 0.05 mg·g −1 . The EDS spectrum clearly shows that the Au element is distributed among Si and O, and 0.02% Au is adsorbed on the surface of the quartz baking slag. To further prove the adsorption mechanism for the gold cyanide solution and quartz slag, infrared spectroscopy (IR) and X-ray photoelectron spectroscopy (XPS) were used to characterize the surface of quartz slags. Infrared spectroscopy analysis shows that new peaks emerge at 1429 cm −1 , 1878 cm −1 , and 1996 cm −1 after the elution experiment, and the characteristic peaks for inorganic cyanide are observed at 1878 cm −1 and 1996 cm −1 . This shows that after high-temperature activation of the quartz baking slag, chemical adsorption of gold cyanide occurs. The results obtained from X-ray photoelectron spectroscopy (XPS) show that during the adsorption process, Au-Si is adsorbed together, and Au shows a valence of + 1, which indicates that Au(CN) 2− ions are adsorbed onto the quartz activated at high temperature. Density functional theory (DFT) was used to determine the adsorption mechanism for Au(CN) 2− ions and different sites on the surface of quartz (1 0 1) before and after high-temperature activation (three Au-O, Au-Si, and N-Si adsorption sites). During the high-temperature activation process, the Au-O bonds and interactions on the surface of gold cyanide and quartz gradually transform into Au-Si bonds and interactions, and the N-Si bonds are also enhanced. This shows that the adsorption of gold cyanide onto quartz baking slag is enhanced after high-temperature activation. The simulation calculation result is consistent with the experimental results.
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