Journal of Materials Chemistry C
·
2024
·
IF 5.7
Xin Huang,Tingting Zhang,Haomiao Zhang,Jiahui Yang,Tingting Cui,Rui Cheng,Jian Yu
In recent years, the rapid advancement of carbon dots (CDs) has established them as highly promising candidates in the field of fluorescent nanomaterials. Microfluidic technology, known for its efficiency in nanomaterial synthesis, has encountered significant challenges in the production of CDs due to insufficient fluid driving force, a consequence of the high-pressure conditions generated in microfluidic channels during high-temperature reactions. This limitation has significantly constrained the application of microfluidic technology in synthesis of CDs. To address this issue, this study developed a controllable, high-pressure gas driven microfluidic platform, enabling the large-scale production of CDs with multicolor fluorescence emission. By precisely regulating the pressure in feedstock tank and the opening of control valves, continuous and stable fluid flow and reactions were maintained in high-temperature heated channels, even when using low-boiling-point solvents. Adjustments in reaction temperature and precursor selection facilitated the large-scale synthesis of CDs emitting blue, green, yellow, and red fluorescence (B-CDs, G-CDs, Y-CDs and R-CDs). Furthermore, the excellent biocompatibility and low toxicity of the G-CDs enabled the successful application in cellular imaging. This work provides a novel solution to the challenge of insufficient fluid driving force in microfluidic synthesis of CDs, and it is expected to promote further advancements in the use of microfluidic technology for large-scale production functional nanomaterial.
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Advanced Healthcare Materials
·
2026
·
IF 11
Shuang Liu,Hewen Li,Yuhang Ding,Dengyi Duan,Lin Cao,Kangkang Liu,Wenyi Zhang,Shifeng Cheng,Yiming Li,Yunfei Guo,Xiang Qi,Jianmin Li,Xuening Zhang,Jing Peng,Gang Han,Yang Zhao
Ferroptosis is triggered by iron-dependent lipid peroxidation, which shows great potential in tumor therapy. However, its biomedical applications are constrained by suboptimal therapeutic efficacy, leakage of metal ions from inducing agents, and the absence of noninvasive evaluation methods. In this study, we aimed to develop a self-reducing nano-theranostic agent (Fe@AP-SAS/RGD, FASR) for tumor-targeted ferroptosis therapy and conducted real-time magnetic resonance imaging(MRI) to monitor ferroptosis by encapsulating iron oxide particles in natural apple pectin (AP). In a weakly acidic tumor microenvironment, the strong reducing ability of AP accelerated the transformation of Fe 3+ within FASR into highly active Fe 2+ . Subsequently, the concentration of Fe 2+ increased and boosted the antitumor effect of ferroptosis. Notably, MRI of prostate cancer mouse models after intravenous injection of FASR NPs at varying doses revealed that the T 2 value decreased at the tumor sites and exhibited a linear correlation with the changes in ferroptosis hallmark markers, tumor weight, and volume after treatment. These findings demonstrate the capacity of T 2 mapping to quantitatively evaluate ferroptosis efficacy. This study not only introduced a tumor-targeted and self-reducing strategy to amplify ferroptosis but also pioneered a novel pathway for noninvasive imaging and monitoring of ferroptosis treatment processes within live tumors.
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Advanced Healthcare Materials
·
2026
·
IF 11
Sui Zhou,Wen-Qian Zhang,Yong Li,Rong-Fen Gao,Jia-Yi Ma,Kai Cheng,Jin-Xuan Fan,Jie Yang,Ling-Li Dong,Bo Liu
The deposition of monosodium urate crystals triggers joint inflammation, which serves as a critical factor in gouty arthritis development. However, current monotherapy is unable to simultaneously reduce uric acid and suppress inflammation. We identified through bioinformatics and clinical sample analysis that oxidative stress-related indicators were significantly elevated in patients with gouty arthritis. In light of this clinical finding, we developed a polydopamine-based nanozyme with high superoxide dismutase and catalase activities via bimetallic ion coordination, which was subsequently loaded with uricase, rapamycin, and hyaluronic acid. In the gouty arthritis model, hyaluronic acid could target the CD44 receptor on the surface of macrophages, enhancing nanoprobe accumulation at the joint. The nanoprobe exhibited excellent biocompatibility and eliminated significantly monosodium urate crystals through multienzyme cascade reactions, while simultaneously addressing the accumulation of byproducts such as hydrogen peroxide, thereby markedly alleviating joint swelling and pain. In addition, the levels of Interleukin-1 beta and Interleukin-6 were significantly reduced, and the NF-κB signaling pathway was effectively suppressed. The phenotypic of macrophages was transformed from pro-inflammatory M1 to anti-inflammatory M2 phenotype. Meanwhile, rapamycin effectively suppressed the immunogenicity of uricase and enhanced its therapeutic efficacy in vivo.
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BIOORGANIC CHEMISTRY
·
2026
·
IF 5.1
Gaiqian Song,Ayixia Abudula,Moyisa Simayi,Hongning Liu,Hao Lin
Taxol remains a cornerstone therapy for non-small cell lung cancer, however, the development of acquired resistance continues to pose a significant clinical hurdle. Glutathione S-transferase P1 (GSTP1) and P-glycoprotein (P-gp) have been identified as key mediators of this multi-drug resistance phenotype. Consequently, the dual-target inhibition of these proteins represents a promising therapeutic strategy to circumvent chemoresistance. Here, pentagalloylglucose has been identified as a potential dual GSTP1/P-gp inhibitor through virtual screening. Molecular dynamics simulations validated the stable binding conformations of pentagalloylglucose with both target proteins. Furthermore, microscale thermophoresis and cellular thermal shift assays confirmed the direct binding interaction between pentagalloylglucose and GSTP1, while enzymatic assays demonstrated its potent inhibitory efficacy against the enzyme. Notably, treatment with pentagalloylglucose significantly enhanced the intracellular accumulation of Rhodamine 123, thereby indicating effective inhibition of P-gp mediated efflux. This effect culminated in a marked restoration of taxol sensitivity in A549/Taxol resistant cells. Additionally, pentagalloylglucose treatment inhibited cell metastasis in a concentration-dependent manner, accompanied by the down-regulation of epithelial-mesenchymal transition-related genes. Transcriptomic analysis further revealed that pentagalloylglucose modulates multiple signaling pathways implicated in cell proliferation and metastasis. Collectively, these findings establish pentagalloylglucose as a promising dual-target inhibitor for overcoming taxol resistance. The strategy of simultaneously targeting GSTP1 and P-gp offers a viable approach for the treatment of drug-resistant lung adenocarcinoma, providing a robust scientific foundation for future drug development and structural optimization.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Xu Yizhao,Zhao Tao,Li Zixuan,Chen Jiale,Li Xin,Zhou Xiaomei,Khouchani Mouna,Abdelmajid Takoui,Jiang Zhiqiang,Zhao Long,Zhang Zhanlin
Photothermal therapy (PTT) is recognized for its precise manipulability and exceptional spatiotemporal control but faces challenges such as thermotolerance, weak penetration, and collateral tissue damage. Herein, we presented a strategy that enabled tumor-targeted PTT, reduced interstitial fluid pressure (IFP), promoted deep tumor penetration, enhanced radiosensitization, and counteracted thermoresistance. An engineered bacteria-based delivery system (R.S@BiOI) responsive to low-dose X-ray was constructed via electrostatic adsorption of bismuth oxyiodide quantum dots (BiOI QDs) onto the natural photothermal agent Rhodobacter sphaeroides (R.S). Leveraging the hypoxic targeting capability of R.S, R.S@BiOI facilitated tumor-specific enrichment and penetration. Meanwhile, X-ray-triggered radiolysis of water by surface-bound BiOI QDs generated hydroxyl radicals, which reduced tumor IFP, enhanced the deep and uniform distribution of the R.S@BiOI composite, and minimized collateral thermal damage to surrounding healthy tissues. Furthermore, X-ray irradiation downregulated the expression of heat shock proteins, attenuating cellular thermotolerance and synergistically improving the efficacy of PTT. Meanwhile, R.S@BiOI elicited a robust anti-tumor immune response, which acted in synergy with radiotherapy and PTT to potentiate the overall antitumor efficacy. The bacteria-based delivery system enhanced intratumoral accumulation and improved tumor distribution, resulting in markedly superior tumor growth suppression, prolonged survival in animal models, and a well-tolerated safety profile with no significant systemic toxicity observed in critical organs. Thus, this study presents a strategy for fabricating X-ray-responsive engineered bacteria that potentiate the therapeutic efficacy of PTT in the treatment of prostate cancer. Graphical abstract
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ADVANCED FUNCTIONAL MATERIALS
·
2026
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IF 19.9
Xinming Wang,Weichang Xie,Zichen Wang,Haonan Zhang,Jia Li,Xingjian Gao,Dingjie Zhou,Huaiyu Jiang,Shixing Huang,Qiang Zhao,Xiaofeng Ye
Repairing anisotropic tissues such as the myocardium requires implanted cells to organize into highly ordered structures. However, achieving controlled cell alignment remains a major challenge for current cell delivery patches. Here, we develop a magnetically aligned, fiber-reinforced extracellular matrix (ECM) patch that directs anisotropic cell organization and supports stem cell implantation. Poly-lactic acid fibers containing Fe 3 O 4 are fabricated via electrospinning and controlled hydrolysis, and are aligned uniaxially within ECM hydrogels using an external magnetic field prior to gelation. The resulting ECM–fiber patches exhibit enhanced mechanical strength and reliably guide the alignment of cardiomyocytes, fibroblasts, and endothelial cells. A beating patch is also created by seeding human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). In a nude mouse myocardial infarction (MI) model, implantation of iPSC-CMs@ECM–fiber patches preserves cardiac function, reduces apoptosis, limits fibrosis, and enhances vascularization. Implanted iPSC-CMs demonstrate high viability and low immunogenicity. Molecular profiling reveals transient modulation of early inflammatory responses post-MI, probably mediated through IL-17, IL-3, and IL-1β pathways. Overall, the ECM–fiber patch provides a versatile platform for delivering highly organized cells for in vivo tissue repair.
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Cell Reports
·
2026
·Vol. 45
·期 8
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IF 7.7
Yanmei Cui,Fan Du,Juan Wang,Bing Zhou
Zrt/Irt-like protein (ZIP) family members typically mediate zinc transport into the cytoplasm. Here, we characterize SLC39A11(ZIP11)—an evolutionarily conserved ZIP homologous to Escherichia coli metal ZupT—revealing its context-dependent role in metal homeostasis. ZIP11 could remove Fe 2+ from the endoplasmic reticulum (ER)/Golgi to the cytosol when ER/Golgi Fe 2+ rises. This is relevant to fibrosis, where ZIP13 upregulation supports collagen synthesis and ZIP11 mitigates iron overload. Significantly, AAV8-mediated ZIP11 expression drastically suppresses CCl 4 -induced liver fibrosis in mice, highlighting therapeutic potential. However, ZIP11 normally regulates Mn 2+ partitioning between ER/Golgi and cytosol: its loss reduces ER/Golgi Mn 2+ , increases cytosolic Mn 2+ , and enhances manganese toxicity. ZIP11 and Mn 2+ transporter TMEM165 double deficiency exacerbates Mn 2+ sensitivity, indicating synergy between them. We therefore establish ZIP11 as an ER/Golgi Mn 2+ transporter with Fe 2+ transport plasticity and as an ER/Golgi-to-cytosol iron transporter that acts oppositely to ZIP13 to maintain optimal ER/Golgi iron levels.
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ACS Omega
·
2026
·
IF 5.2
Tao Yang,Tao Wang,Tao Shen,Mingrong Dong,Jinkun Liu,Ming Ni,Yan Zhu
Targeting tumor-specific characteristics of acidic microenvironment, elevated H2O2 levels, and thermosensitivity, this study proposed and developed a copper-doped ZIF-8 nanoplatform coloaded with indocyanine green (ICG) and doxorubicin hydrochloride (DOX), designated as Cu-ZIF-8@ICG&DOX (CZID), to establish a multimodal therapeutic system integrating chemodynamic therapy, photothermal therapy, and chemotherapy. Results showed that the 25% copper doping level optimized the structure, achieving 7.46% actual doping content while limiting the average nanoparticle size to 99.6 nm. Dual loading of ICG and DOX induced morphological transition to spherical core–shell architectures, as confirmed by zeta potential reversal, with maximum drug loading capacities of 23.01 μg/mg for ICG and 122.43 μg/mg for DOX. The ZIF-8 framework exhibited pH-responsive degradation under acidic conditions. Released Cu2+ ions mediated continuous hydroxyl radical generation through glutathione-depletion redox cycling, confirming chemodynamic efficacy. Under 808 nm laser irradiation, ICG enabled enhanced photothermal conversion, showing concentration- and power-dependent temperature elevation. Cellular assays revealed efficient CZID internalization by MCF-7 cells, generating significantly higher intracellular reactive oxygen species levels under irradiation and more intense dead cell staining compared to CZI and CZD groups. Such an enhancement was attributed to photothermally accelerated ZIF-8 degradation, promoting Cu2+ ions and DOX release, thereby strengthening chemodynamic–chemotherapy synergy. At the working concentration of 50 μg/mL, CZID induced 95.36% apoptosis in MCF-7 cells while maintaining over 70% viability in MCF-10A normal cells, validating its precise antitumor potential.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Rimei Huang,Shuman Wang,Liqian Zheng,Xiaolu Guo,Li Chen,Shenghai Zhang,Aihui Wang,Junxin Bin,Yaxuan Lin,Shichen Ji,Hong Liang,Xing-Can Shen,Bang-Ping Jiang
The utility of calcium carbonate (CaCO 3 ) in photo-activated scenarios has been severely restricted by the inherent lack of near-infrared (NIR) absorption capability. Herein, we present a defect engineering strategy to modulate nanosized CaCO 3 and successfully synthesize boron-doped black CaCO 3 nanocube ( b -CaCO 3-x ) with oxygen vacancies (OVs) via a thermal reduction approach employing sodium borohydride as a reducing agent. The existence of OVs is confirmed by Spherical Aberration-Corrected Transmission Electron Microscope (STEM). b -CaCO 3-x exhibits remarkable NIR absorption characteristics. Acting as an anchoring core, b -CaCO 3-x is used to construct a composite hydrogel via cross-linking between on its surface Ca 2 + and carboxyl groups of sodium alginate (SA). By further incorporating glucose oxidase (GOx) and catalase (CAT), this multifunctional hydrogel is developed for accelerate diabetic wound healing via photothermal sterilization and bio-activated reaction. Notably, the b -CaCO 3-x component endows the hydrogel with NIR-responsive photothermal sterilization to efficiently suppress wound infection. More importantly, the hydrogel can oxygenate endothelial cells to activate the extracellular signal-regulated kinase (Erk1/2) and heme oxygenase 1 (HO-1) signaling pathways for accelerating wound healing via in situ bio-activated dual reaction: the overexpressed hydrogen peroxide (H 2 O 2 ) is catalyzed to generate oxygen (O 2 ), and the acidic microenvironment decomposes b -CaCO 3-x to manufacture carbon dioxide (CO 2 ). Collectively, this work provides a viable approach to tailor the absorption characteristics of CaCO 3 , expanding its potential in photo-activated biomedical applications.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yixiu Ni,Ting Feng,Shengye You,Aokang Zhang,Feng Liang,Wei Dong,Yizhong Bao
Current treatments for diabetic wounds affecting the oral mucosa frequently yield insufficient results. Key challenges complicating recovery include bacterial colonization, oxidative damage, and impaired blood vessel formation during tissue repair. To bridge this substantial therapeutic void, our research introduces an injectable hydrogel (named as SQD1) engineered specifically to promote healing within diabetic oral ulcers. This innovative biomaterial combines a polysaccharide network derived from dialdehyde scleroglucan and quaternized chitosan, further enhanced by incorporating shikonin nanoparticles. Upon local injection, SQD1 rapidly transitions into a protective hydrogel layer. The dressing demonstrates robust antimicrobial efficacy alongside potent scavenging of reactive oxygen species. These combined actions effectively transition the lesion environment away from chronic inflammation toward a productive proliferative healing state. A significant advantage involves the material's inherent biodegradability following therapy completion, guaranteeing total bodily assimilation once its wound-healing functions conclude. Collectively, results from both laboratory and animal studies confirm that SQD1 markedly hastens repair processes in oral mucosal injuries. Representing a significant stride forward, this hydrogel technology offers a highly promising approach for managing diabetic oral ulcerations, ultimately aiming to enhance patient prognoses associated with this difficult pathology.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Sui Zhou,Yong Li,Yi-Tong Zhou,Meng-Wen Ma,Kai-Lin He,Kai Cheng,Jin-Xuan Fan,Bo Liu,Ling-Li Dong,Yuan-Di Zhao,Xin Liu
A multi-functional nanoprobe manganese carbonyl@platinum@zinc ion-coordinated polydopamine-hyaluronic acid (MPZH) was designed to remodel the inflammatory microenvironment and low-temperature photothermal cascade therapy for rheumatoid arthritis. We found that Zn 2+ contained in MPZH significantly increased the superoxide dismutase activity of polydopamine after forming a zinc ion-coordinated polydopamine complex with polydopamine. DFT theoretical calculations revealed that the energy required for the degradation of superoxide anion to hydrogen peroxide by zinc ion-coordinated polydopamine was reduced by 3.94 eV compared with polydopamine. MPZH stimulated macrophage polarization toward the M2 phenotype by removing large amounts of reactive oxygen species from the joints and reduced the secretion of pro-inflammatory factors and downregulated the NF-κB inflammatory signaling pathway. The reaction of manganese carbonyl with hydrogen peroxide to generate carbon monoxide inhibited the overproliferation of fibroblast-like synoviocytes while significantly downregulating the expression of heat shock protein 70 and reducing the heat resistance of fibroblast-like synoviocytes. Additionally, the loaded Pt nanoparticles enhanced the photothermal conversion efficiency of zinc ion-coordinated polydopamine (45.26 %). Under this “double enhancement” effect, MPZH achieved a potent low-temperature photothermal therapy capabilities. In the mouse model of collagen-induced arthritis, MPZH demonstrated an effective inhibitory effect and excellent biocompatibility against rheumatoid arthritis. After MPZH treatment, immunofluorescence staining of joint sections revealed significantly inhibited synovial erosion. This work presents an effective strategy for mitigating rheumatoid arthritis progression and remodeling the inflammatory microenvironment.
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ACS Omega
·
2025
·
IF 4.3
Kun Du,Bei Wang,Ning Yang,Jian Jin,Wei Liu,Feifei Pu,Lili Zou,Zilu Qu,Liuqing Chen
Drug-induced liver injury is the main cause of acute liver failure and has become a major health problem. Nowadays, topical and transdermal drug delivery has appeared as a popular approach to deliver drugs, and its risk of inducing hepatotoxicity requires careful evaluation before approval for application to humans. To date, hepatotoxicity resulting from topical administration has rarely been studied due to the lack of effective research models. Here, a highly biomimetic liver–skin microphysiological system (LS-MPS) was developed, providing a dynamic and physiologically similar microenvironment to mimic in vivo liver, skin, and cyclic flow between them. The three-dimensional (3D) liver microtissue and 3D skin microtissue were successfully established on the LS-MPS. The skin microtissue showed high cell viability and physiologically similar dermal and epidermal layers. More importantly, the barrier and permeability functions of skin were maintained for long-term culture. The 3D liver microtissue showed high cell viability, biomimetic cell arrangement, and active metabolic function. In addition, the LS-MPS was applied to evaluate the topical delivery of drug-induced liver injury, demonstrating its potential in drug safety testing. Thus, this study provides a promising platform to assess complex drug toxicity, which contributes to the development of new drugs.
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