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International Journal of Polymeric Materials and Polymeric Biomaterials · 2023 · IF 3.2

Preparation and sustained release bacteriostatic performance of pH-responsive complex hydrogel bacteriostatic microspheres for oral drug delivery

Wenqin Xu,Xing Li,Xianmei Wu,Guanghua Pan,Nanchun Chen,Xiuli Wang,Qinglin Xie

pH-responsive hydrogel antibacterial microspheres were prepared by complex coacervation method and used as drug carriers to load the antibiotic substitute potassium diformate (KDF). The results showed that the three-dimensional network structure of the composite hydrogel was formed among the polysaccharide components, and Zeolite A loaded with KDF was uniformly dispersed in it. The results of drug release behavior and kinetics in vitro showed that the drug release rate was higher and the release mechanism followed the Ritger-Peppas model, which indicated that the antibacterial microspheres had a good pH response. In vitro, the carrier showed broad-spectrum antibacterial activity, good biocompatibility, and degradability.

CAS / MDL: 9000-69-5

研究领域: 药学 · 生物材料 · 药物递送系统

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Materials Today Communications · 2021 · IF 3.383

Preparation and antibacterial effect of potassium diformate hydrogel composites

Zhongxin Yang,Yuyan Li,Xiaonan Zhang,Bei Fu,Yuhang Yang,Nanchun Chen,Xiuli Wang,Qinglin Xie

Potassium diformate (KDF) is a novel substitute for antibiotics. To achieve controlled release of KDF and extend its antibacterial effect, composite hydrogel antibacterial microspheres of sodium alginate (ALG)/konjac glucomannan (KGM)/ethyl cellulose (EC)/zeolite P were prepared using a sharp-hole coagulation bath. Considering the swelling rate of hydrogel as the response value, the Plackett Burman (PB) design experiment was performed to show that ALG , KGM, zeolite P, and calcium chloride (CA) were the most important influencing factors. Then, the steepest ascent test was performed to approach the maximum response area, and the response surface analysis method was used to establish the continuous variable surface model and investigate the structure-activity relationship and swelling property of the hydrogel microspheres. The results showed that the four factors in descending order of influence were zeolite P > ALG > KGM > CA, and that ALG/CA, KGM/ALG, and zeolite P/ALG interacted. In vitro drug release behavior showed that microspheres improved the drug loading rate and encapsulation efficiency, and prevented the premature release of KDF in gastric juice. The release kinetics also followed the Ritger-Peppas model. Under simulated gastrointestinal environment, in vitro antibacterial tests showed that the minimum inhibitory concentrations (MIC) of the antibacterial agents against Escherichia coli , Staphylococcus aureus, and Bacillus subtilis were 12 mg/mL, 12 mg/mL, and 24 mg/mL, respectively, indicating that the microspheres effectively inhibited the growth of bacteria in the intestine. Our results indicated that hydrogel microspheres can be used as potential drug delivery systems.

CAS / MDL: 9004-57-3

研究领域: 生物材料学 · 药剂学 · 微生物学

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Preparation and sustained release bacteriostatic performance of pH-responsive complex hydrogel bacteriostatic microspheres for oral drug delivery

Preparation and antibacterial effect of potassium diformate hydrogel composites