JOURNAL OF NANOPARTICLE RESEARCH
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2024
·Vol. 26
·期 2
·1-13
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IF 2.1
Ye Haiyang,Zhang Li,Qiu Xiaonan,Qiu Jianghong,Xu Wenqing,Xu Xiao,Yu Huijun,Zou Shengqiang,Du Fengyi,Zheng Guojun,Wu Yunchao
Photothermal therapy (PTT) can kill the tumor in situ, but fail to trigger strong antitumor immune response against its recurrence and metastasis. Herein, mannose-grafting Fe-doped carbon dots (M/Fe-CDs) were prepared via hydrothermal carbonization and chemical modification. The prepared M/Fe-CDs had characteristics of excellent optical qualities, good water solubility, and outstanding biocompatibility. Compared with pure CDs, the doping of Fe atom endowed the M/Fe-CDs with a high photothermal conversion efficiency (from 12.1 up to 30.1%). Under 808-nm NIR irradiation, the M/Fe-CDs could lead to local hyperthermia to kill tumor cells. Importantly, the M/Fe-CDs were capable of loading CpG-ODNs via electrostatic absorption and delivering them into the cytoplasm of dendritic cells (DCs). Finally, the CpG-ODNs-loading M/Fe-CDs could significantly increase the CD80/86 expression on the DCs surface. These results demonstrated that the M/Fe-CDs could be used as a versatile nanoplatform to combine the PTT and immune activation for tumor treatment.
研究领域:
生物医学工程
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肿瘤免疫学
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纳米医学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Hua Wei,Hongli Li,Yutong Zhang,Xin Wang,Zihan Li,Mingyang Zhou,Yongqian Lei,Pengran Guo,Jian Liu,Shenghong Yang
Carbon dots (CDs) nanozymes open a new horizon for fabricating multi-mode analysis systems, but their practical applications are still limited by complicated synthesis strategy and single-function nature. Herein, a new type of iron and nitrogen co-doped carbon dots nanozyme was developed through simple pyrolyzing the solid mixture of ferrous bis-glycinate and ethylenediamine dihydrochloride. The Fe,N-CDs exhibit good optical properties that can emit obvious blue fluorescence and possess excellent peroxidase-like activity that can catalyze H 2 O 2 to generate reactive oxygen species. Based on the fluorescence and peroxidase-like activity of the Fe,N-CDs, a multi-mode detection platform for DA was constructed effectively, including naked eye colorimetric, UV–Vis ratiometric absorption, fluorescence quenching, and scanometric. The limit of detection can reach 10 nM, and the calibration curve was linear up to 30 μM. The multi-mode sensing system was successfully applied for the accurate determination of DA in various actual samples with a satisfactory recovery of 89.0–118.0 %.
研究领域:
分析化学
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生物医学工程
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材料科学
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DOI
高影响因子
ANALYTICAL SCIENCES
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2023
·
IF 1.6
Yang Yu Meng,Yan Yuan,Zhou Jia Ying,Huang Cheng Zhi,Zhen Shu Jun,Zhan Lei
Real-time monitoring of hypochlorous acid (HClO) in biological systems is of great significance for exploring and regulating its pathological functions because abnormal production of HClO is closely related with many diseases, such as atherosclerosis, rheumatoid arthritis, and cancer. Herein, we developed a reliable fluorescent Fe-doped carbon dots (Fe-CDs) for the sensitive and selective detection of biological HClO using ferrocenecarboxylic acid and m -phenylenediamine as precursors through a one-step solvothermal procedure. The Fe-CDs exhibited excellent a wide HClO detection range from 20 nmol/L to 1000 nmol/L with corresponding limits of detection at 7.8 nmol/L. The sensing mechanism is based on the chemical oxidation of the hydroxyl groups on the surface of Fe-CDs by HClO. In addition, Fe-CDs also displayed high photoluminescence yield, excitation-independence emission, as well as good biocompatibility, enabling the successful imaging of endogenous and exogenous HClO in HeLa cells. These results revealed that Fe-CDs holds great promise as a robust fluorescent probe for investigating HClO-mediated biological events. Graphical abstract
研究领域:
分析化学
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生物医学
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Zongbo Zhang,Shiliang Song,Yan Ding,Jianhai Yu,Wenting Wu,Jin Li,Xin Wang,Yong Guo,Liang Gong
The precise and controllable preparation of carbon nanomaterials under mild conditions poses a great challenge, especially for metal-catalysed multiphase preparation. This work proposes an efficient method that utilizing high-density ultrasound to enhance the liquid-liquid interfacial reaction system. Iron-doped carbon dots (Fe-CDs) are successfully synthesized in such a normal temperature and atmospheric-pressure reaction condition. It is shown that transient cavitation provides a high-temperature and high-pressure microenvironment for the preparation of Fe-CDs. Moreover, the size of the reactant droplets is reduced from 200.0 ± 17.3 μm to 8.1 ± 2.9 μm owing to the acoustic flow and cavitation effects, which increases the specific surface area of the two reacting phases and improves the mass transfer coefficient by more than 252.0 %. As a result, the yield increases by more than an order of magnitude (from 0.7 ± 0.1 % to 11.9 ± 0.2 %) and the Fe doping rate reaches 20.9 %. The photocatalytic oxidation conversion of 1,4-Dihydropyridine (1,4-DHP) using the obtained Fe-CDs is as high as 98.2 %. This research gives a new approach for the efficient and safe production of Fe-CDs, which is promising for industrial applications.
研究领域:
材料科学
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化学工程
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环境科学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
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2023
·Vol. 11
·期 25
·5898-5909
·
IF 7
Mei Yang,Jun Yao,Borui Su,Nini Xin,Ting Zhou,Mingze Zeng,Chengheng Wu,Dan Wei,Jing Sun,Hongsong Fan
As nanozymes, carbon dots (CDs) have attracted increasing attention due to their remarkable properties. Besides general enzyme activity, their photoluminescence and photothermal properties have been explored rarely, whereas their synergistic effects might produce CDs-based nanozymes of high performance. Here, iron-doped CDs (Fe-CDs) with tunable fluorescence and enhanced peroxidase-like activity were designed to develop a novel “three-in-one” multifunctional platform to provide dual-mode/dual-target detection and near infrared (NIR)-assisted antibacterial ability. This proposed strategy for a H2O2 test exhibited a wide linear relationship with a low limit of detection (LOD) of 0.16 μM (colorimetric) and 0.14 μM (ratiometric fluorescent). Furthermore, due to the nature of cholesterol being oxidized to H2O2 by cholesterol oxidase, sensitive and selective detection of cholesterol was realized, and the LOD was 0.42 μM (colorimetric) and 0.27 μM (ratiometric fluorescent), surpassing that reported previously. This result suggested that Fe-CDs could be used for dual-mode quantification of large family of H2O2-producing metabolites, thereby paving the way for developing multi-mode sensing strategies based on nanozymes. Moreover, this platform showed synergistic effects for antibacterial application, indicating great prospects for bacterial killing as well as wound disinfection and healing. Hence, this platform could contribute to the construction of multifunctional CDs with high performance.
研究领域:
生物医学工程
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分析化学
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纳米技术
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DOI
PubMed
高影响因子
CATALYSIS TODAY
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2025
·
IF 5.3
Xi Shen,Zhenyu Zhao,Hong Li,Xin Gao
The recycling and upcycling of waste plastics into high-value products by pyrolysis is a critical challenge caused by its time/energy-consuming problems, which can be overcome by employing microwave-assisted catalytic pyrolysis due to its rapid pyrolysis rates and high product yields. This study presents a facile method for the synthesis of catalysts for microwave-assisted pyrolysis of waste plastics, utilizing the pyrolytic products as raw materials. In this case, a microwave thermal shock strategy is developed to efficiently anchor iron nanoparticles on carbon nanotubes (CNTs). This method recycles a portion of pyrolysis products back into the catalyst pool for plastic transformation into new CNTs, reducing the consumption for preparing additional catalysts. The precursors exposed to 50 W microwave irradiation reaches above 2000 °C within seconds, allowing Fe nanoparticles to be uniformly impregnated within the carbon nanotube matrix. The formed iron-doped CNTs shows high activity for microwave-assisted pyrolysis, generating CNTs with D/G ratios at 0.31. The recycling and reconstruction of CNTs after multiple pyrolysis form a cross-lined network structure, which facilitates electron transition and can be utilized for fabricating electrocatalysts. Nitrogen doping further improves the onset potential to 0.923 V vs. RHE, making them viable candidates for electrocatalytic applications in oxygen reduction reactions. In summary, our findings demonstrate the feasibility of this approach to reactive pyrolysis products that serve as catalysis for microwave-assisted pyrolysis, with the potential to reduce volatile organic compound emissions and capital expenditure in catalyst preparation, offering a greener and more efficient pathway for plastic waste management and catalyst production.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
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2023
·
IF 8.7
Yanfang Li,Xiaoyun Li,Maoqing Kang,Yuhua Zhao,Qifeng Li,Junwei Wang
A series of microwave absorbers (SFs) were prepared using coal hydrogasification semi-coke as the carbon and ferric nitrate as the magnetic precursors. The absorbers were then incorporated to waterborne polyurethane to prepare composites (WSF). The microwave absorption performance of the composites can be tuned by adjusting the annealing temperature of the hybrids. The composite films can be fabricated to gradient or homogeneous structures by a facile viscosity-controlling method. The film with gradient structure is more conducive to alleviating the impedance mismatch and enhancing the attenuation. The WSF700 composite with gradient structure performs favorable MA property, with the minimum reflection loss of −42.08 dB and effective absorption bandwidth of 6.78 GHz at a thickness of 1.7 mm. The preparation strategy is rather facile, and the ingredients are inexpensive and easily accessible. This work shows great potential for the applications of the composites in MA coatings and flexible electronics.
研究领域:
材料科学
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电磁学
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DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2024
·
IF 3.8
Xie Sijia,Zeng Yating,Li Jinfu,Lu Xuemei,Xiong Hai
Nanozyme technology has gained significant regard and been successfully implemented in various applications including chemical sensing, bio-medicine, and environmental monitoring. Fe-CDs were synthesized and characterized well in this study. As compared to HRP (3.7 mM), the Fe-CDs exhibited a higher affinity towards H 2 O 2 (0.2 mM) using the steady-state kinetic assay and stronger catalytic capability by changing the color of TMB to the blue color of the oxidized state, oxTMB. Additionally, an efficient peroxidase mimic, Fe-CDs/GOx, based on the hybrid cascade system to produce in situ H 2 O 2 for the visual detection of glucose (color change: colorless to blue, and then to green), has been developed in detail, with limits of detection (LODs) for H 2 O 2 and glucose of 0.33 μM and 1.17 μM, respectively. The changes further demonstrate a linear relationship between absorbance and H 2 O 2 concentration, ranging from 10 to 60 μM, and for glucose (1 to 60 μM). To assess the accuracy and detection capability of the Fe-CDs/GOx system, we evaluated a real human serum sample obtained from adult males in a local hospital. In conclusion, Fe-CDs serving as a peroxidase mimic have the potential for various applications in the fields of biomedicine and nanozymes. Graphical Abstract
研究领域:
生物化学
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纳米医学
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分析化学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2024
·
IF 8
Tongtong Zhu,Lei Cao,Xinlu Li,Yuwei Du,Haiyang Yan,Zhimin Chang,Wen-Fei Dong,Li Li
Multidimensional imaging materials are highly sought after in scientific research and clinical applications due to their ability to provide comprehensive imaging data while minimizing experimental interference. The iron-doped carbon dots (TPFe-CDs) prepared in this study possess dual-mode imaging capabilities, combining fluorescence and magnetic resonance imaging, along with photodynamic therapy functionality. In fluorescence imaging, TPFe-CDs exhibit versatility, being effectively excited by either single-photon or two-photon excitation. This versatility enables successful imaging across various biological samples, including cells, organoids, and zebrafish. Moreover, TPFe-CDs demonstrate exceptional three-dimensional imaging capabilities, penetrating depths exceeding 300 µm, thus enabling deeper tissue imaging beyond surface layers. Additionally, TPFe-CDs serve as excellent contrast agents in magnetic resonance imaging, showcasing a T 2 relaxation rate of 10.388 mM −1 s −1 . In mouse models, magnetic resonance imaging revealed potential targeting of TPFe-CDs, primarily accumulating in the thoracic lung region, with minimal distribution observed in the gastrointestinal tract and tail regions. Furthermore, TPFe-CDs exhibit promising photodynamic therapy capabilities, generating reactive oxygen species (ROS) upon laser irradiation, leading to successful cancer cell eradication in experimental settings. The multifunctional nature of TPFe-CDs, with their dual-modal imaging capabilities and therapeutic potential, is garnering significant attention and is poised to make substantial contributions to diverse fields such as biological imaging and clinical therapy.
研究领域:
生物医学工程
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分子影像学
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癌症治疗
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DOI
高影响因子
ANALYTICAL LETTERS
·
2022
·
IF 2.267
Yuhui Weng,Huangjie Li,Mincong Zhu,Aojia Tao,Sha Wang,Wen Weng
Novel nitrogen/iron-codoped carbon dots (N/Fe-CDs) were prepared from citric acid, ethylenediamine, and ferric chloride by a facile one-step solvothermal method and their peroxidase-like activity was evaluated. The structure and composition of the obtained carbon dots were characterized by several methods, including electron microscopy, X-ray diffraction, and spectral techniques. The presence of dopants in the particles was confirmed by X-ray photoelectron spectroscopy and inductively coupled plasma – mass spectrometry (ICP-MS). The obtained N/Fe-CDs displayed excellent peroxidase-like activity and efficiently catalyzed the oxidation of 3,3',5,5'-tetramethylbenzidine in the presence of H2O2, leading to a rapid change in the solution color from colorless to blue. Based on this reaction, H2O2 was determined from 0 to 40 μM under optimal conditions with a detection limit of 9.0 nM. In addition, L-cysteine was shown to cause the blue color to fade. Considering this feature, a highly sensitive, fast, and specific colorimetric method was developed for L-cysteine with a detection limit of 15.8 pM, which is lower than observed in similar studies. Further, this colorimetric method was applied for the determination of L-cysteine in real samples, and the results of recovery and relative standard deviation were satisfactory. The reported catalyst can be prepared conveniently using readily available raw materials and is inexpensive, which is advantageous for its widespread application.
研究领域:
分析化学
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生物医学工程
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yan Tao,Chongying Liao,Fangli He,Yixuan He,Sihui Yang,Liu-Pan Yang,Li-Li Wang
Creatine (CR) is an active compound closely associated with meat quality. However, current techniques for measuring CR in meat face challenges in achieving rapid and low-cost detection. In this study, nanozyme based on iron-doped carbon dots (Fe-LCDs) was synthesized by employing sodium lignosulfonate and iron as the precursors. Iron incorporation was crucial for significantly enhancing the peroxidase-like activity of Fe-LCDs. A cascade sensing platform was developed by integrating creatinase (CRH) and sarcosine oxidase (SOx) with Fe-LCDs. In this system, CR interacts with the catalytic framework to generate superoxide anions, which catalyzes the oxidation of 3,3′,5,5’-Tetramethylbenzidine (TMB) to produce a blue-colored product, enabling colorimetric detection of CR. Furthermore, a sensing platform compatible with smartphones was established, successfully facilitating rapid, sensitive, and visual detection of CR in meat. This research not only synthesized an effective CDs-based nanozyme but also devised a novel and promising nanoparticle-based sensing platform for CR detection.
研究领域:
食品科学
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生物化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2025
·
IF 6.1
Miaomiao Tang,Xia Zhang,Bo Wang
Superhydrophobic solid-liquid composite (SLC) coatings are recognized as a promising material for addressing wear and ice accumulation issues due to their inherent self-lubricating properties. In this study, iron-doped carbon nanotube (CNT@Fe) coatings with photothermal, anti-friction, and wear-resistant properties were successfully fabricated via an aerosol-assisted chemical vapor deposition (AACVD) process. Subsequently, a spin-coating process was employed to apply perfluoropolyether (PFPE) onto the CNT surface, resulting in the formation of solid-liquid composite coatings. The CNT coating inherently proves to be highly stable, self-lubricating, and wear-resistant properties. Following the application of the solid-liquid composite, the film exhibited an average friction coefficient decrease to 0.10, marking a 33 % decrease compared to the 0.15 coefficient of CNT coatings. Additionally, the wear rate decreased by approximately 74 %. The main factors for reducing friction and preventing wear are the self-lubricating and bearing properties of CNT, along with the solid-liquid synergistic lubrication provided by solid-liquid composite coatings. Meanwhile, the superhydrophobicity of the coatings and the photothermal effect result in excellent anti-icing properties, which make it possible to de-ice in 300 s. The coatings exhibit prospective for outdoor anti-icing applications and mechanical component surfaces due to their photothermal and wear resistance characteristics.
研究领域:
材料科学
·
表面工程
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产品关联
DOI
高影响因子
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