Journal of Materials Chemistry A
·
2024
·
IF 10.7
Yiyuan Yao,Shifu Wang,Chaohai Wang,Zetong Wu,Chengming Xiao,Xin Guo,Xin Yan,Junwen Qi,Yujun Zhou,Zhigao Zhu,Yue Yang,Xuning Li,Jiansheng Li
The selective distribution of reactive oxygen species originating from the optimized activation of peroxymonosulfate (PMS) offers opportunities to achieve the effective elimination of contaminants in water, but the synergistic mechanism of this process is still unclear, especially the reaction intermediates on the multi-metal catalysts. Herein, we proposed a coordinate metal regulation strategy to modulate active sites by designing an FeCoMnNiCu Prussian blue analogue-derived high-entropy alloy system that possesses a 0D-1D hybrid nanoarchitectonic structure. The electronegativity differences between the metals induce significant variation in the coordination environment during pyrolysis, creating highly active Fe, Co, and Mn sites and secondary active Ni and Cu sites, thus enhancing interfacial electron transfer and reducing the adsorption energy of PMS activation. In situ Raman analysis and DFT calculations revealed that FeIVO and ˙OH species were involved in the excitation process followed by the efficient elimination of various pollutants, which represents a breakthrough in the design of multi-metal Fenton-like catalysts for sustainable water decontamination.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Hui Jiang,Huimin Zhu,Donglei Jiang,Muze Cheng,Jinye Yu,Xinmei Liu,Jie Yang,Rui Sun,Jun Yang
Effective detection of foodborne pathogenic bacteria is a crucial demand for global food security, yet conventional approaches for detection are often constrained by their reliance on species-specific targets, limiting their capability for broad-spectrum pathogenic bacteria recognition. This study aimed to introduce a novel electrochemical biosensor designed for conserved virulence factor-based broad-spectrum pathogenic bacteria recognition. We combined a prefabricated ready-to-use NaAlg@paper scaffold with a four-channel electrode device including an integrated culture chamber. This setup allowed for rapid cell immobilization on the electrode surface and supported long-term three-dimensional cultivation. The human NLR family apoptosis inhibitory protein–NLR family CARD domain-containing protein 4 (hNAIP–NLRC4) complex was expressed in HEK293 cells to construct HEK293/hNAIP–NLRC4 bioengineered cells as the sensing element, thereby enabling the specific detection of the type III secretion system (T3SS), which is a highly conserved virulence factor. This design effectively eliminated the interference caused by the complex receptor profiles of native immune cells. Based on this strategy, the sensor exhibited a linear range of 2.8 × 10² to 2.8 × 10⁷ CFU/mL for detecting Salmonella typhimurium with a detection limit of 1.7 × 10² CFU/mL. Moreover, this method successfully distinguished pathogenic from nonpathogenic Escherichia coli and specifically detected a broad spectrum of pathogenic bacteria carrying T3SS. These findings demonstrate the potential of conserved virulence factor-oriented biosensing for broad-spectrum recognition of pathogenic bacteria and offer a reliable technical solution to enhance food safety.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Yi Li,Yong Tang,Yujing Wang,Junyin Chen,Chun Huang,Jianwei Zhao,Lirong Qin
Aqueous zinc‑ion batteries (AZIBs) are promising for safe and low‑cost energy storage, yet their practical application is hindered by limited cathode cyclability and poor low‑temperature performance. Herein, a ternary composite of V 3 O 4 /Fe 3 O 4 /V 1.5 Fe(CN) 6 nanorods is directly grown on carbon cloth via a simple hydrothermal method. The electrode exhibits a unique activation behavior: its specific capacity gradually increases by more than 300% during the initial galvanostatic charge‑discharge cycles, reaching 530.1 mAh/g at 1 A/g. Ex situ XRD and XPS reveal that activation induces lattice expansion and an increase in V 4 + and Fe 3+ contents without phase transformation. The VF‑20 electrode delivers exceptional long‑term stability (89% retention after 4200 cycles at 4 A/g) and remarkable low‑temperature performance (69 mAh/g at −40 °C and 0.1 A/g). This work provides a new paradigm of activation‑driven performance enhancement for multiphase cathodes in AZIBs.
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ACS Food Science & Technology
·
2026
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IF 3
Dimoso Noel,Feng Yue,Tang Anqi,Yang Zhen-Quan
Maize bran is a nutrient-rich byproduct
with limited
applications.
This study evaluated the impact of co-culture fermentation using yeast
and lactobacillus strains on bran functionality. The findings indicated
that co-fermentation for 72 h significantly improved the microstructure,
hydration, and oil absorption properties of bran. Soluble proteins
increased the most during single-yeast fermentation for 24 h. Yeast
and Pediococcus pentosaceus co-fermentation
for 72 h increased total phenolics by 1.42-fold and exhibited the
strongest reducing power (4.50 mg/g), DPPH • (32.37
μmol/g), ABTS •+ (298.00 μmol/g), and • OH (68.42%) scavenging activities. Yeast and L. fermentum presented the second most total phenolics,
DPPH • , and • OH scavenging activities.
Single-yeast fermentation for 48 h demonstrated the highest iron chelation
rate at 43.52%. Yeast and L. plantarum exhibited superior total flavonoid content (1.95 mg/g). Further,
fermentation treatments modified the flavor profile, with increased
phenylethyl alcohol and 3-methylbutanoic acid contents. These results
provide valuable insights into the potential of co-fermentation to
enhance maize bran functionality.
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Journal of Bioresources and Bioproducts
·
2026
·
IF 19.9
Yusi Bu,Guoxi Xia,Minglei Zhang,Jiabo Wang,Qiuhua Chen,Guoxiang Wang,Xiaolian Shi,Fang Sui
The development of robust biomimetic interfaces remains challenging due to the inherent instability of native cell membranes when integrated into functional devices. Herein, we reported a bio-based functional composite in which a chitosan-derived conductive hydrogel served as a multifunctional matrix to achieve unprecedented stabilization of red blood cell membranes (RBCMs). Leveraging the three-dimensional polycationic network and abundant amino groups of this natural polysaccharide, the hydrogel electrostatically anchored RBCMs while preserving their native fluidity and membrane-bound acetylcholinesterase conformation-overcoming a long-standing bottleneck in biomembrane-based material engineering. Integration of carboxylated multi-walled carbon nanotubes endowed the composite with efficient electron transfer capability without compromising biocompatibility. The resulting biomimetic interface retained 85.8% of its initial electrochemical response after 7 days of continuous operation and enabled sensitive detection of organophosphate pesticides in real agricultural samples (apples, oranges, and tomatoes). This work established chitosan hydrogel as a versatile bio-based platform for constructing stable biomembrane composites, expanding the application scope of natural polysaccharides in functional material design for environmental monitoring.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Yan Jiang,Tongtong Zhang,Qiong Wu,Jingwen Zhao,Fengna Xi,Jianmin Wu
Developing highly sensitive electrochemiluminescence (ECL) systems is crucial for the analysis of tumor biomarkers. Herein, mildly oxidized porous silicon (MOPSi) was firstly employed to immobilize cerium oxide (CeO 2 ) nanozymes to amplify the ECL response of the luminol-dissolved oxygen (DO) system in a near-neutral condition for Alpha-fetoprotein (AFP) immunoassay. MOPSi nanoparticles possess a unique Si core/SiOₓ shell structure that enables the stable anchoring and dispersion of CeO 2 via Ce-O-Si bonds. Notably, CeO 2 -MOPSi/ITO exhibits a markedly higher ECL intensity than CeO 2 /ITO and MOPSi/ITO owing to the robust heterostructure formed between CeO 2 and MOPSi. The CeO 2 -MOPSi heterointerface enables a self-cascade catalytic process that comprises efficient oxygen reduction to produce superoxide anion radicals (O 2 •- ) and H 2 O 2 , followed by the in-situ conversion of the generated H 2 O 2 into additional O 2 •- . The abundant O 2 •- reacts with luminol radical anion (L •- ), leading to an enhanced ECL response. Moreover, an AFP immunosensor was fabricated by anchoring antibodies onto MOPSi surface. The proposed sensor shows a broad linear range from 10 fg/mL to 10 ng/mL with a detection limit of 3.3 fg/mL. This work provides a novel strategy for integrating the MOPSi carrier with nanozymes to develop advanced ECL systems for high-performance bioanalysis. Download: Download high-res image (123KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Baoli Wang,Yuhang Zhang,Yijun Zhang,Yan Deng,Feng Yang
Uniform Co 3 O 4 nanoparticles with abundant active sites loaded on the N-doped graphite carbon was prepared. • Co 3 O 4 /NC based electrochemical sensor was fabricated to detect chloramphenicol in environmental samples. • The proposed sensor presents wider linear ranges and lower detection limit. Chloramphenicol (CAP), a typical broad-spectrum antibiotic, poses considerable threats to human health due to its residues transferring through the food chain. Thus, the development of fast and highly sensitive detection technologies for CAP is of great practical importance. Herein, a Co 3 O 4 @NC nanocomposite was prepared via a controllable thermal decomposition-oxidation approach. This composite was further employed as an electrode modification material to construct a novel electrochemical platform, which was designed for the quantitative detection of CAP. Characterizations revealed that Co 3 O 4 nanoparticles were wrapped in the carbon sheet in the prepared Co 3 O 4 @NC nanocomposite with a specific surface area of 285.5 m 2 /g, along with affluent oxygen vacancy active sites. Electrochemical performance measurements indicated that Co₃O₄@NC exhibits excellent electrocatalytic reduction activity toward CAP. Under optimized experimental conditions, differential pulse voltammetry (DPV) was employed to detect CAP, and the sensor emerged a linear detection range of 0.1–500 μmol/L with a low detection limit of 12.4 nmol/L, outperforming most electrochemical sensors for CAP reported in previous papers. Additionally, it owned good selectivity, as the relative standard deviation (RSD) of the CAP detection signal was less than 5% even as the other familiar interfering species were concomitant. It also demonstrated remarkable stability, repeatability, and anti-interference ability. When applied to the actual determination of CAP residues in environmental samples, the sensor yielded recovery rates of 97.02%–104.23% for marine sediment samples and 99.77%–104.06% for seawater samples, with all RSD values below 5.1%. This study realizes the structural and performance regulation of Co₃O₄ materials through a simple and feasible strategy, providing a new sensing platform for the rapid detection of trace CAP and offering novel insights into the application of metal oxides in electrochemical sensing fields. Download: Download high-res image (126KB) Download: Download full-size image
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xinyi Wang,Yuying Lin,Rubing Xiong,Jing Liu,Yue Liu,Zijie Li,Yongmei Chen,Yong Xia,Zhiqi Li,Lei Mou,Meiling Liu
Background Continuous lactate monitoring provides valuable information on metabolic dynamics during exercise and recovery. Enzymatic lactate sensors commonly use lactate oxidase, whose catalytic response depends on local oxygen availability. As physiological oxygen levels fluctuate, a calibration model established under one oxygen condition may generate substantial measurement bias under another condition. Existing wearable lactate sensors generally use a single calibration model and therefore cannot compensate for oxygen-dependent changes in sensor response. The key problem addressed in this study is the lack of an oxygen-adaptive calibration strategy for accurate continuous lactate monitoring in complex physiological microenvironments. Results We developed a wearable electrochemical platform based on a carbon nanotube/Prussian blue/lactate oxidase interface and integrated it with a custom portable microcircuit. The system classified currents less negative than −0.8 μA as hypoxic and those more negative than −0.8 μA as aerobic, and applied the corresponding calibration model in real time. The sensor showed linear responses from 2 to 12 mM lactate, with sensitivities of 0.2247 μA/mM under aerobic conditions and 0.01256 μA/mM under hypoxic conditions. Plasma measurements agreed closely with a commercial biochemical analyzer (r = 0.9860). In rats, sensor readings correlated strongly with blood lactate assay results during both aerobic (r = 0.9766) and hypoxic (r = 0.9316) phases. The oxygen-adaptive strategy achieved a mean absolute relative difference of 4.86%, compared with 59.72% and 1028% for the single aerobic and hypoxic calibration models, respectively. Significance and novelty This study introduces an oxygen-adaptive calibration strategy that converts oxygen-dependent signal variation from a source of error into a basis for real-time model selection. By combining oxygen-condition classification with condition-matched calibration, the platform markedly improves lactate measurement accuracy across aerobic and hypoxic conditions. This approach provides a practical framework for continuous biosensing in physiologically variable microenvironments.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Bao Jiang,Yanhui Niu,Xiuxin Jin,Yuntao Huang,Qin Hu,Yaxin Luo,Jialing Hua
Rational Interface Engineering: We successfully synthesized a GO/MoS 2 /TiO 2 ternary nanocomposite with carefully engineered heterojunction interfaces. This structure not only prevents the restacking of MoS 2 and aggregation of TiO 2 but also facilitates efficient charge separation and accelerates electron transfer rates compared to single or binary counterparts. • Significant Synergistic Enhancement: Rather than simply mixing components, our design yields a substantial improvement in electrochemical performance. The sensor exhibits a 2-fold increase in current response and a significantly lower detection limit compared to the individual MoS 2 electrodes. This result strongly validates the effectiveness of our interface engineering strategy in overcoming the intrinsic limitations of single-component materials. • Self-Cleaning and Anti-Fouling Capability: A distinct advantage of our ternary system is its excellent anti-fouling property. The incorporation of TiO 2 endows the sensor with self-cleaning capabilities (attributed to its photocatalytic activity/surface properties), effectively mitigating electrode passivation caused by the adsorption of oxidation products. This ensures superior operational stability and reproducibility, addressing a common bottleneck in APAP detection. • Practical Robustness: We successfully applied the sensor to the determination of acetaminophen in real pharmaceutical tablets and water samples with satisfactory recovery rates, proving its potential for practical applications in complex matrices. Efficient detection of acetaminophen (APAP) is critical for public health and environmental safety, but traditional electrochemical sensors often suffer from severe electrode passivation and ambiguous interfacial sensing mechanisms.To address these challenges, To address these fundamental challenges, this study constructs a novel photo-assisted electrochemical platform based on a GO/MoS 2 /TiO 2 ternary heterojunction, systematically characterized via XRD, TEM, FTIR, and XPS. Explicitly shifting the focus from conventional metric-chasing (e.g., pursuing extreme detection limits) to rational material design, this work thoroughly elucidates the structure–activity relationship and underlying synergistic mechanisms through comprehensive kinetic investigations (e.g., CV, EIS, and DPV). Experimental results demonstrate that the strategically designed cascaded band structure significantly boosts electrocatalytic activity and interfacial charge transfer. Furthermore, by leveraging the distinct structural advantages of the distinct structural advantages of GO/MoS 2 alongside the photo-assisted properties of TiO 2 , the sensor achieves a dual-mode “anti-fouling and self-cleaning” capability that effectively resolves surface fouling caused by oxidation products. Consequently, the sensor exhibits robust performance with a detection limit of 0.07 µM (S/N = 3) and three wide linear response ranges (7.865∼12.155 µM, 12.155∼71.5 µM and 71.5∼715 µM). Ultimately, this systematic study provides not only a robust platform for real-world APAP monitoring but also a theoretical blueprint for designing next-generation, passivation-resistant sensing interfaces. A photo-assisted GO/MoS 2 /TiO 2 ternary heterojunction sensor was constructed for ultrasensitive electrochemical detection of acetaminophen with enhanced charge transfer and excellent anti-fouling performance.(This graphical abstract was generated using AI tools) Download: Download high-res image (252KB) Download: Download full-size image
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Yu Meng,Long Chen,Siyuan Ye,Yucheng Xie,Zhanyong Wang,Ying Jia,Jie Luo,Lei Wei,Qichong Zhang
Fiber-shaped iontronic synapses (FEISs) are emerging as promising building blocks for next-generation wearable neuromorphic computing due to their ability to emulate biological signal transmission and plasticity. However, their practical application remains limited by poor environmental adaptability, high energy consumption, and inadequate rectification behavior. Herein, we report a FEIS with anti‑freezing capability that simultaneously achieves ultralow energy consumption and a high rectification ratio. The FEIS is constructed by directly assembling tetrachlorobenzoquinone and zinc hexacyanoferrate onto carbon nanotube fibers via π–π stacking, combined with a sucrose-modified polyacrylamide hydrogel electrolyte that inhibits ice formation through hydrogen bond regulation. Our FEIS exhibits stable synaptic operation at −20°C, with an ultralow energy consumption of 17 fJ per synaptic event, and a high rectification ratio of 17.9, enabled by asymmetric Faradaic reactions and ionic relaxation kinetics. These characteristics enable the FEIS to achieve robust unidirectional information transmission and stable synaptic operation, even under cryogenic conditions. Furthermore, the FEIS demonstrates reliable operation in ionic logic circuits and robotic control systems, achieving 95.2%-digit recognition accuracy at −20°C. This work expands the operational boundaries of flexible iontronic neuromorphic devices for applications in extreme environments.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·40273-40290
·
IF 7.8
Qian Huifeng,Pan Xiaoyu,Liang Shujie,Wang Sheliang,Yu Debao,Lu Jinyun,Li Shunchang,Jin Xinyi,Tong Haijiang,Yu Zhangsen
Burn wounds are highly susceptible to bacterial colonization, particularly by multidrug-resistant pathogens, which often result in refractory infections, excessive inflammation, and delayed healing. Herein, we report the rational design and construction of a multifunctional nano-antimicrobial agent, designated mPB@PHMB, through the co-assembly of mesoporous Prussian blue (mPB) with the polymer polyhexamethylene biguanide (PHMB). The resultant nanocomposite integrates potent antibacterial activity with the capacity to modulate the inflammatory microenvironment. Notably, mPB@PHMB exhibited pronounced bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA). Benefiting from the intrinsic multi-enzyme-mimetic activities of mPB, the nanocomposite efficiently scavenged intracellular reactive oxygen species, thereby alleviating oxidative stress-induced cellular injury. Transcriptomic profiling and protein analyses revealed that mPB@PHMB markedly suppressed the NF-κB pathway activation, attenuated lipopolysaccharide-induced M1 macrophage polarization, and reduced the production of pro-inflammatory cytokines. Biocompatibility assessments demonstrated negligible acute cytotoxicity toward skin fibroblasts and no overt toxicity in healthy C57BL/6 mice, underscoring the favorable safety profile of mPB@PHMB. Furthermore, in a murine model of MRSA-infected burn wounds, topical treatment with mPB@PHMB reduced the bacterial burden by approximately 90%. Concurrently, treatment with mPB@PHMB substantially decreased the proportion of M1-polarized macrophages, suppressed the expression of inflammatory cytokines, and alleviated the inflammatory milieu within the wound bed, thereby accelerating tissue repair and wound closure. Collectively, these findings establish mPB@PHMB as a promising nano-therapeutic platform that synergistically couples antimicrobial action with immunomodulatory functions, offering a robust and translatable strategy for the management of burn wounds complicated by multidrug-resistant bacterial infection.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Minghui Wang,Qiaolin Guo,Zhenyong Hu,Yue He,Lai Zhang,Cuifei Chen
An ultrasensitive biosensor has been developed for miR-375 detection. • HRP is embedded into COFs to form stable HRP@COFs co-precipitated nanospheres. • The HRP@COFs preserved enzymatic activity and enhanced catalytic efficiency. • The biosensor has been successfully validated using clinical samples. The dysregulated expression of microRNA (miRNA) in various cancers has attracted considerable attention owing to their crucial roles in tumor initiation and progression. Among them, miR-375 has been recognized as a prospective biomarker for early malignancy detection and therapeutic monitoring. In this study, a highly sensitive electrochemical biosensor has been developed based on horseradish peroxidase (HRP)-embedded covalent organic framework (HRP@COFs) co-precipitated nanospheres for the detection of miR-375. The HRP@COFs nanocomposite effectively preserves the enzymatic activity of HRP while providing the structural stability and high loading capacity of COFs, thereby enhancing catalytic efficiency and signal amplification. In the presence of target miR-375, the azide-modified H1 hairpin probes on the HRP@COFs surface are activated, leading to the formation of a rigid H1-H2 duplex structure through competitive hybridization with H2 hairpins. The resulting H2-H1-HRP@COFs complexes are subsequently anchored onto the electrode surface via click chemistry. Upon the addition of H 2 O 2 , HRP catalyzes aniline polymerization and deposition, resulting in a significant electrochemical response. This biosensor achieves ultrasensitive detection of miR-375 with a detection limit as low as 230 aM. It has been successfully validated using clinical samples, demonstrating great potential for reliable breast cancer diagnosis. This work highlights the synergistic advantages of integrating HRP with COFs, providing a robust and efficient platform for microRNA detection and expanding the applications of COFs-based materials in biosensing and clinical diagnostics. Download: Download high-res image (151KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）