CHEMICAL PAPERS
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2022
·Vol. 76
·期 10
·6427-6435
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IF 2.146
Chen Songlin,Cheng Congliang
The challenges associated with electro-Fenton during water treatment involve changing the traditional cathode to one showing high efficiency, low cost, and easy preparation. H 2 O 2 electrogeneration in the electro-Fenton process can be promoted by a transition metal-doped cathode. Therefore, an iron-doped cathode can greatly enhance H 2 O 2 production and promote the Fenton reaction to lend efficient pollutant degradation ability. This study proposes a low-cost and easy-prepared iron-deposited graphite cloth cathode (G-Fe). The presence of iron renders G-Fe conductive and supports the active sites for H 2 O 2 production. Aeration was a critical factor for H 2 O 2 electrogeneration. A total of 17.126 and 8.345 mg/L H 2 O 2 was produced from the G-Fe surface, with and without the aeration condition (current density of 100 mA/m 2 in 60 min with a neutral pH), respectively. The degradation rate of methyl orange with a cathode of G-Fe with aeration at 100 mA/m 2 was 97.5%, which was higher than the value obtained with graphite cloth as the cathode in an aeration environment or in G-Fe without aeration.
研究领域:
环境科学
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材料科学
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化学工程
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高影响因子
JOURNAL OF POWER SOURCES
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2023
·
IF 9.2
Chang Li,Yushuang Xu,Wenjun Deng,Na Shen,Yan Chen,Chao Huang,Jinlin Zhu,Runduo Zhu,Wenxia Zou,Rui Li
Among aqueous batteries , the research on the battery employing metal as the anode is still mainly focused on the aqueous zinc-ion battery. Compared with zinc, iron has better stability for reversible deposition, lower cost, and higher specific capacity, which is suitable for aqueous batteries. In this study, an aqueous iron-organic battery is constructed by employing polyaniline as the cathode, Fe plate as the anode, and Fe(CF 3 SO 3 ) 2 as the electrolyte, which demonstrates the hybrid storage mechanism of iron plating/stripping in the anode and transmission of CF 3 SO 3 − in the cathode. The polyaniline-Fe battery delivers a specific capacity of 105.8 mAh g −1 at a current density of 0.05 A g −1 and a stable cycle performance over 5,000 cycles with almost no capacity fading at a current density of 0.2 A g −1 , which provides a new direction for the development of aqueous iron-ion batteries.
研究领域:
材料科学
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电化学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Jun Ma,Long Chen,Yue Liu,Tianyuan Xu,Haodong Ji,Jun Duan,Fengbin Sun,Wen Liu
The large consumption of acetaminophen (APAP) worldwide and unsatisfactory treatment efficiencies by conventional wastewater treatment processes give rise to the seeking of new technology for its effective removal. Herein, we proposed a facile one-step hydrothermal method to synthesize defective iron deposited titanate nanotubes (Fe/TNTs) for peroxymonosulfate (PMS) activation and APAP degradation. The retarded first-order reaction rate of APAP degradation by Fe/TNTs was 5.1 times higher than that of neat TNTs. Characterizations indicated iron deposition effectively induced oxygen vacancies and Ti 3+ , facilitating the electrical conductivity and PMS binding affinity of Fe/TNTs. Besides, oxygen vacancies could act as an electron mediator through PMS activation by iron. Moreover, the formation of Fe–O–Ti bond facilitated the synergistic redox coupling between Fe and Ti, further enhancing the PMS activation. SO 4 •− was the major radical, causing C–N bond cleavage and decreasing the overall toxicity. In contrast, APAP degradation by neat TNTs-PMS system mainly works through nonradical reaction. The Fe/TNTs activated PMS showed desired APAP removal under mild water chemistry conditions and good reusability. This work is expected to expand the potential application of titanate nanomaterials for PMS activation, and shed light on facile synthesis of oxygen defective materials for sulfate-radical-based advanced oxidation processes .
研究领域:
环境科学
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材料科学
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化学工程
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DOI
高影响因子
BMC Complementary Medicine and Therapies
·
2025
·Vol. 25
·期 1
·451
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IF 3.4
Pan Sunfeng,Xiong Lie,Li Jiakun,Wang Zhenjun,Su Yujuan,Fang Gaofeng,Zhu Minda,Shi Hanqiang,Li Jiayan,Liu Zhaoyan,Han Chunmao,Shi Yanbo
Background Venous leg ulcer (VLU) is among the most severe clinical manifestations of chronic venous disease (CVD) and imposes substantial burdens on both patients and society. VLU pathogenesis is closely associated with the impairment of vascular endothelial cells. In this study, tissue samples from the patients’ s skins around wound at different stages of CVD were collected during operation and used to elucidate the involvement of ferroptosis in the pathogenesis of VLU. Also the potential mechanism through which Huoxue Shengji (HXSJ) decoction alleviates ferroptosis in human umbilical vein endothelial cells (HUVECs) was investigated. Methods During surgical procedure such as great saphenous vein high ligation and stripping surgery, matched skin tissues from the normal, hyperpigmentation (HPT), lipodermatosclerosis (LDS), and VLU regions were collected from 10 patients with VLU, and the levels of iron and glutathione peroxidase 4 (GPX4) were quantified to evaluate ferroptosis. In vitro, HUVECs were used to iron overload induction using exogenous 100 µM ferric ammonium citrate (FAC) or 100 µM hemin, or ferroptosis induction with 10 µM erastin, and treated with 10 µg/ml HXSJ decoction for 24 h. Subsequently, lipid peroxidation (LPO) damage, mitochondrial function, and key genes involved in ferroptosis were assessed. Results Iron deposition in the affected skin of patients with CVD gradually increased before progression to VLU and significantly decreased during the VLU stage. Moreover, GPX4 expression increased significantly in the HPT stage but was gradually suppressed with further deterioration of CVD. The in vitro results indicated that in both the iron overload and ferroptosis models, HXSJ decoction effectively upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), solute carrier family 7 member 11 (SLC7A11, xCT), and GPX4, which was accompanied by the inhibition of malondialdehyde and protein carbonylation production, the alleviation of ferrous ion accumulation, and the restoration of mitochondrial function. Conclusions This study demonstrated that iron accumulation-mediated inactivation of GPX4 serves as a crucial mechanism in VLU formation through ferroptosis induction. Notably, the therapeutic mechanism through which HXSJ decoction alleviates ferroptosis involves Nrf2/xCT/GPX4 pathway activation and a reduction in ferrous ion accumulation. These findings may provide novel insights into VLU pathogenesis and give possible reason for developing traditional Chinese medicine therapies targeting ferroptosis and VLUs. Graphical
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PubMed
高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2020
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IF 6.17
Kang Han,Xiaofang Jin,Xin Guo,Guoli Cao,Siyu Tian,Yiming Song,Yuanyuan Zuo,Peng Yu,Guofen Gao,Yan-Zhong Chang
The transcription factor NF-E2-related factor 2 (Nrf2) is a central regulator of cellular antioxidant and detoxification response. The association between Nrf2 activity and iron-related oxidative stress in neurodegenerative diseases has been studied, and Nrf2 was found to transcriptionally regulate the expression of iron transporters and ferroptosis-related factors. However, the role of Nrf2 in age-related motor dysfunction and its link to iron metabolism dysregulation in brain have not been fully elucidated. In this study, with different ages of Nrf2 knockout (KO) and wild type (WT) mice, we investigated the effects of Nrf2 deficiency on brain oxidative stress, iron metabolism and the motor coordination ability of mice. In contrast to the predicted neuroprotective role of Nrf2 in oxidative stress-related diseases , we found that Nrf2 KO remarkably improved the motor coordination of aged mice, which was associated with the reduced ROS level and decreased apoptosis of dopaminergic neurons in substantia nigra (SN) of 18-month-old Nrf2 KO mice . With high-iron and Parkinson's disease (PD) mouse models, we revealed that Nrf2 KO prevented the deposition of brain iron, particularly in SN and striatum, which may subsequently delay motor dysfunction in aged mice. The regulation of Nrf2 KO on brain iron metabolism was likely mediated by decreasing the ferroportin 1 (FPN1) level on brain microvascular endothelial cells , thus hindering the process of iron entry into the brain. Nrf2 may be a potential therapeutic target in age-related motor dysfunction diseases for its role in regulating brain iron homeostasis .
研究领域:
神经科学
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分子生物学
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衰老研究
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神经退行性疾病
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DOI
PubMed
高影响因子
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