FOOD HYDROCOLLOIDS
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2023
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IF 10.7
Yuhuan Zhang,Beibei Wang,Chunmeng He,Lin Shi,Jianke Li
Iron deficiency is the utmost critical problem of nutrition worldwide. Polysaccharide-iron chelate is a promising iron supplementation that exhibits good stability, high absorption rate, and fewer adverse reactions, but it still owns drawbacks of extra energy and lower iron content with respect to inorganic ones. Carboxylated polysaccharide-iron has been proven with enhanced iron content, however with poor aqueous solubility. Here, Fe 3+ concentrations controlled highly soluble carboxylated inulin-iron chelates were synthesized to promote the sustained release and efficient supplement of iron with no extra energy. Inulin, soluble dietary fiber, was initially reacted with succinic anhydride (SA) to get carboxylated inulin (IN-SA) consequently enhancing the complexing ability of Fe 3+ and its bioavailability. Interestingly, the aqueous solubility of the IN-SA-iron chelate (IN-SA-Fe) directly correlated with the Fe 3+ concentrations. Relatively higher or lower Fe 3+ concentrations resulted in highly soluble IN-SA-Fe, otherwise, leading to insolubility precipitates. The possible mechanism was proposed as the polymerization reaction of IN-SA in different degrees with Fe 3+ acting as the cross-linker. Moreover, IN-SA-Fe was demonstrated with properties of sustained slow-release of iron in artificial gastric juice and good in vivo biosafety. This work provides a simple, efficient, no extra energy soluble iron supplement for the treatment of iron deficiency.
研究领域:
营养学
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食品科学
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医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
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IF 3.412
Shan Liang,Yu Huang,Youn Young Shim,Xiang Ma,Martin J. T. Reaney,Yong Wang
Nanocomposites, based on iron salts and soluble flaxseed gum (FG), were prepared as potential treatments of iron deficiency anemia (IDA). FG was extracted, characterized, and formulated into iron-loading nanocomposites via ion-exchange against FeCl3, Fe2(SO4)3, FeCl2, and FeSO4·7H2O. FG-iron nanocomposites preparation condition was optimized, and physicochemical properties of the nanocomposites were investigated. In vitro release kinetics of iron in simulated gastric fluid (SGF) was also evaluated. FG heteropolysaccharide, consisting of rhamnose (33.73%), arabinose (24.35%), xylose (14.23%), glucose (4.54%), and galactose (23.15%) monosaccharides, linked together via varieties of glycosidic bonds, was a good recipient for both ferric and ferrous irons under screened conditions (i.e., 80 °C, 2 h, I/G = 1:2). Iron loaded contents in the nanocomposites prepared from FG-FeCl3, FG-Fe2(SO4)3, FG-FeCl2, and FG-FeSO4·7H2O were 25.51%, 10.36%, 5.83%, and 22.83%, respectively. Iron in these nanocomposites was mostly in a bound state, especially in FG-FeCl3, due to chelation forming bonds between iron and polysaccharide hydroxyl or carboxyl groups and formed stable polysaccharide-iron crystal network structures. Free iron ions were effectively removed by ethanol treatments. Because of chelation, the nanocomposites delayed iron release in SGF and the release kinetics were consistent with Korsmeyer-Peppas model. This indicates that such complexes might reduce side effects of free iron in human stomach. Altogether, this study indicates that these synthetic FG-iron nanocomposites might be developed as novel iron supplements for iron deficiency, in which FG-FeCl3 is considered as the best option.
研究领域:
食品科学
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医学
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材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
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2018
·Vol. 54
·期 1
·170-182
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IF 2.383
Hong He,Fengping An,Hui Teng,Qun Huang,Hongbo Song
Summary This study aimed to synthesise a complex of agar oligosaccharides (AOS) with ferric iron and to evaluate its physicochemical and structural characteristics. Based on single factor, Plackett–Burman and response surface optimal experiments of three factors at three levels, the optimised chelate conditions of the AOS-iron (III) complex were mass ratio of AOS to iron ions of 4.5:1 g:g, reaction temperature of 74 °C and reaction time of 60 min. Under these conditions, the iron content and total sugar content were 14.03 ± 0.42% and 66.07 ± 0.96%, respectively. The physicochemical analysis showed that AOS–iron (III) was soluble and steady at physiological pH, and it was easily reduced to iron (II). The structural characteristics of AOS and AOS–iron (III) were analysed by Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction and Nuclear magnetic resonance, and results showed that the iron (III) ions were chelated to AOS by –OH groups and –COOH groups and widely dispersed on the AOS backbone. Therefore, AOS–iron (III) could be a candidate for iron supplementation to treat iron deficiency anaemia.
研究领域:
化学
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材料科学
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营养学
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Yiqiao Pei,Ye Zhang,Fang Tian,Yanrong Zhao,Xuguang Zhang,Steve W. Cui,Huali Wang,Jianbo Zhang,Hao Wang
Iron supplementation has been an important and complicated health topic. Available iron preparations generally have issues such as instability, inadequate absorption, and low consumer acceptability. This study provided a novel ferric pyrophosphate (FePP) delivery system, the FePP-casein-phosphopeptide-dextran (FCD) complex, with sodium pyrophosphate (NaPP) as a solvent promoter and casein-phosphopeptide (CPP) and β-glucan as wall materials. Compared to FePP, FCD showed better properties, including good water solubility (95% resolubilization), color stability (pH 3.5–6.5), compatibility with sensitive nutrients like vitamin C (VC), and lipid oxidation stability (delayed by approximately 50%). In vitro, FCD demonstrated gradual iron release in the gut with a release rate exceeding 80%. In vivo, FCD effectively alleviated iron deficiency anemia (IDA) symptoms in mice, with superior overall efficacy to FePP. Therefore, this novel FCD iron delivery system had considerable potential to be applied in nutritional food systems or iron supplements.
研究领域:
营养学
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食品科学
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生物医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Jianglan Yuan,Congxin Lei,Yuchen Duan,Hanxin Zeng,Junzhe Ma,Dongliang Chen,Xu Kang
Heme is widely recognized as an effective iron supplement. In vitro experiments suggested a relatively low bioaccessibility of free heme due to its strong hydrophobicity. The study prepared a β-lactoglobulin-heme nanocomplex (β-Lg-He) to improve the bioaccessibility of heme. The results indicated that heme could spontaneously bind to β-Lg mainly through hydrogen bonds and van der Waals forces to form water-soluble and uniform nanocomplexes. Simulated gastrointestinal digestion experiments showed that bioaccessibility of heme in β-Lg-He was more than 80%, while that of free heme was only about 8.0%, and the serum iron levels of mice in β-Lg-He groups were higher than those in heme groups and control groups. The results of in vivo experiments revealed that β-Lg-He could have a more beneficial effect on the intestinal microbiota of mice than free heme, which was an additional function for the high-efficiency iron supplement.
研究领域:
食品科学
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营养生物化学
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分子生物学
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纳米技术
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微生物学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2024
·
IF 8.3
Zehui Su,Ting Du,Jianxing Feng,Jianlong Wang,Wentao Zhang
Nanozyme has been proven to be an attractive and promising candidate to alleviate the current pressing medical problems. However, the unknown clinical safety and limited function beyond the catalysis of the most reported nanozymes cannot promise an ideal therapeutic outcome in further clinical application. Herein, we find that ferric maltol (FM), a clinically approved iron supplement synthesized through a facile scalable method, exhibits excellent peroxidase-like activity than natural horseradish peroxidase-like (HRP) and commonly reported Fe-based nanozymes, and also shows high antibacterial performance for methicillin-resistant Staphylococcus aureus (MRSA) elimination (100%) and wound disinfection. In addition, with added effects inherited from contained maltol, FM can accelerate skin barrier recovery. Therefore, the exploration of FM as a safe and desired nanozyme provides a timely alternative to current antibiotic therapy against drug-resistant bacteria.
研究领域:
纳米技术
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生物医学工程
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药学
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微生物学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·
IF 29.4
Ruixue Duan,Yueping Li,Ruru Zhang,Xuelan Hu,Yi wang,Jianfeng Zeng,Mingyuan Gao
Acute kidney injury (AKI) induced by ischemia reperfusion is closely related to mitochondrial dysfunction. Nicotinamide adenine dinucleotide (NAD + ) can enhance the mitochondrial function and restrain the following inflammation, but it is hardly delivered and lacks renal targeting ability. To address these problems, we herein use an ultra-small Fe 3 O 4 nanoparticle as a carrier to deliver nicotinamide mononucleotide (NMN), a precursor of NAD + . An outstanding sophistication of the current design is that once NMN is attached on the surface of Fe 3 O 4 nanoparticles through its phosphate group, the remaining part is structurally highly similar to nicotinamide riboside, which provides an opportunity to deliver the NAD + precursor into renal cells through nicotinamide riboside kinase 1 on cell membrane. It was demonstrated that NMN-loaded Fe 3 O 4 nanoparticles can effectively reverse AKI induced by ischemia reperfusion. In-depth studies indicated that a well-timed iron replenishment following anti-inflammation treatment plays a determined role in recovering AKI, which distinguishes the current study from previously strategies centering on anti-ROS (reactive oxygen species), anti-inflammation or even iron elimination. This article is protected by copyright. All rights reserved
研究领域:
肾病学
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药学
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纳米技术
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2019
·
IF 3.22
Biao Yuan,Cong Zhao,Chen Cheng,De-chun Huang,Shu-jie Cheng,Chong-jiang Cao,Gui-tang Chen
Grifola frondosa protein was hydrolysed using Alcalase, and the resulting hydrolysates (CGFP) were filtered using 5 and 1 kDa nominal cut-off ultrafiltration membranes and separated using Sephadex gel chromatography . Two main fractions, named GFP-1 and GFP-2 were obtained. CGFP-Fe and GFP-Fe were synthesized using ferrous chelation. Results showed that the GFP-2 fraction with molecular weight of 963 Da had the highest Fe(II) chelating activity (2680 ± 40 μg/g). UV spectrum showed that the Fe(II) shifted the maximum absorption to shorter wavelengths. The peptides measured using FTIR showed that the GFP-Fe peptide and the un-chelated peptide had different C–O and C= O absorption peaks. The effects of CGFP, CGFP-Fe, GFP2-2 and GFP-Fe on splenocytes proliferation and cytokines secretion were studied in vitro . Both the GFP-2 and GFP-Fe had good immune-enhancing activity. Furthermore, GFP-Fe showed an ability to promote the proliferation of splenocytes and peritoneal macrophages. The iron-chelating peptide of Grifola frondosa still maintained its immune enhancing activity after in vitro gastrointestinal digestion. The results suggested that GFP-Fe might be beneficial as a new iron supplement and as an immunological enhancement .
研究领域:
生物化学
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免疫学
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营养学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）