Advanced Healthcare Materials
·
2022
·Vol. 11
·期 15
·2200467
·
IF 11.092
Wansu Zhang,Shangyu Chen,Pengfei Sun,Shuai Ye,Quli Fan,Jun Song,Pengju Zeng,Junle Qu,Wai-Yeung Wong
The luminescence of traditional phosphorescence-based hypoxia probes is limited to the visible and first near-infrared wavelength regions (<1000 nm), which has defects of higher light scattering and lower penetration depth in contrast with the second near-infrared wavelength window (NIR-II, 1000–1700 nm) for optical bioimaging. Herein, 5,15-bis(2,6-bis(dodecyloxy)phenyl)-porphyrin platinum(II) (PpyPt) with J-aggregation induced NIR-II phosphorescence is reported. J-aggregates of PpyPt are confirmed by the X-ray diffraction data in the crystalline state. Moreover, the emission and excitation spectra of PpyPt in the solid states reveal NIR-II luminescence feature of PpyPt in J-aggregates. More importantly, by preparation of water-soluble PpyPt nanoparticles (PpyPt NPs 4.76 ) with J-aggregates, it has NIR-II phosphorescent lifetime of microseconds and good oxygen-sensitivity in water. Moreover, the good biological hypoxia-sensing potential of PpyPt NPs 4.76 is demonstrated in cells and 4T1-tumor-bearing mice. This study provides an efficient strategy to design NIR-II phosphorescent probe for sensitive tumor-hypoxia detection through the construction of J-aggregates.
研究领域:
生物医学工程
·
光学成像
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ORGANIC ELECTRONICS
·
2016
·
IF 3.471
Jie Zhang,Xunjin Zhu,Aiguo Zhong,Wenping Jia,Fengshou Wu,Dan Li,Hongbo Tong,Chenglin Wu,Wenyuan Tang,Ping Zhang,Lei Wang,Deman Han
The condensation of different groups substituted salicylaldehydes with aniline and 2,4,5-trifluoroaniline, afforded five one-armed Schiff base ligands HL 1 , HL 2 , HL 3 , HL 4 and HL 5 . And their platinum(II) complexes Pt(L 1 ) 2 , Pt(L 2 ) 2 , Pt(L 3 ) 2 , Pt(L 4 ) 2 , Pt(L 5 ) 2 and PtL 5 · DMSO were prepared through the metallation of ligands with K 2 PtCl 4 . All ligands and complexes were characterized by 1 H NMR, infrared spectroscopy , mass spectrometry and single crystal X-ray diffraction. And their thermal stability, photophysical properties, and electrochemical behaviors were investigated in detail. Using these complexes as phosphorescent emitting materials, blue to orange light-emitting devices were fabricated with moderate efficiencies. The maximum current efficiency, power efficiency, and brightness for the 3.0 wt % Pt(L 3 ) 2 doped OLED are 1.12 cd A −1 , 0.62 l m W −1 and 1521 cd m −2 , respectively. Given the synthetic simplicity and ease of structural variation, the results here indicate that these platinum(II) Schiff base complexes are good candidates for phosphorescent OLEDs.
研究领域:
材料化学
·
发光材料
·
有机电子学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2015
·
IF 4.762
Fangfang Zhong,Ahmet Karatay,Liang Zhao,Jianzhang Zhao,Cheng He,Caishun Zhang,Halime Gul Yaglioglu,Ayhan Elmali,Betül Küçüköz,Mustafa Hayvali
Pt(II) dbbpy bisacetylide (dbbpy = 4,4′-di(tert-butyl)-2,2′-bipyridine) complex (Pt-1) with two different Bodipy ligands was prepared with the goal to attain broad-band visible light absorbing, efficient funneling of the photoexcitation energy (via resonance energy transfer, RET) to the energy acceptor and high triplet formation quantum yields. Construction of the above-mentioned molecular structural motif is challenging because two different arylacetylide ligands are incorporated in the complex; normally two homoleptic acetylide ligands were used for this kind of N∧N Pt(II) complexes. A reference complex with trans bis(tributylphosphine) Pt(II) bisacetylide protocol (Pt-4) was prepared for comparison of the photophysical properties. The two different Bodipy ligands in Pt-1 and Pt-4 constitute singlet/triplet energy donor/acceptor, as a result the harvested photoexcitation energy can be funneled to the triplet state confined on one of the two Bodipy ligands. The photophysical properties of the complexes were studied with steady state UV–vis absorption and luminescence spectroscopies, femto- and nanosecond transient absorption spectroscopies, cyclic voltammetry, as well as DFT/TDDFT calculations. Fluorescence/phosphorescence dual emission were observed for the complex. The ultrafast intramolecular singlet/triplet energy transfer in Pt-1 was confirmed by the transient absorption spectroscopy (kFRET = 2.6 × 1011 s–1, ΦFRET = 87.1%) followed by an intersystem crossing (kISC = 1.9 × 1010 s–1), and the triplet state lifetime (τT) is 54.1 μs. The reference complex Pt-4 shows drastically different kinetics with kFRET = 6.9 × 1010 s–1, ΦFRET = 81.0%, kISC = 5.83 × 109 s–1, and τT = 147.9 μs. Different singlet oxygen (1O2) quantum yields (ΦΔ = 75% and 70%) and triplet state quantum yields (ΦT = 91% and 69%, respectively) were observed for complexes Pt-1 and Pt-4.
研究领域:
化学
·
光物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Qifei Shen,Kai Gao,Peijuan Zhang,Zhiqin Zhao,Anran Gao,Yanzi Xu,Chao Chen,Kai Chen,Lingjie Meng,Heng Wang,Mingming Zhang,Dongfeng Dang
Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging to balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc is prepared. It is observed that emission in the near-infrared region from 600 to 1000 nm with a high photoluminescence quantum yield value of 7.92% in solids is recorded for DTPABT-Mc. In addition, the ability to produce both type I and type II ROS under light irradiation is also observed, leading to potential application in photodynamic therapy (PDT) and chemotherapy. After that, 4T1@DTPABT-Mc-NPs, covering DTPABT-Mc nanoparticles with 4T1 cell membranes, are prepared to enhance their tumor-targeting ability. This finally results in effective therapeutic performance in vivo, effectively inhibiting tumor growth. These results suggest that DTPABT-Mc-NPs exhibit excellent synergistic therapeutic effects by combining PDT and chemotherapy, providing new ideas to design agents for diagnosis and therapy in the future.
研究领域:
生物医学工程
·
癌症治疗学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2021
·
IF 5.221
Li Yongguang,Fei Yuexuan,Sun Hongcheng,Yu Shuangjiang,Liu Junqiu
Organoplatinum (II) complexes are promising candidates for the construction of smart supramolecular materials due to their unique flat structures. This accompanied by intriguing luminescent properties, prompts the molecules to aggregate after external stimuli. Nevertheless, the utilization of photo-responsive subunits to modulate their assemble behaviors and functions are still rarely explored. In this work, azobenzene (azo)-appended tridentate platinum (II) complexes with different linkers have been designed and synthesized. The intermolecular hydrogen bonding, π-π stacking, and metal-metal interactions were finely controlled through the tiny alteration of the linkers, which was found to play a vital role in self-assembly, and photophysical and photoisomerization properties. Some of them exhibited dual emission bands originating from metal-perturbed triplet intraligand (3IL) and metal-metal to ligand charge transfer (3MMLCT) excited states due to the different intermolecular interactions. Based on this, the manipulation of switchable luminescence as well as the controllable morphologies have been realized by photoisomerization.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 36
·24878-24886
·
IF 3.9
Depeng Li,Qingqing Guan,Xiaoyun Hu,Yuhong Su,Zhen Su
A new simple Pt(II) terpyridyl salt that shows reversible response towards acetonitrile and irreversible response towards methanol has been reported, accompanied with the colorimetric/luminescent changing from red to yellow. Experimentally and theoretically, the spectroscopic change derives from the hydrogen bonds between crystal water in the Pt(II) terpyridyl salt and external organic molecules, and the different strength of hydrogen bond leads either reversible or irreversible stimuli-response. Furthermore, this Pt(II) terpyridyl salt has been on one hand applied as a probe for sensing acetonitrile in water solution, with high selectivity, good reversibility, proper sensitivity and fast response rate, and on the other hand as advanced anticounterfeiting materials. The current study provides a new approach to acquire and design either reversible or irreversible stimuli-responsive luminescent materials.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2023
·
IF 9.9
Su Zhen,Li Depeng,Zhang Lixin,Tian Si,Su Yuhong,Hu Xiaoyun,Xiong Duan,Guan Qingqing
Smart materials that integrate multi-stimuli response, full reversibility, and dual-visual read-out channel are highly desired for anti-counterfeiting and information encryption applications. Herein, we developed a multiresponsive perchlorate terpyridyl Pt(II) nano complex which could undergo fully reversible conversion between three forms stimulated by water or formaldehyde molecule due to the extent of Pt–Pt interaction. Meanwhile, a dual-visual channel, i.e., the colorimetric channel changed from yellow to orange or red and the corresponding luminescent channel from orange to orange-red or red, has also been found. The weak and equivalent strength of ion-dipole interaction and hydrogen bond that generated between formaldehyde/water and Pt(II) salt result in the easy-control reversibility between the three forms. Furthermore, by introducing different polymer matrices, 1 Cl·ClO 4 @PMMA ( 1 Cl·ClO 4 : [Pt(tpy)Cl]·ClO 4 , tpy: 2,2′:6′,2″-terpyridine), PMMA: poly(methyl methacrylate)) and 1 Cl·ClO 4 @PVA (PVA: polyvinyl alcohol) are successfully constructed, which exhibit different reversible behaviors since the PMMA and PVA matrix exert different influences on the strength of hydrogen-bond. Those smart Pt(II) salt nanostructures present great potential for high-security-level anticounterfeiting application.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2020
·Vol. 97
·期 2
·317-326
·
IF 2.721
Jingjie Tang,Dongting Huang,Fei Meng,Peng Li,Fang Peng,Junsheng Huang
Hypochlorite (ClO⁻) is of great importance either for the metabolism of living organisms or as disinfectant in daily life. However, improper concentration levels of ClO⁻ lead to serious health problems including erythrocyte damage, cardiovascular problems, neuron degeneration, lung/kidney injury and cancer. Therefore, a sensitive and selective detection method is required for the visualization and measurement of ClO⁻. In this work, a novel platinum(II) complex-based luminescent probe Pt-CHO was synthesized and utilized to detect ClO⁻. This “turn-off” probe exhibits high sensitivity, excellent selectivity, good pH stability, low limit of detection and instantaneous response ability. Moreover, the luminescent response is caused by the oxidation of aldehyde into carboxyl groups combined with the coordination of hydroxyl groups at the Pt center, which is rarely reported. The cell imaging of HeLa cells proved the considerable potential of the probe for ClO⁻ imaging in living cells.
研究领域:
生物化学
·
分析化学
·
医学诊断
✓ 已验证
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2023
·
IF 3.8
Ying-Xian Li,Liu-Ping Yang,Meng Yang,Ji-Jun Jiang,Gao-Feng Liu,Hsiu-Yi Chao
Three bipyridine platinum(II) complexes Pt-2-Pt-4 bearing indolyl ligand(s) have been synthesized through the hydroamidation of acetylide ligand(s) of Pt-1 . The structures of Pt-1-Pt-4 were determined by single crystal X-ray diffraction. The photophysical properties of these structurally related complexes Pt-1-Pt-4 have been studied. Pt-1-Pt-4 in the solid state show emission peaks at 525–570 nm, which are assigned as the mixture of 3 LLCT and 3 MLCT excited states. Solids Pt-1-Pt-4 exhibit mechanoluminescence, and Pt-4G can be recovered back to solids Pt-4 upon adding a few drops of diethyl ether. This study provides a new way to synthesize bipyridine platinum(II) indolyl complexes using intramolecular hydroamidation of alkynyl moieties.
研究领域:
无机化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 14
·6646-6652
·
IF 3.269
Ke Zhang,Lingling Luo,Wenjie Li,Honglin Zhang,Yi Zhang,Jiupeng Zhao,Yao Li
The preparation of polystyrene (PS) beads loaded with platinum octaethylporphyrin (PtOEP) via a swelling method has been well incorporated into dissolved oxygen (DO) sensing detection. The experimental results showed that the highest value of I0/I100 was 7.26 and the loading ratio of PtOEP was 51.33%; the luminescent intensity declined by only 2.23% under UV light for 1 hour. The response and recovery times were 16 s and 180 s, respectively. The peak position and intensity of the emission spectrum in buffer solutions with different pH values did not change. This indicates that this oxygen sensor has excellent sensitivity, light stability, reversibility, and pH resistance. Moreover, on this basis, we incorporated another oxygen insensitive dye, coumarin 6 (C6), to prepare a ratiometric oxygen sensor, which showed high sensitivity towards O2 with superior quenching efficiency. Finally, this oxygen sensor was used to monitor the content of DO in fish tank, tap water, and the Songhua River. All the measured results were well within the reference range.
研究领域:
生物化学
·
材料科学
·
环境监测
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Guo Zeng,Minghui Duan,Yifan Xu,Fahuan Ge,Weiguo Wang
A platinum (II)-doped graphitic carbon nitride (Pt 2+ @g-C 3 N 4 ) nanozyme was prepared in this work. Compared to g-C 3 N 4 , Pt 2+ @g-C 3 N 4 shows enhanced peroxidase-like activity. According to DFT calculations and ESR measurements, the Pt on the surface of g-C 3 N 4 accelerates the decomposition of H 2 O 2 into OH and consequently accelerates TMB oxidation. Furthermore, as a proof of concept, the obtained Pt 2+ 2.30 @g-C 3 N 4 was applied in the detection of glucose with an LOD of 0.01 mM. The reproducibility and precision tests of the glucose detection method based on Pt 2+ 2.30 @g-C 3 N 4 show that this method is reliable and feasible for the detection of glucose.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 182
·期 3
·687-693
·
IF 3.719
Tian Li,Wang Binbin,Chen Ruizhan,Gao Ye,Chen Yanling,Li Tianjiao
A glassy carbon electrode (GCE) was modified with a film containing titanium dioxide and a Pt(II)-porphyrin complex, and its response to quercetin was investigated employing cyclic voltammetry and chronoamperometry. The oxidation current caused by quercetin is largely enhanced under UV illumination. The effects of pH value, mass of TiO 2 in the film, UV illumination time and applied potential were studied. Under optimized conditions, the peak current at a typically applied voltage of +0.4 V depends linearly on the concentration of quercetin in the 0.002 to 50 mg L −1 range. The detection limit (at an SNR of 3) is 0.8 μg L −1 . The method was successfully applied to the determination of quercetin in (spiked) samples of tea and apple juice.
Figure Cyclic voltammograms of the TiO 2 /PtP/GCE in the absence and presence of various concentrations of quercetin in 0.1 M NaOH. a-e: 0, 0.1, 0.2, 0.3 and 0.4 mg L -1 .
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）