Environmental Chemistry
·
2018
·Vol. 15
·期 5
·306-316
·
IF 2.923
Weifeng Liu,Lei Qin,Zhuolin An,Lin Chen,Xuguang Liu,Yongzhen Yang,Bingshe Xu
Environmental context Because of the multiple industrial applications of metals, contamination by metal ions is widespread and can at times endanger the environment and the health of human beings. We prepared ion-imprinted adsorbents to achieve selective recognition and smart separation of low-concentrations of copper ions from water. These smart imprinted materials have high potential for selective adsorption and removal of contaminant copper ions, particularly at very low concentrations. A temperature-responsive magnetic adsorbent (poly(N-propyl acrylamide) grafted magnetic carbon microspheres, Cu2+-IIP) was synthesised by ion imprinting technology for low concentration Cu2+ removal. Cu2+-IIP was prepared by using N-propyl acrylamide as a thermo-sensitive functional monomer, N,N-methylene-bis-acrylamide as a cross-linker and ammonium persulfate as an initiator. The morphologies and microstructures of samples were characterised by transmission electron microscopy, Fourier transform infrared spectrometry, thermogravimetry and vibrating sample magnetometry. Adsorption experiments were conducted in terms of kinetics, isotherms and selective recognition adsorption at low feed concentrations. Results indicate that Cu2+-IIP possesses good recognition selectivity and affinity for Cu2+, and can be separated from the treated solution quickly by applying an external magnetic field. The adsorption capacity towards Cu2+ depends on temperature and reaches a maximum value of 45.46 mg g−1 at 35 °C, higher than that of the non-imprinted polymer. The adsorption behaviour of Cu2+ on Cu2+-IIP can be well defined with both the pseudo-second-order kinetic model and Langmuir isotherm model. Cu2+-IIP performs good adsorption selectivity towards Cu2+ because the relative selectivity factors of Cu2+ with respect to Ni2+, Zn2+ and Cd2+ are 7.14, 7.60 and 6.77, respectively. The adsorption capacity of Cu2+-IIP remained 88.41 % after five cycles.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
American Journal of Translational Research
·
2024
·Vol. 16
·期 5
·2011
·
IF 1.7
Ling Cao,Lili Tan,Liping Li
Objectives: The increasing issue of bacterial resistance, coupled with inadequate progress in developing new antibiotics, necessitates exploring alternative treatments. Antibacterial biomaterials, such as silver and copper, possess advantageous properties such as heat resistance, durability, continuity, and safety. Particularly, they can effectively eliminate pathogenic bacteria while preserving cellular integrity, emphasizing the necessity of identifying optimal metal ion concentrations for practical application. Caenorhabditis elegans ( C. elegans ) can serve as a noteworthy model in this context. This study employed a C. elegans infection model to assess the efficacy of antibacterial metal ions. Methods: Hematoxylin-eosin (HE) staining and inductively coupled plasma mass spectrometry (ICP-MS) assay were utilized to determine the toxic levels of metal ions in mice. Additionally, RNA sequencing (RNA-seq) and assessment of reactive oxygen species (ROS) production in the C. elegans model were conducted to elucidate the mechanisms underlying metal ion toxicity. Results: Silver ion concentrations ranging from 10 -6 to 10 -7 M and copper ion concentrations ranging from 10 -4 to 10 -5 M exhibited antimicrobial properties without eliciting cytotoxic effects. Analysis of the transcriptome data derived from mRNA isolated from C. elegans indicated that CRKP infection activated the FoxO signaling pathway, potentially leading to ROS accumulation and C. elegans demise. Conclusions: In conclusion, C. elegans serves as a comprehensive infection model for assessing antibacterial metal ions.
研究领域:
微生物学
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2021
·
IF 2.495
Yinyin Wang,Yun Ai,Yilin Zhang,Yuanyuan Ren,Jilin Wang,Fangyuan Yao,Wenyu Li,Ying Zhou,Yanni Sun,Jianli Liu,Cuiling Wang
A new probe TR-V (Indolo[2,1–b]quinazoline-6,12-dione,6-{(6Z),(2′E)-2′- [(2-hydroxy-3-methoxyphenyl)methylene]hydra zinylidene}) based on tryptanthrin has been synthesized for selective and rapid detection of Cu 2+ . The synthetic route is facile, economical and viable. TR-V reacts in Tris-HCl buffer solution (pH = 8.0) with cupric to a deep yellow chelate which has a significant peak at 450 nm in the UV–Vis spectra. The reaction is instantaneous, ranging from light yellow to dark yellow and the change in color can be observed with the naked eye. Over 13 competitive metal ions do not interfere in the determination. The detection limit is 84 nM (R 2 = 0.9998). Thus, this method was selected for the analysis of copper ions in tap, bottled water and traditional Chinese medicine samples under optimized experimental conditions.
研究领域:
分析化学
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环境科学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 7
·9780-9791
·
IF 4.223
Huang Wenqiu,Zhou Yuping,Zhao Ting,Tan Liju,Wang Jiangtao
In this study, the marine microalgae Skeletonema costatum and Nitzschia closterium were exposed to different forms of copper, such as a metal salt (Cu 2+ ), a nano-metal (nano-Cu), and nano-metal oxide (nano-CuO). During a 96-h exposure to nanoparticles (NPs) and salt, the cell number, Cu 2+ concentration in the culture medium, morphology, and intracellular amino acids were measured to assess the toxicity of the copper materials and the toxicity mechanism of the NPs. As results, the toxicity of Cu 2+ , nano-Cu, and nano-CuO to marine phytoplankton decreased in order. The EC 50 values of Cu 2+ and nano-Cu for S. costatum and N. closterium ranged from 0.356 to 0.991 mg/L and 0.663 to 2.455 mg/L, respectively. Nano-Cu inhibits the growth of marine phytoplankton by releasing Cu 2+ ; however, nano-CuO is harmful to microalgae because of the effect of NPs. The secretion of extracellular polymeric substances by microalgae could also affect the toxicity of nano-Cu and nano-CuO to microalgae. S. costatum was more sensitive to copper than N. closterium . Cu 2+ , nano-Cu, and nano-CuO all reduced per-cell amino acids and the total output of algae-derived amino acids by affecting the growth of the phytoplankton. This study helps to understand the risk assessment of nano-Cu and nano-CuO to marine microalgae.
研究领域:
海洋生物学
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环境科学
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生态毒理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Hao Hu,Lei Xue,Yelin Yao,Linlong Deng,Haibin Wang
A novel fluorescent probe, WH , was successfully designed and synthesized. WH demonstrated continuous detection capabilities for Cu 2+ and EDTA in the HEPES system. Specifically, the introduction of copper ions resulted in fluorescence quenching, while the addition of EDTA led to the recovery of fluorescence. The detection limits of WH for Cu 2+ and EDTA were calculated to be 29.66 and 172.13 nmol· L −1 , respectively. Moreover, WH exhibited AIE property in THF/H 2 O system. According to the Job's plot, 1 H NMR titration and mass spectrometry, WH could form a complex with Cu 2+ in a 1:1 ratio, and the combinding constant was 8.2 × 10 3 L mol −1 . WH exhibited outstanding selectivity, high sensitivity, large Stokes shift and strong anti-interference ability. Furthermore, WH had been successfully applied in the detection of Cu 2+ in beer and red wine, showcasing its promising potential for practical application.
研究领域:
分析化学
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材料科学
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环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2023
·
IF 3.5
Kun Lei,Jinyang Feng,Yuna Sun,Donghua Wu,Xiujian Zhao,Xiao Ma
Doped Cu + glass was prepared by ion exchange method. It was found that the accumulation zone of copper ions would be formed on the glass surface during the process of ion exchange, and there was an extreme point of copper ion distribution concentration about 10 µm inside the glass surface after ion exchange. The exchange depth of copper ions in the sample increased with the increase of ion exchange time. At low ion exchange temperatures, the Cu elements exchanged into the vitreous body exists in the form of Cu + and Cu 2+ . With the exchange of Cu + into the glass, the degree of polymerization of the glasses continued to increase. By raising the ion exchange temperature, a large number of spherical Cu 2 O grains formed on the surface of the sample, continuing to raise the temperature, these spherical grains agglomerated and adhered to form lamellae structure, mainly composed of oxides of Cu 2 O and CuO. The PL spectra showed that the ion-exchanged glass exhibited broadband blue-green emission light with a central wavelength of 468 nm and half-height width of 154 nm under 290 nm excitation. The luminescence intensity appeared to increase firstly and then decrease with increasing the ion exchange time. Dispersed spherical Cu 2 O grains were generated on the surface of the sample exchanged at 410 °C for 16 h. Co-composite luminescence of the spherical Cu 2 O semiconductor and the Cu + doped in the glass effectively increased the luminescence intensity of the samples. In addition, the samples showed a favorable thermal stability of luminescence.
研究领域:
材料科学
·
光学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 27
·期 1
·812-822
·
IF 2.914
Xu Suyun,Yan Ning,Cui Minghao,Liu Hongbo
In this study, ozone-oxidation was used to treat synthetic chemical plating solution containing Cu(II)/Ni(II)-EDTA solution to realize the purpose of decomplexation. The effects of solution pH, initial concentration of Cu(II)/Ni(II)-EDTA, the molar ratio of EDTA to Cu(II)/Ni(II), and the coexistence of Cu(II)/Ni(II) on their removal efficiencies were investigated. The degradation of EDTA-Cu(II) and EDTA-Ni(II) were mainly attributed to OH oxidation, and the removal rates of Cu(II)/Ni(II) depend on the complete decomplexation. The removal rates of Cu(II) and Ni(II) was affected by the pH of solution, and the optimal pH was found to be 7–9; nevertheless, their removal rates can still be up to 90% even in acidic pHs of 3~5. When the molar ratio of EDTA to Cu(II)/Ni(II) increased from 1:1 to 3:1, the kinetics of metal ion removal rate declined from 0.0788 and 0.1139 min -1 to 0.0250 and 0.0271 min -1 . The synergistic effect was found in the Cu(II)/Ni(II) blended system due to the higher catalytic capability and the lower complexation affinity toward EDTA for Ni(II). In summary, ozone oxidation can be considered as an effective technology to realize the complete decomplexation of Cu(II)/Ni(II)-EDTA that contained in chemical plating industry wastewater.
Graphical Abstract
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Haifang Liu,Huayu Han,Leyang Shi,Yong Long,Wenfen Zhang,Yun Chen,Zheng Zhou,Jianbo Liu
Copper plays essential role in human life, as it participates in several physiological processes, such as antioxidant defense, keeping blood vessels integrity, and neurotransmitter synthesis. In the nervous system in particular, copper is essential for neuronal function. Research has shown that alterations in copper levels, either excess or deficiency, may cause neurodegeneration, such as Alzheimer’s disease, Parkinson’s disease, Wilson’s disease, and others. Thus, careful tracking of the levels of copper in serum is important for preventing neurodegeneration. This study reports a new CD-based fluorescence turn-on copper (II) probe with exceptional selectivity, high sensitivity, and considerable enhancement of emission intensity. As a result of these attractive sensing properties, copper ion in serum of patients with neurodegenerative diseases were monitored.
研究领域:
神经生物学
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生物无机化学
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生物传感
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转化医学
·
临床诊断
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Panpan Xue,Huilan Zhuang,Sijie Shao,Hai Cai,Shumin Tang,Ying Sun,Xuemei Zeng,Shuangqian Yan
Abnormal copper and iron ion metabolism promotes tumor proliferation but also presents a potential target for cancer therapy. However, simultaneously modulating these two ions is challenging, and the downstream therapeutic mechanisms remain unexplored. Here, we introduce Fe ss TMiR, a biodegradable ionic nanoregulator designed to modulate copper and iron ion homeostasis for tumor treatment. Fe ss TMiR comprises ferrous ions and disulfanediyldiacetic acid-assembled nanovectors (Fe ss NV) combined with tetrathiomolybdate (TM), an anti-copper agent. Under the acidic and high-glutathione conditions of the tumor microenvironment, Fe ss TMiR decomposes into ferrous ions and TM, leading to elevated iron and reduced copper levels. Transcriptome analysis reveals that this dual ion modulation induces cancer cell death via ferroptosis, apoptosis, and autophagy by affecting multiple pathways, including metal ion metabolism, glutathione metabolism, and oxidative stress. Additionally, Fe ss TMiR inhibits angiogenesis and reduces the expression of programmed cell death ligand 1 (PD-L1). Notably, Fe ss TMiR elicits robust antitumor immune responses in breast tumor mouse models, including dendritic cell maturation, Treg cell reduction, and enhanced T cell tumor infiltration. This study underscores the potential of modulating iron and copper homeostasis in tumor therapy, enhancement of antitumor immune responses, and activation of ferroptosis.
研究领域:
肿瘤学
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生物化学
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Fanyong Yan,Zhangjun Bai,Yuan Chen,Fanlin Zu,Xing Li,Jinxia Xu,Liang Chen
A novel FRET ratiometric fluorescent probe (CMH-GA-CDs) was designed for the detection of Cu 2+ in aqueous solution. The CMH-GA-CDs were prepared through grafting 7-diethylaminocoumarin-3-carbohydrazide (HCM) on the surface of glyoxylic acid-modified carbon dots (GA-CDs) by amidation reaction. In the absence of Cu 2+ , a FRET pair from the CDs to CMH units was established, in which the CMH-GA-CDs exhibited dual emission bands centered at 400 nm (CDs) and 458 nm(CMH), respectively, under optimal excitation wavelength of CDs (λ ex = 340 nm). Upon addition of 30 μM Cu 2+ to CMH-GA-CDs solution, Cu 2+ coordinated with the heteroatoms N and O, which caused the inhibition of FRET process and the change of fluorescence intensity ratio I 458 /I 400 from 1.95 to 0.91. The ratio of I 458 /I 400 exhibited a good linear relationship with the concentration of Cu 2+ in the range of 0–10 μM and the limit of detection was as low as 0.21 μM. Furthermore, The CMH-GA-CDs were used for the detection of Cu 2+ in tap water and lake water with satisfactory recovery ratio between 91% and 104%, demonstrating the promising applicability for detecting Cu 2+ in water samples.
研究领域:
分析化学
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材料科学
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环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
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2021
·
IF 1.751
Guo Lina,Yuanyuan Gao,Limin Han
A tridentate Schiff base probe L (2-NC5H4)C(H)=N(C6H4OH-2) was synthesized via a facile reaction. Probe L showed weak fluorescence emission that originated from intermolecular proton transfer in solution. With addition of Cu2+, the emission of L was quenched by the paramagnetic nature of Cu2+. However, after the solution of L and Cu2+ was refluxed, the emission presented a completely opposite result changing from fluorescent quenching to fluorescent enhancement. The fluorescent enhancement was attributed to a planar cis-structure of Cu2+ complex. Hence, a strategy for change of emission behavior of fluorescent probe L to Cu2+ was developed; a “turn on” mode of detection Cu2+ was realized in methanol solution. A simple refluxing made probe L work as a light-up fluorescent sensor for Cu2+ in methanol solution and gave improvement of sensitivity and selectivity in detection of Cu2+. When H2O was added into the solution of the Cu2+ complex, fluorescent enhancement increased and it can be used to detect water content in methanol.
研究领域:
化学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 9
·1463
·
IF 3.164
Xiaoxiao Zhang,Xuejuan Shi,Liang Ma,Xuan Pang,Lili Li
Chitosan (CS) stacking mats with excellent performance for adsorption of copper ions (Cu(II)) in wastewater were fabricated by alternating electrospinning/electrospraying. The hierarchical structure of the stacking membranes was designed by CS micro-hemispheres sandwiched between CS fibers. The CS stack membranes prepared by the electrospinning technology could effectively increase the specific surface area, and thus, facilitate the adsorption of copper ions. CS stacking membranes with three layers reached adsorption equilibrium within 60 min, and had a maximum absorbance of 276.2 mg/g. The absorbance performance was superior to most of the reported CS adsorbents. Compared with CS fiber mats which were dominated by CS chemical structure during adsorption, the stacking structure of CS membranes contributed to the high efficient capability, and exhibited the multilayer adsorption behavior. This study may develop a promising method for the design of environmentally-friendly natural polymer adsorbents to remove Cu(II) in wastewater.Keywords:chitosan;sandwiched stacking structure;copper ions;adsorption
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）