Analytical Methods
·
2022
·Vol. 14
·期 18
·1803-1809
·
IF 3.532
Dingmin Liu,Pengcheng Huang,Fang-Ying Wu
A colorimetric assay was described for determination of tetracyclines (TCs) in complex matrices based on dual regulation of gold nanoparticle (AuNP) aggregation and in situ silver metallization. The reaction between p-aminophenol and silver ions (Ag+) catalyzed by aptamer (Apt)-functionalized AuNPs promoted the in situ deposition of Ag shells on AuNPs to afford core–shell bimetallic NPs (Au@AgNPs). When the target is present, Apt is separated from the AuNP surface through the Apt-target interaction. With the desorption of Apts, AuNPs catalyzed the formation of more aggregated Au@AgNPs with a thinner Ag shell, corresponding to the solution color gradually changing from orange-yellow to brown. Using A600/A410 as the determination signal, the assay gave visible linear relationships for TCs in the range of 0.3–6.0 μmol L−1 with a detection limit (LOD) of 33.6 nmol L−1. In particular, the assay was successfully applied to detect TCs in real samples with the recovery rate ranging from 91.2% to 106% and relative standard deviation (RSD) less than 4.6%. These results meet the requirements of sample analysis.
研究领域:
分析化学
·
纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2021
·
IF 8.001
Huanmei Yuan,Hao Bai,Hao Chen,Zefei Zhang,Haifei An,Weijian Tian
Phase change micro/nanocapsules with high thermal conductivity shells have extensive application prospects in solar energy storage systems and electronics cooling. To improve the heat transfer of the capsules, a method of preparing Ag-shell coated phase change micro/nanocapsules was developed, where the AgBr ultrafine solid particles are introduced to enhance the rigidity of emulsion droplets in the liquid-solid phase transition process, and by employing hydroquinone as the reductant to repeatedly reduce the AgBr that had been adhered to the surface of the emulsion droplets, an Ag shell is formed on the surface of the cores. In this work, palmitic acid (PA) is used as the core material, and the prepared PA/Ag nanocapsules (100–600 nm) exhibit high thermal storage capability and good thermal reliability. The bulk thermal conductivity of the nanocapsules can be as high as 4.072 W/(m·K), indicating that the Ag shell can effectively improve the thermal conductivity of the nanocapsules. Besides, the thermal response of the nanocapsules is estimated by simulating a single-particle heat transfer process considering nanoscale effects , and the results demonstrate that the thermal response time of PA/Ag nanocapsule (350 nm) in working fluid (water, 80 °C) could be as short as 150ns.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yongyu Lu,Zhanxun Che,Fangyuan Sun,Sen Chen,He Zhou,Pengju Zhang,Yang Yu,Lei Sheng,Jing Liu
Magnetic liquid metal is regarded as a promising material due to its integration of fluidic, metallic, and magnetic properties simultaneously. Previously, few methods of fabricating magnetic liquid metal have been proposed. However, either the alloying reaction inside the matrix or the poor performance in electrical and thermal conduction is troublesome in practical applications. Here, inspired by the mussel in nature, polydopamine is introduced to in situ reduce and immobilize silver shells on the surface of iron particles, and then the modified particles mix with liquid metal to prepare liquid metal-based magnetic suspensions (LMMSs). The silver shells can prevent iron particles from alloying with liquid metal and enhance the electrical and thermal conductivities of the LMMS concurrently. Besides, the LMMS thus obtained can keep its magnetism intact for a long period, at least during the 60 days of the test. Compared to directly mixing bare iron particles with liquid metal, the maximum electrical conductivities increase by at least 13.69% and the thermal conductivities increase by almost 4 times in the LMMS. The LMMS also exhibits potential applications in patterning and magnetic manipulation. This work puts forward a new strategy for preparing a LMMS with appealing properties and its broad applications are expected in the future.
研究领域:
材料科学
·
纳米技术
·
生物仿生学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2023
·
IF 6.1
Bo-Ling Ma,Zhi-Ling Zhang
Alkaline phosphatase (ALP) is a crucial biomarker for clinical diagnosis, which is closely related to the physiological homeostasis regulation process of human body. And the abnormal level of ALP is associated with numerous diseases, such as liver dysfunction, bone diseases, diabetes, and so on. In order to meet the demand of personalized healthcare, it is particularly important to develop a miniaturized point-of-care testing (POCT) device for ALP detection. Herein, a portable solid-phase colorimetric sensor based on enzyme-induced metallization signal amplification strategy was constructed for ALP detection. The AuNPs modified on the glass slides acted as crystal seeds, allowing Ag + in the solution to be reduced and deposited on the surface of AuNPs, which further formed the gold core and silver shell (Au@Ag) complex and generated visual signals. The visual signals were recorded by a smartphone and quantified using open-source ImageJ software. Under the optimal conditions, the proposed method exhibited a good linear relationship from 2.0 to 16.0 pM, and the detection limit was as low as 0.9 pM. In addition, it was further successfully applied for ALP detection in non-transparent and complex samples (milk, different types of cells). A sensitive, low cost, rapid and convenient solid-phase sensor was developed for ALP detection, which was expected to provide a promising strategy for POCT devices.
研究领域:
生物医学工程
·
临床诊断
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 6
·3059-3066
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IF 3.591
Zhiwen Pan,Junqi Yang,Weijia Song,Puqiang Luo,Junyan Zou,Jie Peng,Bo Huang,Zhi Luo
This paper reports a two-step seed-mediated synthesis of gold core@silver shell nanoparticles (Au@Ag NPs). The plasmonic properties of Au@Ag NPs were controlled through the etching effect of H2O2 generated from the oxidation of glucose. Therefore, we used Au@Ag NPs as surface-enhanced Raman scattering (SERS) substrates and 4-mercaptobenzoic acid (4-MBA) as the Raman tag to detect glucose concentration. This method exhibits a rapid detection process (5 min), a determination range from 10−1 M to 10−6 M and a detection limit of 10−6 M, which indicate that Au@Ag NPs can serve as sensitive SERS sensors for clinical detection of blood sugar.
研究领域:
生物传感
·
医学诊断
·
纳米技术
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Zhixiang Ye,Li Lin,Ziyang Tan,Yu-Jia Zeng,Shuangchen Ruan,Jian Ye
Gap-enhanced Raman tags (GERTs) with built-in Raman molecules show excellent surface-enhanced Raman scattering (SERS) performance and great potential for biomedical applications. In this work, we add a silver (Ag) shell to gold (Au) single-shell GERTs (Au@BDT@Au) to form Au-Ag hybrid multi-shell nanoparticles . It is found that this modification enhances the SERS performance of the NPs and that the thickness of the Ag shell is a key factor in determining the enhancement. Double-shell bimetallic GERTs with a Au core, Au shell and exterior 2 nm-thickness silver shell (Au@BDT@Au@BDT@Ag) show the best SERS performance and good photostability. Moreover, we utilize the double-shell bimetallic GERTs to develop a new kind of SERS-based lateral flow immunoassay (LFIA), acheiving limit of detection as low as 0.7 mIU/mL (0.077 ng/mL). We demonstrated a simple way to fabricate sub-100 nm multi-shell bimetallic GERTs for use as SERS probes with strong Raman signals with potential for in vivo and in vitro application as bioimaging and biosensing probes.
研究领域:
生物医学工程
·
纳米技术
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2023
·Vol. 15
·期 36
·4645-4655
·
IF 3.1
Chao Sun,Li Ye,Lizheng Wang,Zhiming Hu,Jianjun Ding
Aiming at the difficulty of traditional pesticide sampling, a low-cost and convenient flexible surface enhanced Raman scattering (SERS) gold core–silver shell-sponge (Au–Ag-sponge) substrate was synthesized by chemical reduction. The SERS substrate consisted of Au–AgNPs and a melamine sponge. The sponge had a rich open pore structure, which could well “capture” Au–AgNPs, generating a large number of “hot spots”. The SERS enhancement activity of the flexible substrate was characterized with rhodamine 6G (R6G) Raman probe molecules. The substrate showed good activity to 10−12 M rhodamine 6G with an enhancement factor (EF) of 7.72 × 106. Applying this substrate to the qualitative and quantitative detection of pesticide residues, the results showed that the Raman intensity was well related to the concentration of pesticide solution with the range of 0.1–10 mg L−1 of thiram and 1–10 mg L−1 of diquat. Furthermore, the substrate was analyzed by finite difference time domain (FDTD) simulation and the results were in good agreement with the experimental results. The reason for the difference in Raman signals of pesticide molecules on the same substrate was the different binding modes of Au–AgNPs on the sponge. Finally, we pointed out the advantages of flexible substrates in the field of pesticide residues, as well as future opportunities and challenges.
研究领域:
分析化学
·
环境科学
·
农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2015
·Vol. 17
·期 3
·1-10
·
IF 2.184
Zhang Ya-Fang,Wang Jia-Hong,Ma Liang,Nan Fan,Cheng Zi-Qiang,Zhou Li,Wang Qu-Quan
Silver-coated gold nanoshells with 1,4-BDT molecules as the spacer (Ag/BDT/Au) were synthesized on the surface of SiO 2 nanospheres. The surface plasmon resonance of Au/SiO 2 and Ag/BDT/Au/SiO 2 nanoparticles with single and double shells were tuned by adjusting the thickness of Au and Ag nanoshells. The enhanced local field in the gap of Au and Ag shells is demonstrated by measuring Raman scattering and nonlinear refraction. The results show that the Raman intensity is enhanced by 17 times and the nonlinear refractive index is enhanced by 30 % due to the growth of Ag shells.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2023
·
IF 4.3
Mengjie Lu,Xiaojuan Fu,Huihui Xie,Min Liu,Peng Wei,Weidong Zhang,Yahong Xie,Ying Qi
In this work, the sensitive colorimetric detection of Cu 2+ was realized based on the redox reaction of the outer silver shell of silver coated gold nanobipyramids (Au@Ag nanoparticles) and Cu 2+ . The decrease of the silver nanoshell thickness leads to the tremendous blue shift of the longitudinal localized surface plasmon resonance (LSPR) peak and accompanies a vivid color change from yellow to cyan which could be employed to quantitatively detect the concentrations of Cu 2+ . This nanoprobe displays a linear range of 0.5–100 μM with a limit of detection (LOD) of 0.16 μM and has the most obvious color change with the lowest LOD of 12 μM by naked eyes. In this case, the Au@Ag nanoparticles (Au@Ag NPs) are gradually etched from the nanorods to nanorices because the silver shell of Au@Ag NPs is etched by the Cu 2+ . In the process of anti-interference and actual water detection, it can be seen that the prepared detection sensor has specific selectivity for Cu 2+ , and has a certain application value in the detection of Cu 2+ content in food .
研究领域:
纳米技术
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2019
·
IF 4.916
Jie Chang,Amin Zhang,Zhicheng Huang,Yunsheng Chen,Qian Zhang,Daxiang Cui
The rapid identification of living cancer cells is highly crucial for cancer diagnosis, prognosis, and treatment monitoring. However, it is a great challenge to develop an effective way for rapid identification and imaging of cancer cells in a living state. Moreover, synthesis of monodisperse nanoparticles (NPs) with high sensitive surface-enhanced Raman scattering (SERS) activity is also a tough work. Herein, we creatively reported a convenient method to synthesize the novel NPs as the substrate of SERS sensors, which possessed a gold nanobipyramid core and silver nanorod shell. These gold nanobipyramid core and silver nanorod shell NPs (Au NBP@Ag NRs) were further modified with 4-mercaptobenzoicacid (4-MBA, Raman reporter molecule) and then conjugated with reduced bovine serum albumin (rBSA) and folic acid (FA) on their surfaces, to finally acquire Au NBP@Ag NR-MBA-rBSA-FA nanoprobes. In this system, With the enhancement factor (EF) of Au NBP@Ag NRs was about 4 × 10 7 , it could significantly enhance Raman signal for Raman reporter molecules, and 4-MBA molecules performed high SERS signals based on their structures; the nanoprobes have favorable specificity and biocompatibility owing to the modification of rBSA which effectively avoided the nonspecific attachment of non-targeted cells. Moreover, the obtained SERS nanoprobes have excellent sensitivity for gastric cancer cells (MGC-803 cells) due to the conjugation of folic acid. Thus, the finally obtained Au NBP@Ag NR-MBA-rBSA-FA nanoprobes possess excellent detection efficiency for living MGC-803 cells. Therefore, our synthesized nanoprobes exhibit ultrasensitive SERS-activity, excellent specificity and superior cancer cells targeting ability, which could be applied for rapid identification and Raman imaging of living cancer cells via the SERS signal detection of the nanoprobes.
研究领域:
生物医学
·
纳米医学
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2018
·
IF 4.244
Kaiqiang Wang,Da-Wen Sun,Hongbin Pu,Qingyi Wei
Plasmonic core-shell nanomaterials have attracted great attention and offered wide applications in surface-enhanced Raman spectroscopy (SERS) due to their unique localized surface plasmon resonance (LSPR) characteristics. In this study, the SERS performance of Ag coated Au nanoparticles aggregates (Au@AgNAs) substrate was explored. The fabrication of Au@AgNAs involved using spherical Au nanocrystals of 32 nm in diameter as the seeds, and ascorbic acid was used as the reductant. The thickness of the Ag shell deposited onto the Au surface was finely tuned from 3 to 13 nm by changing the amount of AgNO 3 precursor. Results in this study suggested that the LSPR of the Au core was rapidly attenuated with increasing Ag shell thickness, while the LSPR bands for Ag shell blue-shifted from 390 to 420 nm. Au@AgNAs with the Ag shell thickness of 8.5 nm exhibited excellent SERS activity, which could realize detecting R6G at an ultralow concentration of 1 × 10 −12 M. Besides, the prepared Au@AgNAs showed well homogeneity and reproducibility, and the limit of detection of thiram was calculated as 1.09 × 10 −9 M, indicating that the Au@AgNAs substrate could be potentially used for high-performance SERS sensing applications.
研究领域:
纳米材料科学
·
光学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Nisar Hussain,Yuzhu Li,Ning Li,Abid Hussain,Manzoor Hussain,Mengke Su,Honglin Liu
Surface-enhanced Raman scattering (SERS) is an emerging swift and nondestructive detecting method, offering a unique structural signature of analytes down to ultrasensitive levels. Herein, we present a novel SERS-based core-shell nanostructure with optimized silver shell thicknesses, capped with 2-mercaptoethylamine (2-MCE), to simultaneously detect multiple agrochemical residues in fruit samples. Compared to unmodified Au@AgNPs, the modified Au@Ag@2-MCENPs integrated with SERS exhibited improved sensitivity and stability, exhibiting a strong relationship between the SERS intensities and pesticide concentrations in the fruit samples, with LODs of 0.006 and 0.008 ppm for thiacloprid and 0.007 and 0.009 ppm for oxamyl in pear and apple fruit samples, respectively. Moreover, the method showed satisfactory recoveries ranging from 80 % to 106.5 % for thiacloprid and 81.8 % to 110.2 % for oxamyl in both fruit samples. Furthermore, this method presented rapid and simultaneous detection capabilities, significantly reducing analysis time compared to traditional methods, making it suitable for detecting other toxic chemical residues in agricultural products.
研究领域:
分析化学
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）