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Natural Products and Bioprospecting · 2025 ·Vol. 15 ·期 1 ·1-8 · IF 4.9

Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro

Wang Zi-Jiao,Tan Bang-Yin,Zhao Yun,Wang Chang-Bin,Zhao Yun-Li,Luo Xiao-Dong

Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum . Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1–34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1– 3 , 6 , 8 , 10 , 14 , 17–19 , 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH. Graphical

CAS / MDL: 298-93-1

研究领域: 药理学 · 植物化学

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