Open Chemistry
·
2021
·Vol. 19
·期 1
·377-384
·
IF 1.554
Xilian Zhang,Shanshan Luo,Xiaodan Wu,Minghui Feng,Yingying Li,Haoyun Han,Wenkui Li
The surface-modified zinc oxide quantum dots (ZnO QDs) have broad application prospects in the field of biomedicine because of their good water solubility, dispersibility, and high fluorescence stability. The alkali bases play important roles in controlling the morphology, size distribution, dispersity, and fluorescence intensity of the synthesized ZnO QDs. In this article, ZnO QDs were synthesized to induce hydrolysis–condensation reaction. The influences of alkali bases (LiOH, NaOH, and KOH) and the ratio of n (Zn 2+ ): n (OH − ) on the properties of synthesized ZnO QDs were investigated. The results show that the particle size of the ZnO QDs prepared using LiOH and NaOH as raw materials are smaller than that using KOH. ZnO QDs prepared at the ratio of n (Zn 2+ ): n (LiOH) = 1:1 have the best fluorescence performance and dispersibility.
研究领域:
材料科学
·
生物医学
✓ 已验证
DOI
高影响因子
APPLIED OPTICS
·
2021
·Vol. 60
·期 8
·2304-2313
·
IF 1.98
Xiaoju Wang,Xi Chen,Guobin Xu,Jie Li,Jiaqi Guo,Qi Wang
Fluorescent anti-counterfeiting is one of the most widely used anti-counterfeiting technologies at present. The demand to develop new anti-counterfeiting materials and technology is more and more urgent. Zinc oxide quantum dots (ZnO QDs) have superior fluorescent properties under ultraviolet light, making them a suitable replacement for traditional phosphors for anti-counterfeiting printing, which is environmentally friendly and meets the needs of sustainable development. In this paper, water-soluble ZnO QDs with an average particle size of 5.64 nm were prepared. Paper coated by ZnO QDs was obtained after ultrasonic treatment, which could emit bright yellow fluorescence when excited by ultraviolet light. As the concentration of ultrasonic solution is increased, the loading amount of ZnO QDs on the coated paper increased gradually, reaching the maximum when the concentration is increased to ${1}\;{\rm mol}\;{{\rm L}^{- 1}}$, which then does not change with an increase in concentration. The fluorescent intensity of the coated paper was consistent with the changing trend of the loading amount. The coated paper has excellent optical stability, is easy to recycle, and provides simple identification of authenticity by ultraviolet light and anti-copy functionality. Their application in packaging and printing is of great significance to the development of complex, concealed and non-repeatable anti-counterfeiting technology.
研究领域:
材料科学
·
印刷技术
·
环境保护
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 11
·7713-7720
·
IF 1.354
Zhang Jing,Chen Jiada,Yuan Zhefan,Feng Jie
Bio-compatible, non-toxic and low-cost ZnO quantum dots (QDs) have been widely used in biological field. However, their instability in biological media limits their application greatly. Thus it is of great importance to improve their stability. In this study, water-soluble ZnO quantum
dots were synthesized utilizing zwitterion ligand to resist aggregation in biological media. Results showed that the zwitterion coated ZnO QDs can be stable both under harsh salt condition and in serum for at least 30 days while maintaining part of its fluorescence intensity. This work provides
a kind of excellent stable ZnO QDs with potential application in vivo.
研究领域:
生物医学
·
纳米材料科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2012
·
IF 3.628
Tong Chen,Tong Zhao,Dongfeng Wei,Yanxia Wei,Yuanyuan Li,Haixia Zhang
Core–shell structured multifunctional nanocarriers (NCs) of ZnO quantum dots-conjugated gold nanoparticles (Au NPs) as core and amphiphilic hyperbranched block copolymer as shell were synthesized for targeted anticancer drug delivery. The amphiphilic hyperbranched block copolymer contained poly( l -lactide) (PLA) inner arm and folate (FA)-conjugated a sulfated polysaccharide from Gynostemma pentaphyllum Makino (GPPS-FA) outer arm. The structure and properties of core–shell structured multifunctional nanocarriers were characterized and determined by UV–visible spectra, FT-IR spectra, X-ray diffraction (XRD), fluorescence spectroscopy and TEM analyses. The release results indicated that camptothecin (CPT) release from NCs at pH 7.4 was much greater than that at pH 5.3. The cytotoxicity studies showed that both the blank NCs and the CPT-loaded NCs provided high anticancer activity against Hela cells. Furthermore, nanocarriers gained specificity to target model cancer cells in this study due to the enhanced cell uptake mediated by FA moiety. The results indicated that the NCs not only had great potential as tumor-targeted drug delivery nanocarrier, but also had an assistant role in the treatment of cancer.
研究领域:
药剂学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haodong Wang,Cancan Qian,Lanlan Sun,Hao Jiang,Xiaodong Wang,Jianghu Cui,Desong Yang
The use of nano-pesticide delivery systems to suppress crop disease has great potential in sustainable agriculture. Herein, a pH-responsive salicylic acid (SA) conjugation based on aminopropyl-functionalized ZnO quantum dots (SA-ZnO QDs) with a loading capacity of 13.4 wt% was prepared by an amidation reaction. Results indicated that SA-ZnO QDs could release SA rapidly in an acidic condition, which corresponded to the pH of the water-soaked lesions where the bacterial fruit blotch disease often spread. The antibacterial activity of the synthesized SA-ZnO QDs was about 1.6 times and 1.3 times higher than that of SA and aminopropyl-functionalized ZnO QDs, respectively. A pot experiment showed that foliar application of SA-ZnO QDs could reduce the incidence of bacterial fruit blotch disease (54.46%) by increasing the antioxidant defense systems (44.33–79.59%) and nutrient absorption (23.19–26.95%). More importantly, we observed that, after the application of SA-ZnO QDs, the systemic acquired resistance and flavone biosynthesis were activated in infected melon seedlings, which was revealed by metabolomics. This work demonstrates the important role of the quantum-delivery system in improving crop disease suppression for sustainable agriculture.
研究领域:
植物病理学
·
纳米生物学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2018
·
IF 1.206
Xinyu Lin,Yilin Wu,Yue Hao,Qian Sun,Yongsheng Yan,Chunxiang Li
Novel core-shell molecularly imprinted polymers were prepared based on zinc oxide quantum dots for the determination of 2,4,6-trichlorophenol by fluorescence. Principally, ZnO quantum dots and 2,4,6-trichlorophenol were chosen as the core substrate and the template molecule, respectively. The specific recognition sites for 2,4,6-trichlorophenol were obtained during the polymerization process in presence of 3-aminopropyltriethoxysilane and tetraethylorthosilicate. Molecularly imprinted ZnO quantum dots were characterized by transmission electron microscopy and Fourier transform infrared spectroscopy and the optical properties were evaluated by spectrofluorometry. Under the optimal conditions, molecularly imprinted ZnO quantum dots were successfully applied to the sensitive determination and selective recognition of 2,4,6-trichlorophenol in water. A linear relationship was obtained to cover the concentration range of 0–160 µmol L−1 with a correlation coefficient of 0.9931 calculated by the Stern–Volmer equation. The products were used for the determination of 2,4,6-trichlorophenol in the water from local rural areas and the results strongly supported that the molecularly imprinted ZnO quantum dots were suitable for the determination of 2,4,6-trichlorophenol in real examples.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Dandan Fang,Huizhu Ren,Yitian Huang,Hong Dai,Defu Huang,Yanyu Lin
Herein, an ultrasensitive electrochemiluminescence (ECL) immunosensor based on a high performance probe of Nb 2 CTx MXene immobilized ZnO quantum dots (QDs) was constructed for Thyroglobulin (Tg) detection. ZnO QDs with good biocompatibility and catalytic property was for the first time utilized as coreaction accelerator in Ru(bpy) 3 2+ /S 2 O 8 2− system and enhanced ECL signal. Specifically, ZnO QDs can facilitate S 2 O 8 2− reduction to generate more SO 4 − , and then reacted with cathodic radical of Ru(bpy) 3 2+ , realizing 2-fold enhancement in ECL intensity. Additionally, Nb 2 CTx MXene possesses excellent properties and was used as prominent supporter, improving the loading capacity of Ru(bpy) 3 2+ and ZnO QDs, and accelerating the electron transfer, resulting in ECL signal enhancement. Furthermore, Nb 2 CTx MXene acted as temperature controller and increased the electrode surface temperature by converting laser energy into heat, further amplified ECL signal. Because of the high sensitivity, good specificity and favorable stability, the proposed immunosensor realized sensitive detection of Thyroglobulin and had a great application prospect in bioanalysis and clinical diagnosis.
研究领域:
分析化学
·
生物医学工程
·
临床诊断
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Li Qiu,Weirui Zhang,Shuyun Wang,Xu Zhang,Yanbao Zhao,Liuqin Cao,Lei Sun
pH/enzyme-responsive nanocarriers based on porous silica (pSiO 2 ) nanospheres (NSs) were developed for controlled release of drug. The pSiO 2 NSs present uniform spheres and have an average diameter of 100 nm. The pSiO 2 NSs with high specific surface area (835 m 2 ·g − 1 ) and the pore volume (1.24 cm 3 ·g − 1 ) are suitable for drug loading and the loading capacity reaches to 29% for amoxicillin (AMX) model drug. In this system, protocatechuic acid (PCA) and L-glutamic acid (Glu) as linkers were grafting onto the surface of pSiO 2 NSs to conjugate the capping lids. Acid-decomposable ZnO quantum dots (QDs) were introduced to block the partial pores of pSiO 2 via amido bonds, which could act as gates and fluorescence probes. To minimize the premature release, hyaluronic acid (HA) was further coating on the outer surface of pSiO 2 , which would be degraded by over-expressed hyaluronidase (Hyal-1) in the tumor microenvironment. The controlled release of the drug from the ZnO/HA-gated delivery system was realized by the acidic dissolution of ZnO QDs and enzymatic hydrolysis of HA. The obtained ZnO/HA-gated pSiO 2 delivery system would achieve minimized premature release and responsive release under a physiological environment.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2024
·Vol. 16
·期 1
·1-16
·
IF 31.6
Wang Wenxiao,Wang Yaqi,Yin Feifei,Niu Hongsen,Shin Young-Kee,Li Yang,Kim Eun-Seong,Kim Nam-Young
An optoelectronic memristor with bioinspired neuromorphic behavior was proposed based on Ag/TiO 2 Nanowires: ZnO QDs/FTO.
The proposed device establishes superior long/short-term synaptic plasticity in response to electrical and light stimuli, and a neuromorphic computing task is effectively implemented based on its optoelectronic performance.
The device emulated complex biological associative learning behaviors, including the four features of acquisition, extinction, restoration, and generalization.
研究领域:
材料科学
·
神经科学
·
光电技术
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Li Qiu,Yanbao Zhao,Binjie Li,Zhihua Wang,Liuqin Cao,Lei Sun
For the purpose of reducing the adverse effect of antitumor drugs, a novel type of protease/redox/pH stimuli-responsive fluorescent porous silica (pSiO 2 ) nanocarrier was designed. In this system, oxidized glutathione (GSSG), a kind of peptide with disulfide linkage, was grafted onto the pSiO 2 nanospheres (NSs) via amido bonds. After that, acid-decomposable, luminescent ZnO quantum dots (QDs) were introduced to seal the nanopores of pSiO 2 NSs via covalent attachment. The ZnO QDs behave as a dual-purpose entity that not only act as a fluorescence probe for drug-release monitoring but also play the role of gatekeeper that controls the drug release. The obtained ZnO-gated pSiO 2 -GSSG NSs delivery system would achieve minimized premature release under a physiological environment. The controlled release of the drug from the ZnO-gated delivery system was realized by the acidic dissolution of ZnO QDs, reduction of disulfide bonds and cleavage of the amino bonds, leading to ZnO falling off from the surface of pSiO 2 NSs. The constructed ZnO-gated pSiO 2 -GSSG NSs delivery system has promising applications in site-specific drug release for tumor chemotherapy.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）