Dong Zhu,Hong-Mei Wen,Wei Li,Xiao-Bing Cui,Li Ma,An Kang
pH-responsive systems have attracted special research interest in drug delivery. Herein, we report a pH-responsive system based on the “COOH–Zn2+–drug” architecture via coordination bonding in ZnS nanospheres' mesopores. PAA-functionalized porous ZnS nanospheres were employed as cargo carriers for hosting metal ion (Zn2+) binders and drug molecules to form the “COOH–Zn2+–drug” architecture. The cleavage of either the “COOH–Zn2+” or the “Zn2+–drug” coordination bond, in response to pH variation, gives rise to a significant release of drug molecules under weakly acidic conditions (pH 5–6.5). We anticipate that the porous ZnS nanospheres and subsequently prepared pH-responsive system may prove to be a significant step toward the development of a finely pH-sensitive drug delivery system that minimizes drug toxicity.
Dong Zhu,Zhao Yi Miao,Rui Xiang Yang,Hong Mei Wen,Wei Li,Jun Chen,An Kang,Chen-Xiao Shan,Sheng Yu,Yue Hu
The current widely utilized polymer or C8, C18 end-capped material-based sorbents for solid-phase extraction could not capture alkaloids well only based on “like dissolves like” principle. In this paper, a layer-by-layer functionalized porous Zinc sulfide nanospheres-based solid-phase extraction (SPE) combined with liquid chromatography time-of-flight/mass spectrometry (LC-TOF/MS) and gas chromatography-mass spectrometry (GC-MS) was developed for the specific enrichment and identification of alkaloids from complex matrixes, Crinum asiaticum var. sinicum crude extracts. The functionalized porous Zinc sulfide nanospheres were prepared by the amidation reaction of poly-(acrylic acid) (PAA) homopolymer with amino groups onto the porous ZnS nanospheres. Tandem LC-TOF/MS spectrometry presented that the almost all of the twenty-three main peaks in elution fraction from the SPE could be inferred as alkaloids with ion of mass according to the nitrogen rule and hit formula with Peak View1.2@software from AB SCIEX, and seven alkaloids including two new found chemical entities were directly identified from their GC-MS spectra and retention indices. We believe that this SPE protocol can also be utilized in the future to selectively enrich alkaloids from extracts of other plant species .
危险品化学品经营许可证（带存储）