ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Xianfeng Wang,Chengxiang Chu,Jiayi Lv,Yuanyuan Jia,Libo Lin,Mei Yang,Suyi Zhang,Danqun Huo,Changjun Hou
High-performance analysis of heavy metal ions is great importance in both environment and food safety. In this work, a facile and reliable colorimetric sensor was presented for simultaneous detection of Cu 2+ and Cr 3+ based on indicator-displacement assay (IDA). As a typical silicate nanomaterials , ZnSiO 3 hollow nanosphere (ZSHS) exhibited an outstanding ion exchange capacity. Zincon was incorporated with the ZSHS to form a zincon/ZSHS hybrid ionophore with a blue color. Upon the addition of Cr 3+ , IDA reaction and selective ion exchange occurred with the color change of zincon/ZSHS ionophore from blue to yellow. With such a design, colorimetric measurement of Cr 3+ was realized. The linear concentration for Cr 3+ detection ranged from 0.5 μM to 75 μM with the LOD of 83.2 nM. Furthermore, we also screened different kinds of complexing agents that may respond with zincon/ZSHS ionophore and various metal ions. It was found that tartaric acid (TA) showed the chelation capability of Zn 2+ -TA is stronger than that of Zn 2+ -zincon. Thus zincon/ZSHS/TA presented a yellow color due to the chelation reaction of Zn 2+ -TA, releasing the zincon as a free state. After addition of Cu 2+ , a stronger chelation reaction of Cu 2+ -zincon occurred. This process involved in the color change from yellow to blue and realized colorimetric measurement of Cu 2+ . The detection limit of Cu 2+ was calculated to be 43.7 nM with linear range from 0.1 to 20 μM. In addition, the zincon/ZSHS nanoprobe was successfully applied for simultaneous measurement of Cu 2+ and Cr 3+ in sorghum and river water, indicating that the zincon/ZSHS nanoprobe provided a promising sensing platform in environment and food safety.
研究领域:
环境科学
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食品安全
·
分析化学
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2021
·
IF 0.782
Chun-Jing Li
We report a direct cross-coupling reaction between (het)aryl pivalates/tosylates and di(het)arylzinc species in 2-methyltetrahydrofuran/N-methyl pyrrolidone (1:1), which occurs via C–O bond cleavage under microwave irradiation. The reaction takes place smoothly in short reaction times without the addition of any catalyst or ligand. The reaction is suitable for a broad scope of substrates and exhibits good functional group compatibility, utilizes a simple work-up procedure, and gives the desired products in high purity.
研究领域:
有机化学
·
合成化学
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DOI
高影响因子
Asian Journal of Organic Chemistry
·
2018
·Vol. 7
·期 12
·2527-2533
·
IF 2.496
Wei-Ze Li,Zhong-Xia Wang
Graphical Reaction of quinoline N -oxides and pyridine N -oxides with arylzinc reagents under transition-metal-free conditions was studied. The reaction was carried out in toluene (for quinoline N -oxides) or THF (for pyridine N -oxides) at 100 °C and required 2 equiv. of arylzinc loadings and the presence of 2.5 equiv. of TFAA, affording 2-arylquinolines and 2-arylpyridines, respectively, in 24% to 95% yields. Reaction of quinoline N -oxides and pyridine N -oxides with arylzinc reagents under transition-metal-free conditions was studied. The reaction was carried out in toluene (for quinoline N -oxides) or THF (for pyridine N -oxides) at 100 °C and required 2 equiv. of arylzinc loadings and the presence of 2.5 equiv. of TFAA, affording 2-arylquinolines and 2-arylpyridines, respectively, in 24% to 95% yields. Functional groups OMe, F, Cl, Br, CF 3 , C(O)NH 2 , COOR and NO 2 were tolerated. Mechanistic studies showed that the reaction of quinoline N -oxides proceeded via a 2-arylquinolin-1(2 H )-olate intermediate, and the reaction of pyridine N -oxides via a 5-arylpenta-2,4-dienal oxime intermediate.
研究领域:
有机化学
·
合成化学
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产品关联
DOI
高影响因子
Chem Catalysis
·
2023
·
IF 9.4
Jinhui Han,Xirong Liu,Hao Jin,Panchi Guo,Liang Xu,Pengfei Li,Miao Zhan
Summary Transition-metal-catalyzed allylic alkylation of α -boryl metallic reagents has provided unique access to chiral homoallylic organoboron compounds . However, these organoboron products possess only one stereogenic center, which is derived exclusively from either allylic electrophiles or gem -diborylalkanes. The construction of contiguous stereocenters from both α -boryl metallic reagents and allylic electrophiles has remained elusive. We report a straightforward method to prepare secondary α -monoboryl organozinc reagents through α -deprotonation of benzylboronates and in situ Li/Zn exchange that was then applied in the iridium-catalyzed allylic alkylation reaction through a doubly stereoconvergent process. Various boron-containing 1,2-stereodiads were obtained in good yields with decent diastereo- and enantioselectivities . Compared to the deborylative allylic alkylation using gem -diborylalkane, this study demonstrates high atom economy and a wide substrate scope. A preliminary mechanism study demonstrated that the stereoconvergent and kinetic resolutions of racemic carbonates proceed simultaneously.
研究领域:
有机化学
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催化
·
合成化学
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2026
·
IF 5.6
Xiaolei Shi,Zhuannian Liu,Yifei Wang,Benlong Wei
The K-CP/MnO 2 composite was prepared by loading manganese dioxide (MnO 2 ) nanosheets onto potassium hydroxide (KOH) activated carbonized polyaniline (K-CP) via low-temperature hydrothermal reaction. The composite demonstrated high efficiency in removing Pb 2+ and Zn 2+ in the hybrid capacitive deionization (HCDI) technology. K-CP/MnO 2 presents a core-shell structure with conductive K-CP as the core and electrochemically active MnO 2 constructed by porous nanosheets as the shell. The disordered entanglement of K-CP and MnO 2 nanoflakes significantly increases the interlayer spacing, optimizes the pore distribution, creates favorable conditions for charge and ion transport, and realizes the synergistic effect of electric double layer (EDL) adsorption and Faradaic reactions. The specific capacitance (SC) of K-CP/MnO 2 at 5 mV s −1 is 112.03 F g −1 , which is nearly 3.76 times that of CP (29.82 F g −1 ). At a voltage of 1.2 V (100 mg L −1 ), the electrosorption capacity (SAC) of the K-CP/MnO 2 electrode for Pb 2+ and Zn 2+ is 124.66 and 96.86 mg g −1 , respectively. After 15 adsorption/desorption cycles in the HCDI device, the adsorption capacity for Pb 2+ and Zn 2+ is retained at 86.81% and 82.59%, respectively. The experiments indicate that the removal of Pb 2+ primarily occurs through electrosorption, redox reactions, and surface complexation, while Zn 2+ is inserted into the channel provided by MnO 2 and participates in the solid phase reaction. The K-CP/MnO 2 composite prepared in this study offers a novel approach for designing high-performance HCDI electrodes and achieving the selective removal of heavy metals.
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产品关联
DOI
高影响因子
Regenerative Biomaterials
·
2025
·
IF 8.1
Ding Jiaxin,Gao Binbin,Sang Zelin,Dai Zhen,Chen Zhenhua,Mei Xifan
Spinal cord injury (SCI) is a kind of health problem characterized by oxidative stress and neuronal apoptosis, which pose major challenges to the recovery of patients. Recently, the application of photothermal nanotechnology in medicine has opened up exciting new avenues for the treatment of SCI. This innovative approach leverages the unique properties of nanomaterials to enhance therapeutic outcomes. In our study, we developed a novel nanotherapeutic system named ZnO-ZIF8@H, which is designed to deliver targeted neuroprotective effects. We meticulously evaluated its performance under near-infrared (NIR) irradiation, which is known to promote local heating and stimulate biological processes. The data indicated that the application of ZnO-ZIF8@H combined with NIR irradiation significantly reduced oxidative stress levels in the affected tissues. This was evidenced by a marked decrease in malondialdehyde (MDA) levels, a well-known indicator of lipid peroxidation and cellular damage. Simultaneously, the treatment notably enhanced the activity of superoxide dismutase (SOD) and glutathione (GSH) enzymes. These findings suggest that ZnO-ZIF8@H+NIR could both protect cells from oxidative damage and boost the internal antioxidant defenses, highlighting its potential as an effective therapeutic strategy for mitigating secondary injuries following spinal cord trauma. It also suppressed neuronal apoptosis, as evidenced by TUNEL staining and decreased Cleaved-Caspase3 expression in NeuN-positive neurons. These results indicated that ZnO-ZIF8@H+NIR effectively reduces secondary damage from SCI by alleviating apoptosis and oxidative stress, offering a promising approach for the therapy of SCI.
研究领域:
神经生物学
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生物材料学
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纳米医学
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创伤修复
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氧化应激
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分子神经科学
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转化医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Xiaohui Jia,Yuhe Dong,Jihui Lu,Zhenyuan Yang,Ran Xu,Xiang Zhang,Jingyi Jiao,Zixuan Zhang,Yixuan Lin,Fuhao Chu,Penglong Wang,Tian Zhong,Haimin Lei
On-demand responsive hydrogels are a promising solution for effective wound management as they can adjust their properties in response to changes in the wound environment, allowing them to provide tailored support for the healing process. However, the conventional hydrogels may not fully meet the diverse demands of the intricate healing process. Herein, a novel glycyrrhizic acid (GA) based self-assembly hydrogel coordinated with copper and polyphenol (GCP hydrogel) was developed to exhibit triggered release behavior in response to the microenvironment. The GCP hydrogel coordinated with copper and protocatechuic acid (PA) and self-assembled with GA, also exhibits enzyme-like properties by mimicking the cascade process of superoxide dismutase (SOD) and catalase (CAT), effectively scavenging reactive oxygen species (ROS). Furthermore, the on-demand release of Cu 2+ at different stages of the wound healing process can not only enhance the antibacterial ability of methicillin-resistant Staphylococcus aureus (MRSA) but also intelligently promote angiogenesis with outstanding biocompatibility. In addition, the GCP hydrogel effectively modulated the activity of macrophages in response to inflammatory stimuli, exhibiting remarkable anti-inflammatory abilities and promoting tissue regeneration. The multifunctional GCP hydrogel platform has the potential to create a dynamic microenvironment that is conducive to tissue regeneration, making it an ideal candidate for smart wound management.
研究领域:
生物材料学
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医学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Xianbin Sun,Jing Yu,Xudong Li,Haijun Chen,Yu Gao
Inorganic antimicrobial materials have the advantages of high safety, strong durability, stable antimicrobial performance, and good heat resistance compared with organic antimicrobial materials. In this study, Fe-doped small zinc oxide nanoparticles (FZO-NPs) with different iron contents were synthesized and then modified with 3-aminopropyltriethoxysilane (APTES) and poly(ethylene glycol)−600 (PEG-600) to afford FZO-APs. FZO-APs which were fully characterized can disperse in water with good dispersity and improved stability. In antimicrobial tests, FZO-AP4 displayed excellent antimicrobial effects under 10 min of 365 nm UV light against Gram-negative bacteria Escherichia coli ( E. coli ) and Gram-positive bacteria Staphylococcus aureus ( S. aureus ) with a minimum inhibitory concentration (MIC) of 0.20 and 0.15 mg/mL, respectively. The antimicrobial mechanism studies revealed that the consumption of glutathione (GSH) and ascorbic acid (ASA), and the generation of reactive oxygen species (ROS) could trigger lipid peroxidation (LPO) and ultimately induce ferroptosis in bacterial cells. The cause of the cell wall/membrane damage and the released Zn/Fe ions from the nanoparticles inside the bacterial cells further promote the antimicrobial effects. In addition, FZO-AP4 showed high inhibitory effects on bacterial biofilm formation and significantly disrupted the formed biofilm. Interestingly, higher bacterial biofilm residuals and bacterial survival were found in E. coli than in S. aureus after FZO-AP4 treatment, suggesting a potential link between the quorum sensing (QS) system of the bacteria and their different susceptibility towards FZO-AP4. This study proved the antibacterial effects of small water-soluble FZO-APs which is meaningful for the design and development of new inorganic nano-material for antimicrobial applications.
研究领域:
材料科学
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纳米技术
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微生物学
·
生物医学工程
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-12
·
IF 5.479
Wang You,Huo Danqun,Wu Huixiang,Li Jaiwei,Zhang Qinghai,Deng Bo,Zhou Jing,Yang Mei,Hou Changjun
Carboxylic acids (CAs) have been reported as potential biomarkers of specific diseases or human body odors. A visual sensor array is described here that is based on indicator displacement assays (IDAs). The arrays were prepared by spotting solutions of the following metal complexes: Murexide-Ni(II), murexide-Cu(II), zincon-Zn(II) and xylenol orange-Cu(II), with the capability of discrimination of 15 carboxylic acids (CAs) and the quantitation of pyruvic acid (PA). Clear differences can be observed through distinctive difference maps obtained within 5 min by subtraction of red, green and blue (RGB) values of digital images after and before exposure to analytes. After an analysis of multidimensional data by pattern recognition algorithms including HCA, PCA and LDA, excellent classification specificity, and accuracy of >96% were obtained for all samples. The IDA array exhibited a linear range from 10 to 1500 μM with a theoretical detection limit of 3.5 μM towards PA. Recoveries of real samples varied from 84.8% to 114.3%. As-fabricated IDA sensor array showed an excellent selectivity among other organic interfering substances and a good batch to batch reproducibility, demonstrating its robustness. All these observations suggested that the IDA sensor array is one of the most promising paths for the discrimination of CAs.
Schematic diagram of indicator displacement assay (a), the procedure for acquisition of difference maps (b), and pattern recognitions for CAs (c). The method uses hierarchical cluster analysis (HCA), principal component analysis (PCA) and linear discriminant analysis (LDA)
研究领域:
分析化学
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生物传感器
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 23
·1800011
·
IF 13.325
Zhiyong Song,Yang Wu,Qi Cao,Huajuan Wang,Xiangru Wang,Heyou Han
To satisfy the ever-growing demand in bacterial infection therapy and other fields of science, great effort is being devoted to the development of methods to precisely control drug release and achieve targeted use of an active substance at the right time and place. Here, a new strategy for bacterial infection combination therapy based on the light-responsive zeolitic imidazolate framework (ZIF) is reported. A pH-jump reagent is modified into the porous structure of ZIF nanoparticles as a gatekeeper, allowing the UV-light (365 nm) responsive in situ production of acid, which subsequently induces pH-dependent degradation of ZIF and promotes the release of the antibiotic loaded in the mesopores. The combination of the UV-light, the pH-triggered precise antibiotic release, and the zinc ions enables the light-activated nanocomposite to significantly inhibit bacteria-induced wound infection and accelerate wound healing, indicating a switchable and synergistic antibacterial effect. The light irradiated accumulation of acid ensures the controlled release of antibiotic and controlled degradation of ZIF, suggesting the therapeutic potential of the metal–organic frameworks-based smart platform for controlling bacterial infection.
研究领域:
药学
·
纳米技术
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Yao Huang,Fengyu Tian,Leilei Sun,Chenhui Ji,Craig A. Grimes,Qingyun Cai
Accurate detection and localization of micrometastases are extremely important for tumor diagnosis and comprehensive treatment. However, it is clinically difficult to finely localize micrometastases, especially focal lesions smaller than 1 mm. To that purpose, this work designed a tumor microenvironment factor (glutathione, GSH)-activated second near-infrared transparency window (NIR-II) fluorescent probe for visualization of micrometastases. It is constructed by complexing copper ions with 3-mercaptopropionic acid-modified silver sulfide (Ag 2 S-MPA) quantum dots . The experimental results showed that the probe has good and stable GSH activation properties and can achieve tumor-specific NIR-II fluorescence imaging. Further, in vivo imaging experiments demonstrated that the probe can precisely localize melanomas with a diameter of < 0.1 mm in lung micrometastases. This work provides a potential strategy for the development of novel tools for localization and visualization of micrometastases.
研究领域:
肿瘤学
·
医学影像学
·
生物化学
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产品关联
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2022
·
IF 5.141
Zekai Sheng,Fengming Hou,Leilei Zou,Yihang Li,Jiaxin Li,Jin Li,Libang Ai,Wei Wei,Ang Wei
Aspergillus fumigatus ( A. fumigatus ) is a representative significant pathogenic fungus and its spores are arduous to inactivate. Herein, an efficient and environmental-friendly photocatalytic method to eliminate A. fumigatus spores was demonstrated. Zn-Ti layered double hydroxide (Zn-Ti LDH), showed the admirable activity with above 99.34% disinfection rate under visible light illumination for 6 h. The compelling sterilization activities were ascribed to the potent synergistic effect of zinc ions (Zn 2+ ) and reactive oxygen species (ROS). The attack of these species caused the eradication of fungal cell structure, and resulting in the leakage of cytoplasmic as demonstrated by scanning electron microscope, confocal laser scanning microscope and potassium ions (K + ) leakage test. In addition, Zn-Ti LDH released Zn 2+ and ROS only under visible light irradiation, which endows the material light-triggered bactericidal property. Overall, these findings not only provide a green and sustainable way to control A. fumigatus contaminations, but also can be as an example to control other toxic fungi in future study.
研究领域:
微生物学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）