JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 34
·50843
·
IF 3.125
Xuefei Shao,Junnan He,Xuemei Zhao,Yubin Zheng,Nan Zheng
Cationic polyesters have been widely utilized as efficient gene delivery carriers. Their ability in binding genes was majorly based on the electrostatic effect between the positive charges of polymers and the negatives charges of genes. It has been well known that large numbers of positive charges on the polymers would lead to undesired toxicity although strong gene binding capability. It was of great interest to developed a polymer with reduced positive charges while enhanced gene condensation ability. In this work, a library of polyesters functionalized by zinc-coordinated-dimethylpyridinium amine (DPA-Zn) have been successfully prepared by the polycondensation method starting from dimethyl 1,3-acetonedicarboxylate and 10 diols, followed by the post-modification using dimethylpyridinium amine and zinc nitrate. The post-modification efficiency was systemically evaluated and the optimized functionalization efficiency could reach around 50%. The gene condensation ability of the targeting polymers was also evaluated using gel retardation assay and dynamic light scatting. The results indicated that DPA-Zn functionalized polyesters could bind gene into nanocomplexes with the sizes around 200 nm.
研究领域:
生物材料学
·
基因递送
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产品关联
DOI
高影响因子
DESIGNED MONOMERS AND POLYMERS
·
2022
·
IF 3.718
Hong-Mei Liu,Xiao-Na Shang
Through the self-assembly reaction of 5-substituted isophthalic acid and bis(imidazolyl) ligands with Cd(II) ion or Zn(II) ion, two new coordination polymers with the chemical formulae of [Cd(5-meo-ip)(bmip)]n (1) and [Zn(5-pro-ip)(bip)]n·2 n(H2O) (2) (5-meo-H2ip = 5-methoxyisophthalic acid, 5-pro-H2ip = 5-propoxyisophthalic acid, bmip = 1,3-bis(2-methylimidazolyl)propane bip = 1,3-bis(imidazolyl)propane) were successfully obtained and structurally characterized by a series of characterization techniques. Moreover, compounds 1–2 show intense blue luminescence at room temperature. Furthermore, the assessment of their treatment activity on the uterine fibroids combined with ultrasound therapy was evaluated and the specific mechanism was investigated at the same time. Firstly, the effect of compound treatment on uterine fibroids apoptosis was detected via flow cytometry. Next, the apoptotic signaling pathway activation was detected through the Caspase-3 and Caspase-8 Activity Assay Kit.
研究领域:
材料科学
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医学
·
生物化学
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DOI
PubMed
高影响因子
Materials Advances
·
2022
·Vol. 3
·期 13
·5476-5487
·
IF 0
Po Wang,Yi-Lin Zhang,Kai-Lai Fu,Zhuang Liu,Ling Zhang,Chen Liu,Yi Deng,Rui Xie,Xiao-Jie Ju,Wei Wang,Liang-Yin Chu
Effective approaches are urgently needed to avoid the formation of thrombosis and bacterial infections during long-time intravenous implanation. Of particular importance are the surfaces of implants that not only satisfy the demand of an antibiofouling ability to repel thrombocytes, proteins, and bacteria, but also provide an antibacterial property without cytotoxicity to normal cells, which would be biosafe to blood. Here, we explore the implementation of such antibiofouling and antibacterial functions in a superhydrophilic nanostructured surface containing zinc-coordinated polydopamine (PDA/Zn). The formation mechanism of the zinc-coordinated polydopamine nanostructure was demonstrated with the growth and intertwining of the PDA/Zn nanowires via Zn–N and Zn–O bonds. The PDA/Zn nanostructured surface inhibited the attachment of biological substances, such as blood platelets and bovine serum albumin, as well as possessing excellent antibacterial properties. This work reports the fabrication mechanism of a PDA/Zn surface with a nanostructure and superhydrophilicity, which has potential for preventing biomaterial-associated biofouling and infections.
研究领域:
生物医学工程
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材料科学
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表面科学
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产品关联
DOI
Additive Manufacturing
·
2021
·
IF 10.998
Yuchao Wu,Mingen Fei,Tingting Chen,Chao Li,Tengfei Fu,Renhui Qiu,Wendi Liu
Thermoplastic elastomers exhibit high softness, stretchability, recoverability, and reprocessibility, but their manufacture requires high cost and long processing time. Photocuring 3D printing is a remedial processing method as it enables rapid fabrication at room temperature. However, it is difficult to print thermoplastic elastomers by photocuring 3D printing because the generated linear polymers easily dissolve in liquid precursors during printing. Herein, stretchable, self-healing, and renewable palm oil (PO)-based elastomers were prepared from UV-responsive vinyl PO monomers via photocuring 3D printing. Fast solid-liquid separation was achieved via hydrogen bonds and Zn 2+ -ligand coordination (non-covalent crosslinking) to slow down the dissolution of crosslinked polymers in the monomer liquid . The non-covalent bonds endowed the elastomers with high tensile strength (~4.2 MPa) and elongation at break (~851%). Additionally, the elastomers are mainly prepared from biobased, renewable, and low-cost PO feedstocks . Most importantly, the dual dynamic crosslinked network resulted in superior stress relaxation, shape programming, and self-healing behavior of the elastomers. The method described may enhance the application scope of thermoplastic elastomers and 3D printing.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Wu Jine,Liao Chenyi,Li Tianyu,Zhou Jing,Zhang Linjuan,Wang Jian-Qiang,Li Guohui,Li Xianfeng
Membranes with fast and selective ion transport are essential for separations and electrochemical energy conversion and storage devices. Metal-coordinated polymers are promising for fabricating ion-conducting membranes with molecular channels, however, the structures and ion transport channels remain poorly understood. Here, we reported mechanistic insights into the structures of metal-ion coordinated polybenzimidazole membranes and the preferential K + transport. Molecular dynamics simulations suggested that coordination between metal ions and polybenzimidazole expanded the free volume, forming subnanometre molecular channels. The combined physical confinement in nanosized channels and electrostatic interactions of membranes resulted in a high K + transference number up to 0.9 even in concentrated salt and alkaline solutions. The zinc-coordinated polybenzimidazole membrane enabled fast transport of charge carriers as well as suppressed water migration in an alkaline zinc-iron flow battery, enabling the battery to operate stably for over 340 hours. This study provided an alternative strategy to regulate the ion transport properties of polymer membranes by tuning polymer chain architectures via metal ion coordination.
研究领域:
材料科学
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电化学
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能源存储
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Po Wang,Jue-Ying Gong,Yao Li,Xiao-Bao Tian,Rui Xie,Xiao-Jie Ju,Wei Wang,Da-Wei Pan,Zhuang Liu,Liang-Yin Chu
The combat against contamination by trace amounts of water and bacteria in aviation fuel remains a challenge, necessitating a comprehensive strategy. Here, a superamphophilic antimicrobial membrane is developed by featuring a stable zinc-coordinated polydopamine metallo-polymeric framework (PDA/Zn) on the skeleton of polyethylene terephthalate (PET) non-woven fabric. The formation of the PDA/Zn framework is streamlined through dopamine polymerization synchronized with metallo-ion coordination. This work delves into the intrinsic stability and superamphiphilic properties of the PDA/Zn framework, as well as systematically investigates its performance in fuel dehydration and carbophilus elimination. The resulting membrane exhibits a high gravity-driven flux and achieves a significant reduction in water content to below 10 ppm in aviation fuel, attributed to a demulsification and aggregation mechanism. Furthermore, our findings highlight the nearly complete antibacterial multifunctionality of the proposed membrane. It effectively prevents bacterial attachment at the liquid-solid interface and brings about bacterial eradication through the presence of Zn 2+ ions and the mechanical puncturing effect of nanostructure cusps. This work not only advances applications in water dehydration and bacterial elimination but also pioneers opportunities for designing advanced functional membranes with multifaceted functionalities, including anti-fouling, self-cleaning, and antimicrobial properties, setting the stage for broader applications in membrane field.
研究领域:
材料科学
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化学工程
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环境科学
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纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yu Han,Kai Zhang,Ning Xin,Xintao Gao,Guohua Ma,Jingtong An,Yantao Li
Despite recent advancements in lipid nanoparticles (LNPs)-based messenger RNA (mRNA) delivery, significant challenges persist in the structural optimization and functional modulation of their components for cancer immunotherapy, particularly regarding inadequate organ-specific targeting, and insufficient immune activation. Notably, metal ions have demonstrated emerging immunomodulatory potential, yet their coordinated self-assembly within LNPs as adjuvants to enhance the immunotherapeutic efficacy remains largely unexplored. To address these limitations, we combine newly designed imidazole-based LNPs with functional metal ions (Zn 2+ ) to develop novel Zn-coordinated LNP-based mRNA vaccines. A total of 48 imidazole-based ionizable lipids were designed and synthesized, among which C2–13 LNPs emerged as the top-performing formulation in terms of transfection efficiency. By innovatively incorporating Zn 2+ into C2–13 LNPs via coordination interaction, we further developed the novel metal-coordinated mRNA delivery systems, referred to as Zn-C2–13 LNPs. Compared to their non-metal counterparts, Zn-C2–13 LNPs exhibited markedly improved transfection efficiency and antigen presentation in vitro . Impressively, the synergistic effect of the optimized LNP formulation and Zn 2+ in the Zn-C2–13/mOVA systems (Zn-C2–13 LNPs loading ovalbumin mRNA) resulted in superior spleen-selective expression and immune response, significantly boosting the efficacy of cancer immunotherapy in the B16F10 ovalbumin-expressing (B16F10-OVA) melanoma tumor model. Collectively, this novel metal-coordinated LNPs improve specific organ targeting and immune responses, presenting a promising strategy to advance mRNA vaccine-based cancer immunotherapy.
研究领域:
免疫学
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肿瘤学
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纳米医学
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分子生物学
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转化医学
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Hao Deng,Yang Li,Ruihua Chen,Chao Ma,Junpeng Jiang,Daoyang Han,Bingbing Fan,Hailong Wang,Rui Zhang,Gang Shao
The coordinated metal single-atoms (MSA) can significantly enhance the electromagnetic wave (EMW) absorption properties of materials through adjusting local electron structure and polarization relaxation. The symmetric electronic environments for EMW absorption have been extensively studied, but the asymmetric electron dispersion from an atomic-scale perspective is blurring puzzle. In this work, the amorphous polymer-derived SiZnCN ceramics with porous “Cheese” structure were prepared by regulating Zn coordination and pyrolysis temperature. The SiZnCN (15 wt% ZnAc doping) ceramics pyrolyzed at 1400 °C exhibits an effective absorption bandwidth (EAB) of 4.96 GHz at an ultrathin thickness of 1.28 mm. This SiZnCN ceramics after oxidized at 500 °C still possesses excellent high-temperature EMW absorption performance. Benefiting from the porous structure and coordinated single Zn atoms, the asymmetric electronic environment in amorphous SiZnCN ceramics is established, promoting electron/dipole and interfacial polarization. This work proposes an effective strategy to optimize electromagnetic wave absorption for high temperature by coordinating asymmetric electronic environments in disordered structures.
研究领域:
材料科学
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电磁功能材料
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陶瓷工程
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纳米材料
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介电性能
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Zheng Huang,Ya-Ping Xiao,Yu Guo,Hui-Zhen Yang,Rui-Mo Zhao,Ji Zhang,Xiao-Qi Yu
Gene and protein therapy have shown great potential in the treatment of severe human diseases. It’s increasingly necessary for the development of multifunctional vectors that can stabilize the gene / protein and deliver them into cells. Herein, a novel polymer composed of fluorinated linkage and Zn-coordinated macrocyclic polyamine (cyclen) was designed and synthesized via ring-opening polymerization. The Zn-cyclen moiety contributes to the gene transfection efficiency, while the fluorinated backbone might afford the protein delivery ability. Experimental results demonstrated that Zn-coordination could improve the water solubility of the polymer and the stability of the polyplexes formed with DNA. For gene transfection, the target polymer ZnCF4 could give similar to or slightly higher efficiency than the golden standard PEI 25 kDa in various cell lines. Several assays revealed that the improvement of transfection efficiency by the Zn-coordination might come from higher polyplex stability, better cellular uptake, and efficient endosome escape. For protein delivery, the Zn-coordination could also largely enhance the efficiency. β-Galactosidase assay revealed that ZnCF4 could not only effectively transfer protein into cells, but also maintain the protein activity. These results suggest that the title polymer might be a versatile platform for the delivery of various bioactive macromolecules , showing its potential in gene and protein therapy.
研究领域:
生物技术
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分子生物学
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药学
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基因治疗
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蛋白质治疗
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产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Dazhi Chen,Li Yang,Shulan Ni,Chaofan Jin,Chunyi Xu,Xingjie Zan,Yang Wang,Hong Zhu
Developing high-payload systems that dynamically respond to physiological fluctuations is crucial not only for improving the precision, safety, and efficacy of protein therapies but also for addressing biosafety concerns associated with carriers, reducing administration frequency, minimizing infection risks, and enhancing patient compliance. However, achieving precise control over protein release in the high-payload carriers remain a major challenge. In this study, a physiology-responsive, high-payload insulin (Ins) granule is engineered for long-term glucose management, using Ins as a model—an essential hormone that must be released in response to blood glucose changes for effective glycemic control in diabetic patients. The [(Ins&GOx)@Zn]@[TA&Fe] granules achieve an Ins loading capacity (LC%) exceeding 80%, significantly higher than the previously reported maximum of ≈40%. These granules extend the glucose-regulating effect of free Ins, typically limited to 3 h, to 6 days with a single injection, without any observed risk of hypoglycemia. Long-term administration (28 days, 4 injection cycles, 7 days injection −1 ) shows no significant physiological toxicity or immune response. This approach offers a promising strategy for developing intelligent, high-payload delivery systems for protein-based therapeutics, advancing more precise, safe, and patient-compliant treatments.
研究领域:
生物医学工程
·
药物递送系统
·
纳米医学
·
糖尿病研究
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蛋白质治疗
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Jie Bai,Jie Wang,Yecheng Feng,Yongfang Yao,Xubo Zhao
Polymeric micelles from block copolymers have gained increasing attention in cancer drug delivery. However, the fabrication of polymeric micelles that are stable in biological fluids and unstable at tumor sites remains a principal challenge. To achieve the tunable stability for the polymeric micelles, Zn coordination-induced core-crosslinked polymeric micelles have been proposed and confirmed. Herein, a block copolymer bearing imidazole pendants is synthesized which is capable of self-assembling into polymeric micelles in water. After core-crosslinking, it can be found that the critical micelle concentration (CMC) of the core-crosslinked polymeric micelles is significantly lower than that of non-crosslinked polymeric micelles. Particularly, the drug-loaded core-crosslinked polymeric micelles are fragile and easily affected by the slightly acidic environments, which makes it possible to turn the polymeric micelles back to hydrophilic polymers and therefore disassemble micelles to unload cargoes. The drug-loaded core-crosslinked polymeric micelles display adequate toxicity as a result of their low IC 50 value of 3.713 ± 0.166 μg/mL. Collectively, Zn coordination-induced core-crosslinked polymeric micelles offer a design idea for practicable drug delivery system in cancer therapy.
研究领域:
药学
·
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2024
·
IF 4.4
Hui-Zhen Yang,Jia-Jia Chen,Lan Zhang,Xiao-Li Tian,Rong Wang,Lin Pu,Xiao-Qi Yu,Ji Zhang
Nitric oxide (NO) / β-Lapachone (Lap) combined therapy by causing oxidative stress is an effective tumor therapy strategy. Herein, a dual-responsive lipid nanoparticles (LNPs) LSNO for NO / Lap co-delivery were constructed from the zinc-coordinated lipid ( DSNO(Zn) ) and the hydrophobic drug Lap in the presence of helper lipids (DOPE and DSPE-PEG 2000 ). The zinc-coordinated structure in LSNO might elevate the Zn 2+ content in tumor cells, contributing to antioxidant imbalance. The fluorescent assays proved the light-triggered NO release and fluorescent self-reporting abilities of LSNO . In addition, the LNPs had good drug release behavior under high concentration of GSH, indicating the NO / drug co-delivery capacity. In vitro antitumor assays showed that the NO / Lap combination treatment group could induce more significant tumor cell growth inhibition and cell apoptosis than individual NO or Lap treatment. The following mechanism studies revealed that NO / Lap combination treatment led to distinct oxidative stress by producing reactive oxygen species (ROS) and peroxynitrite anion (ONOO – ). On the other hand, the intracellular redox balance could be further disrupted by Lap-induced NADPH consumption and Zn 2+ / NO-induced reductase activities downregulation, thus promoting the degree of cell damage. Besides, it was also found that NO and Lap could directly damage nuclear DNA and induce mitochondrial dysfunction, thereby leading to caspase-3 activation and tumor cell death. These results proved that LSNO could serve as a promising multifunctional tumor therapy platform.
研究领域:
药学
·
纳米技术
·
癌症研究
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）