APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Cong Liu,Yanhui Li,Qian Duan
A novel hybrid organic/inorganic magnetic and thermal dual-responsive core-shell green photocatalyst zinc-tetracarboxyl-phthalocyanine- g -Fe 3 O 4 @SiO 2 @TiO 2 - g -poly( N -isopropyl acrylamide) had been prepared. Firstly, Fe 3 O 4 @SiO 2 @TiO 2 (FST) was prepared with core-shell structure, then thermosensitive poly( N -isopropylacrylamide) (PNIPAM) immobilized on the surface of 3-(methacryloxypropyl)-trimethoxysilane (MPS) modified FST by radical polymerization. Below the lower critical solution temperature (LCST), PNIPAM was hydrophilic to ensure them disperse uniformly in aqueous solution, and above LCST, PNIPAM became hydrophobic to accelerate the separation of FST from water. Secondly, zinc-tetracarboxyl-phthalocyanine (ZnTcPc) grafted on the surface of FST- g -PNIPAM by ester bonds and sensitized TiO 2 to broaden absorption light range from ultraviolet to visible region to enhance photocatalytic activity. The photocatalytic test revealed that the decomposition rate of Rhodamine B (RhB) came to 91.8% after 60 min with ZnTcPc- g -FST- g -PNIPAM under visible light. When exposed under sun light, the degradation efficiency reached to 96.9%. It meant ZnTcPc- g -FST- g -PNIPAM was more suitable for organic pollutant degradation in nature. In addition, ZnTcPc- g -FST- g -PNIPAM performed efficient synergistic effect of thermal (>LCST) and magnetic responded recovery for reusing. And the degradation rate of RhB under recyclable photocatalyst was reduced 9.6% after 4 cycles. Above all, ZnTcPc- g -FST- g -PNIPAM would be an efficient photocatalyst with magnetic and thermal dual-responsive recovery used in water treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 3
·418
·
IF 3.164
Shuning Liu,Chenchen Liu,Changyu Liu,Ling Tu,Yong You,Renbo Wei,Xiaobo Liu
Barium titanate (BT) and polyarylene ether nitrile (PEN) nanocomposites with enhanced dielectric properties were obtained by using carboxylatedzinc phthalocyanine (ZnPc-COOH) buffer as the plasticizer. Carboxylated zinc phthalocyanine, prepared through hydrolyzing ZnPc in NaOH solution, reacted with the hydroxyl groups on the peripheral of hydrogen peroxide treated BT (BT-OH) yielding core-shell structured BT@ZnPc. Thermogravimetric analysis (TGA), transmission electron microscopy (TEM), TEM energy dispersive spectrometer mapping, scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared (FTIR) demonstrated successful preparation of BT@ZnPc. The fabricated BT@ZnPc was incorporated into the PEN matrix through the solution casting method. Rheological measurements demonstrated that the ZnPc-COOH buffer can improve the compatibility between BT and PEN effectively. With the existence of the ZnPc-COOH buffer, the prepared BT@ZnPc/PEN nanocomposites exhibit a high dielectric constant of 5.94 and low dielectric loss (0.016 at 1000 Hz). BT@ZnPc/PEN dielectric composite films can be easily prepared, presenting great application prospects in the field of organic film capacitors.Keywords:barium titanate;polyarylene ether nitrile;zinc phthalocyanine;dielectrics;rheology
研究领域:
材料科学
·
电气工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS SCIENCE FORUM
·
2020
·
IF 0
Shu Guo Dong,Gui Hua Cui,Qian Duan
A novel end-functionalized glycopolymer poly (3-O-methacryloyl-D-glucofuranose) -b-poly (2-Diethylaminoethyl Methacrylate) (PMAGlc-b-PDEA-ZnTAPc) with zinc (II) teraamaninophthalocyanine was synthesized. First, a pH-responsive copolymer PMAIpG-b-PDEA was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Then PMAIpG-b-PDEA reacted with ZnTAPc and deprotected to form a water-soluble and pH-responsive photosensitizer. The structure of the PMAGlc-b-PDEA-ZnTAPc was characterized by 1H NMR and GPC. The photophysical properties were evaluated by UV-Vis and fluorescence spectra. The PMAGlc-b-PDEA-ZnTAPc can generate singlet oxygen species with good singlet oxygen quantum yields (Φ△=0.38), which is believed to be the major cytotoxic reactive oxygen species (ROS) for photodynamic therapy. The ZnPc functionalized glycopolymer will be used as a potential photosensitizer in the fields of photodynamic therapy.
研究领域:
材料科学
·
生物医学工程
·
药物化学
✓ 已验证
DOI
MOLECULES
·
2024
·Vol. 29
·期 8
·1845
·
IF 4.2
Sitong Lai,Bing Wang,Kunhui Sun,Fan Li,Qian Liu,Xie-An Yu,Lihe Jiang,Lisheng Wang
The integration of a multidimensional treatment dominated by active ingredients of traditional Chinese medicine (TCM), including enhanced chemotherapy and synergistically amplification of oxidative damage, into a nanoplatform would be of great significance for furthering accurate and effective cancer treatment with the active ingredients of TCM. Herein, in this study, we designed and synthesized four matrine-proteolysis-targeting chimeras (PROTACs) (depending on different lengths of the chains named LST-1, LST-2, LST-3, and LST-4) based on PROTAC technology to overcome the limitations of matrine. LST-4, with better anti-tumor activity than matrine, still degrades p-Erk and p-Akt proteins. Moreover, LST-4 NPs formed via LST-4 self-assembly with stronger anti-tumor activity and glutathione (GSH) depletion ability could be enriched in lysosomes through their outstanding enhanced permeability and retention (EPR) effect. Then, we synthesized LST-4@ZnPc NPs with a low-pH-triggered drug release property that could release zinc(II) phthalocyanine (ZnPc) in tumor sites. LST-4@ZnPc NPs combine the application of chemotherapy and phototherapy, including both enhanced chemotherapy from LST-4 NPs and the synergistic amplification of oxidative damage, through increasing the reactive oxygen species (ROS) by photodynamic therapy (PDT), causing an GSH decrease via LST-4 mediation to effectively kill tumor cells. Therefore, multifunctional LST-4@ZnPc NPs are a promising method for killing cancer cells, which also provides a new paradigm for using natural products to kill tumors.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2016
·
IF 0
Xia Dong,Chang Wei,Hongli Chen,Jingwen Qin,Jie Liang,Deling Kong,Tianjun Liu,Feng Lv
Real-time tracking of a drug delivery system and its therapeutic effects in vivo are crucial to designing a novel pharmaceutical system and revealing the mechanism of drug therapy. Multispectral fluorescence imaging can locate the drug and carrier simultaneously without interference. This advanced method enables the tracking of a drug delivery system. Herein, a doxorubicin (Dox) loaded zinc phthalocyanine incorporated hydrogel was developed as a dual fluorescent drug delivery system to monitor the release of the drug and the degradation of the carrier. An injectable thermosensitive hydrogel based on a four-arm poly(ethylene glycol) (PEG)–poly(ε-Caprolactone) (PCL) copolymer was prepared and characterized with a zinc phthalocyanine core as the drug carrier. The hydrogel degradation and drug delivery in vivo were tracked by a multispectral fluorescence imaging system in nude mice bearing hepatic tumors. Moreover, the real-time tumor inhibition progress was tracked in vivo for 18 days by bioluminescence imaging. A multispectral analysis can separate the fluorescence signals from the drug and carrier in the Dox loaded hydrogel and provide their location in the tumor tissue. The drug release and hydrogel degradation can be drastically tracked respectively without mutual interference. The fluorescence imaging results reveal improved tumor inhibitory effects of the Dox loaded hydrogel. Optical imaging allows for visible tracking of the entire drug delivery process. The Dox loaded phthalocyanine incorporated thermosensitive hydrogel is a potential visible drug delivery system for tumor therapy.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2024
·
IF 4.1
Lu Li,Feng Qin,Yongda Wang,Lixin Peng,Zhiguo Zhang,Tao Jia
The determination of the Stern-Volmer constant ( K SV ) for photosensitizers, a key parameter for characterizing energy transfer efficiency to oxygen, enables the understanding and optimization of photosensitizer functionality. In this study, a strategy was proposed for determining the K SV by replacing the analysis of the oxygen-dependent behavior of fluorescence intensity with a direct correlation between singlet oxygen quantum yield (Φ Δ ) and molecular oxygen. Zinc phthalocyanine (ZnPc) was selected for this work due to its promising photosensitizing properties. Through theoretical analysis using the rate equation model and experimental absorption measurements, the K SV of ZnPc was found to be 2.4(2) μM −1 . To verify the accuracy of the K SV , an oxygen-varying correlated fluorescence methodology was applied, reinforcing the reliability of the results. In addition, the determination of the K SV is achievable even in the absence of specific Φ Δ values and without the use of a standard reference.
研究领域:
生物化学
·
光动力治疗
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2018
·
IF 4.816
Liangfeng Huang,Gaofei Wei,Xiaoqi Sun,Yali Jiang,Zeqian Huang,Yanjuan Huang,Yifeng Shen,Xiaoyu Xu,Yunhui Liao,Chunshun Zhao
Therapeutic effects of photodynamic therapy (PDT) are limited by the selectivity of photosensitizer (PS). Herein, a novel tumor-targeted drug-PS conjugate (Gan-ZnPc) which integrated with zinc phthalocyanine (ZnPc) and Ganetespib has been developed. ZnPc is a promising PS with remarkable photosensitization ability. Ganetespib is a heat shock protein 90 (Hsp90) inhibitor with preferential tumor selectivity and conjugated to ZnPc as a tumor-targeted ligand. The multifunctional small molecule conjugate, Gan-ZnPc, could be bound to extracellular Hsp90 and then selectively internalized into the tumor cells, followed by the generation of abundant intracellular reactive oxygen species (ROS) upon irradiation. Besides, Gan-ZnPc can arrest cell proliferation and induce apoptosis by the inhibition of Hsp90. Herein, with combination of the inhibition of Hsp90 and the generation of cytotoxic ROS, Gan-ZnPc implements tumor selectivity, concentrated PDT and chemotherapy in a synergistic manner, which results in highly effective anti-tumor activity in vitro and in vivo.
研究领域:
药理学
·
肿瘤学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Jinyun Peng,Xueying Li,Yuxia Liu,Wenfeng Zhuge,Cuizhong Zhang,Yingying Huang
Developing materials with excellent photoelectric activity is critical to improving the sensitivity of photoelectrochemical (PEC) sensors. Herein, we reported a convenience method to synthesize phthalocyanine polymer dots (Pdots), which dope zinc phthalocyanine (ZnPc) into a conjugated polymer poly[(9,9-di- n -octylfluorenyl-2,7-diyl)- alt -(benzo{2,1,3}thiadia-zol-4,8-diyl)] (P8BT). The synthesized materials were characterized by energy dispersive spectrometry (EDS), electrochemical impedance spectroscopy (EIS), fluorescence (FL) spectroscopy, transmission electron microscopy (TEM), ultraviolet-visible diffuse reflectance spectroscopy (UV–vis DRS), and dynamic light scattering (DLS). Then, ZnPc-P8BT-Pdots were modified on an indium tin oxide (ITO) electrode by repeated immersion to develop an ultrasensitive PEC sensor for dopamine (DA) detection. Semiconducting polymers in ZnPc-doped forms exhibit a typical photocurrent reduction in comparison with the original polymers . As the photocurrent was weakened, energy was transferred from the conjugated polymers to ZnPc. The photocurrent intensity of ZnPc-P8BT-Pdots/ITO increases as the concentration of DA increases under blue light irradiation . Under the best experimental conditions, the PEC sensor realized the detection of DA (2.5 nM-125 μM) with a limit of detection (LOD) of 1.69 nM (S/N = 3). Moreover, the ZnPc-P8BT-Pdots/ITO sensor for the detection of DA exhibited superior PEC performance, high sensitivity, rapid response, and favorable stability. This study indicated that ZnPc-P8BT-Pdots possess the promising potential to construct PEC sensors for pharmaceutical analysis.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2021
·
IF 9.127
Meiying Yu,Yunfei Li,Xuepeng Chen,Xiaole Yuan,Nan Li,Weihua He,Yujie Feng,Jia Liu
Cathode membrane adding zinc phthalocyanine (ZnPc) is an efficient strategy to improve catalytic performance and antifouling properties. The maximum current density and the lowest charge transfer impedance of cathode membrane with the 0.07 g ZnPc (ZnPc-7) are 11.7 A m −2 and 5.3 Ω. The ZnPc-7 is also proven to be an excellent 4e − catalyst. The ZnPc-7+E (E is electric) produces the minimum total permeability decay rate and the lowest irreversible permeability attenuation rate under electric field, which are decreased by 19% and 64% than the control+E. The ZnPc enhances the antifouling performance and reproducible positive effect under electric field. The foregoing can be attributed to that ZnPc with superior conductivity produces rapid electrochemical response and stronger electrostatic repulsion force under electric field condition, thus reducing the membrane fouling . This work provides a simple strategy for the improvement of antifouling performance of filtration cathode membranes in microbial fuel cells .
研究领域:
环境科学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Shunhu Zhang,Chun Tian,Xiaowu Jiang,Xiang Xu,Haitao Zhao,Jiyuan Sun,Lifen Zhang,Zhenping Cheng
To improve the solubility and recyclability of the NIR photocatalyst, two synthetic strategies, namely “living” polymers with permanent NIR photocatalyst by reversible addition-fragmentation chain transfer (RAFT) polymerization and “non-living” polymers with recyclable NIR macro-photocatalyst (macro-PC) by conventional radical polymerization, were developed by copolymerization of hydrophilic and polymerizable zinc phthalocyanine (ZnTAPc-MAm or ZnTAPc-Am) monomers. The resultant macro-PCs from RAFT polymerization were endowed with permanent NIR photocatalysis due to the attachment of zinc phthalocyanine moieties, and the features of both “living” and permanent NIR photocatalyst of the “living” macro-PCs were verified by much simple multiple chain extensions via RAFT polymerization in water (only involved in “living” polymers and fresh monomer) under irradiation with NIR LED light ( λ max = 730 nm) at room temperature. In addition, the resultant water-soluble “non-living” macro-PCs from conventional radical polymerization were endowed with only NIR photocatalysis property but they could be easily recycled just by centrifugation, which facilitates to synthesize tailored polymers by recyclable PCs under NIR irradiation.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2017
·
IF 3.473
YanHui Li,Dehai Zhao,Yanwei Li,Yongzhe Liu,Qian Duan,Toyoji Kakuchi
A novel zinc(II) tetraaminophthalocyanine ended block copolymer methoxypolyethylene glycol- b -poly(N-isopropylacrylamide) (MPEG- b -PNIPAAM-ZnTAPc) had been synthesized through an easy way. First, the diblock copolymers MPEG- b -PNIPAAM were synthesized by atom transfer radical polymerization (ATRP) and functionalized with one molecule of maleic anhydride (MA) by ATRP, and then reacted with ZnTAPc to form a water-soluble and thermoresponsive photosensitizer . The lower critical solution temperatures for the copolymers can be easily controlled by changing the ratio of MPEG and PNIPAAM. In aqueous solution, the thermosensitive copolymers will self-assemble into micelles and characterized by dynamic light scattering and transmission electron microscopy , and the sizes of micelles will increase with temperature increasing. In the micelles, ZnTAPc will aggregate to induce fluorescence quenching. As a photosensitizer, MPEG- b -PNIPAAM-MA-ZnTAPc can generated singlet oxygen species with good quantum yields (Φ Δ = 0.23), which were believed to be the major reactive oxygen species. And the copolymer had low dark cytotoxicity and high phototoxicity based on MTT assay, so the MPEG- b -PNIPAAM-ZnTAPc will used in the field of photodynamic therapy and photocatalytic oxidation .
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
DOI
高影响因子
CHEMICAL PHYSICS LETTERS
·
2017
·
IF 1.815
Shuning Liu,Chenchen Liu,Xinying Luan,Rui Yao,Yakai Feng
The far-red/near infrared photoluminescence of zinc phthalocyanines would be strongly quenched once they are aggregated, which will obviously hinder their wide applications in environmental, energy related and biomedical fields. Herein, the ultra-small sized semiconductor quantum dots with core-shell structures (CdSe@CdS) have been firstly synthesized and then assembled with a dendritic zinc phthalocyanine (ZnPc) in the H 2 O/DMF mixed solvent to obtain monodispersed nanospheres. Finally, it was found that the resultant ethanolic colloids can be employed as a sensitive and specific fluorescent nanoprobe for silver ions discrimination with a limit of detection (LOD) approaching to 10 − 8 mol/L.
研究领域:
材料科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）