FISH & SHELLFISH IMMUNOLOGY
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2018
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IF 3.185
Wei Shi,Xiaofan Guan,Yu Han,Cheng Guo,Jiahuan Rong,Wenhao Su,Shanjie Zha,Yichen Wang,Guangxu Liu
Exposure to heavy metals such as Cadmium (Cd) may exert detrimental impacts on the immune responses of marine bivalve species. However, the immunotoxicity of Cd on blood clams remains unknown to date. Furthermore, though Cd 2+ is known to compete with calcium (Ca 2+ ) ions for their binding sites in cells and inhibit Ca 2+ influx, whether Cd 2+ weakens the immune responses of marine bivalves through inducing intracellular Ca 2+ disorders still remains unclear. Therefore, the immunotoxicity of Cd 2+ at different waterborne Ca 2+ concentrations on blood clam, Tegillarca granosa , were investigated in the present study. Results obtained demonstrated that the total number, phagocytic activity , and red granulocytes ratio of the haemocytes were all significantly reduced after 10 days exposure of individuals to 25 μg/L Cd 2+ . However, when the waterborne Ca 2+ concentrations were elevated by 10% and 20% (approximately 370 and 410 mg/L, respectively), mitigation effects on the immune responses of individuals were detected. In addition, though the expressions of genes from the Ca 2+ signaling and Ca 2+ -related apoptosis pathways were significantly altered by Cd 2+ exposure, the expression patterns of these genes were similar to that of the control when the waterborne Ca 2+ concentrations were elevated, suggesting a relieving effect of waterborne Ca 2+ on Cd 2+ induced toxicity to haemocytes. The results obtained in the present study revealed that waterborne Cd 2+ may hamper the immune responses of T. granosa through influencing Ca 2+ signaling and Ca 2+ -related apoptosis pathways, which can be partially mitigated by elevating the waterborne Ca 2+ concentrations.
研究领域:
海洋生物学
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毒理学
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2024
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IF 7.6
Mengli Han,Zhao Chen,Genlou Sun,Yuxi Feng,Yuxia Guo,Shiqie Bai,Xuebing Yan
Cadmium (Cd) poses a significant threat to plant growth and the environment. Nano-Fe 3 O 4 is effective in alleviating Cd stress in plants. Elymus nutans Griseb. is an important fodder crop on the Qinghai-Tibetan Plateau (QTP). However, the potential mechanism by which nano-Fe 3 O 4 alleviates Cd stress in E. nutans is not well understood. E. nutans were subjected to single Cd, single nano-Fe 3 O 4 , and co-treatment with nano-Fe 3 O 4 and Cd, and the effects on morphology, Cd uptake, antioxidant enzyme activity, reactive oxygen species (ROS) levels and programmed cell death (PCD) were studied to clarify the regulatory mechanism of nano-Fe 3 O 4 . The results showed that Cd stress significantly decreased the germination percentage and biomass of E. nutans . The photosynthetic pigment content decreased significantly under Cd stress. Cd stress also caused oxidative stress and lipid peroxidation, accumulation of excessive ROS, resulting in PCD, but the effect of nano-Fe 3 O 4 was different. Seed germination, seedling growth, and physiological processes were analyzed to elucidate the regulatory role of nano-Fe 3 O 4 nanoparticles in promoting photosynthesis, reducing Cd accumulation, scavenging ROS, and regulating PCD, to promote seed germination and seedling growth in E. nutans . This report provides a scientific basis for improving the tolerance of Elymus to Cd stress by using nano-Fe 3 O 4 .
研究领域:
环境科学
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植物生理学
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农学
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纳米技术
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
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IF 9.038
Dong Hui Liang,Yongyou Hu
Little information is available regarding the kinetics, products, and pathways of simultaneous SMX degradation and Cd(II) immobilization from wastewater. In this study, a novel bacterium ( Achromobacter sp. L3) with SMX degradation and Cd(II) immobilization capabilities was isolated. The boundary conditions of SMX degradation were as follows: initial pH 6–8, temperature 25–30 °C, and SMX concentration 10–40 mg/L −1 . The boundary conditions of Cd(II) immobilization were as follows: initial pH 7–9, temperature 25–35 °C, and SMX concentration 10–30 mg/L −1 . The maximum SMX degradation and Cd(II) removal were 91.98% and 100%, respectively. The SMX degradation and Cd(II) immobilization data fitted well with the pseudo-first-order kinetic model, indicating that the two pollutants conform to the same degradation rule. Moreover, the microbial degradation , sediment adsorption, and intermediates identified in the experiments were used to explore the mechanisms of SMX and Cd(II) removal. These results indicate that microbial removal and sediment adsorption play equally important roles in Cd(II) immobilization; however, microbial degradation plays a decisive role in SMX degradation. Furthermore, the relationship between aerobic denitrification, SMX degradation, and Cd(II) immobilization was proposed. These results may provide valuable insights for treatment of wastewater polluted by antibiotics and heavy metals.
研究领域:
环境微生物学
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废水工程
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污染控制
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产品关联
DOI
PubMed
高影响因子
PLANT PHYSIOLOGY AND BIOCHEMISTRY
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2025
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IF 5.7
Jing Sun,Shuxin Tu,Zhenli Zhu
Cadmium (Cd) pollution in farmland soils threatens food safety, making it essential to study soil-crop Cd transport mechanisms and develop remediation strategies. While organosilicon-modified materials demonstrate potential in blocking metal uptake by crops, their underlying mechanisms remain underexplored. This study employed stable isotope 114 Cd tracing to investigate Cd absorption, translocation, allocation in soil-pakchoi system mediated by organosilicon (DMDCS and D6). Results revealed that organosilicon induced Cd redistribution in soils, enhancing its sequestration into non-reactive fractions. Specifically, DTPA-Cd decreased by 13.14-24.19%, while RES-Cd increased by 70.3-106.8%. Organosilicon also inhibited Cd uptake and translocation in pakchoi, reducing root and shoot Cd concentrations by 30.0-33.2% and 54.6-57.1%, respectively, with a 35% decline in translocation factor (TF). This reduction stemmed from diminished Cd accumulation (12.09-17.73% decrease) in soluble subcellular fractions. Among the plant parts, Cd isotopes were markedly fractionated: shoots were isotopically heavier than roots. Silicone application attenuated this fractionation intensity, with Δ 114/110 Cd shoot-root decreased from 0.33 to 0.08. We suggest that organosilicon suppressed the enrichment of exogenous isotopes in plant edible parts due to a 28.1% decrease in Cd isotope exchangeability (E- value) and vacuolar compartmentalization. This study provides new insights into organosilica-mediated Cd dynamics in pakchoi, laying the foundation for future Cd regulation strategies.
研究领域:
环境科学
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土壤学
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植物生理学
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农业化学
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生态毒理学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
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2025
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IF 7.7
Huan Zhou,Jin Zhang,Long-Long Fan,Zhi Yuan,Qi Lu,Gang Liu,Yu-Hong Nie,Yi-Fan Hu,Shen-Dong Xu,Xu-Dong Zhang,Ye-Xin Luo,Hua-Long Zhu,Wei Chang,Yong-Wei Xiong,Hua Wang
Chaohu Lake, a vital freshwater resource for surrounding communities, faces environmental stress due to industrial and mining activities, leading to metal contamination. However, the potential ecotoxicological effects of these metals remain unclear. To address this knowledge gap, we analyzed spatial metal distributions in the lake and developed a Drosophila model exposed to region-specific raw water samples. Our results revealed significantly elevated total metal levels in the western region compared to other areas. Male Drosophila exposed to western raw water exhibited >20% reduced climbing ability and reproductive deficits, suggesting metals as likely contributors to these adverse effects. Notably, the primary characteristics of the observed reproductive dysfunction included a >20% reduction in motor activity and a more than twofold increase in brain aging in offspring following paternal exposure to western water. Comparative analysis with China’s surface water standards identified barium (Ba), molybdenum (Mo), and cadmium (Cd) as key metals in the western region. Crucially, paternal exposure to these metals alone recapitulated the offspring’s motor decline and brain aging. We conclude that Ba, Mo, and Cd may be the key metals responsible for Chaohu Lake water-induced paternal motor/reproductive dysfunction and impaired offspring motor performance, with brain senescence potentially mediating the offspring’s motor deficits.
研究领域:
环境毒理学
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生态毒理学
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神经毒理学
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生殖生物学
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金属生物学
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淡水生态学
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遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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