CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Chao Wei,Ji Tan,Shun Xing,Hongqin Zhu,Naijian Ge,Haifeng Zhang,Xuanyong Liu
Interventional therapy represents the primary treatment modality for cardiovascular disease associated with vascular obstruction. However, conventional stents are susceptible to thrombosis and infection, leading to serious threats to patient health and, in some cases, mortality. In this study, a Ta/Ta 2 O 5 /Ni 3 N film was prepared in situ on the nitinol (Ni-Ti) stent using a sequential plasma immersion ion implantation method. As tantalum has a negative charge under physiological conditions and nickel nitride adsorbs protons in solution, the introduction of tantalum and nickel nitride is expected to allow the surface charge of the material to be tailor-made. The film displays excellent hemocompatibility and reduced platelet adhesion, based on the combined effect of “mosaic-like” charge distribution of the film and the high dispersion/polarity component ratio in the surface tension. Ammonia species is an important physiological signaling molecule, which could be produced by the affinity of nitrogen in nickel nitride with protons in solution. In turn, ammonia species modulates the cellular NRF2/HO-1 signaling pathway, thereby enhancing cell viability. Furthermore, ammonia species increases intracellular eNOS gene expression, which enhances cell migration and promotes early endothelialization. Additionally, the depletion of protons by nickel nitride can disrupt bacterial metabolism, which results in the production of reactive oxygen species (ROS) and nitric oxide (NO) within the bacteria, achieving a killing efficacy of over 99.9% for both gram-negative Escherichia coli and gram-positive Staphylococcus aureus . It is anticipated that this straightforward, multifaceted inorganic bioactive film approach will prove an invaluable solution for enhancing the reliability of stents and reducing the burden on patients.
研究领域:
生物材料学
·
心血管医学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS LETTERS
·
2018
·
IF 2.687
Long Meng,Yang Li,Kai Pan,Ye Zhu,Wei Wei,Xiaojie Li,Xiaoya Liu
Photo-crosslinking copolymer Poly (2-Hydroxyethyl methacrylate- co -2-(Dimethylamino) ethyl methacrylate- co -7-hydroxy-4-methylcoumarin methacrylate) (PHDC)) was first synthesized by free radical polymerization of 7-hydroxy-4-methylcoumarin methacrylate (CA), 2-Hydroxyethyl methacrylate (HEMA) and 2-(Dimethylamino)ethyl methacrylate (DMA). Then, the copolymers were self-assembled into colloidal particles and immobilized on the NiTi alloy by a simple one-step electrophoretic deposition. After irradiation, a photo-crosslinked coating was obtained. The structure and morphology were characterized by OCA and SEM. The copolymer coatings could significantly decrease the release of nickel ions into the environment and reduce cytotoxicity inducing by nickel ions according to immersion experiment. Meanwhile, the coatings have good cytocompatibility. This work provides a simpler polymer coating method to inhibit the release of toxic ions by inducing ion adsorption with certain molecular structures, which have potential for biomedical applications such as artificial bone and bone fixation device.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Yan L. Tian,Yue C. Zhao,Cheng J. Yang,Fu J. Wang,Xian P. Liu,Xiu B. Jing
In this paper, micro/nano-scale structures were fabricated on nitinol alloy (NiTi) to realize tunable anisotropic wetting and high adhesive capability. Laser texturing and silanization process are utilized to change the morphological and chemical properties of substrates. It is noted that these treated substrates exhibit the joint characteristics of anisotropic wetting and high adhesive capability. In order to investigate the influences of laser-texturing and silanization processes on NiTi, these surfaces were evaluated using scanning electron microscope (SEM), a white light confocal microscope , X-ray photoelectron spectroscopy (XPS) and goniometer . The relationship between water volume and anisotropic wetting was also established. From the experimental testing, we can obtain the following conclusions: (1) the anisotropic wetting characterized by the difference between the water contact angles (WCAs) in the vertical and parallel directions ranges from 0° to 20.3°, which is far more than the value of natural rice leaves. (2) the water sliding angles (WSAs) kept stable at 180°, successfully mimicking the adhesive ability of rose petals. (3) the silanization process could strengthen the hydrophobicity but weaken anisotropic wetting. These bio-inspired NiTi surfaces have a tremendous potential applications such as microfluidic devices , bio-mimetic materials fabrication and lab on chip.
研究领域:
材料科学
·
仿生学
·
表面工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 3
·1551-1561
·
IF 3.069
Long Meng,Yunan Wu,Kai Pan,Ye Zhu,Xiaojie Li,Wei Wei,Xiaoya Liu
Nickel-titanium alloy (NiTi alloy) has recently received an increasing amount of attention. However, the release of toxic nickel ions and the threat of implant infections has limited its clinical applications. Thus, we report a promising copolymer coating with excellent nickel ion (Ni2+) inhibition release, cytocompatibility, and antimicrobial properties to solve these safety issues involving NiTi alloy implantation. Quaternized copolymers poly (7-hydroxy-4-methylcoumarin methacrylate-co-2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) (PCHD-Q) with many hydroxyl and tertiary amine groups were first synthesized, self-assembled into nanoparticles, and then deposited on NiTi substrate through electrodeposition. After UV irradiation, scanning electron microscopy (SEM) images revealed that homogeneous, continuous, and dense coatings were obtained. The coatings showed good improvement of protective behavior for the NiTi alloy in an in vitro environment and could significantly decrease the release of Ni2+ through physical barriers and physical adsorption, which could obviously reduce cytotoxicity inducing by Ni2+. According to in vitro cell viability and antibacterial tests, the quaternized coating materials not only provided a relatively stable biointerface for cell adhesion, spreading and growth, but also obtained excellent antimicrobial activity for the bare NiTi alloy against S. aureus and E. coli. These results suggested that our coatings materials have the potential for improving the safety and success rate of NiTi-based implantations.
研究领域:
材料科学
·
生物医学工程
·
表面涂层技术
✓ 已验证
产品关联
DOI
高影响因子
Micromachines
·
2022
·Vol. 13
·期 8
·1160
·
IF 3.523
Zheng Fang,Yang Cheng,Qing Yang,Yu Lu,Chengjun Zhang,Minjing Li,Bing Du,Xun Hou,Feng Chen
Slippery liquid-infused porous surfaces (SLIPSs) have become an effective method to provide materials with sliding performance and, thus, achieve liquid repellency, through the process of infusing lubricants into the microstructure of the surface. However, the construction of microstructures on high-strength metals is still a significant challenge. Herein, we used a femtosecond laser with a temporally shaped Bessel beam to process NiTi alloy, and created uniform porous structures with a microhole diameter of around 4 µm, in order to store and lock lubricant. In addition, as the lubricant is an important factor that can influence the sliding properties, five different lubricants were selected to prepare the SLIPSs, and were further compared in terms of their sliding behavior. The temperature cycle test and the hydraulic pressure test were implemented to characterize the durability of the samples, and different liquids were used to investigate the possible failure under complex fluid conditions. In general, the prepared SLIPSs exhibited superior liquid repellency. We believe that, in combination with a femtosecond laser, slippery liquid-infused porous surfaces are promising for applications in a wide range of areas.Keywords:SLIPS;femtosecond laser;NiTi alloy;liquid repellency;sliding performance
研究领域:
材料科学
·
激光加工
·
表面工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2017
·
IF 8.402
Zhu Jin,Keqin Wu,Jingwen Hou,Kunhong Yu,Yuanyuan Shen,Shengrong Guo
An antitumor drug/esophagus stent combination can palliatively relieve malignant esophageal stricture and exert local chemotherapy to cancer. It is vital for effective treatment of cancer to control drug release and facilitate drug penetration into deep tissue after the combination is placed in the malignant strictured esophagus part. In this study, we firstly designed and prepared a novel antitumor drug/esophagus stent combination: a magnetocaloric nitinol stent coated with a bilayered film that consisted of one ethylene-vinyl acetate copolymer (EVA) layer as drug blocking layer and one EVA layer containing 10% paclitaxel (PTX) and 30% temperature sensitive phase-change fatty alcohol (1-tetradecanol, 1-hexadecanol or 1-octadecanol). The drug release and penetration into rabbit esophagus wall from the combination were investigated. It was found that, under an alternating electromagnetic field at a power of 0.1 kW, the combination was heated to 43 °C, the PTX was faster and more released from the combination, as well as the amount of PTX in esophagus tissue or its deep muscle tissue penetrated from the combination was much higher than that without alternating electromagnetic field. The pathological data showed that the combination was biocompatible and safe after placement in rabbit esophagus even under an alternating electromagnetic field. Overall, the PTX could be magnetocalorically released and effectively penetrated into esophagus wall from the PTX/nitinol stent combination.
研究领域:
生物医学工程
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2022
·Vol. 18
·期 39
·2202908
·
IF 15.153
Shun Xing,Donghui Wang,Haifeng Zhang,Feng Peng,Ling Wu,Lidan Liu,Yuqin Qiao,Naijian Ge,Xuanyong Liu
Gallbladder cancer is a common malignant tumor of the biliary system with a high fatality rate. Nitinol (Ni–Ti) stents, a standard treatment for prolonging patients’ lives, are susceptible to reocclusion and cannot inhibit tumor recurrence because they lack antitumor and antibacterial activity. Herein, an arsenic-loaded layered double-hydroxide film is constructed on Ni–Ti, forming a micro “chemical factory.” The LDH plays the role of a “processer” which absorbs highly toxic trivalent arsenic (As(III)) and processes it into lowly toxic pentavalent arsenic (As(V)). It also acts as a “quality-inspector,” confining As(III) in the interlayer and releasing only As(V) (the finished product) to the outside. This control mechanism minimizes the toxicity during contact with normal tissue. The acidic microenvironment and overexpression of glutathione in tumor tissues not only accelerates the release of arsenic from the platform but also triggers the in situ transformation of arsenic from lowly toxic As(V) to highly toxic As(III), exerting a strong arsenic-mediated antineoplastic effect. Such a microenvironment-responsive “chemical factory” with arsenic processing and screening functions is expected to prevent tumor overgrowth, metastasis, and bacterial infection and provide new insights into the design of Ni–Ti drug-eluting stents for gallbladder cancer treatment.
研究领域:
肿瘤学
·
生物材料
·
生物医学工程
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 42
·19936-19945
·
IF 4.682
Zhang Jing,Yao Qingyun,Tang Shuangmei,Yang Chao,Liu Qifan,Zang Limin,Qiu Jianhui
Flexible linear aqueous zinc-ion hybrid supercapacitors are considered as ideal materials for flexible and wearable electronic devices due to their advantages of safety, high flexibility and good wearable ability. Materials based on shape memory can satisfy the needs of fatigue resistance and deformation recovery, and have great advantages in the assembly of flexible wearable devices. In this paper, aqueous zinc-ion hybrid supercapacitor with shape-memory function was assembled by using PANI/NiTi shape-memory alloy wire as the cathode electrode and flexible zinc wire as the anode electrode. The device can be bent into different angles from 0° to 180°, after repeated bending for 200 times and heating to its deformation temperature, the original shape can still be restored, and the capacitance retention rate is up to 90%, with good mechanical resistance. By assembling with flexible zinc wire, the potential window can be expanded to 1.6 V, and the energy density has been greatly improved. Its energy density can reach 55.9 Wh kg −1 at 3 A g −1 , which greatly improves its energy density and has great development potential in flexible and portable electronic devices.
研究领域:
材料科学
·
能源存储
·
柔性电子
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shun Xing,Haifeng Zhang,Zhenhao Hou,Feng Peng,Lidan Liu,Donghui Wang,Naijian Ge,Xuanyong Liu
Portal vein tumor thrombus (PVTT) formed by cancer cell invasion is a major cause of high mortality in hepatocellular carcinoma (HCC), and the formation of thrombus will be accelerated by bacterial colonization on the surface of the implant after surgery. In this work, Polypyrrole-coated arsenic-loaded layered double hydroxide films were in situ constructed on the nickel-titanium alloy for the efficient killing of tumour cells by thermo-therapeutic synergistic chemotherapy. The good near-infrared photothermal conversion ability of polypyrrole enables the sample surface temperature to be raised to about 51 °C at a low photothermal power (0.5 w/cm 2 ), while the elevated temperature could further accelerate the release of drug arsenic. In addition, when NIR light is not applied, the polypyrrole coating also cleverly acts as a “barrier layer” to reduce the natural release of arsenic in normal tissues to avoid toxicity issues. In vivo and in vitro experiments have demonstrated that the platform exhibits excellent antitumor and antibacterial abilities. In contrast to the systemic toxicity issues associated with systemic circulation of nanotherapeutic drugs, this in situ functional film is expected to be used in localised interventions for precise drug delivery, and is also more suitable for surgical treatment scenarios in PVTT surgeries.
研究领域:
肿瘤学
·
生物材料学
·
医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Anqi Sun,Xiuhong Huang,Yanpeng Jiao,Xiangyu Wang,Jun Wen
Recently, just taking endothelialization of stent as an interventional treatment of aneurysms is unsatisfactory. This treatment also has impacts the occlusion rate of the aneurysm. In accordance with that, the authors aims to construct a novel biological factor-coated stent with dual biological effects of anticoagulation and endothelialization for the improvement of the occlusion rate of aneurysms and reduction of the risk for treatment of aneurysm with intravascular interventional therapy. The Ni-Ti alloy sheets loaded with VEGF and anti-CD34 antibody were put into use for stimulating the construction of the biological factor-coated stents, for the Ni-Ti alloy sheets could help improve the proliferation of endothelial cell (EC), recognize effectively and adhere to endothelial progenitor cell (EPC). Blood compatibility characterization methods (water contact angle, platelet activation test, clotting time evaluation and protein adsorption test) were applied for study the influence of the interaction between the Ni-Ti alloy sheets and blood. Cell experiments (HUVEC proliferation experiment, migration experiment and EPC capture experiment) were resorted to investigate the ability of the sheets to promote the proliferation of HUVEC and to capture EPCs. With the mature of the construction technology, the Enterprise stent with the biological factors were optimized accordingly, the biological function of that were verified by cell experiments. Studies showed that Ni-Ti alloy sheets and enterprise stents can successfully load with VEGF and anti-CD34 antibody. The below achievements can be realized including a better blood compatibility and effects of the constructed sheets and enterprise stents on promoting HUVEC proliferation and adhesion of EPC. It was meaningful of conversion to clinical application to improve the cure rate of the aneurysm and the safety of the intravascular treatment.
研究领域:
生物医学工程
·
心血管医学
·
材料科学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Jiaming Lin,An Yan,Anfei Huang,Qinglian Tang,Jinchang Lu,Huaiyuan Xu,Yufeng Huang,Tianqi Luo,Zhihao Chen,Anyu Zeng,Xiaojun Zhu,Chao Yang,Jin Wang
Nickel–titanium (NiTi) alloy is a widely utilized medical shape memory alloy (SMA) known for its excellent shape memory effect and superelasticity. Here, laser powder bed fusion (LPBF) technology was employed to fabricate a porous NiTi alloy scaffold featuring a topologically optimized dominant cellular structure that demonstrates favorable physical and superior biological properties. Utilizing a porous structure topology optimization method informed by the stress state of human bones, two types of cellular structures—compression and torsion—were designed, and porous scaffolds were produced via LPBF. The physical properties of the porous NiTi alloy scaffolds were evaluated to confirm their biocompatibility, while their osteogenic efficacy was investigated through both in vivo and in vitro experiments, with comparisons made against a traditional octahedral unit cell structure. NiTi alloy porous scaffolds can be nearly net-shaped via LPBF and exhibit favorable physical properties, including a low elastic modulus, high hydrophilicity, a specific linear expansion rate, as well as superelastic and shape memory effects. These scaffolds demonstrate excellent biocompatibility, support in vitro osteogenesis, and possess significant in vivo bone ingrowth capabilities. When compared to titanium alloys, NiTi alloys show comparable osteogenic properties in vitro but superior bone ingrowth properties in vivo. Additionally, among octahedral-type, torsion-type, and topologically optimized compression-type porous scaffolds, the latter demonstrates enhanced bone ingrowth properties. LPBF technology is effective for manufacturing porous NiTi alloy scaffolds with fine pore structures and excellent mechanical properties. The scaffolds based on topologically optimized dominant cellular structures facilitate satisfactory and efficient bone formation.
研究领域:
材料科学
·
生物医学工程
·
组织工程
·
增材制造
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2022
·
IF 10.761
Xueqing Hao,Jielong Zhou,Juning Xie,Xianrui Zou,Baoe Li,Chunyong Liang,Yu Zhang,Feng Peng,Donghui Wang
Preferable antibacterial property and osteogenesis are the permanent pursuit for metallic implants. However, it is difficult to satisfy both the properties. In fact, implants may be contaminated with bacteria during storage and surgery, leading to inflammation. Therefore, the antibacterial property of biomaterial surfaces is required not only in the human environment but also at room temperature. In this study, porous structures loaded with a thermosensitive poly ( N -isopropylacrylamide) (PNIPAM) hydrogel on a nitinol (NiTi) substrate were constructed. When the temperature is 25 °C, almost all bacteria cannot adhere to the sample surface due to the abundant hydration layer of the PNIPAM hydrogel. Meanwhile, when the temperature is 37 °C, the structure of the PNIPAM hydrogel collapses and the hydration layer disappears due to the temperature change. However, the porous structures lock water in the pores, which results in a high-hydration-rate sample surface. This surface has few bacterial adhesion sites; nevertheless, the adhesion of larger cells to the surface is not impeded by the porous structure. In addition, the PNIPAM hydrogel is soft and biocompatible, so the sample can have better cell adhesion and proliferation than a bare NiTi alloy. Based on these results, it can be concluded that the porous NiTi sample loaded with the thermosensitive PNIPAM hydrogel has the antibacterial property before implantation and the dual function of inhibiting bacterial adhesion and promoting cell adhesion and proliferation after implantation, which shows promising applications in the biomedical field such as orthopedic implantation.
研究领域:
生物材料
·
生物医学工程
·
骨科
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）