PROGRESS IN ORGANIC COATINGS
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2025
·
IF 7.3
Chunquan Li,Yujiao Zhang,Zengjie Zuo,Liqiu He,Fang Yuan,Shuilin Zheng,Zhiming Sun
The migration of free antibacterial agents in the coating will lead to the rapid decline of the antibacterial effect. Consequently, achieving sustained antibacterial efficacy has become a critical focus currently. In this study, through liquid-phase ion exchange and dry modification, Cu 2+ and cetyltrimethylammonium chloride (CTAC) were successively loaded onto stellerite (STI) to synthesize Cu 2+ /STI and Cu 2+ /CTAC/STI composites, then Polyvinyl alcohol (PVA) was used as the matrix to construct Cu 2+ /CTAC/STI/PVA antimicrobial coatings. The results demonstrated that the modified material retained the crystal structure of stellerite while achieving superior antibacterial properties. The incorporation of stellerite not only enhanced the stability of the antibacterial agent but also facilitated its unique delivery function. Specifically, stellerite served as an effective reservoir for antibacterial components, enabling efficient sterilization through the synergistic release of CTAC and Cu 2+ coupled with bacterial adsorption. In addition, Cu 2+ /CTAC/STI/PVA coating exhibited excellent bacterial efficacy and long-lasting antimicrobial performance, indicating the promising application prospects of stellerite-based antibacterial composites in functional coating fields.
研究领域:
材料科学
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微生物学
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 39
·6311-6321
·
IF 4.776
Yuanxiu Hong,Yuejing Xi,Junxue Zhang,Dongdong Wang,Hailong Zhang,Ning Yan,Shisheng He,Jianzhong Du
We present an antibacterial polymersome–hydrogel composite that combines the advantages of both antimicrobial peptides and antibiotics. The polymersomes are self-assembled from poly(ε-caprolactone)-block-poly(lysine-stat-phenylalanine) [PCL-b-P(Lys-stat-Phe)], exhibiting long-acting intrinsic antibacterial capabilities against both Gram-positive and Gram-negative bacteria. In addition, penicillin is encapsulated into the polymersomes, showing quick and enhanced antibacterial activities. Furthermore, a dynamic hydrogel network is prepared based on the Schiff base linkages between the aldehyde groups of dibenzaldehyde-functionalized PEG (DF-PEG) and the amino groups of chitosan. During this process, the penicillin-loaded polymersomes are grafted into the hydrogel networks by Schiff base linkages to afford polymersome–hydrogel composites, which exhibit two-stage antibacterial behavior: (1) penicillin can be released from the hydrogel networks for quick antibacterial function; (2) the polymersomes and the remaining penicillin can be further released for long-term antibacterial effects. Overall, this polymersome–hydrogel composite represents a new type of injectable antibacterial biomaterial for quick and long-acting antibacterial applications.
研究领域:
生物材料
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微生物学
·
药剂学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Chen-Zheng Yan,Zhi-Yang Zhang,Chun-Yan Li,Song-Hai Wu,Yong Liu,Xu Han
Although the slippery liquid-infused porous surfaces (SLIPSs) exhibit highly antifouling performance against various working liquids, the loss of lubricant always deteriorates their long-term durability. Herein, a spongy composite of polyvinylidene difluoride (PVDF) and hydrangea-type perfluorooctyltrimethoxysilane (POTS)-modified mesoporous silica nanoparticles (MSNs) has been successfully prepared via the spraying method and used as the substrate for SLIPSs, which exhibits satisfactory storage and lock capacities for lubricant to enhance its durable antifouling performances. After infusing perfluoropolyether (PFPE) into the spongy substrate, a stable POTS-MSNs@PVDF@PFPE is prepared, which exhibits high amphiphobic performances (WSA of 1.68 ± 1.13° and OSA of 5.99 ± 1.34°) and high repellence to various working liquids, indicating its high antifouling performance. The long freezing time of 121.50 s and the low ice-adhesion strength of 25.67 kPa also indicate its high anti-icing performances. Furthermore, the high stability of POTS-MSNs@PVDF@PFPE after various thermal, chemical, and mechanical testing indicates its satisfactory durability. Actually, the abundant micropores of POTS-MSNs@PVDF provide adequate space for locking PFPE, thus prolonging its antifouling performances. This study provides an insight into the development of SLIPSs capable of maintaining long-term antifouling performance in harsh environments.
研究领域:
材料科学
·
表面工程
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产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
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2025
·
IF 6.3
Xiaoyu Chen,Jianwei Zhang,Hengtong Xia,Zhihao Chen,Xiaoshuang Yin,Ying Liu,Wenzhong Yang
Scale and biofouling are two critical problems in industrial circulating cooling water systems, urging the development of innovative solutions to address both issues simultaneously. The direct usage of liquid scale inhibitors and biocides often fails to provide long-term effective control and results in significant wastage of agents. In this work, the melamine formaldehyde resin/clove oil/1‑hydroxy ethylidene-1,1-diphosphonic acid (MCH) microcapsules were successfully synthesized by double emulsion water-in-oil-in-water (W/O/W) in-situ polymerization method. The 1‑hydroxy ethylidene-1, 1-diphosphonic acid (HEDP) acted as a scale inhibitor and clove oil as a natural biocide, which offered a comprehensive solution to both scaling and biofouling issues. The as-prepared MCH microcapsule exhibited a smooth multinuclear spherical structure, a uniform size. UV–vis results confirmed the successful encapsulation of HEDP and clove oil within the MF shell, with encapsulation amounts of approximately 7.47 % and 23.67 %, respectively. Remarkably, the release of the HEDP and clove oil could extend up to 60 h and 160 h, respectively, which was consistent with the First-order model, displaying an excellent sustained-release performance. Static scale inhibition experiments indicated that the microcapsules possess sustained scale inhibition ability. The scale inhibition efficiency of the dynamic release solution of MCH microcapsules remained above 90 % for the initial 14 h, with the highest scale inhibition rate exceeding 98 %. Furthermore, these microcapsules displayed remarkable antibacterial activity against Escherichia coli and Bacillus subtilis, with both antibacterial rates exceeding 99.9 %. Overall, the sustained release of the scale inhibitors and biocides ensures long-term control and reduction in agent wastage, which presents a promising application in addressing the scaling and biofouling issues in industrial circulating water systems.
研究领域:
材料科学
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环境工程
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工业水处理
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产品关联
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 13
·期 1
·86
·
IF 5.719
Lie Wu,Yihong Kang,Yuhao Deng,Fan Yang,Rui He,Xue-Feng Yu
The antifogging coating based on super-hydrophilic polymer is regarded as the most promising strategy to avoid fogging but suffers from short-term effectiveness due to antifogging failure induced by water invasion. In this study, a black phosphorus nanosheets (BPs) hybrid polymer hetero-network coating (PUA/PAHS/BPs HN) was prepared by UV curing for the first time to achieve long-term antifogging performance. The polymer hetero-network (HN) structure was composed of two novel cross-linked acrylic resin and polyurethane acrylate. Different from physical blending, a covalent P-C bond between BPs and polymer is generated by UV initiated free radical reaction, resulting in BPs firmly embedded in the polymer HN structure. The BPs enriched on the coating surface by UV regulating migration prevent permeation of water towards the inside of the coating through its own good water-based lubricity and water absorption capacity. Compared with the nonhybrid polymer HN, PUA/PAHS/BPs HN not only has higher hardness and better friction resistance properties, but also exhibits superior water resistance and longer antifogging duration. Since water invasion was greatly reduced by BPs, the PUA/PAHS/BPs HN coating maintained antifogging duration for 60 min under a 60 °C water vapor test and still maintained long-term antifogging performance after being immersed in water for 5 days.Keywords:black phosphorus;hybrid;polymer;hetero-network;coating;long-term antifogging
研究领域:
材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
CORROSION SCIENCE
·
2023
·
IF 8.3
Shupei Liu,Xinfang Zhang,Jinsong Rao,Liang Yu,Wei Lu,Huan Zhou,Shibo Chen,Yuxin Zhang,Xiaoying Liu
Ni-Co Layered Double Hydroxide (LDH) shows great application potential in the field of anti-corrosion. However, the poor carrying capacity limits the performance of anticorrosion performance. In this study, Ni-Co hydrotalcite was grown on the surface of DE, and Ni-Co/DE@SP microcapsule with corrosion inhibitor loading up to 14.7% was successfully prepared. The adsorption capacity of Ni-Co/DE@SP for Cl − in 600 mmol/L NaCl solution was 6.72 mmol/g. It is worth noting that the impedance modulus of the prepared composite coating (EP/Ni-Co/DE@SP) is two orders of magnitude higher than that of the pure resin coating, and the wear resistance was improved by 33%.
研究领域:
材料科学
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腐蚀与防护
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表面工程
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产品关联
DOI
高影响因子
Materials Express
·
2024
·Vol. 14
·期 3
·423-430
·
IF 0.7
He Ke,Pengjiazi Fu,Wu Yanqi,He Yanting,Hu Qing,Wu Jia,Cui Guangxun,Zhang Jun,Jin Jun
There are growing concerns and worries about the safety of public facilities and equipment. Therefore, coating products with antibacterial properties have become the key to solve this problem, and there is an urgent need to develop new antibacterial architectural coatings. In this study,
polystyrene nano-microspheres (PS NMS) were prepared from styrene as raw material. PS nano-microcapsules (PS NMC) were prepared by solute co-diffusion method (SCM) using PS NMS as a template, which were modified to obtain PS-OH NMC. CuS nanoparticles (CuS NPs) with antibacterial activity were
further loaded to prepare CuS@PS-OH NMC with long-term antibacterial activity. The SEM results showed that the particle size of CuS@PS-OH NMC was about 410 nm, which was larger than that of PS-OH NMC. The characterization of UV and IR spectra confirmed that CuS NPs were not only encapsulated
into PS NMC in large quantities, but also adhered to its surface in a small amount. CuS@PS-OH NMC has good water solubility and can slowly release Cu2+, showing good long-term antibacterial properties against Methicillin-resistant Staphylococcus aureus (MRSA). The CuS@PS-OH
NMC developed in this study has excellent performance, good antibacterial effect, environmental friendliness, low price, etc. More importantly, it can efficiently and long-term inhibit MRSA, and can be used as a potential antibacterial architectural coating for special scenarios such as hospitals,
schools and densely populated places, which has excellent social and economic value.
研究领域:
材料科学
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微生物学
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医学
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DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
·
IF 4.9
Xinru Zhu,Yulin Chen,Yumeng Li,Wenwen Cui,Xiaoying Wang,Lele Mao,Yue Li,Letian Zhang,Ying Chen,Mei Dong,Qingsong Wang
This study aimed to employ eutectic technology to formulate a stable, organic solvent-free and high-concentration capsaicin cream. Herein, menthol was selected to form a eutectic with capsaicin from ten compounds. The eutectic mixtures (EMs) were characterized by polarized optical microscopy (POM), differential scanning calorimetry (DSC), Fourier Transform Infrared (FT-IR) spectroscopy, and X-ray diffraction (XRD). The stability of the EMs in the cream was prolonged for over 8 months due to the interactions among capsaicin, menthol, Span 40, and polyvinyl alcohol (PVA). The rheological properties were further enhanced by incorporating white petrolatum and anhydrous calcium hydrogen phosphate into the eutectic cream, which indicated improved physical stability and spreadability. Moreover, the retention of capsaicin in porcine skin was comparable between the eutectic cream group (4% w/w capsaicin) and the Qutenza® group (8% w/w capsaicin). Once applied the capsaicin eutectic cream (4% w/w) to chronic constriction injury (CCI) model in mice, mechanical and thermal pain were alleviated in a manner similar to Qutenza®. Overall, the capsaicin eutectic cream was successfully prepared by combining eutectic, with a specific mixture of surfactant and PVA. Also, the cream showed excellent permeability and storage stability for topical application, which provided a promising potential for the development of long-acting analgesic drugs.
研究领域:
药剂学
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疼痛管理
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药物递送系统
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产品关联
DOI
高影响因子
Theranostics
·
2024
·
IF 12.4
Jing Liu,Weiwei Wu,Fei Peng,Deying Gong,Yi Kang,Yujun Zhang,Congyan Liu,Yuncheng Li,Guoyan Zhao,Feng Qiu,Wensheng Zhang
Rationale: To meet the need of long-acting analgesia in postoperative pain management, slow-releasing formulations of local anesthetics (LAs) have been extensively investigated. However, challenges still remain in obtaining such formulations in a facile and cost-effective way, and a mechanism for controlling the release rate to achieve an optimal duration is still missing. Methods: In this study, nanosheets formed by a self-assembling peptide were used to encapsulate ropivacaine in a soft-coating manner. By adjusting the ratio between the peptide and ropivacaine, ropivacaine particles with different size were prepared. Releasing profile of particles with different size were studied in vitro and in vivo . The influence of particle size and ropivacaine concentration on effective duration and toxicity were evaluated in rat models. Results: Our results showed that drug release rate became slower as the particle size increased, with particles of medium size (2.96 ± 0.04 μm) exhibiting a moderate release rate and generating an optimal anesthetic duration. Based on this size, formulations at different ropivacaine concentrations generated anesthetic effect with different durations in rat sciatic nerve block model, with the 6% formulation generated anesthetic duration of over 35 h. Long-acting analgesia up to 48 h of this formulation was also confirmed in a rat total knee arthroplasty model. Conclusion: This study provided a facile strategy to prepare LA particles of different size and revealed the relationship between particle size, release rate and anesthetic duration, which provided both technical and theoretical supports for developing long-acting LA formulations with promising clinical application.
研究领域:
药剂学
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生物医学工程
·
疼痛管理
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产品关联
DOI
PubMed
高影响因子
Current Drug Delivery
·
2021
·Vol. 18
·期 2
·224-233
·
IF 2.565
Xie Shuyu,Zhang Xiaoqiu,Luo Wanhe,Meng Kuiyu,Chen Dongmei,Pan Yuanhu,Tao Yanfei,Huang Lingli,Liu Zhenli,Wang Yulian,Yuan Zonghui
Objective: A ceftiofur hydrochloride long-acting oily suspension with no irritation was prepared by testing and optimizing the types and amounts of organic solvents, suspending agents, and surfactants. Methods: Its properties, stability, injection site irritation, in vitro
release, and pharmacokinetics in pigs were evaluated. The optimum formulation was used ethyl oleate, aluminum monosterate, and span-80 as organic solvents, suspending agents, and surfactant, respectively. The drug microparticles were uniform long strip with size of 1.53 ± 0.11 μm
and no agglomerations, and were evenly dispersed. The re-dispersed time, sedimentation rate and pH value of the suspension were 4 s under a magnetic shaker rotating at 20 r/min, 1 and 5.0, respectively. It could go through 7-gage needle smoothly with withdrawal volume of 9.9 mL/min. Results:
The suspension showed good stability when stored away from light, no irritation at the injection site and sustained release in PBS buffer. After intramuscular administration, the drug concentration above 0.15 μg/mL was last for 120 h. Its elimination half-life (T1/2ke), mean
residence time (MRT), and bioavailability were increased by 1.73, 1.62, and 2.16 times compared to Excenel®. Conclusion: The results suggested that the suspension had excellent sustained-release and will make ceftiofur hydrochloride more effective and convenient to use.
研究领域:
兽医学
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药物制剂
·
药理学
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DOI
PubMed
高影响因子
CROP PROTECTION
·
2021
·
IF 2.571
Feng Zheng,Tiantian Li,Hanhong Xu,Pengtong Hu,Ruifei Wang,Zhixiang Zhang,Jinliang Jia
Using plant essential oil instead of chemical pesticides to control melon fly ( Bactrocera cucurbitae (Coquillett)) is still a great challenge in agricultural practices, which must effectively slow down the volatility rate of plant essential oil. In this study, citral as a natural plant essential oil was blended with environmentally friendly castor oil based waterborne polyurethane (PU). The interaction, chemical resistance, adhesion property and sustained release behavior of the composites with different citral content were clarified, and the efficacies against the melon fly under field conditions were explored. The results indicated that the composites prepared exhibited excellent adhesion behavior on bitter gourds ( Momordica charantia L.) even under rainfall washing, meanwhile the chemical resistance of composites could be tailored via controlling citral content. Low citral content composite films could be washed off by alcohol without worrying about the safety of that on crops. The composite prepared exhibited long-lasting repellent behavior against melon fly. The composite can be prepared via a simple technology and low cost, which has great value for plant essential oil applied in agriculture and can provide a new approach for melon fly control.
研究领域:
农业科学
·
昆虫学
·
材料科学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2014
·
IF 2.045
Yongzhao Zhang,Xia Guo,Jianbing Ji
(2R,3S,4S,5S)-6-(Hydroxymethyl)-tetrahydro-2H-pyran-2,3,4,5-tetraol (d-glucose) solubility in 1-dodecanol, 1-decanol, and 1-octanol from 343.15 K to 393.15 K was determined, respectively. The solubility of d-glucose increased with an increase in temperature and decreased with the increase of fatty alcohol chain length. The modified UNIQUAC model, S-UNIFAC model, and mS-UNIFAC model were applied to predict the solubility data; the interaction parameters were determined. Of the three models, the modified UNIQUAC model showed better prediction accuracy.
研究领域:
化学工程
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）