Bioresources and Bioprocessing
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2021
·Vol. 8
·期 1
·1-16
·
IF 4.578
Ding Qiang,Liu Yadi,Hu Guipeng,Guo Liang,Gao Cong,Chen Xiulai,Chen Wei,Chen Jian,Liu Liming
Microbial organelles are a promising model to promote cellular functions for the production of high-value chemicals. However, the concentrations of enzymes and nanoparticles are limited by the contact surface in single Escherichia coli cells. Herein, the definition of contact surface is to improve the amylase and CdS nanoparticles concentration for enhancing the substrate starch and cofactor NADH utilization. In this study, two biofilm-based strategies were developed to improve the contact surface for the production of shikimate and L-malate. First, the contact surface of E. coli was improved by amylase self-assembly with a blue light-inducible biofilm-based SpyTag/SpyCatcher system. This system increased the glucose concentration by 20.7% and the starch-based shikimate titer to 50.96 g L−1, which showed the highest titer with starch as substrate. Then, the contact surface of E. coli was improved using a biofilm-based CdS-biohybrid system by light-driven system, which improved the NADH concentration by 83.3% and increased the NADH-dependent L-malate titer to 45.93 g L−1. Thus, the biofilm-based strategies can regulate cellular functions to increase the efficiency of microbial cell factories based on the optogenetics, light-driven, and metabolic engineering.
研究领域:
合成生物学
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微生物工程
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DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·Vol. 11
·期 12
·9868-9880
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IF 1.5
Hongying Li,Xueliang Wang,Tao Wang,Zhaoxia Wang,Wei Zhao
A modified electrode was fabricated by casting graphene oxide (GO) suspension onto the surface of active glassy carbon electrode (GCE), and it can significantly enhanced the oxidation peak currents of m-trihydroxybenzene (m-THB) and p-nitrophenol (p-NP). Based on this, a sensitive analytical method towards their simultaneous determination was established. Many influencing factors such as the type of electrolyte, acidity, scan rates and concentrations were explored. Under the optimal experimental conditions, the oxidation peak currents of m-THB and p-NP were linearly increased with their concentrations ranging from 9 to 100 μM, with the detection limits both of 1 μM. Comparing with other reported methods, this sensor showed wider linear range and lower detection limit. In addition, the proposed method was successfully used to analysis of real environmental water samples with satisfactory recoveries, which verified the practicability of the sensor.
研究领域:
分析化学
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环境科学
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电化学
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传感器技术
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污染物检测
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DOI
高影响因子
DESALINATION
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2025
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IF 9.8
Xuewu Zhu,Feiyue Ge,Xinwei Kang,Liping Qiu,Jinyu Li,Xiaozhen Lu,Bin Liu,Daoji Wu,Zhe Yang,Daliang Xu
Conventional polyamide nanofiltration (NF) membranes face limitations in water treatment due to perm-selectivity trade-offs and chlorine sensitivity. This study introduced a phloroglucinol (PG) post-treatment strategy to construct polyester-polyamide interpenetrating network (IPN) NF membranes capable of overcoming these limitations. The IPN membranes featured a unique Turing surface morphology and a compact crosslinked network, which increased the effective filtration area while forming a thinner yet denser selective layer. This structural design enhanced hydrophilicity and negative surface charge, resulting in improved water permeance (24.5 L·m −2 ·h −1 ·bar −1 ) and a high organic matter rejection of 90.7 %. Notably, the modified membranes demonstrated remarkable chlorine stability, maintaining over 93 % of their initial rejection efficiency even after extreme chlorine exposure (20,000 ppm·h). This advancement addresses the rapid degradation of traditional polyamide membranes in chlorinated environments. Such extraordinary stability arises not only to from the inherent chlorine resistance of the polyester network but also from the multi-layered protective architecture enabled by the unique IPN configuration. The proposed IPN strategy provides an effective pathway for developing next-generation potable water treatment membranes.
研究领域:
环境科学
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材料科学
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化学工程
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水处理技术
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DOI
高影响因子
Pharmaceutics
·
2022
·Vol. 14
·期 11
·2478
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IF 6.525
Yihua Jiang,Yinxiang Cheng,Mengyuan Xia,Bingrui Zhang,Qiaoce Ding,Liye Lu,Jian-Rong Wang,Xuefeng Mei
Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 µg/mL). Herein, we aimed to modulate its solubility through cocrystallization. Eight cocrystals of DHEA with pyrocatechol (CAT), hydroquinone (HQ), resorcinol (RES), phloroglucinol (PG), 1,5-dihydroxy naphthalene (DHN), p-hydroxybenzoic acid (PHBA), gallic acid (GA), and 5-hydroxyisophthalic acid (5HIPA) were designed and synthesized. Some basic characterization tools, including powder X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, and Fourier transform infrared spectroscopy, were also applied in our work for basic analyses of cocrystals. It is indicated that DHEA-GA exhibits its superiority in dissolution and pharmacokinetic behaviors. While the area under the curve values of DHEA-GA is improved at the ratio of 2.2, the corresponding bioavailability of DHEA is expected to be accordingly increased.Keywords:DHEA;cocrystallization;crystal structure;solubility;bioavailability
研究领域:
药学
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材料科学
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化学
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
·
IF 19
Wenhao Yu,Yaojie Liu,Mo Xian,Ximin Chen,Zongjiang Yu,Long Jiang,Chao Xu
Surface molecular-imprinting is an efficient and eco-friendly route to resource recovery. Yet most studies prioritize template–monomer affinity and seldom integrate radical-polymerization characteristics upfront, risking an affinity–performance gap. Using phloroglucinol (PG) as a model, a 3D “binding energy–SOMO/LUMO gap–steric hindrance” screening framework is established that identifies N-vinylimidazole (VIM) for matrix grafting and 2-(dimethylamino)ethyl methacrylate (DMAEMA) for imprinting. Surface radical polymerization on VIM-grafted chloromethylated polystyrene with DMAEMA (imprinting monomer) and PG (template) affords CMPS-VIM-MIP. The material exhibits an equilibrium adsorption capacity of 118.4 mg g −1 , 2.6 times that of the commercial resin NKA-II (45.5 mg g −1 ). In the fermentation system, the capacity decreases by 19.9% yet remains 4.0 times that of NKA-II. Mechanistic analysis reveals that imidazolium sites induce long-range electrostatic polarization, while multiple hydrogen bonds between the polymer's carbonyl/tertiary-amine groups and the hydroxyl groups of PG, act cooperatively to form high-affinity imprinting cavities. This multidimensional co-screening of functional monomers delivers concurrent gains in adsorption performance and offers a generalizable route for the green recovery of high-value phenolics.
研究领域:
环境化学
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高分子科学
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吸附技术
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绿色资源回收
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分子识别
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DOI
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2019
·
IF 0.931
Hui YU,Yan-Fei CHEN,Hui-Qin GUO,Wen-Tian MA,Jing LI,Shui-Gen ZHOU,Sen LIN,Liu-Shui YAN,Ke-Xin LI
Molecularly imprinted carbon microspheres (MIC) were synthesized by one-pot hydrothermal method with perfluorooctane sulfonate (PFOS) as template, Camellia oleifera seed shell as carbon precursor and phloroglucinol as additive. The as-prepared PFOS-MIC was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), specific surface area and pore size distribution analyzer (BET), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetry/differential thermal analyzer (TG/DTA). The results of SEM, HRTEM and FT-IR showed that the PFOS-MIC had a particle size of about 1.5 μm, the activated binding sites were formed by a large number of interconnected hydrogen bonds. The adsorption properties of PFOS on PFOS-MIC and the corresponding non-imprinted carbon microspheres (NIC) such as adsorption kinetics, pH effect and adsorption isotherms were investigated. The results showed that the adsorption kinetics of PFOS on both NIC and PFOS-MIC fitted well with the secondary-kinetic model ( R 2 > 0.994). Under the experimental conditions of 20 °C and pH = 3, the adsorption equilibrium time was 1.5 and 3.0 h, respectively. The lower pH was in favor of the adsorption. The adsorption isotherms data fitted better to the Langmuir model ( R 2 > 0.993) than that of Freundlich model, and the maximum adsorption capacity at 20 °C was 2.93 and 5.38 mg g −1 for NIC and PFOS-MIC, respectively. Adsorption selectivity results indicated that the PFOS-MIC had good adsorption selectivity for PFOS, even in coexistence with the structural similar surfactants.
研究领域:
材料科学
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环境科学
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化学工程
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分析化学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Shengjun Du,Minglong Guo,Guangxing Yang,Qiao Zhang,Zhiting Liu,Feng Peng
The highly-efficient separation of CH 4 /N 2 mixture on carbon materials is significantly hindered by the inherent trade-off that exists between CH 4 adsorption capacity and CH 4 /N 2 separation selectivity. Herein, we have constructed a type of novel carbon materials (PGC- x ) with well-controlled ultramicropores ranging from 0.48 to 0.57 nm for CH 4 /N 2 separation. The Zn-based salt template was in-situ confined into the polymer framework during the co-assembly of phloroglucinol and glyoxylic acid. The subsequent evaporation of Zn at high temperature gives rise to the adjustable ultramicropore structure, effectively devoid of mesopores and macropores. Benefiting from the optimal pore size of 0.50 nm, PGC-1 demonstrated high CH 4 uptake of up to 1.50 mmol/g. Meanwhile, the CH 4 /N 2 (15/85 and 85/15, v/v) separation selectivity of PGC-1 at 298 K and 1.0 bar reached 5.8 and 6.0, respectively. Dynamic breakthrough experiments proved that PGC-1 could be used as efficient adsorbent for capturing low or high concentration of CH 4 from N 2 . This work offers a promising design principle for optimizing porous structure of carbon materials, with the aim of minimizing the selectivity-capacity trade-off that often arises in the separation of diverse gas pairs.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
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IF 3.8
Yali Yang,Jia Chen,Xiaojing Liang,Bei Liu,Kaijun Quan,Xiuhui Liu,Hongdeng Qiu
In this paper, three imidazole- and C18- bifunctional silica stationary phases (Sil-Im-C18) were prepared by adjusting introduction interval of octadecyltrichlorosilane (ODS) and 3-imidazol-1-ylpropyl(trimethoxy)silane (TMPImS), which can be used for reversed-phase liquid chromatography (RPLC) and ion exchange chromatography (IEC) with adjustable performance. The successful preparation of Sil-Im-C18 were confirmed by the characterizations of elemental analysis, infrared spectroscopy (FTIR) and contact angle (CA). Chromatographic performance of Sil-Im-C18 were evaluated by the separation of Tanaka test mixture, alkylbenzenes, linear PAHs and a set of analytes with different properties (uracil, phenol, 1,2-dinitrobenzene and naphthalene), and compared with commonly used C18 column. It was found that the chromatographic performance of Sil-Im-C18 changed significantly with the difference in bonding amount of imidazole and C18. Sil-Im-C18 demonstrated the excellent separation performance towards polycyclic aromatic hydrocarbons (PAHs), phenylesters, phenylamines , phenols and inorganic anions, and notably, nucleobases and nucleosides can be separated using pure water as mobile phases . The van Deemter plot showed that the column efficiency of Sil-Im-C18-3 was 64,933 plate· m − 1 for naphthalene, indicated that Sil-Im-C18 was reasonably chromatographic columns. The RSD values of retention time were 0.22 %-0.61 % for 10 needles alkylbenzenes injected continuously at 50 °C to investigate thermal stability and repeatability, all the fluctuations of k of naphthalene were less than 2.3 % for Sil-Im-C18-1 during flushing 24 h with the mobile phase at different pH values (pH = 3 and 8), the retention time of alkylbenzenes were almost same for Sil-Im-C18-1 at different time, the RSD values of retention time of alkylbenzenes were 0.45 %-2.28 % for two batches Sil-Im-C18-1, revealing the excellent repeatability, thermal stability, durability and reproducibility of Sil-Im-C18, and implying a commercial prospect.
研究领域:
分析化学
·
色谱技术
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Ling Li,Jing Ma,Yuan Cui,Chong Liu,Hao Li,Dayang Xie,Tinghong Wang,Yanwei Li,Yanhui Li
Antibiotic resistance induced by antibiotic abuse is considered as one of the most serious public health problems. Antibacterial photodynamic therapy (APDT) using an efficient photosensitizer has been gaining increasing attention in recent years owing to its high efficacy and lack of drug resistance. Herein, we reported a photosensitizer system composed of tetra-aminophenyl porphyrin (TAPP) loaded in a guanidinium-based ionic covalent framework (COFTGTp) via π–π interactions to form TAPP/COFTGTp. The aim was to use it for APDT, which will not only solve the problems with TAPP as a photosensitizer, wherein it easily aggregates in aqueous solution and is ineffective against Gram-negative bacteria, but can combine the antibacterial activity of the cationic COFTGTp with the APDT induced by TAPP to achieve optimal antibacterial effects on both Gram-positive and Gram-negative bacteria. After TAPP loading in COFTGTp, the stability of TAPP/COFTGTp in aqueous solution was enhanced compared with TAPP, and the drug-loading efficiency could reach 27%. Under white-light irradiation, TAPP/COFTGTp can be activated to catalyze oxygen conversion into reactive oxygen species (ROS) including singlet oxygen (1O2); this will annihilate bacteria via the full use of the positive charge of cationic COFTGTp, which closes the distance between the bacteria and ROS. In addition, MTT and hemolysis experiments showed that TAPP/COFTGTp was almost noncytotoxic and did not cause hemolysis. Most remarkably, the minimum inhibitory concentrations (MICs) of TAPP/COFTGTp for E. coli and S. aureus were 100 μg mL−1 and 50 μg mL−1, respectively. As a result, TAPP/COFTGTp is expected to be an antibacterial material and have promise for substituting traditional antibiotics to solve antibiotic resistance and the emergence of superbacteria.
研究领域:
材料科学
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微生物学
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药理学
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DOI
高影响因子
Catalysts
·
2024
·Vol. 14
·期 10
·707
·
IF 3.8
Zengjing Guo,Shuguang Ning,Shicheng Xu,Yongying Zhang,Yifan Dong,Hongjing Han
Ambient condition-determined chemical CO2fixation affords great promise for remitting the pressure of CO2release. The construction of a microporous environment easily captures CO2molecules around the reactive sites of the catalyst to reinforce the reaction process. Herein, multi-hydroxyl-containing hyper-crosslinked organic polymers (HCPs-OH-n) are synthesized by the polymerization of 1,4-dichlorobenzyl (DCX) andm-trihydroxybenzene in the monosaccharide form in a Friedel–Crafts alkylation hypercrosslinking process (FCAHP). By tuning the DCX ratio in the FCAHP, the structural properties can be regulated to create a more microporous surface in the HCPs-OH-n; meanwhile, the formed multi-hydroxyl species in the microporous environment could induce the easy interaction between hydroxyls and epoxides by forming a hydrogen bond, which improves the activation of epoxides during the cycloaddition reaction to synthesize the cyclic carbonates at ambient conditions. The structural properties suggest that HCPs-OH-npossess a large surface area with appreciable microporous and mesoporous distribution. As expected, the HCPs-OH-3 bearing the most abundant mesoporosity affords the highest reactivity in the chemical CO2fixation to cyclic carbonates and is endowed with rational recoverability.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Hui Wang,Xuefeng Zhang,Xiangfeng Wu,Yewei Kang,Yirui Huang,Zhaoye Zhao,Ziyan Li,Tingting Zhou,Junchuan Wang,Wei Zhu,Chengsi Pan
Bimetallic iron-based metal organic frameworks (MFe-MOFs) exhibit promising photocatalytic properties but face challenges typical of pristine MOFs, including low photoresponsive activity, inadequate band gap regulation, and weak photoconductivity. Here, we designed porphyrin-based COFs (TpPAM-COFs) to serve as a shell grown on NH2-Fe-MIL-101 nanoparticles (NPs) using an in situ solvothermal approach. Subsequently, a ligand-anchoring full-range metallization process was applied to introduce hetero metal ions throughout the core–shell composites, establishing a type-II scheme heterojunction (Fe/Cu-M@PC-Cu) via covalent bonding between NH2-Fe/Cu-MIL-101 and Cu-TpPAM-COFs. The Cu-TpPAM-COF shell, with broad light absorption range, enhanced the generation of photogenerated electrons, facilitating the reduction of Cu2+ and Fe3+ within the Fe/Cu-M@PC-Cu heterojunction and promoting the regeneration of Cu+ and Fe2+ Fenton active sites. Moreover, rapid electron transfer between Fe3+ and Cu+ centers amplified the Fe3+/Fe2+ redox cycle, accelerating the catalytic decomposition of H2O2 and increasing ·OH radical production. Additionally, the optimized bandgap structure of Cu-TpPAM-COFs enhanced the oxidation capacity, as evidenced by the Fe/Cu-M@PC-Cu composite achieving exceptional photo-Fenton catalytic efficiency with 92.7% tetracycline hydrochloride (TCH) degradation in 35 minutes, surpassing that of most reported similar catalysts. Furthermore, the composite showed excellent stability, with only an 11.9% loss in photo-Fenton degradation efficiency after 8 cycles, highlighting its great potential for addressing challenging environmental pollutants.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xiaoxia Zhang,Jinchang Liu,Han Zhang,Qinming Zhang,Jiwei Shen,Yinmao Wei,Chaozhan Wang
In this study, guanidine-linked covalent organic framework (TPDG Cl ) was synthesized via a solvothermal method. The presence of guanidine groups in its structure facilitates electrostatic interactions and provides hydrogen bonding sites, enabling the selective enrichment of perfluoroalkyl carboxylic acids (PFCAs) from environmental water samples. The material exhibits rapid kinetic mass transfer, which facilitates the efficient removal of samples containing PFCAs from aqueous solutions within 5 min. Furthermore, TPDG Cl exhibits several advantageous properties, including high selectivity for PFCAs, a high adsorption capacity (2005 mg/g), excellent chemical stability, and remarkable recyclability (five cycles). Additionally, density functional theory (DFT) studies have demonstrated that the adsorption of PFCAs on TPDG Cl is enhanced by ion exchange, hydrophobic interactions, hydrogen bonding interactions and ordered channel structures. Finally, TPDG Cl was used as an adsorbent for dispersive solid-phase extraction (d-SPE), in combination with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), to develop an analytical method for the efficient extraction and sensitive detection of PFCAs. The developed method exhibits highly sensitivity, with detection and quantification limits of 0.64–0.85 ng/L and 2.6–3.4 ng/L, respectively. The recoveries of actual water samples ranged from 75.4% to 113.7%. Moreover, TPDG Cl effectively reduces the levels of PFCAs in real water samples to less than 70 ng/L within only 1 h. These results indicate that TPDG Cl is an effective adsorbent for removing PFCAs from environmental water samples.
研究领域:
环境科学
·
材料科学
·
分析化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）