ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Zhipeng Chen,Rui Ye,Jingbo Yang,Yinyan Lin,Weihsian Lee,Jingwei Li,Lei Ren,Bin Liu,Lelun Jiang
Microneedle arrays (MAs) are among the most promising transdermal drug delivery systems in the last decades due to its minimally invasive nature, convenient operation, and first-pass-metabolism avoidance. However, most MA fabrication methods are difficult to operate, need multiple steps, or require expensive equipment. A novel magnetorheological drawing lithography approach was proposed to rapidly fabricate a flexible microneedle array (FMA) for transdermal drug delivery. A 3D structural liquid MA was drawn in one step from the droplets of curable magnetorheological fluid and maintained its shape under an external magnetic field. The liquid MA was subsequently solidified and sputter-coated with the Ti/Au film to fabricate FMA. FMA morphology, mechanical properties, and transdermal drug delivery performance in vitro were experimentally investigated. FMA consisted of a 5 × 5 cone-shaped microneedle array on a PET flexible substrate. FMA exhibited good strength and excellent penetration performance. It could easily penetrate into skin without breakage, creating microchannels for the promotion of skin permeability. Drugs could be well permeated and diffused in the skin along the microchannels created by FMA. Finally, a dissolvable microneedle array (DMA) was also fabricated by a micromolding technique using FMA as a master template. The DMA exhibited good dissolvable and permeable performance in the agarose block.
研究领域:
生物医学工程
·
药物传递系统
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Jingjing Wang,Guotao Duan,Yue Li,Guangqiang Liu,Weiping Cai
A simple and facile strategy is presented to fabricate the metal nanodisk and nanohole arrays based on a wet etching-assisted polystyrene colloidal lithography. Gold is chosen to demonstrate the validity of such a strategy. The hexagonally arranged Au nanodisk and nanohole arrays are thus fabricated with large area and good uniformity. The structural parameters of the arrays, such as thicknesses, diameters, and spacings of the nanodisks or nanoholes, are facilely tunable and controllable by predeposition conditions, etching conditions and colloidal monolayer structure. More importantly, these arrays can be produced on any supporting substrates, such as conductive or nonconductive and even flexible substrates with flat, rough, or even curved surfaces. In general, the presented strategy is low in cost, simple in operation and arbitrary in substrate, and the as-prepared arrays could find potential devices’ applications with nice compatibility in the fields of optics, surface-enhanced Raman spectroscopy, biosensing, and so forth.
研究领域:
纳米技术
·
材料科学
·
光学
·
生物传感
✓ 已验证
DOI
高影响因子
Small
·
2023
·Vol. 19
·期 45
·2302998
·
IF 13.3
Haoqiang Feng,Shitao Shen,Mingliang Jin,Qilin Zhang,Mengjun Liu,Zihao Wu,Jiamei Chen,Zichuan Yi,Guofu Zhou,Lingling Shui
Droplet array is widely applied in single cell analysis, drug screening, protein crystallization, etc. This work proposes and validates a method for rapid formation of uniform droplet array based on microwell confined droplets electro-coalescence of screen-printed emulsion droplets, namely electro-coalescence droplet array (ECDA). The electro-coalescence of droplets is according to the polarization induced electrostatic and dielectrophoretic forces, and the dielectrowetting effect. The photolithographically fabricated microwells are highly regular and reproducible, ensuring identical volume and physical confinement to achieve uniform droplet array, and meanwhile the microwell isolation protects the paired water droplets from further fusion and broadens its feasibility to different fluidic systems. Under optimized conditions, a droplet array with an average diameter of 85 µm and a throughput of 10 6 in a 10 cm × 10 cm chip can be achieved within 5 s at 120 Vpp and 50 kHz. This ECDA chip is validated for various microwell geometries and functional materials. The optimized ECDA are successfully applied for digital viable bacteria counting, showing comparable results to the plate culture counting. Such an ECDA chip, as a digitizable and high-throughput platform, presents excellent potential for high-throughput screening, analysis, absolute quantification, etc.
研究领域:
生物技术
·
微流控技术
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 16
·3962-3972
·
IF 5.256
Shunsheng Ye,Hongyu Wang,Hongyang Su,Lingxia Chang,Shuli Wang,Xuemin Zhang,Junhu Zhang,Bai Yang
A facile strategy is reported for the electrostatic self-assembly of homogeneous and gradient plasmonic nanoparticle arrays with tunable interparticle distances and optical properties. The interparticle distance is dominated by the surface charge density of the substrate, which is tuned via thermal annealing according to the temperature-dependent molecular mobility of the polymer. Oxygen plasma is employed to endow neutral polystyrene (PS) films with sufficient charges, enabling subsequent electrostatic adsorption. The density of surface charges can be readily tuned via a thermal annealing step after plasma treatment, which is confirmed by quantitative analyses of oxygen and nitrogen using X-ray photoelectron spectroscopy. Afterwards, PS films with regulated charge densities reshape the double layers around nanoparticles to various degrees during the assembly, leading to tunable interparticle separations. UV-Vis spectroscopy reveals tunable plasmonic properties owing to the critical role of interparticle separation in plasmon coupling. Here such structures are demonstrated to act as wavelength-selective substrates for multiplexed acquisition of surface enhanced Raman scattering. Alternatively, by applying a temperature gradient in the annealing step, we create a macroscopic surface with a continuous gradient in plasmonic properties. Such a “plasmonic library” can be a promising material for fast screening of interparticle distance or extinction spectrum in specific applications on one single substrate.
研究领域:
纳米材料
·
光学
·
表面化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Donghua Jia,Feng Zheng,Yaxuan Li,Yingying Niu,Yue Yang,Xiaodong Mao,Qiang Zhen,Peng Li,Yi Yu
In this work, two-dimensional V 2 O 5 nanosheet arrays/one-dimensional Co 3 O 4 nanoneedle arrays (2D VNSAs/1D CNNAs) composite is successfully prepared on nickel foam substrate. A variety of structural characterization techniques (SEM, XRD, EDS, TEM, and XPS) show that the as-prepared composite is V 2 O 5 monocrystal with a layered structure grafting by Co 3 O 4 polycrystal with a 1D needle-like structure. The VNSAs/CNNAs composite is used as supercapacitor electrode material. In a three-electrodes system, it shows high specific capacitance (C s ) values (1023 F g −1 @5 mV s −1 from CV curve and 826 F g −1 @0.5 A/g from GCD curve), a high coulombic efficiency (98.6 %@10 A/g), a good cyclic stability (92.7 % after 6000 cycles), a low charge transfer resistance (2.7 Ω), and a fast ionic diffusion rate (2.01 × 10 −8 cm 2 s −1 ). In a two-electrodes system, the assembled VNSAs/CNNAs//VNSAs/CNNAs symmetric supercapacitor has C s values of 445 F g −1 @5 mV s −1 and 363 F g −1 @0.5 A/g. Its cycle stability and rate capability could reach up to 92.3 % and 90.7 % after 6000 cycels, respectively. It also shows a high energy density (E d ) of 127.3 Wh kg −1 @400 W kg −1 and can retain 72.2 Wh kg −1 @8000 W kg −1 . The excellent electrochemical properties indicate that VNSAs/CNNAs composite can greatly increase the E d of supercapacitors.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Hanqin Gong,Feng Zheng,Jiahe Xu,Chencen Sun,Liangchao Gao,Pengfei Hu,Yang Li,Yu Gong,Qiang Zhen,Sajid Bashir
We first report a composite of molybdenum disulfide (MoS 2 ) nanoflake arrays (MNFs) and tungsten trioxide (WO 3 ) nanorod arrays (WNRs) directly grown on a copper (Cu) substrate. This composite is characterized in detail by scanning and transmission electron microscopes (SEM/TEM), X-ray diffraction (XRD), Raman and X-ray photoelectron spectroscopy (XPS). All of the evidences indicate that the obtained composite is a heterojunction. The supercapacitive properties of MNFs-WNRs composite heterojunction are measured systematically by using cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) and electrochemical impedance spectroscopy (EIS) techniques. The heterojunction exhibits a high specific capacitance of 522 F g −1 at 0.5 A g −1 , a high capacitance retention (95%) after 5000 cycles and a low charge transfer resistance (1.0 Ω). And this kind of heterojunction has advantages of both MoS 2 and WO 3 , which can be a better candidate for supercapacitive electrode material .
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2014
·
IF 4.086
Yuxiu Li,Xiangheng Niu,Jie Tang,Minbo Lan,Hongli Zhao
Facilitating the glucose electro-oxidation reaction is always of great scientific sense due to its wide applications in sensing, catalysis and biofuel cells. On the road to improving the electrocatalysis of glucose, one-dimensional materials mainly including nanowires and nanotubes are commonly proposed because of their fascinating characters, and both of them are reported capable of offering better catalytic performance compared to commercial Pt/C and Pt black catalysts. However, so far it still confuses us that which structure can provide more favorable properties towards the direct electro-oxidation of glucose. Here we carry out a systematically comparative study of nonenzymatic electrochemical sensors based on vertical nanowire and nanotube arrays for glucose detection. By using bimetallic Pt-Pd as a general model, we demonstrate that nanotube arrays, owing to their larger catalytic area and higher catalyst utilization, show higher activity for glucose electro-oxidation and enzyme-free analysis than nanowire arrays. These findings may be helpful for the future design of more efficient catalyst structures for glucose oxidation and other reactions.
研究领域:
分析化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Jiajia Tao,Zezhou Gong,Guang Yao,Yunlang Cheng,Miao Zhang,Jianguo Lv,Shiwei Shi,Gang He,Xiaoshuang Chen,Zhaoqi Sun
TiO 2 nanorod arrays (NRAs) were hydrothermally grown on transparent fluorine-doped tin oxide (FTO) substrates, and were converted into nanotubes (NTAs) by hydrothermally in situ etching. Ag nanoparticles (NPLs) were sensitized on the NRAs and NTAs by a simple photodeposition approach (products were denoted as Ag-TiO 2 NRAs and NTAs). The Ag-TiO 2 NTAs samples possessed a large specific surface area (116 m 2 g -1 ) with Ag NPLs homogeneously dispersed among the TiO 2 NTAs. The Ag-TiO 2 NTAs exhibited significantly enhanced photocatalytic activities (98.8%) in degradation of methyl orange (MO) compared to Ag-TiO 2 NRAs (92.6%), TiO 2 NTAs (86.2%), and NRAs (81.7%). The enhanced photocatalytic activities can be attributed to the large specific surface area of TiO 2 NTAs and strong surface plasmon resonance (SPR) of Ag NPLs. In addition, Ag-TiO 2 NTAs showed easy recovery feature in the recovery process and high durability in the recycling test, which was expected to be an efficient and practical photocatalyst used for waste water treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Pan Yalong,Han Lijun,Shen Junxue,Li Jing,Sun Taolei,Yu Yao
Pesticide contamination is a global challenge, threatening agricultural production and environmental safety. To address the urgent need for efficient and reliable pesticide detection methods, we developed a novel multi-channel colorimetric sensor array based on HAuCl 4 -mediated oxidation reactions. This innovative system incorporates six distinct colorimetric channels coupled with advanced multivariate statistical analysis, enabling simultaneous detection and discrimination of multiple pesticide residues. Through systematic optimization of key reaction parameters, the developed sensor improved selectivity and classification accuracy, particularly for structurally similar pesticides. The platform successfully identifies 11 different classes of pesticides and distinguishes five specific pesticides across various concentration levels. This approach overcomes the limitations of traditional single-target detection methods by employing multi-parameter analysis for accurate pesticide identification. Notably, the proposed method offers several practical advantages, including simple operation, rapid detection (within 30 min), high sensitivity (detection limits of 6 μg/mL), and cost-effectiveness by eliminating the need for expensive instrumentation. These features make the developed sensor array particularly suitable for on-site pesticide screening and food safety monitoring applications. Graphical
研究领域:
分析化学
·
环境科学
·
食品安全
·
传感器技术
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Horizons
·
2024
·
IF 12.2
Fengming Hu,Qian Zhou,Ruolin Liu,Yanfei Zhu,Yuanzhe Liang,Dan Fang,Bing Ji,Zhiming Chen,Jianyi Luo,Bingpu Zhou
Electronic skin (E-skin) has attracted considerable attention for simulating the human sensory system for use in prosthetics, human–machine interactions, and healthcare monitoring. However, it is still challenging to fully mimic the skin function that can de-couple stimuli such as normal/tangential forces, contact/non-contact behaviors, and react to high-frequency inputs. Herein, we propose fully bionic E-skin (FBE-skin), which consists of a magnetized micro-cilia array (MMCA), a micro-dome array (MDA), and flexible electrodes to completely duplicate the hairy layer, epidermis/dermis interface, and subcutaneous mechanoreceptors of human skin. The optimized MDA and interdigital electrode enable the FBE-skin to perceive static forces with a linear sensitivity of 96.6 kPa−1 up to 100 kPa, while the branch of electromagnetic induction allows the FBE-skin to sensitively capture dynamic stimuli with vibrating signals up to 100 Hz. The top-down integration of MDA and MMCA not only replicates the three-dimensional structure of human skin, but also synergistically provides the FBE-skin with bionic rapidly adapting (RA) and slowly adapting (SA) receptors. Consequently, the FBE-skin is capable of perceiving dynamic/static, normal/tangential, and contact/non-contact stimuli with a broad range of working pressures and frequencies. We expect that the design of FBE-skin will be promising for widespread applications from intelligent sensing to human–machine interactions.
研究领域:
生物医学工程
·
材料科学
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2025
·
IF 3.5
Haikuan Chen,Xiaoyan Sun,Zhouwei He,Dejian Kong,Qinglong Zhang,Youwang Hu,Ji'an Duan
This article presents a method for fabricating fused silica quasi-periodic microlens array (MLA) by gel casting and template transfer. While keeping slurry viscosity consistent, by precisely controlling polyvinyl alcohol (PVA) content to adjust solid content, which can alter sintering shrinkage and regulates microlens focal length. This study determined an appropriate viscosity threshold of 300 mPa·s. The green body can be transformed into a fused silica MLA by sintering in a vacuum atmosphere at 1300 °C for 30 min. Additionally, this study established a quantitative relationship between the PVA content and the characteristic dimensions of the microlens. After measuring the prepared multifocal microlens array (MF-MLA), it was found that by adjusting the PVA content, the focal length can vary in the range of −320.03 μm to −37.14 μm and −110.56 μm to −25.29 μm. This approach provides an efficient, adaptable, and environmentally friendly way for the production of fused silica micro-optical components.
研究领域:
光学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 20
·6787-6794
·
IF 6.843
Cong Wang,Yunfan Xue,Junjie Huang,Kefeng Ren,A. Greiner,S. Agarwal,Jian Ji
Coating modification such as drug-eluting coating is one of the most important approaches for the functionalization of biomedical devices. However, the throughputs are limited in conventional coating methods and the concept of miniaturization is rarely fulfilled. A droplet microarray (DMA), as a unique high-throughput platform, can avoid cross-contamination and reduce the consumption of materials which is inherently suitable for coating research yet is difficult to apply with coating materials via traditional methods. Here, we bring up a facile method based on ultrasonic spray deposition to integrate coating materials into a DMA. Several common polymer materials were selected to fabricate a DMA, and the obtained DMA showed the ability to anchor water droplets and form specific patterns. Coating arrays with a typical sandwich structure were also prepared for the high-throughput screening of drug-eluting coatings to demonstrate the potential of the platform in coating research. This developed method is efficient and compatible and enriches the choices of materials that can be applied in DMAs.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）