APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
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IF 24.319
Yujie Cao,Tianran Sheng,Jinfei Mei,Peng Qian,Deqian Huang,Liangquan Sheng,Guoping Sheng
Herein, peroxymonosulfate (PMS)-like Fenton oxidation catalyst (DR-Vo-Co 3 O 4 ) with rich oxygen vacancies and carved flower-like structures were constructed using Co 3 O 4 as precursor via deep reduction strategy. DR-Vo-Co 3 O 4 could activate PMS to achieve almost 100% degradation of sulfadiazine (SD) within 1 min with ultra-high efficiency, possessing a degradation rate constant ( k ) value as high as 5.9 ± 0.2 min −1 , which was 86 and 5 times higher than the unreduced and reported maximum, respectively. Furthermore, the catalytic system showed unparalleled reactivity towards 14 different types of contaminants, with the maximum k value even exceeding 20 min −1 . The carved flower-like structure of DR-Vo-Co 3 O 4 catalysts not only facilitated PMS adsorption, but also provided more reaction sites for PMS activation. Meanwhile, rich oxygen vacancies could effectively tune the DR-Vo-Co 3 O 4 surface electronic state to further accelerate charge transfer, significantly enhancing PMS oxidation efficiency. Catalytic mechanism analysis revealed that 1 O 2 and O 2 •− played a dominant role in contaminant degradation.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2016
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IF 5.31
Pengchao Xie,Yizhou Guo,Yiqun Chen,Zongping Wang,Ran Shang,Songlin Wang,Jiaqi Ding,Ying Wan,Wei Jiang,Jun Ma
A novel advanced oxidation process, combined zero-valent iron and sulfite (Fe 0 /sulfite) system containing oxygen, was firstly developed to efficiently degrade organic pollutants at weak acidic and neutral conditions by selecting X-3B as a target compound. The removal of X-3B was attributed to the formed reactive radicals, such as SO 4 - , SO 5 - and HO , in the Fe 0 /sulfite system, and SO 4 - was evidenced as the principal reactive species. The quite low removal efficiency of X-3B (less than 5%) after reaction for 90 min with purging nitrogen gas suggests oxygen to be an essential factor for producing SO 4 - in the system. Optimal dosages of Fe 0 and sulfite were suggested to be 0.5 mM and 1.0 mM, respectively, in the system as both the two chemicals would scavenge the reactive radicals at overdosing. The presence of 2 mM bicarbonate significantly inhibited the removal of X-3B from 74.1% to 37.5% in the system. Halide ions inhibited the removal of X-3B following a trend that Cl − < Br − < I − . HSO 3 − , being effective in complexion of Fe(II) and transferring Fe(III) to Fe(II), is the main species during pHs 4–6, which results in the good reuse of Fe 0 and the highest removal efficiency of X-3B at weak acidic condition. Fe 0 /sulfite system was also evidenced to be effective in the treatment of actual textile effluents along with improving biodegradability, and the removal of nitrobenzene, methylparaben, bisphenol A, imipramine and amitriptyline. Overall, this study provided a cheap and easy operational advanced oxidation process in treatment of aqueous organic pollutants.
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高影响因子
RSC Advances
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2017
·Vol. 7
·期 83
·52661-52671
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IF 3.108
Zhihong Yao,Shishi Li,Zifei Qin,Xiaodan Hong,Yi Dai,Baojian Wu,Wencai Ye,Frank J. Gonzalez,Xinsheng Yao
Norbakuchinic acid (NBKA) is the most abundant metabolite of bakuchiol (a hepatotoxicity and nephrotoxicity component in Psoralea corylifolia L.) in plasma and urine. The present study aimed to identify human UDP-glucuronosyltransferase (UGT) isoforms involved in NBKA glucuronidation, and to assess the inhibition potential of NBKA against recombinant UGTs. NBKA glucuronidation was determined using human liver microsomes (HLM) and human intestine microsomes (HIM) as well as expressed UGTs. The mechanisms of NBKA-UGT interactions were explored through kinetic characterization and modeling. As a result, two glucuronides (G1 and G2) were detected by HLM and HIM. G2 was dominantly produced with CLint values of 3.21 and 0.96 μL min−1 mg−1 in HLM and HIM, respectively. Furthermore, based on the relative activity factor (RAF) approach, UGT1A9 and 2B7 represented 5.98 and 46.16% of G2 in HLM, respectively. In addition, G2 was both significantly correlated with propofol-glucuronidation (r = 0.681, p = 0.015) and AZT-glucuronidation (r = 0.832, p = 0.0008). Also, NBKA glucuronidation showed marked species differences. Moreover, NBKA displayed broad-spectrum inhibition against human UGTs. Kinetic analyses showed that inhibition of these UGTs followed competitive (UGT1A1), mixed (UGT1A3, 1A6, 1A10, 2B7, 2B15 and 2B17) and non-competitive (UGT1A4, 1A7, 1A8 and 1A9) mechanisms, with Ki values ranging from 2.48 to 20.31 μM. Among them, NBKA exhibited moderate inhibitory effects against UGT1A1, 1A3, 1A4, 1A7, 1A8, 2B15 and 2B17 (both IC50 and Ki values lower than 8 μM). In contrast, the effect of NBKA was activating for UGT2B10. Taken altogether, these findings together demonstrate that NBKA has a potent and broad-spectrum inhibitory effect against most human UGTs and thus suggest that much caution should be exercised when high-dose BK is co-administered with UGT substrates.
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高影响因子
CHEMICAL RESEARCH IN TOXICOLOGY
·
2024
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IF 3.7
Ximei Li,Lihua Xin,Lan Yang,Yi Yang,Wei Li,Mingyu Zhang,Yufen Liao,Chen Sun,Weiwei Li,Ying Peng,Jiang Zheng
Amitriptyline (ATL), a tricyclic antidepressant, has been reported to cause various adverse effects, particularly hepatotoxicity. The mechanisms of ATL-induced hepatotoxicity remain unknown. The study was performed to identify the olefin epoxidation metabolite of ATL and determine the possible toxicity mechanism. Two glutathione (GSH) conjugates (M1 and M2) and two N-acetylcysteine (NAC) conjugates (M3 and M4) were detected in rat liver microsomal incubations supplemented with GSH and NAC, respectively. Moreover, M1/M2 and M3/M4 were respectively found in ATL-treated rat primary hepatocytes and in bile and urine of rats given ATL. Recombinant P450 enzyme incubations demonstrated that CYP3A4 was the primary enzyme involved in the olefin epoxidation of ATL. Treatment of hepatocytes with ATL resulted in significant cell death. Inhibition of CYP3A attenuated the susceptibility to the observed cytotoxicity of ATL. The metabolic activation of ATL most likely participates in the cytotoxicity of ATL.
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PubMed
高影响因子
eLife
·
2024
·
IF 6.4
Lu Yang,Zijin Lin,Ruijing Mu,Wenhan Wu,Hao Zhi,Xiaodong Liu,Hanyu Yang,Li Liu
Blood–brain barrier (BBB) prevents neurotoxins from entering central nervous system. We aimed to establish and characterize an in vitro triple co-culture BBB model consisting of brain endothelial cells hCMEC/D3, astrocytoma U251 cells, and neuroblastoma SH-SY5Y cells. Co-culture of SH-SY5Y and U251 cells markedly enhanced claudin-5 and VE-cadherin expression in hCMEC/D3 cells, accompanied by increased transendothelial electrical resistance and decreased permeability. Conditioned medium (CM) from SH-SY5Y cells (S-CM), U251 cells (U-CM), and co-culture of SH-SY5Y and U251 cells (US-CM) also promoted claudin-5 and VE-cadherin expression. Glial cell line-derived neurotrophic factor (GDNF) levels in S-CM and US-CM were significantly higher than CMs from hCMEC/D3 and U-CM. Both GDNF and US-CM upregulated claudin-5 and VE-cadherin expression, which were attenuated by anti-GDNF antibody and GDNF signaling inhibitors. GDNF increased claudin-5 expression via the PI3K/AKT/FOXO1 and MAPK/ERK pathways. Meanwhile, GDNF promoted VE-cadherin expression by activating PI3K/AKT/ETS1 and MAPK/ERK/ETS1 signaling. The roles of GDNF in BBB integrity were validated using brain-specific Gdnf silencing mice. The developed triple co-culture BBB model was successfully applied to predict BBB permeability. In conclusion, neurons enhance BBB integrity by upregulating claudin-5 and VE-cadherin expression through GDNF secretion and established triple co-culture BBB model may be used to predict drugs’ BBB permeability.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Moying Yang,Yan Yao,Haotian Shen,Fei Teng,Yunuo Liu,Yuyang Ma,Bin Di,Mengxiang Su
Depression has gradually become a serious public health problem. Traditionally, data on depression are mainly derived from questionnaires or antidepressant prescriptions, and these methods may suffer from update delays and survey bias, resulting in a low actual prevalence of depression. To monitor the prevalence of depression in near real-time, this study developed an analytical method of UPLC-MS/MS by wastewater-based epidemiology to detect 10 typical antidepressants and metabolites in four provinces of China. The method has high sensitivity in that the lower limit of quantification was 2 ng/L. And the method provides recoveries and matrix effects ranging from 85.12 % to 102.98 % and 84.95 % to 112.75 %, respectively. The results showed that among the four provinces, the highest average detected concentration of antidepressants was in Jiangsu (91.82 ± 150.46 ng/L), followed by Guangxi (76.06 ± 130.44 ng/L), Anhui (61.53 ± 94.09 ng/L), and Hainan (27.87 ± 28.33 ng/L). Most wastewater treatment facilities had antidepressants such as venlafaxine, fluvoxamine, and agomelatine. The average back-calculated consumption of venlafaxine and fluvoxamine was 815.88 ± 2015.96 mg/day/1000 inh and 497.02 ± 405.21 mg/day/1000 inh, respectively. Based on this study, the estimated prevalence in the population over 15 in Jiangsu, Anhui, and Hainan was finally determined to be 4.90 %, 5.36 %, and 2.93 %, indicating regional diversity. This study offered a workable way to track the prevalence of depression using wastewater-based epidemiology, which aided public health agencies in comprehending the state of depression prevalence.
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Algal Research-Biomass Biofuels and Bioproducts
·
2025
·
IF 4.5
Wenjie Yuan,Yicheng Wu,Yeling Zhou,Bingjun Shu,Jinqi Cai,Haiyan Fu
Traditional wastewater treatment processes have a relatively low removal rate of the tricyclic antidepressant amitriptyline. This study employed Chlorella vulgaris as the test organism to investigate the effects of exposure to different concentrations of amitriptyline on various biological functions of the microalga. The results showed that the physiological activities of C. vulgaris were inhibited by amitriptyline primarily through the disruption of photosynthesis, the imbalance of the antioxidant system, and the suppression of photosynthesis-related gene expression. The content of chlorophyll a was significantly reduced by 72.0 %, while the activities of superoxide dismutase and catalase were increased to 217.5 % and 67.2 %, respectively. The transcriptional levels of PsaB and PsbC genes were significantly suppressed by 75.5 % and 57.2 %, respectively. After 8 days of exposure to 5 mg/L amitriptyline, the maximum removal rate of amitriptyline by C. vulgaris was determined to be 62.62 %, with biodegradation identified as the predominant removal pathway. The removal of amitriptyline followed pseudo-first-order kinetics, with a degradation half-life of 5.93 days. The study provides theoretical foundations for optimizing microalgal based treatment processes of amitriptyline contaminated wastewater and delivers critical data support for environmental risk assessment of amitriptyline.
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高影响因子
MOLECULES
·
2025
·Vol. 30
·期 18
·3835
·
IF 4.6
Teer Wen,Fangying Hu,Yao Yue,Chuqiao Li,Yunfei He,Jiafeng Ding
Amitriptyline (AMT), a widely prescribed antidepressant, and its metabolites have emerged as significant environmental contaminants, posing substantial risks to aquatic organisms and human health. Systematic and in-depth investigations into advanced anode materials, coupled with a profound elucidation of their electrochemical mechanisms, are imperative for the development of efficacious technologies for AMT removal. In this study, a series of amorphous carbon-encapsulated zinc oxide (C@ZnO) modified anodes were systematically synthesized and incorporated into a persulfate-based electrochemical system (CZ-PS) to comprehensively elucidate the catalytic mechanisms and mass transfer efficiencies governing the degradation of AMT via electroperoxidation. Notably, the CZ-PS system achieved a 97.5% degradation for 5.0 mg/L AMT within 120 min under optimized conditions (200 C@ZnO electrode, pH 7.0, current density 20 mA/cm2, PS concentration 0.5 mM), significantly outperforming the single PS system (37.8%) or the pure electrocatalytic system. Quenching experiments and EPR analysis confirmed hydroxyl radicals (•OH) and sulfate radicals (SO4•−) as the dominant reactive species. Both acidic and neutral pH conditions were demonstrated to favorably enhance the electrocatalytic degradation efficiency by improving adsorption performance and inhibiting •OH decomposition. The system retained >90% degradation efficiency after 5 electrode cycles. Three degradation pathways and 13 intermediates were identified via UPLC–MS/MS analysis, including side-chain demethylation and oxidative ring-opening of the seven-membered ring to form aldehyde/carboxylic acid compounds, ultimately mineralizing into CO2and H2O. It demonstrates strong engineering potential and provides a green, high-efficiency strategy for antibiotic wastewater treatment.
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PubMed
高影响因子
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