Maintaining probiotic viability during storage and gastrointestinal transit is crucial for supplement efficacy. This study was to investigate the protective effects of modified arabinoxylan (AX) by feruloylation in tablets. AX was feruloylated with various ferulic acid (FA) contents (0–106 mg/g) into high (H-FAX), medium (M-FAX), and low (L-FAX) FA content matrices. Tube inversion test revealed that increased FA content reduced the critical concentration for gel formation, with H-FAX showing gelation at 25 % w/v compared to 35 % w/v for L-FAX. The FAX matrices demonstrated superior protection of probiotic during tablet compression compared to conventional excipients, maintaining viability above 7.95 × 10 9 CFU/tablet. Higher FA content improved mechanical properties resulted in better probiotic survival rates in simulated gastric (pH 2.0) and intestinal (pH 7.2) conditions. Storage at 4 °C maintained probiotic viability above 4.67 × 10 9 CFU/tablet for 12 months. The FAX matrix's protective barrier slowed probiotic release and shielded cells from harsh gastrointestinal conditions, while bound ferulic acid's antioxidant effects enhanced survival, ensuring effective colon delivery. These findings demonstrate that FAX matrices' potential in probiotic tablet formulations, with FA content being critical for optimizing protection. This work provides new insights for developing improved probiotic delivery tablets using naturally derived polymers.
Ou Juan-ying,Huang Jun-qing,Song Yuan,Yao Sheng-wen,Peng Xi-chun,Wang Ming-fu,Ou Shi-yi
Corn bran is a byproduct produced from corn milling; it is rich in ferulic acid and hemicellulose. In this research, the effects of feruloylated oligosaccharides (FOs) from maize bran on the microbial diversity and profiles in rat feces were investigated through 16S rRNA sequencing. FOs significantly increased bacterial richness and diversity compared with the control and xylooligosaccharides (XOS) alone. In comparison with the control group and the group administrated with XOS, FOs orally administered at 300 mg/kg increased OTU in feces by 57.0 and 24.8 %, and Chao value by 93.4 and 37.6 %, respectively. FOs also influenced obesity- and diabetes-associated bacteria. Oral administration of FOs at 300 mg/kg decreased the ratio of Firmicutes to Bacteroidetes from 477.7:1 to 55.1:1; greatly increased the reads of bacteria that were previously found resistant against diabetes in rats, such as Actinobacteria , Bacteroides , and Lactobacillus ; whereas decreased diabetes-prone bacteria, such as Clostridium and Firmicutes .
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