CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
JiCheng Liu,ZhaoYang Yao,Shun Gao,Xue Zou
BiOI/Bi 2 WO 6 /MXene composite was successfully synthesized via a solvothermal method, confirmed by XPS/XRD. • Optimal composite degraded 89.3% ranitidine and mineralized 56.0% in 2 h. • EPR analysis indicated that superoxide radicals (•O₂ − ) dominate the degradation process. Ranitidine, a widely used acid-suppressing drug, can undergo nitrosation in aquatic environments to generate N -nitrosodimethylamine (NDMA), a potent carcinogen that poses a serious threat to aquatic ecosystems. To address its persistence against natural degradation, a ternary BiOI/Bi₂WO₆/MXene composite was fabricated via a one-pot solvothermal synthesis. Heterojunction construction effectively broadened its visible-light harvesting capacity. Characterizations by SEM, TEM, XRD, and UV–Vis DRS confirmed the successful formation of the heterojunction with markedly enhanced visible-light absorption. Combined with band structure analysis and radical trapping experiments, a Z -scheme charge transfer mechanism was proposed. Visible-light photocatalytic tests showed that the optimal sample exhibits a high degradation efficiency of 89.3% for RAN, with a 47% relative enhancement compared with pristine BiOI. Radical identification revealed that superoxide radicals (·O₂ − ) were the dominant reactive species. The synergistic effect between the electron-conductive MXene and the interfacial heterojunction accelerated photogenerated carrier separation and ·O₂ − production. Moreover, the composite retained 72.35% of its degradation efficiency after three cycles, demonstrating good stability. This work provides a novel material design strategy for visible-light-driven ranitidine degradation and offers a theoretical basis for mitigating NDMA formation risks.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Yizhe Ding,Jiacheng Shi,Yuqian Lin,Qiya Sun,Yuxiang Zhao,Xi Wang,Qian Ping,Lin Wang,Yongmei Li
In this study, a novel riboflavin-mediated ultraviolet/peracetic acid system (RF/UV/PAA) was developed to enhance the degradation of ranitidine. Under optimal conditions, ranitidine was completely removed within 15 min, leading to a 68.9% mineralization rate due to the combined action of radical (hydroxyl radicals (·OH) and carbon-centered organic radicals (R-C·) and nonradical (singlet oxygen ( 1 O 2 )) reactive oxidative species (ROS). Electron paramagnetic resonance and quenching experiments indicated that RF significantly promoted ROS generation, with the respective contributions of ·OH, R-C· and 1 O 2 to ranitidine removal being 54.5%, 15.8%, and 24.3%, respectively. Demethylation, monooxygenation, dioxygenation, and C-S bond cleavage were identified as the primary degradation pathways for ranitidine. These pathways were initially inferred from structural analysis of transformation products (TPs) and subsequently validated through density functional theory (DFT) calculations and the TP-Transformer model. Furthermore, an integrated DFT-machine learning (ML) framework was employed to elucidate the degradation mechanism, with a specific focus on the interactions of principal molecular features with ROS. The results revealed that FractionCSP3 (SHAP value = 0.30) and MolWt (SHAP value = 0.44) were the dominant predictors of ·OH and 1 O 2 reactivity, respectively, whereas FormalCharge (SHAP value = 0.40) governed the R-C·-mediated processes. In addition, SHAP-based interaction analysis revealed that electron-rich sites facilitate ·OH attack, conjugated π-systems promote 1 O 2 reactivity, and molecular polarization drives R-C· reactions. Our study provides not only an effective technology for ranitidine removal but also a quantitative, interpretable framework for predicting reactivity and guiding the design of photo-assisted advanced oxidation processes.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2026
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IF 5.2
Yuzhe Wang,Lu sheng,Lin Bu,Huijuan Li,Jianxin Wu,Qing Huang
Phospholipid vesicle-based permeation assay (PVPA) is widely applied as in vitro skin alternative model by mimicking stratum corneum to evaluate the transdermal application of drugs and chemicals. However, it is composed of lipid components only, which suffer from limitations of achieving accurate permeability prediction. To remedy this shortcoming, inactive immortalized human keratinocytes (HaCaT) were integrated as component to construct epidermal-mimicking model: EpiPVPA. The EpiPVPA could tolerate the pH 3–10 as well as up to 30% ethanol and was stable for 2 weeks at 4 ℃. And the permeation evaluation by Franz diffusion test of 14 drugs demonstrated that EpiPVPA model is comparable to porcine skin with strong correlation. After quantitative structure–property relationship (QSPR) analysis of physicochemical descriptors of 14 drugs, HLB, TPSA, and log P were selected as main factors applied to build multiple linear regression (MLR) equation, and the corresponding linear correlation R 2 was elevated to 0.9010. EpiPVPA model is feasible to be applied to permeation evaluation of drugs and cosmetics.
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WATER RESEARCH
·
2022
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IF 13.4
Li Chen,Tahir Maqbool,Ghazanfar Nazir,Congyu Hou,Yanna Xu,Yulong Yang,Xihui Zhang
A composite manganese-based catalytic ceramic membrane (Mn-CCM) was developed by a solid-state sintering method, and its effectiveness toward activation of peroxymonosulfate (PMS) for the degradation of 11 pharmaceutical and personal care products (PPCPs) mixture was tested. The optimized Mn-CCMs/PMS system showed remarkable degradation efficiencies for PPCPs mixture with total removal >90% in ultrapure water, river water and natural organic matter (NOM) solution. The Mn-CCMs/PMS system showed the contribution of different phenomena in PPCPs removal in the order of catalytic oxidation (54.7%, Mn-CCMs/PMS) > noncatalytic oxidation (42.3%, PMS oxidation) > adsorption (3.0%, by Mn-CCMs). The singlet oxygen ( 1 O 2 ) was the dominant reactive oxygen specie for the degradation of PPCPs in all water matrices proved by the quenching experiments and electro-paramagnetic resonance (EPR) spectroscopy. The extraordinary stability of Mn-CCMs for the activation of PMS has been noted in terms of repeatability experiments for PPCPs degradation with fewer leaching of Mn (1.9 to 3.6 µg/L). Mineralization was achieved in the range of 28–65% for different water matrices. The toxicity of the PPCPs mixture was reduced by 85.9%. The Mn-CCMs/PMS system showed a reduction (25–100%) in precursors of different carbon- and nitrogen-based disinfection by-products. This study found the Mn-CCMs/PMS system as a feasible purification unit for removing trace concentrations of PPCPs (ng/L) in real drinking water matrices.
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JOURNAL OF CONTROLLED RELEASE
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2023
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IF 10.8
Jiezhou Pan,Haotian Liao,Guidong Gong,Yunxiang He,Qin Wang,Lang Qin,Yaoyao Zhang,Hirotaka Ejima,Blaise L. Tardy,Joseph J. Richardson,Jiaojiao Shang,Orlando J. Rojas,Yong Zeng,Junling Guo
Drug-dependent design of hydrogels is currently required for engineering the controlled release of therapeutics, which is a major contributor to the technical challenges relating to the clinical translation of hydrogel-drug systems. Herein, by integrating supramolecular phenolic-based nanofillers (SPFs) into hydrogel microstructures we developed a facile strategy to endow a range of clinically relevant hydrogels with controlled release properties for diverse therapeutic agents. The assembly of multiscale SPF aggregates leads to tunable mesh size and multiple dynamic interactions between SPF aggregates and drugs, which relaxes the available choices of drugs and hydrogels. This simple approach allowed for the controlled release of 12 representative drugs evaluated with 8 commonly used hydrogels. Moreover, the anesthetic drug lidocaine was loaded into SPF-integrated alginate hydrogel and demonstrated sustained release for 14 days in vivo, validating the potential for long-term anesthesia in patients.
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JOURNAL OF DRUG TARGETING
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2026
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IF 4.7
Weishuo Ju,Ran Zhang,Jingxuan Guo,Shuo Li,Huimin Zhang,Huijia Song,Yanping Sun,Zibin Gao
Accurately and efficiently assessing drug permeability has emerged as a critical challenge in early drug discovery and development, prompting the development of various models. In this study, a polymer planar biomimetic membrane permeation assay (PPBMPA) model was established using a Transwell chamber, and its permeability assessment capability was evaluated using model drugs with high, medium, and low permeability. The underlying permeation mechanism was also investigated. The results demonstrated that the biomimetic membrane spontaneously differentiated into an intestinal-like structure comprising a hydrated layer, a polymersome layer, and a basal layer, thereby mimicking the sequential process of drug permeation across the mucus layer, intestinal epithelium, interstitial space, and into the bloodstream. This highly biomimetic permeation pattern enabled effective differentiation between high and low absorption drugs, exhibiting a strong correlation with Caco-2 permeability (R2 = 0.85). Collectively, these findings suggest that the novel PPBMPA model holds promise as a reliable tool for rapid and reproducible drug permeability prediction.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
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2023
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IF 7.8
Jianrui Niu,Hua Jia,Minghao Yu,Jinyu Zhu,Junjun Ma,Zhuang He,Weizhang Zhong,Yongjiang Hou,Yankai Guo
Advanced oxidation processes based on peroxymonosulfate (PMS) are effective methods for treatment of organic contaminants . Catalysts have a key role in these processes. In this study, we employed a novel penicillin residue-derived nitrogen-rich biochar to activate PMS for tetracycline (TC) degradation. Experimental results indicate that the removal rate reached its maximum (86.2%) within 20 min under the optimal conditions. In addition, after five cycles, the removal efficiency decreased only slightly. A combined analysis of the physical structure and chemical properties with chemical scavengers, electron paramagnetic resonance, and electrochemical tests confirmed that the catalyst had a dual role. Nitrogen doping and C O groups on the catalyst acted as active sites, which could produce superoxide radicals (O 2 •- ) and singlet oxygen ( 1 O 2 ). The catalyst can also act as an electron transfer mediator to enhance the degradation process . Liquid chromatography–mass spectrometry (LCMS) was used to reveal the intermediates of TC degradation, potential degradation pathways are proposed, and the toxicity of the intermediates was analyzed. This research provides an effective strategy for the treatment of tetracycline and new approach to adequately remove antibiotic residues.
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JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Lin Wang,Qiya Sun,Yicheng Dou,Zhipeng Zhang,Tingting Yan,Yongmei Li
A novel ternary recyclable Fe 3 O 4 /graphene/sulfur-doped g-C 3 N 4 (Fe 3 O 4 /GE/SCN) composite catalyst was synthesized and adopted in a visible-light driven catalytic system for the degradation of ranitidine, which is an important precursor of the emerging disinfection by-product of N-nitrosodimethylamine (NDMA). The addition of GE and Fe 3 O 4 significantly improved the interface charge transfer of SCN, increased the light collection efficiency and decreased the photogenerated charge recombination efficiency. Considering both the ranitidine removal efficiency and catalyst recovery, the Fe 3 O 4 mass fraction of 20% (20%-Fe 3 O 4 /GE/SCN) was recommended. Ranitidine (≤ 2 mg/L) was completely removed in 60 min under the conditions of an initial pH of 7.0 and a 20%-Fe 3 O 4 /GE/SCN dose of 1.0 g/L, and its degradation fitted well with the pseudo first-order kinetics model. Electron paramagnetic resonance analysis and trapping experiments confirmed that ·O 2 − , ·OH and h + participated in the degradation of ranitidine. Ranitidine was removed through the pathways of demethylation and hydroxylation based on the analysis of the detected degradation intermediates, and 57.3% of the NDMA formation potential (FP) was reduced after the reaction. The visible-light driven 20%-Fe 3 O 4 /GE/SCN catalytic technology is a promising method not only for the control of NDMA FP but also the catalyst could be recovered and reused.
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RSC Advances
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2016
·Vol. 6
·期 103
·100891-100898
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IF 3.289
Kun Peng,Qiqin Wang,Weijia Chen,Donghai Xia,Zhengyin Zhou,Yuqiang Wang,Zhengjin Jiang,Fuhai Wu
A novel phosphatidic acid functionalized polymeric monolithic column was prepared through the thermally initiated co-polymerization of 12-methacryloyl dodecylphosphatidic acid (MDPA) and ethylene glycol dimethacrylate (EDMA) in the presence of 1,4-butanediol and isopropanol as porogens within 100 μm I.D. capillaries. The polymerization conditions of monolithic columns were systematically optimized in order to obtain good permeability, stability and column efficiency. The reproducibility of the optimized monolithic column was also satisfactory. The physicochemical properties of the monolithic column were evaluated by use of instrumental techniques including scanning electron microscopy, Fourier transform infrared spectra, ζ-potential analysis and micro-HPLC. A series of test compounds such as small peptides, alkylphenones, etc., were employed to investigate the retention mechanism on the poly(MDPA-co-EDMA) monolithic column. The results demonstrate that both hydrophobic and cation-exchange interactions could contribute to the overall retention of analytes. Furthermore, the novel reversed-phase/cation-exchange mixed mode monolithic column was applied to the separations of small peptides, phenols, water-soluble vitamins B, and pharmaceutical compounds. The successful applications indicate the potential of the poly(MDPA-co-EDMA) monolithic column in complex sample analysis.
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Applied Food Research
·
2025
·
IF 6.2
Guodong Shan,Xiuqin Fan,Qingcheng Wang,Li Zhang,Lijun Ge,Weibo Lu,Jing Xue,Kang Chen,Zejun Wang,Qing Shen
The inappropriate use of H2 receptor antagonists (H2RAs) in functional foods (FFs) and food-medicine homology materials (FMHs) designed to enhance gastrointestinal function (IGF) presents health risks due to potential adverse effects. In this study, an analytical method that integrates Captiva EMR-Lipid (CEL) solid-phase extraction (SPE) with liquid chromatography tandem mass spectrometry (LC-MS/MS) has been developed for the detection of H2RAs (nizatidine, famotidine, cimetidine, ranitidine, and lafutidine) in these products. Through the optimization of CEL-SPE parameters, such as using 200 mg of sorbent and eluting with ACN/water (80/20, v/v), the recovery rates of H2RAs in IGF-FF and IGF-FMH ranged from 87.4 % to 94.6 % and 90.2 % to 97.1 %, respectively. The assessment of matrix effects revealed that the five H2RAs exhibit matrix suppression, necessitating the construction of matrix-matched standard curves with correlation coefficients (r 2 ) exceeding 0.9991. The detection limits ranged from 0.4 to 0.8 μg·kg −1 and the quantification limits ranged from 1.3 to 2.7 μg·kg −1 , with recovery rates spanning from 85.4 % to 97.1 % and relative standard deviations ≤ 15 %. The successful development of this technique not only helps safeguard consumer health but also provides scientific basis and technical support for market supervision, thereby preventing and addressing food safety risks.
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Emergent Materials
·
2025
·
IF 4.1
Shi Zhengzheng,Li Jia,Pan Yupeng,Li Xuewei,Zhuang Zile,Li Yihan,Zhang Zheng,Wang Zirui,Luo Qizhi,Chen Xuncai
The Fenton-like reaction has always been hampered by limitations related to its narrow pH range and poor stability. In this study, we successfully developed a novel catalyst composed of Prussian blue (PB) nanoparticles anchored onto carbon-defective g-C 3 N 4 (CD-C 3 N 4 ) nanosheets with a porous structure. Under visible light irradiation for 120 min, the removal efficiencies of tetracycline can achieve remarkably high removal rates as 93.3%. Significantly, this catalyst attains exceptional long-term stability enabling up to 20 cycles, while consistently maintaining a degradation efficiency exceeding 99%. Furthermore, this system exhibits a wide pH tolerance ranging from 3 to 9. Efficient charge separation and the introduction of carbon defects on the g-C 3 N 4 nanosheets contribute to the robust Fe 3+ /Fe 2+ cycles in PB, which support prolonged multiple recycles. ESR and quenching tests indicated that •O 2 − species play a significant role in catalytic degradation, with •OH and h + also being involved in the photo-Fenton reaction. Finally, we proposed potential photo-Fenton degradation pathways for tetracycline(TC) and conducted a comprehensive investigation into the toxicity changes of TC degradation through full-scale zebrafish toxicology assays. This work presents an innovative approach to construct highly stable Fenton-like catalysts through structural defect engineering combined with Fe-Metal organic frameworks(MOFs) loading strategies.
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Journal of Water Process Engineering
·
2024
·
IF 6.3
Yun-fei Zhang,Xin Quan,Sheng-gui Chen,Jian-hui Xu,Dan Li,Lei Li,Si-hao Lv,Jin-ze Li,Yi-hang Zhang,Zhuo-wei Zhong
In this study, silicon nitride-zero-valent iron (Si 3 N 4 -ZVI) powders were obtained through post-milling and employed as a catalyst to activate peracetic acid (PAA) for the removal of Ranitidine (RAN). The system achieved an impressive 90.4 % of degradation efficiency, with a pseudo-first-order kinetic reaction constant 11.3 times higher than that of the ZVI/PAA system. Quenching experiments and Electron Paramagnetic Resonance (EPR) analysis confirmed that both radical and non-radical processes are involved in RAN degradation within the Si 3 N 4 -ZVI/PAA system. Moreover, the identified ten degradation products are less toxic compared to the byproducts from alternative oxidation methods reported by prior literature. The proposed degradation pathway of RAN includes C S cleavage, oxygenation/hydroxylation demethylation, and denitrification. Furthermore, the Si 3 N 4 -ZVI/PAA system showed effectively in treating RAN-contaminated surface water, artificial wastewater, and dissolved organic matter, demonstrating its great ability in treating diverse organic-contaminated water sources. In conclusion, results of this study suggest that the Si 3 N 4 -ZVI/PAA system possess high pollutant removal efficiency, broad applicability, and less environmental and health risks.
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