Catalysis Science & Technology
·
2018
·Vol. 8
·期 24
·6384-6395
·
IF 5.365
Zhiyang Zhang,Yanle Li,Jing Gu,Liping Ding,Nianhua Xue,Luming Peng,Xuefeng Guo,Yan Zhu,Jing Ma,Weiping Ding
The electrostatic field of a dielectric cavity is powerful for modulating many aspects of confined metal clusters. Here we report that the catalytic properties of Ptn clusters confined in X-zeolite cages are strongly tuned by altering the zeolitic field, which is achieved by using different cations (Na+, Cs+, Ca2+ or La3+) to balance the negative framework of the zeolite. Compared with Ptn@LaX, for example, Ptn@CsX shows a surprising ∼5500% enhancement in TOF value for phenol hydrogenation to cyclohexanol. Electrostatic field modulation leads to gradual changes of electronic properties such as the Fermi levels/d-band centers of the Ptn clusters, as revealed by DFT calculations and experimental characterizations. The decreases in Fermi levels of the Ptn clusters benefit the hydrogenation of –CCH groups (phenylacetylene and acetylene) and –NO2 groups (nitrobenzene, o-nitroanisole and o-chloronitrobenzene) but are detrimental for aromatic ring hydrogenation (phenol). These findings are important for the design of high performance catalysts.
研究领域:
化学
·
材料科学
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DOI
高影响因子
Journal of Food Measurement and Characterization
·
2021
·Vol. 15
·期 6
·5345-5359
·
IF 2.431
Zhang Mingjun,Chen Yu,Wei Qunshu,Li Jianbin
The effect of applying an electrostatic field treatment to rum and its underlying reaction mechanism based upon a model system were investigated in this study. A field intensity of 1 kV·cm −1 and processing time of 30 min were the optimal treatment conditions, the content of (desirable) ester was increased to 219.57 ± 4.61 μg·mL −1 , and the content of (undesirable) fusel oil was decreased to 643.37 ± 15.26 μg·mL −1 , compared with the control (208.42 ± 2.31 μg·mL −1 and 707.04 ± 2.21 μg·mL −1 , respectively). In addition, Odorant Activity Value (OAV) analysis showed that there were 15 main flavor components (OAV > 1) in rum, and the concentrations of 13 flavor components were increased after 1 kV·cm −1 electrostatic field treatment, indicating that the flavor quality of rum was improved. When the electrostatic field intensity was 0.5, 1, and 2 kV·cm −1 , the rate constant (k) of the esterification reaction increased in the ethanol-acetic acid model system, and the activation energy decreased from 47.7 kJ·mol −1 to 46.1, 40.6 and 38.6 kJ·mol −1 , respectively. This showed that the electrostatic field treatment was helpful to the esterification reaction in the rum simulation system. 1 H NMR results showed that δET-OH, δH-OH, δCH 3 , and δCH 3 in the ethanol–water model system were all increased when the electrostatic field strength was 0.5, 1, 2, and 4, respectively. This showed that the electrostatic field treatment promoted the hydrogen bond association between ethanol and water molecules in the rum simulation system. Therefore, the maturation process in rum was accelerated and the quality of the rum was improved by electrostatic field treatment.
研究领域:
食品科学
·
化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 2
·1081
·
IF 4.9
Yi Liu,Yang Ge,Yanfan Wu,Yongtong Feng,Han Liu,Wei Cao,Jinsong Xie,Jingzhong Zhang
Three-dimensional (3D) hepatocyte models have become a research hotspot for evaluating drug metabolism and hepatotoxicity. Compared to two-dimensional (2D) cultures, 3D cultures are better at mimicking the morphology and microenvironment of hepatocytes in vivo. However, commonly used 3D culture techniques are not suitable for high-throughput drug screening (HTS) due to their high cost, complex handling, and inability to simulate cell–extracellular matrix (ECM) interactions. This article describes a method for rapid and reproducible 3D cell cultures with ECM–cell interactions based on 3D culture instrumentation to provide more efficient HTS. We developed a microsphere preparation based on a high-voltage electrostatic (HVE) field and used sodium alginate- and collagen-based hydrogels as scaffolds for 3D cultures of HepG2 cells. The microsphere-generating device enables the rapid and reproducible preparation of bioactive hydrogel microspheres. This 3D culture system exhibited better cell viability, heterogeneity, and drug-metabolizing activity than 2D and other 3D culture models, and the long-term culture characteristics of this system make it suitable for predicting long-term liver toxicity. This system improves the overall applicability of HepG2 spheroids in safety assessment studies, and this simple and controllable high-throughput-compatible method shows potential for use in drug toxicity screening assays and mechanistic studies.Keywords:hepatocyte;3D cultures;hydrogel;microspheres;high-voltage electrostatic field;RNA-seq
研究领域:
细胞生物学
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药理学
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毒理学
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产品关联
DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2016
·
IF 2.322
Xin Ding,Linlin Zhang,Yan Gao
Dye-sensitized photoelectrochemical cell (DS-PEC) is an especially attractive method to generate hydrogen via visible light driven water splitting. Electrolyte, an essential component of DS-PEC, plays a great role in determining the photoactivities of devices for water splitting. When using phosphate buffer (pH = 6.4) as electrolyte, the DS-PEC displayed much higher photoactivity than using 0.1 M Na 2 SO 4 (pH = 6.4) as electrolyte. The insight is phosphate anion gathers together to form a negative electrostatic field on TiO 2 surface, which increases the resistance in the TiO 2 /catalyst and electrolyte interface and validly reduces the charge recombination from TiO 2 to the oxidized catalyst.
研究领域:
材料科学
·
能源科学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Di Pan,Pan Chu,Xiongfei Fu,Diya Wen,Hua Song,Shupei Bai,Xuan Guo
The high-voltage electrostatic field (HVEF) has been proposed as an efficient and convenient strategy for microbial inactivation, playing a crucial role in ensuring urban safety and people’s lives and health. However, the effects of the underlying antibacterial molecular mechanism on specific functional capabilities are largely unknown. Here, we systematically investigated the molecular mechanism underlying the inactivation effect of an HVEF against E. coli with a wire-plate-type device. Our experimental analysis revealed that the antibacterial effects primarily stemmed from the local alteration of cell membrane integrity and permeability, which further induced a series of oxidative damage events, including decreased SOD activity, increased ROS levels and MDA content, and, eventually, apoptosis. Theoretically, this process is mediated mainly by energy metabolism, cell motility and membrane transport signalling, as suggested by a multiomic analysis. Through quantitative methods, we showed that FliC , a key flagellar protein, plays a very important role in this process and that the quantity of fliC present on cells influences the HVEF tolerance. These results together reveal the previously unknown mechanism underlying the antibacterial effect of HVEFs and suggest that fliC activity and cell motility are novel components of this mechanism that distinguish HVEF-resistant bacteria from normal bacteria.
研究领域:
微生物学
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分子生物学
·
生物物理学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yuanyuan Hou,Jiaxin Huang,Hao Ma,Qingsong Li,Zerong Xiang,Jiasheng Qian,Guanglin Li,Yanlong Tai,Ru Xia,Shanshan Zhu
The advancement of intelligent soft actuators is progressively emphasizing the incorporation of environmental sensing capability to actuation, thereby enhancing the adaptability and interactivity of artificial systems. In the current situation where the sensing and actuation functions of soft actuators are generally separated, this work proposes an autonomous three-dimensional (3D) noncontact sensory actuator (NSA), based on the coupling of ″dielectric polarization-electrothermal conversion-thermal actuation″ triple effects. Specifically, the NSA hybrid membrane is composed of multiple interpenetrating networks, including a boron nitride nanosheet (BNNS) dielectric network for electrostatic field sensing and polarization, a silver nanowires (AgNWs) percolation network for dielectric enhancement and electrothermal conversion, and thermally contracted shape memory fiber (SMF) and thermally expanded polydimethylsiloxane (PDMS) networks for directional actuation. Based on the principle of electrostatic field and dielectric polarization, the SMF/BNNS composite (SMF-BN) fibrous membrane can logically sense the noncontact 3D motion, static/dynamic state of external objects, and distinguish material categories. Subsequently, the output sensing potential facilitates the built-in AgNWs nanonetwork heater to trigger electrothermal actuation of NSA. Lastly, as a biomimetic tongue, the autonomous noncontact “sensing-decision-actuating” of NSA is verified by seamless energy conversion in the process of sensing “prey” approaching and capturing. The proposed sensory actuator would facilitate multimodal integration for future wearable and human-machine-environment interaction technologies.
研究领域:
智能材料
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软体机器人
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人机交互
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产品关联
DOI
PubMed
高影响因子
NPG Asia Materials
·
2016
·Vol. 8
·期 3
·e243
·
IF 8.772
Ning Chengyun,Yu Peng,Zhu Ye,Yao Mengyu,Zhu Xiaojing,Wang Xiaolan,Lin Zefeng,Li Weiping,Wang Shuangying,Tan Guoxin,Zhang Yu,Wang Yingjun,Mao Chuanbin
Bone has a built-in electric field because of the presence of piezoelectric collagen. To date, only externally applied electric fields have been used to direct cell behavior; however, these fields are not safe or practical for in vivo use. In this work, for the first time, we use a periodic microscale electric field (MEF) built into a titanium implant to induce osteogenesis. Such a MEF is generated by the periodic organization of a junction made of two parallel semiconducting TiO 2 zones: anatase and rutile with lower and higher electron densities, respectively. The junctions were formed through anatase–rutile-phase transition in selective areas using laser irradiation on the implants. The in vitro and in vivo studies confirmed that the built-in MEF was an efficient electrical cue for inducing osteogenic differentiation in the absence of osteogenic supplements and promoted bone regeneration around the implants. Our work opens up a new avenue toward bone repair and regeneration using built-in MEF.
研究领域:
生物材料
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组织工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2025
·
IF 4.8
Sijie Lin,De-Kun Ma,Hehe Zhou,Haifeng Yuan,Cong Wan,Xia Hu
Photocatalytic activity of pristine resorcinol formalde (RF) resin in hydrogen peroxide production is still unsatisfying for practical application because of poor separation efficiency of photogenerated carriers. Contact electrification (CE) between polytetrafluoroehtylene (PTFE) and water (H 2 O) can not only generate hydrogen peroxide (H 2 O 2 ) but also form a strong interfacial electrostatic field (IEF). However, whether the IEF can be used to promote the separation of photogenerated carriers of the photocatalysts is still unclear. Herein, taking RF resin as a model photocatalyst, we have synthesized RF resin/PTFE photocatalytic/contact-electro-catalytic composite catalysts and further demonstrated that the IEF formed between PTFE and H 2 O could be used to facilitate the separation of photogenerated carriers of the RF resins. As a result, H 2 O 2 production rate reached 56.5 µmol·h −1 over RF/PTFE under simultaneous visible light irradiation and ultrasonication, which is 33-times and 2-times higher than those obtained on individual PTFE (1.7 µmol·h −1 ) and RF (28.1 µmol·h −1 ). CE could also enhance H 2 O 2 generation rate of other photocatalysts, showing its generality. Not only that, RF/PTFE could be used to fabricate CE-photocatalysis-self-Fenton system for environmental purification.
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产品关联
DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 19
·3288
·
IF 5.1
Minmin Tang,Yongbiao Ni,Tianli Zang,Wei Gao,Jinzhu Song,Jie Zou,Danke Xu
An improved QuEChERS method based on magnetic nanomaterials was established, and coupled with ultra-high-performance liquid chromatography and a quadrupole electrostatic field orbitrap mass spectrometer, enabling non-targeted screening and quantitative analysis of commonly used pesticide and veterinary drug residues inBrassica rapa chinensis. The combination of magnetic PSA and magnetic multi-walled carbon nanotubes (MWCNTs) was utilized for purification of 121 organic compounds spanning a wide range of polarities. Spiking experiments showed that the developed non-target screening workflow exhibited convincing identification results, with over 89.3% of chemical substances being screened out even at spiking levels as low as 2 μg/kg. The linear ranges of these target substances were between 1 and 200 μg/kg, with determination coefficients all exceeding 0.99. The limits of quantification were between 2 μg/kg and 10 μg/kg. The average recovery rates were in the range of 61.7% to 121.6%. Nineteen compounds were confirmed (meeting all the restriction conditions) and quantified fromBrassica rapa chinensiscollected from vegetable-planting bases in Jiangsu Province. The results indicated that the magnetic bead-based pretreatment strategy can be utilized for the simultaneous screening and quantitative analysis of pesticide and veterinary drug residues inBrassica rapa chinensis.
研究领域:
分析化学
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食品安全
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药物代谢
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环境毒理学
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农产品质量
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质谱分析
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残留检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Chunbei Chen,Zefu Wang,Ziliang Gao,Xiaosi Chen,Shuai Wei,Qiuyu Xia,Qinxiu Sun,Yantao Yin,Yang Liu,Shucheng Liu
This study investigates the effect of high-voltage electrostatic field (HVEF) salting on the quality of salt-reduced Yi Ye Cheng golden pomfret. Results showed that the salt content increased with the voltage ( P < 0.05). The cooking losses of the HVEF-treated groups were significantly lower than those of commercially available products ( P < 0.05). The 3.0 kV group showed the highest hardness and chewiness. HVEF treatment increased the varieties and contents of volatile flavor substances, with the varieties and contents of aldehydes, ketones, and alcohols being highest at 3.5 kV. No ketones with OAV > 1 were detected in the commercially available products, but all the HVEF-treated groups contained 2,3-octanedione. Lipid and protein oxidation increased with the voltage ( P < 0.05), which may account for the changes in water retention, texture and flavor. Therefore, moderate HVEF treatment had a positive effect on the quality. This study provides theoretical guidance for curing and improving the quality of salt-reduced fish products.
研究领域:
食品科学
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食品加工
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水产品技术
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DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2025
·
IF 5.4
Ling Liang,Jisheng Liu,Jiangyi Luo,Yasi Deng,Shiqi Liu,Qingling Xie,Mengyun Wang,Tingsi Guo,Xingwang Leng,Pingan Liu,Wei Wang,Hanwen Yuan
Ethnopharmacological relevance Gardeniae Fructus (Zhizi, ZZ), the fruit of Gardenia jasminoides Ellis, exhibits anti-inflammatory and hepatoprotective effects, etc. Processing alters its properties, enhances therapeutic effects, and reduces toxicity. Furthermore, The chemical composition of ZZ seed and pericarp is significantly different. Studying the alterations in chemical components of the seed and pericarp under various processing conditions and the resulting variances in biological activities is highly valuable. Aim of the study: This study aimed to investigate the changes in the chemical composition and biological activity of ZZ during processing. Materials and methods This study employed high-performance liquid chromatography-diode array detection (HPLC-DAD) and liquid chromatography coupled to electrostatic orbitrap high-resolution mass spectrometry (LC-Orbitrap-MS), along with chemometric analysis and non-targeted metabolomics, to investigate variances in components of ZZ seed and pericarp and their transformations during processing. Lipopolysaccharide (LPS)-induced RAW 264.7 cells were utilized to evaluate the anti-inflammatory effects of ZZ by measuring nitric oxide (NO) production with the Griess reagent method. Furthermore, the levels of pro-inflammatory cytokines (TNF-α, IL-6) were determined using ELISA technique. Acetaminophen (APAP)-induced HepG2 cells were used to investigate the hepatoprotective of ZZ. Results Using non-targeted metabolomics and chemometrics, the study identified 353 differential features between the ZZ raw seed (RS) and the raw pericarp (RP). During processing, 382 and 386 significant features were found in seed and pericarp, respectively. A total of 210 compounds were identified by reference standards, fragmentation pattern, molecular networking, mzCloud, mzVault, in-house database, and a predictive database. Furthermore, bioassay tests showed reduced anti-inflammatory and hepatoprotective effects during processing. Geniposide and trans -crocin I were identified as primary anti-inflammatory and hepatoprotective compounds. Conclusion The chemical difference between the pericarp and seed of ZZ is obvious, and the chemical changes during processing have a significant impact on the activities. Proper processing is crucial for maximizing the therapeutic effects of ZZ.
研究领域:
生药学
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代谢组学
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天然产物化学
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民族药理学
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分析化学
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中药学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 20
·4962
·
IF 4.2
Yu-Dan Wang,Lu-Sheng Han,Gen-Yue Li,Kai-Li Yang,Yan-Long Shen,Hao Zhang,Jian-Feng Hou,En-Peng Wang
This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultra-high-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p< 0.05) and malondialdehyde (MDA) content was more significantly decreased (p< 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p< 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p< 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.
研究领域:
药用植物学
·
化妆品科学
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分析化学
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细胞生物学
·
动物模型
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）