Sensors and Actuators Reports
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2022
·
IF 0
Yiqun Liu,Wei Yue,Yue Cui
The development of simple sensing platforms for evaluating the oral conditions has attracted great attentions for healthcare. Saliva or toothpaste contains various analytes that can indicate health conditions. A salivary glucose sensing platform can provide a convenient and non-invasive alternative detection approach for diabetic patients. Toothbrush is used every day, and it has an easy access to saliva biomarker and toothpaste residues. Here, we demonstrate for the first time an amperometric biosensor on a toothbrush, using glucose as a typical analyte. The carbon graphite ink and the Ag/AgCl ink are painted on a toothbrush as the sensing electrodes, followed by the enzyme immobilization. The sensor shows an excellent detection performance for glucose with a concentration ranging from 0.18 mM to 5.22 mM and a short detection time of less than 5 min. The sensor is promising for the non-invasive monitoring of salivary glucose levels in diabetic patients when they brush their teeth. We anticipate that these results would open up exciting opportunities for developing new toothbrush sensors, as well as advance related healthcare applications.
研究领域:
生物医学工程
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医疗设备开发
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传感技术
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产品关联
DOI
TALANTA
·
2024
·
IF 5.6
Lei Pan,Fan Yang,Shihao Xu,Dan Lin,Changlong Jiang
Abnormal amount of dopamine (DA) in human body is closely relate to various diseases, such as Parkinson's disease, pheochromocytoma. Real-time monitoring DA is crucial for disease warning, diagnosis and treatment. Currently, most methods rely on invasive blood testing for detecting DA, which is only completed with the aid of the medical staffs in hospitals. Herein, a non-invasive fluorescence visual strategy is developed for the real-time monitoring DA, based on luminescent nanoparticles and modified mesoporous zeolite imidazole framework (ZIF-8-NH 2 ) dodecahedrons. During the reaction process, DA is enriched through the spatial configuration of ZIF-8-NH 2 and hydrogen bonding effect. The luminescence of Cr 3+ -doped zinc gallate (ZnGa 2 O 4 :Cr 3+ , ZGC) is inhibited by the photo-induced electron transfer (PET) mechanism to realize sensitively detecting DA. The intelligent sensing platform based on the designed fluorescence probe and color recognition system is structured for real-time detection of DA in urine. Furthermore, a skin-fitting hydrogel patch is prepared by combining a fluorescent probe with chitosan, which enables sensitive and accurate detection of DA in sweat without the complex sample pretreatment. The non-invasive fluorescence detection method provides an effective strategy for quantitatively monitoring DA in human fluids.
研究领域:
医学诊断
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生物传感
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材料科学
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产品关联
DOI
PubMed
高影响因子
Microsystems & Nanoengineering
·
2023
·Vol. 9
·期 1
·1-14
·
IF 7.9
Xue Hailing,Wang Dongyang,Jin Mingyan,Gao Hanbing,Wang Xuhui,Xia Long,Li Dong’ang,Sun Kai,Wang Huanan,Dong Xufeng,Zhang Chi,Cong Fengyu,Lin Jiaqi
Noninvasive brain–computer interfaces (BCIs) show great potential in applications including sleep monitoring, fatigue alerts, neurofeedback training, etc. While noninvasive BCIs do not impose any procedural risk to users (as opposed to invasive BCIs), the acquisition of high-quality electroencephalograms (EEGs) in the long term has been challenging due to the limitations of current electrodes. Herein, we developed a semidry double-layer hydrogel electrode that not only records EEG signals at a resolution comparable to that of wet electrodes but is also able to withstand up to 12 h of continuous EEG acquisition. The electrode comprises dual hydrogel layers: a conductive layer that features high conductivity, low skin-contact impedance, and high robustness; and an adhesive layer that can bond to glass or plastic substrates to reduce motion artifacts in wearing conditions. Water retention in the hydrogel is stable, and the measured skin-contact impedance of the hydrogel electrode is comparable to that of wet electrodes (conductive paste) and drastically lower than that of dry electrodes (metal pin). Cytotoxicity and skin irritation tests show that the hydrogel electrode has excellent biocompatibility. Finally, the developed hydrogel electrode was evaluated in both N170 and P300 event-related potential (ERP) tests on human volunteers. The hydrogel electrode captured the expected ERP waveforms in both the N170 and P300 tests, showing similarities in the waveforms generated by wet electrodes. In contrast, dry electrodes fail to detect the triggered potential due to low signal quality. In addition, our hydrogel electrode can acquire EEG for up to 12 h and is ready for recycled use (7-day tests). Altogether, the results suggest that our semidry double-layer hydrogel electrodes are able to detect ERPs in the long term in an easy-to-use fashion, potentially opening up numerous applications in real-life scenarios for noninvasive BCI.
研究领域:
生物医学工程
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神经科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Ningning Li,Ying Zhou,Hao Sun,Nan Wang,Nan Yang,Peiyao Ren,Lanjun Fu,Yiming Zhang,Wei Liu,Yanjie Li,Juan Jin
Rapid and accurate glucose monitoring is extremely crucial for the health management of diabetic patients. Whereas the non-invasive detection of salivary glucose is promising alternative. In this study, a newly designed MOF/MIPs paper-based microfluidic biomimetic chip (MM-SGM-chips) was successfully constructed based on boron-affinity orientation surface imprinting strategy. The obtained chips demonstrated high adsorption capability (Q e = 213.40 mg·g −1 ), excellent selectivity (IF = 3.7), speedy detection (less than 30 min), and satisfied anti-interference ability for glucose. Moreover, the MM-SGM-chips could be capable of rapid and sensitive quantification of glucose level ranged from 0.1-3.2 mM through visual detection, with a limit of detection as low as 0.02 mM. Furthermore, the real clinical samples in daily period were collected for validating its correlation with serum glucose level. Present works demonstrated the promising potentiality of MM-SGM-chips for home self-test and even point-of-care testing clinical applications.
研究领域:
生物医学工程
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分析化学
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糖尿病研究
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产品关联
DOI
高影响因子
NPG Asia Materials
·
2018
·Vol. 10
·期 4
·177-189
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IF 7.208
Gao Zhong Feng,Sann Ei Ei,Lou Xiaoding,Liu Renyi,Dai Jun,Zuo Xiaolei,Xia Fan,Jiang Lei
Herein, we demonstrate a contact angle (CA)-based naked-eye point-of-care testing platform with rapid pH-responsive superwettability that can switch between superhydrophilic and superhydrophobic properties for quantitative biosensing. The CA of the droplet on the pH-responsive surface approached ~0° at pH 1 and conversely reached 161.4° ± 6.2° at pH 13. We realized the sensitive detection of the pH, urea, and glucose by monitoring the changes in the CA. The traditional invasive diagnosis of diabetes causes pain and brings the risk of infections, such as acquired immune deficiency syndrome (AIDS), hepatitis B, hepatitis C, and syphilis, to the user. To address this issue, we implemented a method for the non-invasive diagnosis of diabetes in human saliva and urine, which avoided the significant drawbacks mentioned above. The accuracy of this method was demonstrated by comparing the results with those from commercial glucometers and theoretical calculations. Interestingly, we successfully monitored glucose levels in sweat before, during, and after cycling. The sensing performance was barely influenced by the temperature, elevation, and droplet color, illustrating promise for expansion to hundreds of millions of potential customers, especially those with color blindness or color weakness. Given its low cost, lack of instruments, and rapid response (within 1 s), this strategy might overcome the limitations of the mechanical stability and durability of superwettable materials and thus might extend the industrial-scale application of bioinspired superwettable systems.
研究领域:
生物医学工程
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材料科学
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诊断学
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产品关联
DOI
高影响因子
SENSORS
·
2024
·Vol. 24
·期 11
·3623
·
IF 3.4
Arif Ullah Khan,Muhammad Tahir,Fazal Ul Nisa,Mizna Naseem,Iqra Shahbaz,Zeyu Ma,Zilu Hu,Abdul Jabbar Khan,Muhammad Sabir,Liang He
Metal-oxide-based gas sensors are extensively utilized across various domains due to their cost-effectiveness, facile fabrication, and compatibility with microelectronic technologies. The copper (Cu)-based multifunctional polymer-enhanced sensor (CuMPES) represents a notably tailored design for non-invasive environmental monitoring, particularly for detecting diverse gases with a low concentration. In this investigation, the Cu-CuO/PEDOT nanocomposite was synthesized via a straightforward chemical oxidation and vapor-phase polymerization. Comprehensive characterizations employing X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), X-ray diffraction (XRD), and micro Raman elucidated the composition, morphology, and crystal structure of this nanocomposite. Gas-sensing assessments of this CuMPES based on Cu-CuO/PEDOT revealed that the response current of the microneedle-type CuMPES surpassed that of the pure Cu microsensor by nearly threefold. The electrical conductivity and surface reactivity are enhanced by poly (3,4-ethylenedioxythiophene) (PEDOT) polymerized on the CuO-coated surface, resulting in an enhanced sensor performance with an ultra-fast response/recovery of 0.3/0.5 s.
研究领域:
材料科学
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环境监测
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传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2024
·
IF 10.7
Jiawang Hu,Nanlin Hu,Donglei Pan,Yan Zhu,Xuan Jin,Shikai Wu,Yuan Lu
Non-invasive detection of tumors is of utmost importance to save lives. Nonetheless, identifying tumors through gas analysis is a challenging task. In this work, biosensors with remarkable gas-sensing characteristics were developed using a self-assembly method consisting of peptides and MXene . Based on these biosensors, a mimetic biosensor array (MBA) was fabricated and integrated into a real-time testing platform (RTP). In addition, machine learning (ML) algorithms were introduced to improve the RTP's detection and identification capabilities of exhaled gas signals. The synthesized biosensor, with the ability to specifically bind to targeted gas molecules, demonstrated higher performance than the pristine MXene , with a response up to 150% greater. Besides, the MBA successfully detected 15 odor molecules affiliated with five categories of alcohols, ketones , aldehydes, esters, and acids by pattern recognition algorithms. Furthermore, with the ML assistance, the RTP detected the breath odor samples from volunteers of four categories, including healthy populations, patients of lung cancer, upper digestive tract cancer, and lower digestive tract cancer , with accuracies of 100%, 94.1%, 90%, and 95.2%, respectively. In summary, we have developed a cost-effective and precise model for non-invasive tumor diagnosis. Furthermore, this prototype also offers a versatile solution for diagnosing other diseases like nephropathy, diabetes, etc.
研究领域:
医学
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生物传感技术
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人工智能辅助医疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
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2022
·
IF 9.224
Huocheng Lv,Peng Du,Weiping Li,Laihui Luo
To settle the challenges of optical thermometry with high sensitivity, a series of Tm3+/Yb3+-codoped Y2Mo3O12 (YMO:Tm3+/2xYb3+) submicron particles were developed via a sol–gel route. Excited by 980 nm, bright upconversion (UC) emissions of Tm3+ are observed, in which the optimum intensity is realized when the Yb3+ concentration is 13 mol %. Moreover, the UC mechanism of the emissions originating from the 1G4 level is a three-photon absorption process, while that of the emission from the 3F2,3 level is a two-photon absorption process. Furthermore, thermally enhanced emission intensities are realized in the studied compounds due to the negative thermal expansion effect. Notably, owing to the coexistence of improved energy transfer and cross-relaxation processes at elevated temperature, the intensities of the UC emissions from the 1G4 level increase and then decrease with raising the temperature, whereas that of the UC emission from the 3F2,3 level is enhanced monotonously as temperature increases. Via analyzing the inconsistent thermal quenching characteristics of the UC emissions, we explored the thermometric behaviors of the synthesized products and found that their sensitivities are dependent on the spectral mode. Through investigating the dependence of the emission intensity rate of the emissions from 3F2,3 → 3H6 to 1G4 → 3F4 transitions on temperature, one knows that the maximum absolute and relative sensitivities of the resultant submicron particles are 0.198 K–1 and 3.27% K–1, respectively. Additionally, the thermometric behaviors of YMO:Tm3+/2xYb3+ submicron particles can also be manipulated via altering the Yb3+ concentration.
研究领域:
材料科学
·
光学
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产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2022
·
IF 6.371
Zifan Zhu,Zheng Li,Xiaoyan Xiong,Xuqi Hu,Xinqi Wang,Nian Li,Tao Jin,Yufang Chen
Oxygen vacancies ZnO/ZnSe heterojunction was designed by incorporating ZnSe into ZIF-8 derived ZnO followed by an annealing process. The as-prepared material possessed excellent acetone sensing properties even at low concentrations and is expected to be used in the non-invasive detection of diabetes in patients. Using a facile hydrothermal method , pristine ZnO and ZnSe were prepared, and then they were mixed and thermally annealed to form the composite. Subsequently, the materials were characterized by using various techniques such as XRD, XPS , EPR, etc. According to the sensing study, the highest response of the material in 1 ppm acetone was as high as 5.8, which was 2.3 times that of pure ZnO. In addition, the as-prepared composite was less sensitive to interfering gases, which indicates the feasibility of developing highly sensitive acetone sensors based on this material. Thus, the material prepared in this work may be applied to the non-invasive detection of diabetes in patients, and hence it is worthy to conduct further in-depth research.
研究领域:
材料科学
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医学传感器
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Yeguang Zhang,Yong Qi,Rongzi Wang,Tun Cao,Wei Ma,Shufen Zhang
Responsive photonic crystals (PCs), which can adjust structural colors in response to external stimuli, show great potential applications in displays, sensors, wearable electronics, encryption, and anticounterfeiting. In contrast, conventional structure-intrusive adjustment manners that external stimuli directly interact with the ordered arrays may lead to structural damage or longer response time. Here, a noninvasive adjustment of the structural colors of two-dimensional (2D) PCs (2D-PCs) is explored based upon diffraction theory. Sealed 2D-PCs and 2D inverse opal photonic crystal (IOPC) flexible devices are prepared. They are highly transparent in air but immediately exhibit intense viewing angle-dependent structural colors after being dipped in water. The mechanism of transparent-iridescent immediate transformation is explained by Bragg’s law. The design mechanism is examined by numerical simulation and spectral shifts in different external media. We demonstrate its applications in the fields of information encryption and anticounterfeiting by using the transparent-iridescent immediate transformation of sealed 2D-PC patterns and 2D IOPC free-standing films sealed on the product surface. Because of the strong contrast between transparency and intense iridescence, reversible and immediate transformation, and durability, sealed 2D-PCs and 2D IOPC flexible devices designed by the noninvasive adjustment strategy will lead to a variety of new applications in displays, sensors, wearable electronics, encryption, and anticounterfeiting.
研究领域:
材料科学
·
光学
·
应用物理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Electronic Materials
·
2025
·
IF 4.7
Kaushlendra Agrahari,Yu-Wu Wang,Chung-En Tsay,Yu-Han Cheng
In the modern era, excess nutrition and uncontrolled diets have given rise to numerous chronic diseases, with diabetes emerging as a significant concern. Regular monitoring of blood sugar is essential for patients, but the invasive nature of blood sampling causes discomfort, deterring frequent testing. Hence, the development of noninvasive methods is imperative. This study utilizes a blend of poly(3-hexylthiophene) (P3HT) and silver nanowires (Ag NWs) to craft organic field-effect transistors (OFETs) for highly sensitive glucose detection. Ag NWs exhibit a strong affinity for oxygen molecules, easily forming silver oxide and preventing the oxygen doping issue in P3HT, resulting in improved OFET characteristics. Additionally, the Schottky barriers between P3HT/Ag NWs are highly sensitive to the released hydrogen ions from glucose oxidation. Consequently, devices fabricated through this methodology demonstrate exceptional sensitivity for detecting extremely low concentrations of glucose solutions. The blended device outperforms pure P3HT, with a 10-times increase in the on/off ratio (∼104) and hole mobility (4 × 10–3 cm2/(V s)). While detecting a 10 μM glucose solution (same level as saliva), the blended device’s normalized response (NR) soared to 24.62. Additionally, for a 20 mM glucose solution (the same level as blood), the NR of P3HT/Ag NWs surged to 428.49, much higher than that of the pure P3HT. The proposed glucose sensor showed a detection limit of 6 μM and a wide linear detection range (10 μM–20 mM), which encompasses the glucose levels found in both saliva and blood. These superior features demonstrate the potential application of P3HT/Ag NWs transistors in the fabrication of a high-performance glucose sensor. This study yields a highly promising avenue for noninvasive blood glucose detection.
研究领域:
生物医学工程
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材料科学
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传感技术
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 27
·275712
·
IF 3.953
Yangchun Feng,Wangyang Yang,Yufang Li,Honglie Shen
In recent years, high-performance acetone gas sensors have attracted great attention for their potential in noninvasive blood glucose monitoring. In this work, black TiO2 (B-TiO2) was introduced as an electron trapping layer between TiO2 and ZnO to form TiO2@B-TiO2@ZnO core–shell nanoparticles, through a simple and safe method. The acetone sensing performance of TiO2@B-TiO2@ZnO varied with the thickness of ZnO. Because of the electron trapping effect of the introduced B-TiO2 layer, the best performing sample exhibited a low optimal operating temperature of 275 °C and a high response of 49.25–50 ppm acetone. In addition, a low detection limit of 170 ppb was obtained. The pretty selectivity of the sample was also been proved. The mechanism of enhanced acetone response was explained by the energy band-based model of TiO2@B-TiO2@ZnO core–shell nanoparticle and depletion layer theory.
研究领域:
材料科学
·
传感技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）