ChemistrySelect
·
2022
·Vol. 7
·期 35
·e202202252
·
IF 2.307
Yayi Li,Di Peng
Graphical A hydrophobic binding-driven and fluorescence-free development of aged latent fingerprints using silane modified zinc oxide nanoparticles both in positive and reversed imaging mode is proposed, exhibiting the high contrast, high sensitivity, high selectivity and wide applicability. The requirement of nonfluorescent developers for aged latent fingerprint development is still of great urgency in forensic science. To enhance the specific interaction between fingerprint residue and nano-developers, a γ-methacryloxy propyl trimethoxyl silane (MPTS) modified zinc oxide nanoparticle (ZnO NP) was synthesized. The crystal structure, morphology, surface functional group, thermostability, UV/Vis spectra, photoluminescence and stability of sedimentation were characterized to prove the hydrophobicity, UV blocking nature and nonfluorescence of as-prepared MPTS-modified ZnO NPs. Additionally, after the specific surface area (SSA) of samples with different MPTS amount was analyzed by BET, a competitive adsorption mechanism between silane-ZnO bonding and silane oligomer-ZnO deposition was suggested. In the demonstration of latent fingerprint development, the powder dusting method was utilized on various surfaces both in positive and reversed imaging modes, exhibiting the high contrast, high sensitivity, high selectivity and wide applicability, even for aged fingerprints. Therefore, it provides a new strategy for fast, efficient and inexpensive development of older latent fingerprints in forensic analysis.
研究领域:
法医学
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材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2023
·Vol. 41
·期 11
·1348-1354
·
IF 5.4
Xin-Yi Zhang,Kai-Li Tian,Jie Liu,Wittaya Ngeontae,Ai-Juan Zhao,Maxim V. Bermeshev,Shi-Qing Wong,Kaspars Traskovskis,Zhijian Chen,Xiang-Kui Ren
Comprehensive Summary A novel polyurethane polymer containing perylene diimide (PDI) unit and aniline segment, denoted as PU-PDI, was designed and synthesized. Their tensile property and photophysical characteristic were investigated using various experimental and theoretical techniques. It is found that the elongation of PU-PDIs can reach more than 1000%, indicating good tensile performance. Moreover, based on the photoinduced electron transfer mechanism, the aniline segments in polyurethane can quench the auto-fluorescence of PDI unit to a negligible value, which overcomes the intractable fluorescence drawbacks of conventional colour filters. The non-emissive characteristic, in combination with the good thermal stability and tensile property of PU-PDI, provides a feasible design strategy to fabricate optical filters with high display quality.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2019
·
IF 2.813
Nadeem Muhammad,Dandan Guo,Yun Zhang,Azeem Intisar,Qamar Subhani,Muhammad Abdul Qadir,Hairong Cui
Analysis of acidic pharmaceuticals in complex biological samples is a challenging and formidable task due to the existence of interfering constituents within the sample matrices. Therefore, in order to avoid analytical column clogging and suppression/enhancement of signals of the analyte of interest, herein a simple, cost-effective and quick online ion chromatography based clean-up setup was introduced. This system was further coupled with a cost-effective homemade photochemically induced fluorimetric (PIF) setup for direct online conversion of non-fluorescent acidic pharmaceutical drugs into their respective fluorescent species. This advantageous system was favorably applied for the determination of four non-fluorescent acidic compounds in two complex biological samples (human serum and oral fluid) with minimum labor and organic solvent consumption. At optimized conditions, the developed method has shown good sensitivity, selectivity, satisfactory recoveries (88.68–102.14%) and low limits of detection (0.35–8.10 μg/L) with minimum or zero matrix effect.
研究领域:
分析化学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Laicui Song,Jin Li
Surface-enhanced resonance Raman scattering (SERRS) in the second near-infrared (NIR-II) window has great potential for improved phototheranostics, but lacks nonfluorescent, resonant and high-affinity Raman dyes. Herein, it is designed and synthesize a multi-sulfur Raman reporter, NF1064, whose maximum absorption of 1064 nm rigidly resonates with NIR-II excitation laser while possessing absolutely nonfluorescent backgrounds. Ultrafast spectroscopy suggests that the fluorescence quenching mechanism of NF1064 originates from twisted intramolecular charge transfer (TICT) in the excited state. Gold nanorods (AuNRs) decorated with such nonfluorescent NF1064 (AuNR@NF1064) show remarkable SERRS performances, including zero-fluorescence background, femtomolar-level sensitivity as well as superb photostability without fluorescence photobleaching. More importantly, AuNR@NF1064 exhibits a nonlinear photothermal effect upon plasmonic fields of AuNRs by amplifying the non-radiative decay of nonfluorescent NF1064, thus achieving a high photothermal conversion of 68.5% in NIR-II window with potential for further augmentation. With remarkable SERRS and photothermal properties, the NIR-II nanoprobes allow for high-precision intraoperative guided tumor resection within 8 min, and high-efficient hyperthermia combating of drug-resistant bacterial infection within living mouse body. This work not only unlocks the potential of nonfluorescent resonant dyes for NIR-II Raman imaging, but also opens up a new method for boosting photothermal conversion efficiency of nanomaterials.
研究领域:
生物医学工程
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纳米医学
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光学成像
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光热治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Li Bowei,Qi Ji,Liu Feng,Zhao Rongfang,Arabi Maryam,Ostovan Abbas,Song Jinming,Wang Xiaoyan,Zhang Zhiyang,Chen Lingxin
Fluorescence analysis is a fast and sensitive method, and has great potential application in trace detection of environmental toxins. However, many important environmental toxins are non-fluorescent substances, and it is still a challenge to construct a fluorescence detection method for non-fluorescent substances. Here, by means of charge transfer effect and smart molecular imprinting technology, we report a sensitive indirect fluorescent sensing mechanism (IFSM) and microcystin (MC-RR) is selected as a model target. A molecular imprinted thin film is immobilized on the surface of zinc ferrite nanoparticles (ZnFe 2 O 4 NPs) by using arginine, a dummy fragment of MC-RR. By implementation of IFSM on the paper-based microfluidic chip, a versatile platform for the quantitative assay of MC-RR is developed at trace level (the limit of detection of 0.43 μg/L and time of 20 min) in real water samples without any pretreatment. Importantly, the proposed IFSM can be easily modified and extended for the wide variety of species which lack direct interaction with the fluorescent substrate. This work offers the potential possibility to meet the requirements for the on-site analysis and may explore potential applications of molecularly imprinted fluorescent sensors.
研究领域:
环境科学
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分析化学
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纳米技术
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 10
·4756-4761
·
IF 3.925
Liping Lin,Qiaoling Zheng,Qiushuang Chen,Meng Fang,Qingjiao Lai,Xinghao He,Jinying Qin,Zu-jin Lin,Rongguang Lin
Fluorescent polydopamine nanoparticles (PDA NPs) have been effectively synthesized by means of self-polymerization of dopamine under the strong alkaline condition of ethylenediamine at room temperature for 2.5 h. The obtained PDA NPs displayed excellent optical properties under the conditions of high ion strength and wide pH range. Utilizing the fluorescent signal of PDA NPs, a fluorescence turn-off sensor for tartrazine detection is proposed. The fluorescence signal changes linearly depending on the tartrazine concentration range of 1.5–45 μM, and a detection limit of 0.55 μM was obtained. The mechanism studies showed that the fluorescence quenching procedure is ascribed to the combined effects of the inner filter and the generation of non-fluorescent ground state complexes between PDA NPs and tartrazine via strong electrostatic interactions. The satisfactory results of the proposed sensor when applied to tartrazine detection in soft drinks and candies promise its practicality for real food samples.
研究领域:
分析化学
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纳米技术
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食品科学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-23
·
IF 12.6
Zou Lan,Wang Rujing,Zhao Mengnan,Li Yuke,Sun Chen,Xie Jinjin,Chen Yan,Jing Qian,Mi Dandan,Shi Sanjun
Pyroptosis, a recently identified cellular demise regulated by gasdermin family proteins, is emerging as a promising avenue in cancer immunotherapy. However, the realm of light-controlled pyroptosis in cancer cells remains largely unexplored. In this study, we took a deliberate approach devoid of any chemical alterations to develop a novel photosensitizer called “pharmaceutical-dots (pharm-dots)” by combining nonemissive polymers (Poly (lactic-co-glycolic acid), PLGA) with nonfluorescent invisible molecules like curcumin, berberine, oridonin into PLGA nanoparticles (PLGA-NPs). Initially, our research commenced with a comprehensive mechanistic comparison study, consolidating fragmented information on optical mechanisms. This exploration revealed that surface passivation atoms play a dominant role in governing the fluorescence emission of PLGA-NPs. Remarkably, these new luminophores, composed of two non-inherently luminous components, exhibit a remarkable synergistic boost in photoluminescence through a “0 + 0 > 2” phenomenon. In-depth investigations uncovered that these luminous PLGA-NPs, capable of generating 1 O 2 , induce pyroptosis under photoexcitation conditions through the caspase-3/gasdermin E (GSDME) pathway. Simultaneously, our findings highlight PLGA-NPs as a novel optical formulation suitable for imaging, displaying substantial biological activity when paired with photoirradiation. This discovery holds the potential to facilitate the application of light-controlled pyroptosis in antitumor therapy, marking a promising stride toward innovative approaches in cancer treatment. Graphical abstract
研究领域:
癌症研究
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生物光子学
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纳米技术
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免疫疗法
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Caixia Qi,Lin Shen,Jin Li,Xun Sun,Lehui Song,Jiadong Chen,Yixuan Wu,Jaebum Choo,Lingxin Chen
Near-infrared (NIR) surface-enhanced resonance Raman (SERRS) nanoprobes have found wide applications in biomedicine; however, almost all of these nanoprobes are fluorescent because the resonant Raman dyes used cannot be fully quenched onto the underlying plasmonic nanoparticles. Therefore, suppressing the fluorescence backgrounds in resonant Raman spectroscopy imaging is extremely important. In this work, we use a black hole quencher, IQ1, as a Raman dye to develop absolutely nonfluorescent NIR resonant SERRS NPs. Ultrafast spectroscopy clarifies that the nonfluorescent mechanism of the dyes is attributed to the ultrafast internal conversion at the subpicosecond scale, which quenches the fluorescence of excited states. The resultant nanoprobes exhibit zero fluorescent background, femtomolar-level sensitivity (100 fM) as well as superb photostability (τ = 10006 s) without fluorescence photobleaching, outperforming that of fluorescent counterparts. More importantly, the SERRS NPs show a synergistic photothermal effect originating from the dye molecule-plasmon interactions, achieving a high photothermal conversion efficiency of 64.94%. Featuring these excellent properties, these SERRS NPs allow for longitudinally photostable cellular imaging and enhanced photothermal elimination of cancer cells. To the best of our knowledge, this is the first example of absolutely nonfluorescent NIR SERRS NPs, opening up promising applications for improved phototheranostics.
研究领域:
生物医学工程
·
纳米技术
·
光学光谱学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）