JOURNAL OF NATURAL PRODUCTS
·
2024
·
IF 3.3
Weihong Wang,Jiaxu Shang,Shupeng Yin,Kunyu Xia,Rui Ma,Weiming Zhu,Peng Fu
Metabolites with high chemical reactivity serve important roles in chemical defenses of organisms. Formaldehyde, as a simple and highly reactive small molecule, can be produced by microorganisms, plants, and animals. Its toxicity is well known, but information about its other biological functions remains scarce. Here, we report that the natural product SEK34b produced by Streptomyces species can react nonenzymatically with formaldehyde in water to yield the methylene-bridged dimer phaeochromycin F. This process can eliminate the toxic substance formaldehyde produced by Staphylococcus aureus. Furthermore, there is a substantial inhibitory impact of phaeochromycin F on S. aureus. We hypothesize that these constitute an integrated system of defense and attack of Streptomyces species against competitors. Our study indicates that formaldehyde can react with vancomycin and tigecycline under mild conditions to generate the derivatives bearing an imidazolidin-4-one moiety, thereby reducing the antibacterial activity of these antibiotics. These data provide a possible chemical interaction mechanism of bacteria involving the nonenzymatic reactions of formaldehyde with highly reactive natural products.
研究领域:
微生物学
·
生物化学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Hui Xue,Jingli Yin,Weifeng Li,Yumei Long
The exploration of enzyme-mimic nanocomposites to replace commercial enzymes is challenging in the construction of biosensors with high performance. Herein, an ultrafast response nonenzymatic glucose sensor was developed based on a Cu2O–TiO2/Ti3C2Tx nanocomposite, which was prepared via an in situ redox procedure using Ti3C2Tx nanosheets both as a reducing agent and a carrier substrate. Structural characterizations, including X-ray diffraction (XRD) and transmission electron microscopy (TEM), revealed that Cu2O nanoparticles with a size of 10–30 nm are uniformly distributed on the surface of the Ti3C2Tx nanosheets and form close contacts through Ti–O–Cu bonds, resulting in favorable stability of the system. The unique heterostructure of Cu2O–TiO2/Ti3C2Tx can produce abundant active sites and facilitate electron transfer, demonstrating enhanced catalytic activity in the electrooxidation of glucose. Consequently, the electrochemical sensor fabricated by modifying a glassy carbon electrode (GCE) with Cu2O–TiO2/Ti3C2Tx nanocomposites exhibited excellent analytical properties for glucose detection, including a fast response time of 0.1 s, a low detection limit of 0.67 μM, and a high sensitivity of 267 μA mM–1 cm–2. In addition, the developed method possesses good anti-interference ability and superior stability and thus has been successfully applied for real sample monitoring. This study offers a way to construct Ti3C2Tx-based heterostructures with tunable physiochemical properties and expands their use in the electrochemical field.
研究领域:
材料科学
·
电化学
·
生物传感
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 11
·117501
·
IF 3.721
Ziyin Yang,Xiao Bai,Chengcheng Qi
NiCo layered double hydroxide (NiCo-LDH) was explored as electrocatalyst for nonenzymatic detection of H2O2, in which NiCo-LDH with different morphologies were synthesized through a hydrothermal method, and then acid-etched NiCo-LDH (E-NiCo-LDH) was obtained via an acid-base reaction. The morphology, composition and structure were characterized by transmission electron microscopy and X-ray diffraction. Electrochemical measurements reveal that E-NiCo-LDH exhibits an excellent electrocatalytic activity toward H2O2 oxidation and the sensor based on E-NiCo-LDH is able to detect H2O2 in a linear range of 2.0 μM to 1.1 mM with a high sensitivity of 728.6 μA mM−1 cm−2 and a low detection limit of 0.2 μM (S/N = 3). This indicated that E-NiCo-LDH is a promising material for electrochemical sensing of H2O2.
研究领域:
材料科学
·
电化学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Qiu-Lan Liu,Yang Yi,Shi-Qi Wang,Hong-Xun Wang,Wei Xu,Ting Min,Li-Mei Wang
Lotus root is the most consumed aquatic vegetable in China. Both the actual boiling of lotus root and the simulated boiling of its extract were performed at different conditions to explore the development of non-enzymatic browning and the loss of reducing sugars, free amino acids, total free phenols and ascorbic acid. The kinetic parameters of zero-order and first-order models indicated that both browning degree and nutrient loss had a positive correlation with boiling time, temperature and pH value. Moreover, nutrient contents and boiling conditions were adopted as independent variables to establish the multiple linear regression model of browning degree ( P < 0.001), which confirmed that reducing sugars and total phenols principally contributed to the browning ( P < 0.01), through caramelization and phenol oxidation. With the addition of baking soda (pH 8), 100 °C boiling decreased the DPPH radical scavenging capacity and ferric reducing antioxidant power of lotus root extract by 62.96% and 58.51%, respectively. Furthermore, 120 °C boiling probably induced the formation of browning products, which possessed cytotoxicity against HepG2 and L02 cells. A short boiling time, as well as an acidic condition induced by added vinegar, is recommended for cooking and processing of lotus root in consideration of nutrition and health.
研究领域:
食品科学
·
植物学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Chengcheng Qi,Wei Xiang,Yongping Dong,Wangbing Zhang
The development of new highly active electrocatalysts is one of the key factors to improve the performance of enzyme-free electrochemical sensors . In this paper, Co 3 V 2 O 8 was proposed as a new electrocatalyst for nonenzymatic oxidation of H 2 O 2 . A facile self-templating strategy was adopted for the synthesis of Co 3 V 2 O 8 nanomaterial which was further characterized by transmission electron microscopy (TEM), powder X-ray diffractometry (XRD), fourier translation infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and electrochemical techniques . The results showed that porous Co 3 V 2 O 8 sphere was constructed from interconnected nanoparticle with a three-dimensional porous structure. Such unique structure made the sensor based on Co 3 V 2 O 8 exhibit good electrocatalytic activity toward H 2 O 2 oxidation, and could detect H 2 O 2 with a low detection limit of 0.34 µM, a wide linear range of 2.0 µM to 6.1 mM and a high sensitivity of 541.4 µA mM −1 cm −2 . This work demonstrated an effective new sensing platform for nonenzymatic detection of H 2 O 2 .
研究领域:
材料科学
·
分析化学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
SURFACE REVIEW AND LETTERS
·
2018
·
IF 0.734
MAO ZHOU,XIAOCAI LIANG,YUQING MIAO
The preparation of ultrathin Ni layer onto the surface of glassy carbon electrode (GCE) by molecule anchoring method was studied in this paper in which two steps were involved: molecule anchoring (GCE-M) and ultrathin Ni layer adsorption (GCE-M-Ni). The result showed that by simply anchoring some molecules (purpald, bismuthiol I, DPTA, EDTA-2Na, ferrotitanium and thiourea) onto the surface of GCE, the adsorption of Ni layer would be improved relatively, thus improving the electrocatalytic ability of GCE toward sucrose, fructose and glucose. It was believed that the anchoring of these molecules helped the following adsorption of Ni layer. Good electrocatalytic characteristics for sugars oxidation of GCE-purpald-Ni were observed in this work with the immediate response, wide linear range from 0 μ M to 800 μ M and low detection limit down to 0.49 μ M for the sensing of total sugar (TS) concentration. The common interfering molecule such as ascorbic acid was proved of no interfering effect on the detection. Also, GCE-purpald-Ni was successfully applied to detect TS concentration in orange juice samples with high recovery rate of more than 85%. It is concluded that the molecule anchoring method can be used to the adsorption of ultrathin Ni layer onto the surface of GCE and works as one of the promising nonenzymatic sensings toward sugars.
研究领域:
分析化学
·
电化学
·
生物传感
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2013
·
IF 3.777
Yuqing Miao,Zhuoyuan Yang,Xiaoyan Liu,Lina Xu,Lei Ouyang,Yingying Gu,Haizhou Chang,Ruizhuo Ouyang
Bismuth has been attracting research interest in recent decades due to its unique properties. Especially, there is a great difference for bismuth between its surface and bulk material properties in which the surfaces are much better metals than the bulk. A ultrathin layer of bismuth was adsorbed onto platinum electrode surface by simple self-assembly. Compared with bare platinum electrode, two greatly increased oxidation peaks were observed at negative and positive potential area with the obtained Bi III -Pt electrode, where Bi 0 or Bi III tends to adsorb more OH which is shared by the below adjacent platinum atom to form a structure of Pt-OH with high electrocatalytical activity. The Bi III -Pt electrode gives high sensitivity and excellent linearship of non-enzymatic glucose sensing, showing potential application for fuel cell, electrocatalysis and electroanalysis.
研究领域:
材料科学
·
电化学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 26
·10073-10080
·
IF 0
Xiaozhe Zhang,Shaodong Sun,Jian Lv,Linli Tang,Chuncai Kong,Xiaoping Song,Zhimao Yang
We have demonstrated a facile anion-assisted strategy for the synthesis of nanoparticle-aggregated CuO nanoellipsoids. Structural and morphological evolutions were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), and field-emission scanning electron microscopy (FESEM). The nanoparticle-aggregated CuO nanoellipsoids serve as a promising electrode material for a non-enzymatic glucose biosensor which shows high sensitivity, good reproducibility, a fast amperometric response and good selectivity. The study is of great importance in the bottom-up assembly of tunable ordered architectures, and offers a chance to understand the formation mechanism and fundamental significance of an anion-assisted strategy for the synthesis of metal oxides. Significantly, it is believed that the anion-assisted synthetic approach reported here could provide a facile way to design more novel metal oxide architectures with well-defined shapes.
研究领域:
材料科学
·
生物传感器
·
电化学
✓ 已验证
产品关联
DOI
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Chengcheng Qi,Chongchao Zhang,Ziyin Yang
Defect engineering was considered as an effective strategy to regulate electrocatalytic activities of transition metal oxides . However, there are seldom reports about metal defects in electrochemical sensing. In this work, Co-defected Co 3 O 4 was synthesized via thermal treatment of glycerolatocobalt (CoGly) precursor for constructing a novel electrochemical nonenzymatic glucose sensor. The obtained nanomaterials were characterized by transmission electron microscopy (TEM), powder X-ray diffractometry (XRD), Raman spectra , X-ray photoelectron spectroscopy (XPS) and electrochemical techniques . The presence of Co defects regulated electronic structure of Co 3 O 4 , which not only speeds up electron transfer rate but also exposes more high-valent Co sites, thus improving electrocatalytic activities. Under optimized conditions, Co-defected Co 3 O 4 electrode exhibited excellent performance for glucose analysis with a wide linear range of 0.2 µM to 0.5 mM, a low detection limit of 0.16 µM. Importantly, an ultrahigh sensitivity of 2595.7 µA·mM −1 ·cm −2 was also obtained, which was about 10 times higher than that of conventional Co 3 O 4 . Therefore, engineering Co 3 O 4 with Co defects is an effective strategy to tailor electrocatalytic activity, which sheds light on the potential applications of metal defects in the field of electrochemical nonenzymatic sensing.
研究领域:
材料科学
·
电化学传感
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2021
·Vol. 10
·期 2
·419
·
IF 4.35
Pei Hu,Zhentao Sun,Yunwen Shen,Yiwen Pan
Hydrogen peroxide (H2O2) has been reported to be used for the illegal treatment of fishery products in order to obtain “fake” freshness. Residues of H2O2in food may be of toxicology concern. In this study, a nonenzymatic sensor was developed based on Fe@PCN-224 metal–organic frameworks wrapped by Nafion to detect H2O2concentration. The hybrid structure of Fe@PCN-224 was fabricated by incorporated free FeIIIions into the center of PCN-224, which was ultra-stable due to the strong interactions between Zr6and the carboxyl group. Scanning electron spectroscopy images exhibited that Nafion sheets crossed together on the surface of Fe@PCN-224 nanoparticles to form a hierarchical and coherent structure for efficient electron transfer. Electrochemical investigations showed that the Fe@PCN-224/Nafion/GCE possessed good linearity from 2 to 13,000 μM (including four orders of magnitude), low detection limits (0.7 μM), high stability in continuous monitoring (current remained nearly stable over 2300 s) and in long-term measurement (current decreased 3.4% for 30 days). The prepared nanohybrid modified electrode was effectively applied to H2O2detection in three different fishery products. The results were comparable to those measured using photometrical methods. The developed electrochemical method has a great potential in detecting the illegal management of fishery products with H2O2.Keywords:Fe@PCN-224;Nafion;nonenzymatic sensor;hydrogen peroxide;fishery products
研究领域:
食品安全检测
·
电化学分析
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 29
·12723-12728
·
IF 3.288
Haiyan Wu,Yu Yan,Qingshuang Huang,Guobin Liang,Fengxian Qiu,Zhaolian Ye,Dan Liu
Copper and nitrogen co-doped carbon quantum dots (Cu,N-CQDs) were prepared by a facile hydrothermal treatment, and they were further employed as a novel sensing material for fabricating a sensitive non-enzymatic glucose sensor. The morphologies and structures of the as-prepared materials were characterized by using UV-vis spectrophotometry, fluorescence (FL) spectrophotometry, Fourier transform infrared (FT-IR) spectrophotometry, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). It is interesting to note that the introduction of Cu into the as-prepared Cu,N-CQDs caused a ca. 4-fold increase over that of N-CQDs in the electrocatalytic oxidation peak current of glucose. The proposed sensor showed excellent sensitivity and selectivity for glucose detection in alkaline medium with a linear range of 5–700 μM, and the detection limit was calculated to be 1.22 μM (S/N = 3). Furthermore, the as-prepared sensor was utilized to detect glucose in a fermentation sample, suggesting the Cu and N co-doped CQDs as a promising candidate for fabricating sensors for the quantification of glucose.
研究领域:
分析化学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2015
·
IF 6.409
Zheng-peng Yang,Xuan Liu,Chun-jing Zhang,Bao-zhong Liu
Transparent photocatalytic surfaces are of ever increasing importance for the enhancement of the photocatalytic efficiency. Here, the highly ordered transparent TiO 2 nanotube arrays were prepared by the anodization and thermal annealing of titanium layer deposited onto the glass substrate , and a novel nonenzymatic piezoelectric sensor was developed for urea detection based on the modification of molecularly imprinted TiO 2 thin film onto transparent TiO 2 nanotube arrays. The performance of the fabricated sensor was evaluated and the results indicated that the sensor exhibited high sensitivity in urea detection, with a linear range from 0.04 to 120 μM and a limit of detection of 0.01 μM. Moreover, the sensor presented outstanding selectivity while used in coexisting systems containing various interferents with high concentration. The analytical application of the urea sensor confirmed the feasibility of urea detection in urine sample.
研究领域:
生物传感技术
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）