Materials Chemistry Frontiers
·
2018
·Vol. 2
·期 11
·2109-2115
·
IF 0
Fuqiang Fan,Shiqian Gao,Shaobo Ji,Yu Fu,Pengpeng Zhang,Huaping Xu
The combination of chemotherapy and radiotherapy could not only enhance cancer treatment efficacy, but also shorten the period of the overall treatment and relieve the anxiety of the patients during the remedy. Herein, we present a novel strategy for coordinating the chemotherapy drug CDDP with a tellurium-containing polymer, which restrained the tumour cytotoxicity of these two portions. After a low dose of γ radiation, CDDP departed from the coordination complexes, and the tumour cytotoxicity of both was restored. In contrast to conventional chemotherapy, this radiation responsive system possesses specific anticancer effects and less toxicity in the non-radiation therapy. In addition, with regard to the premise of therapeutic efficiency, this system effectively lowered the radiated dosage.
研究领域:
肿瘤学
·
聚合物化学
·
放射治疗
✓ 已验证
产品关联
DOI
Bioengineering & Translational Medicine
·
2021
·Vol. 7
·期 2
·e10270
·
IF 10.711
Chaosheng Yu,Zhen Long,Qianhui Qiu,Fang Liu,Yiming Xu,Tao Zhang,Rui Guo,Wen Zhong,Shuixian Huang,Shuaijun Chen
One of the main clinical treatments for advanced nasopharyngeal carcinoma is chemotherapy, but systemic administration can cause serious adverse reactions. New type of nanomaterial which can actively targeting, imaging, and treating nasopharyngeal carcinoma at the same time to enhance the effect of chemotherapy, meanwhile monitoring the intracellular drug release process at the level of single cancer cell was urgently needed. GE11, an EGFR antagonist peptide, was used to target nasopharyngeal carcinoma which has positive expression of EGFR on its nucleus. GE11-modified graphene quantum dots (GQDs@GE11) were used as drug carriers for clinical chemotherapeutics cisplatin (CDDP) and doxorubicin (DOX). The emission spectrum of GQDs (460 nm) and the excitation spectrum of DOX (470 nm) have a good overlap, thus the transfer and release process of DOX can be sensitively detected by the fluorescence resonance energy transfer (FRET). CDDP was used to enhance the chemotherapy effect of nanoprobe, and the loading amount of DOX and CDDP on GQDs@GE11 nanoprobe were up to 67 and 50 mg/g, respectively. In vivo experiments have confirmed that GQDs@GE11/CDDP/DOX nanoprobe can be enriched to tumor site through specific targeting effect, and significantly inhibit tumor cell proliferation. This new type of targeted therapy fluorescent probe provides new ideas for the study of drug release process and the treatment of nasopharyngeal carcinoma.
研究领域:
纳米技术
·
肿瘤学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Yanhui Zhang,Xinyuan Zhang,Liang Zhang,Jinpeng Yao,Shige Wang,Jiulong Zhao,Hongxin Sun,Zhaoshen Li
Cisplatin (cis-diammine-dichloro-platinum II, CDDP) is one of the most commonly used chemotherapeutic agents for the treatment of esophageal cancer, and its clinical application has been greatly limited due to non-specific administration, severe systemic toxicity, and reduced efficacy due to drug resistance. The special physicochemical properties of hydrogels enable them to achieve a sustained controlled release of CDDP and to maintain high local drug concentrations over a long period, but the problem of drug resistance still needs to be addressed. Herein, CS-BA-PVA, a pH-responsive hydrogel is used to co-load CDDP and divalent copper ion (Cu 2+ ) for constructing a drug delivery system CS-BA-PVA@Cu/CDDP to achieve controlled and sustained drug release. Once reaching the acidic tumor microenvironment (TME), CS-BA-PVA@Cu/CDDP specifically responds and disassembles to release CDDP for chemotherapy against cancer. Besides, the simultaneous release of Cu 2+ can deplete the intracellular glutathione (GSH) for increased toxicity of CDDP as well as catalyzing the decomposition of intra-tumoral H 2 O 2 into highly toxic •OH for chemodynamic therapy (CDT). Moreover, the substantially reduced GSH can also protect the yielded •OH from scavenging and thus greatly improve the •OH-based CDT effect. In addition to providing a new drug delivery system CS-BA-PVA@Cu/CDDP, this study is also expected to establish a new form of TME-responsive carrier for highly efficient tumor-specific GSH-depletion-enhanced synergistic chemotherapy/chemodynamic therapy.
研究领域:
药学
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癌症研究
·
纳米技术
·
药物递送系统
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2021
·Vol. 10
·期 21
·2101199
·
IF 9.933
Haihui Wang,Yongfei Liu,Xiaohui Zhu,Chengyun Chen,Zhangcheng Fu,Min Wang,Danying Lin,Zhaowei Chen,Chunhua Lu,Huanghao Yang
Combinatorial CpG oligonucleotide (CPG) and chemotherapy drug represent a promising approach to reactivate immune system. However, these two agents possess different physicochemical properties, hindering the application of direct self-assembly of these two cargos into a single nanostructure. Here, a multistage cooperative nanodrug is developed by the direct self-assembly of cis-platinum (CDDP, Pt), l -arginine ( l -Arg, R), and CPG (defined as PtR/CPG) for antitumor chemoimmunotherapy. First, the CDDP can induce cell apoptosis. Meanwhile, CDDP also promotes the production of H 2 O 2 , catalyzing the conversion of l -Arg into nitric oxide (NO). The generated NO decreases the multidrug resistance of cells toward CDDP. Thus, the synergistic effects of CDDP and NO can trigger immunogenic cell death to produce tumor-associated antigens (TAAs). The TAAs and CPG will induce the maturation of dendritic cells (DCs) and enhance antigen presentation ability of DCs. In this way, the PtR/CPG can reverse the immunosuppressive microenvironment, sensitizing tumors to immune checkpoint inhibitors mediated by the programmed death-ligand 1 (PD-L1) antibody. Furthermore, the PtR/CPG combined with the PD-L1 antibody decreases the exhaustion and dysfunction of cytotoxic T lymphocytes to elicit durable systemic immune response. As a result, the prepared PtR/CPG nanodrug in combination with PD-L1 may be highly significant for cancer immunotherapy.
研究领域:
癌症免疫治疗
·
纳米技术
·
药学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）