Near-infrared AIEgens for lipid droplets imaging in corpus adiposum or trachea of Locusta migratoria and its application in photodynamic therapy
To recognize the lipid droplets (LDs) on the surface of trachea and realize the visualization of trachea, three TPA-based red/NIR fluorophores with high electron donor-acceptor (D-A) strength were designed and synthesized. These molecules showed donor-donor-π-acceptor (D 1 -D 2 -π-A) structure with the character of twisted intramolecular charge transfer (TICT). The photophysical experiment displayed that they had aggregation-induced emission (AIE) performance with red/NIR fluorescence. These AIEgens showed high sensitivity to LDs in living PC12 cells and excised corpus adiposum of Locusta migratoria . The visualization of the trachea is realized due to the large number of LDs distributed on the surface. Also, such compounds can effectively produce reactive oxygen species (ROS) with the irradiation of white light, demonstrating the potential photodynamic therapy (PDT) application on cancer cells. Moreover, the simulated experiment of ROS transferring from LDs simulator (trioctanoin) to cytoplasmic matrix (PBS) was carried out.
危险品化学品经营许可证（带存储）