POLYMER DEGRADATION AND STABILITY
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2020
·
IF 4.032
Yuehan Qian,Fuhao Dong,Lizhen Guo,Jiawen Guo,Hiba Shaghaleh,Yuqi Wang,Xu Xu,Shifa Wang,Shiwei Liu
Limonene is an important subsidiary agricultural product obtained from orange peel that can also be prepared by microbial engineering, but its application degree of deep processing is relatively lower. By studying the application of limonene to silicone rubber, the application field of limonene has been expanded. Triethoxy (2-(4-methylcyclohex-3-en-1-yl)propyl)silane (LTES) was synthesized by a hydrosilylation reaction in the presence of Karstedt's catalyst using limonene and triethoxysilane as raw materials. FT-IR and 1 H NMR were used to determine the structure of the product (LTES). Thereafter, a series of room temperature vulcanized (RTV) silicone rubbers was modified with the LTES cross-linking agent and hydroxy silicone oil under the catalytic action of dibutyltin dilaurate. The results showed that the tensile strength , elongation at break and heat resistance of the synthetic silicone rubber modified with LTES were significantly higher.
研究领域:
材料科学
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有机化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF VETERINARY MEDICAL SCIENCE
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2024
·
IF 1.1
Nianyuan CHEN,Qingxiu CAI,Shujing WANG,Qingyang SONG,Ying XIE,Huijuan SHI,Hongmei LI,Xiaomin ZHAO,Ningning ZHAO,Xiao ZHANG
Protozoan parasites such as Eimeria tenella and Toxoplasma gondii pose significant health challenges in livestock and humans. The limited treatment options and rising drug resistance underscore the urgent need for new therapies. This study investigates myrcene, a monoterpene hydrocarbon classified for its antiprotozoal potential against E. tenella and T. gondii infections. Initially, we examined its effect on the sporulation process of E. tenella oocysts in vitro and its anti-E. tenella activity in vivo. Myrcene significantly reduced the sporulation rate of E. tenella oocysts at 3 and 4 mg/kg. In vivo experiments demonstrated that treatment with 4 mg/kg myrcene significantly reduced E. tenella load and oocyst output, as well as cecal lesion and weight loss caused by E. tenella infection, showing moderate anti-E. tenella activity, with an Anticoccidial Index (ACI) of 161.4. Furthermore, we investigated the anti-T. gondii activity of myrcene both in vitro and in vivo. In vitro studies showed that treatment with myrcene effectively inhibited the invasion rate and intracellular proliferation ability of T. gondii tachyzoite in DF-1 cells in a dose-dependent manner. In vivo administration prolonged the survival time in T. gondii-infected mice, suggesting notable protective effects. Additionally, it mitigated T. gondii-induced hepatosplenic toxicity by reducing parasite load in the liver and spleen, and ameliorating liver function as evidenced by decreased serum transaminase levels. In conclusion, the findings demonstrate promising anti-E. tenella and anti-T. gondii activity exhibited by myrcene warranting further exploration into its mechanisms and potential therapeutic applications.
研究领域:
兽医学
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寄生虫学
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药理学
✓ 已验证
DOI
PubMed
高影响因子
Materials
·
2019
·Vol. 12
·期 21
·3515
·
IF 2.972
Binqing Sun,Lixin Lu,Yong Zhu
The diffusion of five flavor organic molecules, including D-limonene, myrcene, ethyl hexanoate, 2-nonanone, and linalool in low density polyethylene (LDPE) film were investigated by combined experimental and molecular dynamics (MD) simulation studies. The diffusion coefficients derived from the prediction model, experimental determination, and MD simulation were compared, and the related microscopic diffusion mechanism was investigated. The effects of the presence of the flavor organic molecules on the diffusion of O2and H2O in polyethylene (PE) were also studied by MD simulation. Results show that: The diffusion of five flavor molecules in LDPE is well followed to Fick’s second law by the immersion experiment; MD simulation indicates the dual mode diffusion mechanism of the flavor molecules is in LDPE; the diffusion coefficients from MD simulation are close to those from the experimental determination, but are slightly larger than those values; the presence of the flavor organic molecules hinders the diffusion of O2and H2O, which can be well explained from the fraction of free volume (FFV) and interaction energy calculation results derived from MD simulation.Keywords:flavor organic molecules;LDPE film;molecular dynamics simulation;diffusion
研究领域:
材料科学
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化学工程
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高分子科学
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLoS One
·
2021
·Vol. 16
·期 12
·e0260747
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IF 3.24
Yang Yang,Yipeng Chen,Jimiao Cai,Xianbao Liu,Guixiu Huang
The soil-born filamentous fungal pathogen Fusarium oxysporum f. sp. cubense (FOC), which causes vascular wilt disease in banana plants, is one of the most economically important Fusarium species. Biocontrol using endophytic microorganisms is among the most effective methods for controlling banana Fusarium wilt. In this study, volatile organic compounds (VOCs) showed strong antifungal activity against FOC. Seventeen compounds were identified from the VOCs produced by endophytic fungi Sarocladium brachiariae HND5, and three (2-methoxy-4-vinylphenol, 3,4-dimethoxystyrol and caryophyllene) showed antifungal activity against FOC with 50% effective concentrations of 36, 60 and 2900 μL/L headspace, respectively. Transmission electron microscopy (TEM) and double fluorescence staining revealed that 2-methoxy-4-vinylphenol and 3,4-dimethoxystyrol damaged the plasma membranes, resulting in cell death. 3,4-dimethoxystyrol also could induce expression of chitin synthases genes and altered the cell walls of FOC hyphae. Dichloro-dihydro-fluorescein diacetate staining indicated the caryophyllene induced accumulation of reactive oxygen species (ROS) in FOC hyphae. FOC secondary metabolism also responded to active VOC challenge by producing less fusaric acid and expressions of genes related to fusaric acid production were interrupted at sublethal concentrations. These findings indicate the potential of S . brachiariae HND5 as a biocontrol agent against FOC and the antifungal VOCs as fumigants.
研究领域:
植物病理学
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微生物学
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农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）