Mohammed Mustafa Yousif Modwi,Yafei Liu,Fuyuan Li,Ying Lv,Abdalbagi Ismail,Dafaalla Hassan,Huixia Feng
Herein, the eco-friendly corrosion inhibitor Schiff Bases Based on Chitosan has been successfully synthesized, and its new structure was characterized via Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance ( 1 H NMR). The efficiency of corrosion inhibitors was studied via classic weight loss, electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP) methods. The studies indicated that the Per/CS corrosion in 1.0 M HCl has mixed-type behavior with inhibition efficiency with 600 mg L -1 reaching 97 % at 25 °C. Thermodynamic calculations, such as the equilibrium constant of adsorption (K ads ) and the free energy of energy of adsorption (ΔG ads ), suggested that Per/CS exhibits a mixed mode of adsorption. The activation energy, enthalpy, and entropy were calculated and discussed. The results indicated the formation of a protective film of Per/CS inhibitor on the Q235 carbon steel surface, which was investigated via various techniques such as scanning electron microscopy (SEM), Water contact angle, and atomic force microscopy. The X-ray photoelectron spectroscopy indicated the existence of Per/CS molecules on the carbon steel surfaces. Quantum chemical calculations, DFT, and Fukui indices were also applied to describe the adsorption mechanism. Adsorption locator and MD simulations were also performed to describe the ability of the Per/CS molecule to adsorb on the Fe (110).
Zhu Ji-Xiao,Hu Wei-Qiong,Dong Shu-Qi,Yi Li-Tao,Zeng Jin-Xiang,Li Min
Background Perillaldehyde is one of the main components in perilla. Previous studies have shown that perillaldehyde exerted an antidepressant effect in mice, some of which is mediated through regulation of the anti-inflammatory system and the monoamine system. The primary objective of this study was to investigate the possible effects of perillaldehyde on the neurotrophic system and to elucidate whether its antidepressant effect requires brain-derived neurotrophic factor (BDNF) signaling. Methods Mice were exposed to chronic unpredictable mild stress (CUMS) and orally administrated with perillaldehyde for 4 weeks for behavioral testing. Results Perillaldehyde not only reversed the decrease in sucrose preference but also attenuated the increase in feeding latency. In addition, perillaldehyde can attenuate the reduction of CUMS-induced hippocampal BDNF levels. Our further study found that the BDNF receptor tropomyosin receptor kinase B (TrkB) antagonist K252a completely blocked the antidepressant effect of perillaldehyde in mice. Biochemical analysis showed that K252a pretreatment completely prevented the improvement of BDNF, extracellular signal-regulated kinase (ERK) phosphorylation and synaptic protein. Conclusions These results indicated that activation of BDNF-ERK signaling in the hippocampus was required, at least in part for the antidepressant effects of perillaldehyde.
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