Journal of Materials Chemistry B
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2023
·
IF 7
Zhaoying Wu,Rames Kaewmanee,Qianwen Yang,Zimin Wang,EN Xie,Jie Wei,Chao Zhang
Polymer-based composites possess some outstanding advantages over ceramic/metallic/polymeric biomaterials, which is considered as a promising candidate for bone repair. Tantalum (Ta)/polyimide (PI) biocomposites (PT) containing Ta nanoparticles of 20 v% (PT20) and 40 v% (PT40) were fabricated, and luteolin (LU) was loaded on PT40 (LUPT40). Compared with PT20 and PI, PT40 with high Ta content displayed high surface behaviors (e.g., roughness, surface energy, and hydrophilicity). PT40 remarkably improved the cell adhesion and multiplication, and LUPT40 with LU displayed further enhancement in vitro. Moreover, LUPT40 obviously boosted osteoblastic differentiation while suppressed the osteoclastic differentiation. Furthermore, LUPT40 exhibited good antibacterial effects because of the slow release of LU. The in vivo results confirmed that PT40 markedly promoted bone-formation, and LUPT40 further enhanced bone-formation/bone-bonding. In short, incorporation of Ta particles improved surface behaviors of PT40, which stimulated cell-response/bone-formation. Moreover, the slow release of LU from LUPT40 not only promoted cell-response/bone-formation but also enhanced bone-bonding. The synergistic effects of Ta and LU release from LUPT40 enhanced bone-formation/bone-bonding. Therefore, LUPT40 would have great potential for repair of bear-loading bone.
研究领域:
生物材料
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组织工程
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2021
·
IF 14.593
Xiyu Li,Juan Wu,Danxue Li,Qin Zou,Yi Man,Ling Zou,Wei Li
Insufficient early osteogenesis seriously affects the later stage osteogenic quality and osseointegration of dental implants. To promote early osteogenesis, we first designed a Ti dental implant with a built-in magnet (mTi) to produce a local static magnetic field (SMF). Then, a dental implantation system comprising the mTi implant and the superparamagnetic hydroxyapatite (HA:Yb/Ho–Fe, named HYH-Fe) particles was implanted into the alveolar bone of beagles. The results showed that the mTi + HYH-Fe group displayed better early osteogenesis and later stage osseointegration than the Ti + HA and mTi + HA groups. A combination of the local SMF (mTi) and superparamagnetic HYH-Fe particles had a positive effect on the pro-osteogenesis of Ti implants. The results also indicated that week 10 could be adopted as the key time point to evaluate the early osteogenic effect of the mTi + HYH-Fe implantation system, which would be a promising prospect for promotion of osteogenesis, in vivo tracking investigation of material-bone relationships, and clinical applications.
研究领域:
牙科学
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生物材料
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生物医学工程
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骨科学
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产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2023
·
IF 4.6
Mengxia Peng,Quanchao Zhang,Mengna Zhang,Zhiwei Yang,Yizao Wan,Xiaoyan Deng,Honglin Luo
Improved bone bonding ability and antibacterial activity are two critical requirements for implants. In this work, novel dual surface modifications of dealloying and polydopamine/silver coating on a NiTi alloy were conducted. Scanning electron microscopy (SEM) results show a porous layer with interconnected micro- and nano-pores on the dealloyed NiTi alloy. Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) results confirm the formation of a polydopamine/silver coating on the surface of the dealloyed NiTi alloy. The silver nanoparticles (58.9 nm, in the polydopamine/silver coating) on the dealloyed NiTi alloy surface are smaller when compared with pristine NiTi alloy (73.1 nm). Moreover, the dealloyed NiTi alloy with polydopamine/silver coating exhibits better antibacterial activity against Escherichia coli (99.7%) and Staphylococcus aureus (99.4%) than pristine NiTi alloy with the same coating (97.3% and 96.5%, respectively), due to the larger surface area, higher silver content, and smaller silver nanoparticles that trigger more silver ion release. The combined dealloying and coating method is an effective way of increasing antibacterial activity of NiTi alloys. The findings presented in this work may provide a new guidance for the surface modification of NiTi implant materials .
研究领域:
材料科学
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生物材料
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表面工程
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生物医学工程
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产品关联
DOI
高影响因子
Bio-Design and Manufacturing
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2022
·Vol. 5
·期 2
·233-248
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IF 5.887
Su Tingshu,Zheng Ao,Cao Lingyan,Peng Lingjie,Wang Xiao,Wang Jie,Xin Xianzhen,Jiang Xinquan
Following dental implantation, the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation, which can negatively impact osseointegration and cause implant failure. To improve soft tissue sealing around the implant, enhance osseointegration, and improve implant success rates, this paper proposes a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles, investigates the effects of this novel coating on cell adhesion, proliferation, antibacterial activity, osteogenic differentiation, and evaluates its immune-related properties. The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment. Furthermore, it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts, indicating its adhesion-promoting effect. Additionally, bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces. Notably, the PHG coating exhibited antibacterial activity against Streptococcus mutans , as well as anti-inflammatory effects, potentially via the regulation of macrophages. Therefore, the proposed PHG coating may promote soft tissue sealing and bone bonding, providing a potential strategy for the surface modification of dental implants.
研究领域:
牙科学
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生物材料
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组织工程
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）