Nanomaterials
·
2022
·Vol. 12
·期 21
·3830
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IF 5.719
Jun Gao,Hongyan Yang,Zehui Xiang,Biao Zhang,Xiaoping Ouyang,Fugang Qi,Nie Zhao
It is a challenge to develop cost-effective strategy and design specific microstructures for fabricating polymer-based impact-resistance materials. Human shin bones require impact resistance and energy absorption mechanisms in the case of rapid movement. The shin bones are exciting biological materials that contain concentric circle structures called Haversian structures, which are made up of nanofibrils and collagen. The “soft and hard” structures are beneficial for dynamic impact resistance. Inspired by the excellent impact resistance of human shin bones, we prepared a sort of polyurethane elastomers (PUE) composites incorporated with rigid carbon nanofibers (CNFs) modified by elastic mussel adhesion proteins. CNFs and mussel adhesion proteins formed bone-like microstructures, where the rigid CNFs are served as the bone fibrils, and the flexible mussel adhesion proteins are regarded as collagen. The special structures, which are combined of hard and soft, have a positive dispersion and compatibility in PUE matrix, which can prevent cracks propagation by bridging effect or inducing the crack deflection. These PUE composites showed up to 112.26% higher impact absorbed energy and 198.43% greater dynamic impact strength when compared with the neat PUE. These findings have great implications for the design of composite parts for aerospace, army vehicles, and human protection.Keywords:impact resistance;bone-like structures;carbon nanofibers;energy absorption
研究领域:
材料科学
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仿生工程
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复合材料
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2023
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IF 11.2
Hanyu Ren,Andi Guo,Chunhui Luo
Developing artificial substitutes that mimic the structures and performances of natural cartilage is of great importance. However, it is challenging to integrate the high strength , excellent biocompatibility, low coefficient of friction , long-term wear resistance, outstanding swelling resistance, and osseointegration potential into one material. Herein, a sandwich hydrogel with cartilage-mimetic structures and performances was prepared to achieve this goal. The precursor hydrogel was obtained by freezing-thawing the mixture of poly vinyl alcohol, chitosan and deionized water three cycles, accompanied by soaking in sodium hyaluronate solution. The top of the precursor hydrogel was hydrophobically modified with lauroyl chloride and then loaded with lecithin , while the bottom was mineralized with hydroxyapatite . Due to the multiple linkages (crystalline domains, hydrogen bonds , and ionic interactions), the compressive stress was 71 MPa. Owing to the synergy of the hydrophobic modification and lecithin , the coefficient of friction was 0.01. Additionally, no wear trace was observed after 50,000 wear cycles. Remarkably, hydroxyapatite enabled the hydrogel osseointegration potential. The swelling ratio of the hydrogel was 0.06 g/g after soaking in simulated synovial fluid for 7 days. Since raw materials were non-toxic, the cell viability was 100 %. All of the above merits make it an ideal material for cartilage replacement.
研究领域:
生物材料学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
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2021
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IF 8.198
Li Song,Ruixian Dai,Yijun Li,Qi Wang,Chuhong Zhang
As an effective way of power-to-electricity conversion, piezoelectric energy harvesters have received extensive attention in the past decade. However, the relationship between output performance and the topological structure of piezoelectric devices is still unknown. In this study, a simple and fast in-situ chemical foaming assisted fused deposited modeling (FDM) method was developed, and complex three-dimensional (3D) bioinspired bone structures of polyvinylidene fluoride (PVDF) were successfully fabricated. The hierarchical porous structure couples advantages of arbitrary shape design by 3D printing and abundant inner pores inside the printed piezoelectric parts that amplify the stress–strain effect and improve the output capacity. Moreover, with the assistance of ionic liquid, high β-phase content (86.72%) PVDF was achieved, producing an output of ∼13 V and a maximum current density of ∼0.27 μA/cm2, which outperforms most of the PVDF piezoelectric energy harvesters reported so far. Impressively, the as-prepared PVDF device can directly light up eight green LED bulbs and charge a 1 μF commercial capacitor to 3.65 V within 300 s. This work highlights a new 3D printing strategy integrated with a 3D biomimetic structural design for high-performance piezoelectric energy harvesting.
研究领域:
材料科学
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能源技术
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 59
·36923-36928
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IF 3.108
Yueyue Yin,Yong Yang,Liangzhu Zhang,Yongsheng Li,Zhiyuan Li,Weiwei Lei,Yunfeng Ma,Zhengren Huang
Here, we report a facile synthesis of Pd/Au nano-dogbones (NDBs) by loading massive Pd nanoparticles on the two ends of Au nanorods (NRs) via a seed-mediated method. The as-prepared samples were investigated by using TEM, elemental analysis, UV-vis and FDTD simulation. The photocatalytic activity of Pd/Au NDBs was assessed by dehydrogenation of formic acid under visible-to-NIR light irradiation. The Pd/Au NDBs shows much higher enhanced reaction activity compared with samples with core–shell structure due to the increased electron and hole pair separation and total catalytic sites. More importantly, the introduction of Au NRs broadens the photoresponse range and improves the utilization of sunlight efficiently. This finding provides a rational approach to improve photocatalytic performance by forming dogbone structures via integrating plasmonic metals and conventional catalysts.
研究领域:
材料科学
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化学
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产品关联
DOI
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
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2022
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IF 7.419
Hui Jin,Ningning Jiang,Wenshu Xu,Zhongyuan Zhang,Yang Yang,Jingmin Zhang,Hui Xu
In this experimental study, we evaluated the protective effects and the safety of main flavanones derived from Rhizoma Drynariae (Gusuibu) in vitro and in vivo. The MTT assay showed that compared with vehicle treatment, treatment with such flavanones as neoeriocitrin, naringin, and naringenin significantly promoted the viability of osteocyte-like cells. Quantitative real-time PCR showed that neoeriocitrin and naringin significantly attenuated mRNA expressions of RANKL and SOST in osteocyte-like cells. In rats with retinoic acid-induced osteoporosis, total flavonoid of Rhizoma Drynariae (TFRD) , naringin, and naringenin significantly increased the number of trabeculae and improved trabecular bone structure compared with no treatment, without affecting liver and renal function. In addition, naringenin and naringin administration significantly increased bone mineral density of femur neck and femur shaft compared with the osteoporotic model rats. Western blot analysis showed that naringenin and naringin significantly attenuated protein expressions of bone resorption-related factors (TRAP, RANKL and RANK), and inhibited sclerostin expression compared with the osteoporotic model rats. On the other hand, naringin markedly increased protein expressions of ALP and PTH1R, and TFRD and naringenin also promoted PTH1R expression compared with the model rats. In conclusion, such flavanones as naringenin and naringin exhibited antiresorptive properties, and naringin particularly showed potential benefits for osteoporosis treatment.
研究领域:
药理学
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骨科
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分子生物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Jianming Zhao,Ziyuan Fang,Bingxuan Wang,Jinming Li,Abudureheman Bahatibieke,Haoye Meng,Yajie Xie,Jiang Peng,Yudong Zheng
The distinctive composition and functions of osteochondral structures result in constrained regeneration. Insufficient healing processes may precipitate the emergence of tissue growth disorders or excessive subchondral bone formation, which can culminate in the deterioration and failure of osteochondral tissue repair. To overcome these limitations, materials designed for osteochondral repair must provide region-specific modulation of the microenvironment and mechanical compatibility. To address these challenges, we propose a method to create continuous hydrogels with distinct structural and functional properties by a precise cross-linking method. We have developed an innovative polyurethane enriched with dimethylglyoxime, facilitating the coordinated loading and precise release of Zn 2+ . This strategy enables the meticulous control of alginate cross-linking, resulting in an elastic gradient hydrogel that closely resembles the osteochondral interface. The Se Se within the hydrogel effectively modulates the inflammatory microenvironment and fosters the M2 polarization of macrophages. The hydrogel's lower layer is designed to rapidly release Zn 2+ , thereby enhancing bone regeneration. The upper layer is intended to prevent bone overgrowth and stimulate chondrogenic differentiation. This dual-layer strategy allows targeted stimuli to each region, promoting the seamless integration of neoosteochondral tissue. Our study demonstrates the potential of this stratified hydrogel in achieving uniform and smooth osteochondral tissue regeneration.
研究领域:
生物材料
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组织工程
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生物医学工程
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再生医学
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产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2022
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IF 10.633
Lang Bai,Qian Han,Zijie Meng,Baojun Chen,Xiaoli Qu,Meiguang Xu,Yanwen Su,Zhennan Qiu,Yuan Xue,Jiankang He,Jing Zhang,Zhanhai Yin
Substantial challenges remain in constructing the native tendon-to-bone interface for rotator cuff healing owing to the enthesis tissues' highly organized structural and compositional gradients. Herein, we propose to bioprint living tissue constructs with layer-specific growth factors (GFs) to promote enthesis regeneration by guiding the zonal differentiation of the loaded stem cells in situ . The sustained release of tenogenic, chondrogenic, and osteogenic GFs was achieved via microsphere-based delivery carriers embedded in the bioprinted constructs. Compared to the basal construct without GFs, the layer-specific tissue analogs realized region-specific differentiation of stem cells in vitro . More importantly, bioprinted living tissue constructs with layer-specific GFs rapidly enhanced the enthesis regeneration in a rabbit rotator cuff tear model in terms of biomechanical restoration, collagen deposition, and alignment, showing gradient interface of fibrocartilage structures with aligned collagen fibrils and an ultimate load failure of 154.3 ± 9.5 N resembling those of native enthesis tissues in 12 weeks. This exploration provides a feasible strategy to engineer living tissue constructions with region-specific differentiation potentials for the functional repair of gradient enthesis tissues. Statement of significance Previous studies that employed acellular layer-specific scaffolds or stem cells for the reconstruction of the rotator cuff faced challenges due to their insufficient capability to rebuild the anisotropic compositional and structural gradients of native enthesis tissues. This manuscript proposed a living tissue construct with layer-specific, GFs-loaded µS, which can direct in situ and region-specific differentiation of the embedded stem cells to tenogenic, chondrogenic, and osteogenic lineages for functional regeneration of the enthesis tissues. This bioprinted living tissue construct with the unique capability to reduce fibrovascular scar tissue formation and simultaneously facilitate enthesis tissue remodeling might provide a promising strategy to repair complex and gradient tissues in the future.
研究领域:
组织工程
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生物医学工程
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再生医学
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骨科
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BONE AND MINERAL RESEARCH
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2024
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IF 5.1
Tan Zhijia,Chen Peikai,Zhang Jianan,Shek Hiu Tung,Li Zeluan,Zhou Xinlin,Zhou Yapeng,Yin Shijie,Dong Lina,Feng Lin,Wong Janus Siu Him,Gao Bo,Tsun To Michael Kai
Osteogenesis imperfecta (OI) is a group of severe genetic bone disorders characterized by congenital low bone mass, deformity and frequent fractures. Type XV OI is a moderate to severe form of skeletal dysplasia caused by WNT1 variants. In this cohort study from southern China, we summarized the clinical phenotypes of patients with WNT1 variants and found that the proportion of type XV patients was around 10.3% (25 out of 243) with a diverse spectrum of phenotypes. Functional assays indicated that variants of WNT1 significantly impaired its secretion and effective activity, leading to moderate to severe clinical manifestations, porous bone structure and enhanced osteoclastic activities. Analysis of proteomic data from human skeleton indicated that the expression of SOST was dramatically reduced in type XV patients when comparing to the patients with COL1A1 quantitative variants. Single-cell transcriptome data generated from the human tibia samples of patients diagnosed with type XV OI and leg-length-discrepancy respectively, revealed aberrant differentiation trajectory of skeletal progenitors and impaired maturation of osteocytes with loss of WNT1, resulting in excessive CXCL12+ progenitors, fewer mature osteocytes and existence of abnormal cell populations with adipogenic characteristics. The integration of multi-omics data from human skeleton delineates how WNT1 regulates the differentiation and maturation of skeletal progenitors, which will provide a new direction for the treatment strategy of type XV osteogenesis imperfecta and relative low bone mass diseases such as early onset osteoporosis.
研究领域:
遗传学
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骨生物学
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医学遗传学
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蛋白质组学
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转录组学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
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IF 6.1
Wenhui Lyu,Yuyue Zhang,Shaopei Ding,Xiang Li,Tong Sun,Jun Luo,Jian Wang,Jianshu Li,Lei Li
In bone tissue, nerves are primarily located in the periosteum and play an indispensable role in bone defect repair. However, most bone tissue engineering approaches ignored the reconstruction of the nerve network. Herein, we aimed to develop a bilayer hydrogel simulating periosteum-bone structure to induce innervated bone regeneration. The bottom “bone” layer consisted of gelatin methacryloyl (GelMA), poly (ethylene glycol) diacrylate (PEGDA), and nano-hydroxyapatite (nHA), whereas the upper “periosteum” layer consisted of GelMA, sodium alginate (SA) and MgCl2. The mechanical properties of the upper and bottom hydrogels were designed to be suitable for neurogenesis and osteogenesis, respectively. Besides, Mg2+ from the “periosteum” layer released at the early stage (within 7 d), which aligned with the optimal time window for nerve regeneration and osteogenic related neuropeptide release. Simultaneously, the prevention of long-term Mg2+ release (after 7 d) could avoid osteogenic inhibition caused by prolonged Mg2+ exposure. Additionally, the incorporation of nHA in the bottom “bone” layer supported the long-term osteogenesis due to its osteoconductivity and slow degradation. In vitro biological experiments revealed that the bilayer hydrogel (GS@Mg/GP@nHA) promoted neurite growth and calcitonin gene-related peptide (CGRP) expression in rat dorsal root ganglion (DRG) neurons, as well as the osteogenesis of rat bone-derived mesenchymal stem cells (BMSCs). Moreover, the in vivo experiments demonstrated that GS@Mg/GP@nHA hydrogel efficiently promoted nerve network reconstruction and bone regeneration of rat calvarial bone defects. Altogether, the bilayer hydrogel GS@Mg/GP@nHA could promote innervated bone regeneration, providing new insights for biomaterial designing for bone tissue engineering.
研究领域:
组织工程
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生物材料
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再生医学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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