International Journal of Applied Ceramic Technology
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2017
·Vol. 15
·期 4
·903-909
·
IF 1.048
Huan Zhou,Mengmeng Yang,Xinye Ni,Lei Yang,Muralithran G. Kutty
Development of alternatives of bone wax to stop blood transfusion occurred in cancellous bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for bone wax.
研究领域:
生物医学工程
·
材料科学
·
外科医学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Weijing Cao,Shouyang Zong,Yin Zhang,Fan Qiu,Jun Tang,Zhenning Wu,Jiapan Luan
Amino-grafted and vaterite-contained tricalcium silicate cement (A-V-C 3 S) was composited with 58S bioglass/chitosan/carboxy methyl cellulose (BG/CS/CMC, referred as BGs) to surmount the non-absorbability and infection problems of traditional bone wax. Its material, bioactive, biocompatible and antibacterial properties were systematically characterized. The results revealed that A-V-C 3 S/BGs possessed self-setting, injectable, mechanical and degradable abilities. A-V-C 3 S/BGs (1:1 g/g) was optimum owing to its higher compressive strength (9.91 MPa) and lower pH value (7.6 to 8.1) in the test groups. In vitro immersion experiment demonstrated that A-V-C 3 S/BGs had good hydroxyapatite formation ability, and its excellent cell adhesion, low cytotoxicity and superior cell proliferation were verified by mouse embryonic osteoblast precursor cells in cell tests. Compared with A-V-C 3 S, antibacterial experiment illustrated the significantly enhanced antibacterial property of A-V-C 3 S/BGs to Staphylococcus aureus and Escherichia coli .
研究领域:
生物材料学
·
医学工程
·
组织工程
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产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2023
·
IF 8.3
Chuang Liu,Ziyang Liu,Kexin Wang,Yuting Sun,Qianying Liu,Xun Sun,Tingting Yan,Qiang Yang,Xinlong Ma,Huan Zhou,Lei Yang
Though acknowledged as the essential material in bone bleeding control with advantages of low cost, excellent malleability and smooth consistency for operation, traditional bone wax is associated with adverse effects such as foreign body reaction, granuloma growth, and bone healing failure. Herein, we presented a novel ready-to-use bone wax (NBW) based on DCPA (CaHPO 4 ) granules (DCPA-G) and modified waxy starch (MWS), proposed to overcome problems of bone wax but preserving its impressive workability in hemorrhage control. Thanks to rheological and adhesive properties of MWS after exposure to water, NBW was found to be cohesive, malleable, water content dependent tissue adhesive and liquid sealing abilities. Moreover, after hardening under humid environment due to the interaction between MWS and DCPA-G, NBW exhibited compressive strength that is comparable to that of cancellous bone. After smeared to defect model, water leakage was avoided by NBW. Besides, this material showed superior hemostasis and osteogenesis ability over traditional bone wax in vitro . Simultaneously, in vivo tests confirmed the efficiency of NBW in bleeding control and bone regeneration, indicating it a promising candidate in bleeding bone treatment.
研究领域:
生物材料
·
组织工程
·
骨科
·
止血
·
骨再生
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）