INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Meng Yu,Zhiming Wang,Renyan Huang,Zuwei Luo,Renchuan You,Ying Huang,Shuqin Yan,Qiang Zhang
Hydrogels are widely used due to their exceptional biocompatibility and adaptability, but their weak mechanical properties limit their application in biomedical engineering. Herein, we rapidly attained a comprehensive enhancement of silk fibroin hydrogels in mechanical properties by employing a physical-chemical double crosslinking strategy. The SF was ultrasonicated and simultaneously photo-crosslinked to form a di-tyrosine network interspersed with β -sheet blocks, resulting in a SF hydrogel network structure with both rigid and flexible domains. The SF hydrogels exhibited a maximum breaking strength of 59.7 kPa and a Young's modulus of 82.2 MPa, demonstrating significant rigidity and flexibility. Subsequently, the silk screws prepared by this double crosslinking strategy showed extraordinary compressive strength and Young's modulus of 41.8 MPa and 10.9 MPa, respectively. The silk screws cocultured with osteoblasts showed optimal biocompatibility, and the rate of biodegradation could be matched to the rate of osteogenesis. The screw also exhibited high adaptability in the requirements of bone screws. In this study, the SF hydrogels prepared by physical-chemical double crosslinking have extraordinary mechanical properties and biocompatibility, which provides a new avenue for the preparation of high-performance hydrogels and has great potential in bone tissue engineering.
研究领域:
生物医学工程
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材料科学
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Meng Yu,Renyan Huang,Jiahui Hua,Min Ru,Renchuan You,Ying Huang,Shuqin Yan,Qiang Zhang
Hydrogel has attracted tremendous attentions due to its excellent biocompatibility and adaptability in biomedical field. However, it is challenging by the conflicts between inadequate mechanical properties and service requirements. Herein, a rapid and robust hydrogel was developed by interpenetrating networks between chitosan and silk fibroin macromolecules. Thanks to these unique networks, the chitosan-based hydrogel exhibited superior mechanical performances. The maximum breaking strength, Young's modulus and swelling ratio of the hydrogel were 1187.8 kPa, 383.1 MPa and 4.5 % respectively. The hydrogel also supported the proliferation of human umbilical vein endothelial cells for 7 days. Notably, the hydrogel was easily molded into bone screw, and demonstrated compressive strengths of 45.7 MPa, Young's modulus of 675.6 MPa, respectively. After 49-day biodegradation, the residual rate of the screw in collagenase I solution was up to 89.6 % of the initial weight. In vitro , the screws not only had high resistance to biodegradation, but also had outstanding biocompatibility of osteoblast. This study provided a promising physical-chemical double crosslinking strategy to build orthopedic materials, holding a great potential in biomedical devices.
研究领域:
生物材料学
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组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
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2024
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IF 15.8
Renyan Huang,Jiahui Hua,Min Ru,Meng Yu,Lu Wang,Ying Huang,Shuqin Yan,Qiang Zhang,Weilin Xu
The exceptional biocompatibility and adaptability of hydrogels have garnered significant interest in the biomedical field for the fabrication of biomedical devices. However, conventional synthetic hydrogels still exhibit relatively weak and fragile properties. Drawing inspiration from the photosynthesis process, we developed a facile approach to achieve a harmonious combination of superior mechanical properties and efficient preparation of silk fibroin hydrogel through photo-cross-linking technology, accomplished within 60 s. The utilization of riboflavin and H2O2 enabled a sustainable cyclic photo-cross-linking reaction, facilitating the transformation from tyrosine to dityrosine and ultimately contributing to the formation of highly cross-linked hydrogels. These photo-cross-linking hydrogels exhibited excellent elasticity and restorability even after undergoing 1000 cycles of compression. Importantly, our findings presented that hydrogel-encapsulated adipose stem cells possess the ability to stimulate cell proliferation along with stem cell stemness. This was evidenced by the continuous high expression levels of OCT4 and SOX2 over 21 days. Additionally, the utilization of photo-cross-linking hydrogels can be extended to various material molding platforms, including microneedles, microcarriers, and bone screws. Consequently, this study offered a significant approach to fabricating biomedical hydrogels capable of facilitating real-time cell delivery, thereby introducing an innovative avenue for designing silk devices with exceptional machinability and adaptability in biomedical applications.
研究领域:
生物医学工程
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材料科学
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组织工程
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再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
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2024
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IF 5.1
Xueni Zhao,Zhaoyang Liu,Qihe Zhang,Zhipeng Zhu,Lingna Li
Bioceramic implants with complex structures, controllable pore size, and excellent mechanical property are hardly manufactured due to high hardness and brittleness of bioceramics. To address the challenge, the study developed a different way to facilitate the fabrication of a strong and tough hydroxyaptite (HA) microtube (HAMT) and ceramic implants. Ceramic implants such as HA bone cage and screw containing microtube were manufactured through flexible deformation and pressure-assisted forming. The compressive strength of HAMT formed by HA filament with 70 carbon fiber(CF) was 132.4±8.4 MPa, which was 73.68% higher compared to that of HA filament. Furthermore, the HA cage was closely stacked to form dense and uniform structure and had a better mechanical property. The HA bone screw based on the microtube had a compressive strength of 24.5±1.3 MPa and a pullout force of 83.5±1.4 N, which can be used as a bioabsorbable cancellous-bone screw.
研究领域:
材料科学
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生物医学工程
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生物材料
✓ 已验证
DOI
高影响因子
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