APPLIED SURFACE SCIENCE
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2019
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IF 5.155
Li Liu,Qiuyue Yang,Lei Huang,Xiangmei Liu,Yanqin Liang,Zhenduo Cui,Xianjin Yang,Shengli Zhu,Zhaoyang Li,Yufeng Zheng,Kelvin Wai Kwok Yeung,Shuilin Wu
In this work, a conversion coating of phytic acid (PA)/calcium ion (Ca 2+ ) was prepared on a magnesium-strontium (Mg-Sr) alloy surface through a layer-by-layer self-assembly method. The effect of the pH value on the corrosion resistance of coatings was studied systematically. The addition of a Ca 2+ could enhance the intermolecular chelation of PA and repair the defects of the coating itself. The results of electrochemical and immersion testing confirmed that a PA/Ca 2+ conversion coating could adjust the corrosion rate of Mg-Sr alloys. Compared to a bare Mg-Sr alloy, the corrosion current density of Mg&OH&PA(5.5)&Ca 2+ was decreased by about three orders (2.726 × 10 −4 A/cm 2 to 4.304 × 10 −7 A/cm 2 ). In vitro tests showed that a Ca 2+ in the coatings could not only promote the formation of apatite , but also favored osteoblast proliferation. In addition, this conversion coating could significantly enhance the expression of alkaline phosphatase activity by 50–60% compared to a bare Mg-Sr alloy.
研究领域:
材料科学
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生物医学工程
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腐蚀科学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Jiaxin Wu,Zhi Li,Xingliang Meng,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
Promoting mechanical strength and osteoinductivity properties is crucial for dental implants materials. Herein, we synthesized silicocarnotite (CPS) powder via a hydrothermal method, and mixed it with zirconia to create a composite material for preparing four slurries: xCPS-(1−x)ZrO 2 (x = 0, 1/6, 1/3, and 1/2 vol%). The optimal printing parameters for each slurry were investigated. Following the printing of the slurries, debinding was performed on them in the temperature range of 25 °C–600 °C in nitrogen atmosphere and 600 °C–1000 °C in air atmosphere, respectively, followed by sintering at 1350 °C for 2 h. The graded zirconia-based composite ceramics prepared using stereolithography (SLA) exhibited excellent mechanical properties, including a flexural strength of 742.37 ± 22.52 MPa, Vickers hardness of 7.29 ± 0.15 GPa, fracture toughness of 5.34 ± 0.29 MPa m 1/2 , and a relative density of 96.3 %. Compared with zirconia ceramics, the graded composite ceramics displayed higher surface roughness. The graded composite ceramics degraded and released Ca, Si, and P ions, promoting MC3T3-E1 cells proliferation, adhesion, and osteogenic differentiation. These findings suggest that ZrO 2 -CPS/ZrO 2 graded composite ceramics synthesized via SLA holds great potential as dental implants with high osteoinductivity.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Xuan Pei,Haitao Peng,Ya Ren,Lina Wu,Donglin Ma,Changchun Zhou,Li Min,Yujiang Fan,Maling Gou
Osteoinductive biomaterials have emerged as promising platforms for bone regeneration. Nevertheless, conventional calcium phosphate-based systems exhibit suboptimal mechanical properties, particularly under load-bearing conditions, which severely restricts their clinical applicability in critical-sized defect repair. Here, a carbon-based scaffold fabricated through a 3D printing-pyrolysis strategy, featuring osteoinductive coralloid nanostructures on its surface is reported. The scaffold demonstrates a specific strength of 237.5 kN·m kg −1 , surpassing that of commercial orthopedic implants. Notably, the scaffold shows intrinsic osteoinductive properties through successful ectopic bone formation in gluteus maximus, a phenomenon attributed to its nanotopography-mediated activation of mechanotransduction pathways via Yes-associated protein (YAP) nuclear translocation. The scaffold outperformed titanium alloys in repairing both femoral bone defects and cranial bone defects in vivo. Its bone repair efficiency can be further improved by a biomimetic mineralization process. This work highlights the potential of a robust carbon scaffold with a nanostructured surface for osteoinductivity, which will lead to the development of future biomaterials for bone repair.
研究领域:
生物材料学
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再生医学
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骨科
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产品关联
DOI
高影响因子
Engineering
·
2024
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IF 10.1
Xiao Wang,Shuning Zhang,Ai Zhu,Lingyan Cao,Long Xu,Junjie Wang,Fei Zheng,Xiangkai Zhang,Hongyan Chen,Xinquan Jiang
Given its excellent biological properties and the matching of its elastic modulus with that of human bone tissue, medical polyetheretherketone (PEEK) is considered a desirable candidate for bone-implant materials. However, its poor osseointegrative and antibacterial properties greatly limit its clinical application. To address these concerns, a functional PEEK implant is needed. Herein, a novel photo-responsive multifunctional PEEK-based implant material (sPEEK/BP/E7) with both effective osteogenesis and good disinfection properties was constructed via the self-assembly of black phosphorus (BP) nanosheets, mussel-inspired polydopamine (PDA), and bioactive short peptide E7 on sulfonated PEEK (sPEEK). The versatile micro-/nano-structured PEEK surface provides superior hydrophilicity, a favorable osteogenic microenvironment, and excellent photothermal effects under near-infrared (NIR) irradiation. The in vitro results showed that sPEEK/BP/E7 displays enhanced cytocompatibility and osteogenicity in terms of cell adhesion, proliferation, alkaline phosphatase (ALP) activity, matrix mineralization, and osteogenesis-related gene expression, superior to those of the sPEEK and sPEEK/BP samples. In addition to osteogenesis, the multifunctional coating exhibited strong antibacterial activity against both Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ). Furthermore, it was confirmed in a rat femoral infection model that sPEEK/BP/E7 effectively resisted infection caused by S. aureus under NIR light irradiation and promoted osseointegration in vivo . Thus, this work presents a facile strategy to realize improvement of the “functional integration” of new polymer bone-implant materials and provide new ideas for their clinical application.
研究领域:
生物医学材料
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组织工程
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表面改性
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Jiaqi Zhong,Xiaodong Hu,Jieyang Dong,Yujiong Chen,Botao Liu,Mingming Hao,Haijiao Xie,Chunhai Ke,Zhaoxiang Peng
Bone fractures pose significant clinical challenges and require innovative solutions for effective treatment and rapid recovery. Nanoscale protein-based materials are prominent in biotechnology and biomedicine, demonstrating versatility in biological processes and drug delivery. Herein, we designed and fabricated self-assembled keratin nanoparticles via a bisphosphonate (BP)-activated conformation-conservative assembly process. We determined the structural properties of the nanoparticles and explored the immunomodulatory and osteoinductivity functions retained from keratin. In addition, the keratin-BP nanoparticles could repair bone fractures. This study on multifunctional self-assembled protein-drug nanoparticles provides useful baseline data for exploring novel therapeutic options for acute bone fracture and other diseases.
研究领域:
生物技术
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生物医学
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纳米技术
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骨科
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Chao Wang,Siyi Xue,Yufeng Huang,Yangyang Li,Xiao Ma
Hydroxyapatite (HA) nanocrystals in bones typically exhibit a layered structure, characterized by extensive exposure of (100) facet and uniaxial orientation with organic collagen fibers. However, the inherent brittleness of traditional hydroxyapatite particles often complicates the achievement of optimal structural and property characteristics in subsequent composite preparations. Researchers found that high aspect ratio and small crystal size can greatly improve the rigidity of hydroxyapatite. In this study, we synthesized "bamboo lamellar"-like hydroxyapatite particles (LHA) that combine the biological advantages of exposed crystal planes with the mechanical benefits of a higher aspect ratio. We investigated the effects of the calcium complexing agent stearic acid and the alkaline regulator urea on the morphology of LHA samples using XRD, SEM, and TEM, with all final samples exhibiting pronounced laminar characteristics. Biocompatibility studies with pre-osteoblast MC3T3-E1 cells demonstrated that the LHA series samples displayed superior biocompatibility compared to commercially available hydroxyapatite. Alkaline phosphatase (ALP) activity assays indicated that LHA significantly outperformed commercial hydroxyapatite in promoting bone induction. Additionally, MC3T3-E1 cells adhered well to the surface of the LHA film. Incorporating LHA into a chitosan matrix significantly enhanced performance compared to both the pure organic matrix and the commercial hydroxyapatite control group. Thus, this " bamboo lamellar " biomimetic hydroxyapatite particle shows great potential as both an organic enhancer and a promoter of pre-osteoblast-induced bone formation, positioning it as a promising material for bone tissue engineering.
研究领域:
材料科学
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生物医学工程
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组织工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Yulu Yang,Ju Liu,Maowen Chen,Pengfei Gao,Yi Gong,Rui Chen,Yu Tang,Weihu Yang,Kaiyong Cai
Antibacterial titanium implants used in orthopedic and oral tooth repair have been widely researched for reducing the occurrence of second replacement operation. Although possessing a good antibiosis effect, the traditional methods have poor biocompatibility and even may cause damage to the body. Especially for loading antibiotic, after killing pathogenic bacteria, the residual antibacterial drugs may hinder the implant-tissue binding. Here, we develop a novel strategy for Ti implant based on photolithography, which can achieve the near-infrared (NIR) light-controlled antimicrobial agents loading, releasing, and clearing. A grid-like stamp of antibacterial complex and osteogenic growth peptide (OGP) were successfully prepared onto lanthanide-doped upconverting nanoparticles (UCNPs) decorated Ti substrate by selectively flicking antimicrobial agents away and replacing them with OGP. In vitro antibacterial evaluation and cell experiments proved that the modified Ti substrate (Ti-LA/OGP) exerts excellent antibacterial ability, as well as outstanding osteoinductive abilities for osteoblasts adhesion and differentiation. When implanted in infection models, Ti-LA/OGP possesses high antibacterial property at the early stage of implantation. After the success of antibiosis, irradiated with NIR light to remove the residual antibacterial agents, the osteogenesis of Ti-LA/OGP implants can be improved obviously. Moreover, this work may provide a promising strategy for the dynamic study of orthopedic application.
研究领域:
生物医学工程
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材料科学
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组织工程
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2020
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IF 6.155
Peixing Chen,Sixiang Wang,Zhi Huang,Yan Gao,Yu Zhang,Chunli Wang,Tingting Xia,Linhao Li,Wanqian Liu,Li Yang
The presence of excessive reactive oxygen species (ROS) after injuries to the enthesis could lead to cellular oxidative damage , high inflammatory response, chronic inflammation, and limited fibrochondral inductivity, making tissue repair and functional recovery difficult. Here, a multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to not only effectively reduce inflammation by scavenging ROS in the early stage of the enthesis healing but also enhance fibrocartilage formation with fibrochondrogenic induction in the later stages. The in vitro results confirmed the antioxidant capability and the fibrochondral inductivity of the functionalized nanofibers. In vivo studies showed that the multifunctional nanofiber can significantly improve the integration of tendon-bone and accelerate the regeneration of interface tissue, resulting in an excellent biomechanical property. Thus, the incorporation of antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering provides an integrative approach that facilitates damaged tissue regeneration and functional recovery, thereby improving the clinical outcome of the engineered tissue.
研究领域:
组织工程
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生物材料
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骨科
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生物医学工程
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
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2025
·
IF 9.6
Kaili Liu,Yanwen Su,Boyuan Wei,Xiaoyu Guo,Yabo Zhang,Songlin Wang,Sirui Zhang,Yuming Kang,Xiaojing Yu,Hui Zhu,Jiankang He
Marine open traumatic brain injuries (oTBI) face high infection risks due to seawater-borne pathogens, demanding dura scaffolds with dual antibacterial and osteogenic functions under seawater immersion. Conventional scaffolds lack this dual capacity. Here, a biomimetic triple-layer polycaprolactone (PCL)-based scaffold is developed. The cerebral-side electrospun layer incorporates gentamicin sulfate (GS) for antibacterial action, while the cranial-side electrohydrodynamically printed rhombic PCL layer contains nano-hydroxyapatite (nHA) to enhance osteogenesis. A middle GS/PCL electrospun layer reinforces mechanical strength. The PCL/GS/nHA scaffold demonstrates suitable mechanical properties, sustained GS release, and low hemolysis. After seawater immersion or direct S. aureus exposure, it maintains potent antibacterial efficacy and biocompatibility. Additionally, nHA promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro. This multi-functional scaffold combines seawater-resistant antimicrobial performance with osteogenic capacity, offering a promising solution for dura repair in marine environments.
研究领域:
生物材料学
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海洋医学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2024
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IF 5.4
Bianyun Cai,Mintao Xue,Delin Yuan,Xueke Zhou,Yizhou Huang,Zhijun Guo
Bacterial infection and inadequate osseointegration represent significant challenges in the application of titanium (Ti)-based bone implants. Surface modification presents a promising strategy to address these obstacles. Taking advantage of silver ions, black phosphorus nanosheets (BPNs) and polydopamine (PDA), this study developed a versatile platform on the surface of Ti-12Mo-10Zr (TMZ) alloy through a multiple surface modification process, including the anodic oxidation treatment of TMZ alloy, the preparation and addition of silver-loaded BPNs (BPNs/Ag), and the coating with PDA. Our results demonstrated that silver enhanced the stability of BPNs/Ag, which were successfully loaded to the nanostructure of oxidized TMZ surface. PDA coating conferred a pH-responsive property to the surface, prolonged the release of silver ions, and improved the photothermal performance. In acidic conditions that mimic bone defect microenvironment, the platform exhibited good photothermal performance, accelerated Ag + release, enhanced antibacterial efficacy, and increased osteoinductivity. Taken together, due to its advantageous characteristics, the versatile platform provides a valuable solution to improve the surface performance of TMZ alloys.
研究领域:
生物医学工程
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材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
POLYMER TESTING
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2024
·
IF 5
Yuet Cheng,Zheng Pan,Yuntao Lin,Yuling Chen,Xiaolian Li,Hongyu Yang,Yuehong Shen
Artificial materials for the potential treatment of bone defects are very trendy in such research fields. To investigate a hydrogel scaffold with better mechanical strength and osteoinductivity is always a challenge since brittle and soft properties are always the problems in traditional hydrogels. In our study, a novel gelatin/chitosan hydrogel crosslinked by a double network filled with lignin and calcium silicate is fabricated. Enhancements of mechanical strength, low swelling ratio, and improvement in osteoinductivity were achieved in this composite double network hydrogels. The results revealed that lignin was a key factor in raising the compressive strength and stability of the hydrogel because more hydrogen bonds were formed between lignin and the crosslinking network. Even after swelling equilibrium, the compressive strength remained almost unchanged. In addition, the hydrogel groups with a higher ratio of lignin also had lower cytotoxicity and improved osteoinductivity of pre-osteoblasts while the increasing concentration of calcium silicate progressively weakened these performances. Therefore, the gelatin/chitosan double network hydrogel reinforced by lignin would be a potential bone tissue-engineered artificial material.
研究领域:
材料科学
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生物医学工程
·
组织工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
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IF 8.097
Yunzhu Qian,Xuefeng Zhou,Hong Sun,Jianxin Yang,Yi Chen,Chao Li,Hongjin Wang,Tong Xing,Feimin Zhang,Ning Gu
To improve bone regeneration in oral microenvironment, we generated a novel biodegradable, antibacterial, and osteoconductive electrospun PLGA/PCL membrane as an ideal osteogenic scaffold. The novel three-layer membranes were structured with serial layers of electrospun chlorhexidine-doped-PLGA/PCL (PPC), PLGA/PCL (PP), and β-tricalcium phosphate-doped-PLGA/PCL (PPβ). To characterize osteoconductive properties of these membranes, MC3T3-E1 (MC) cultures were seeded onto the membranes for 14 days for evaluation of cell proliferation, morphology and gene/protein expression. In addition, MC cells were cultured onto different surfaces of the three-layer membranes, PPC layer facing MC cells (PPβ-PP-PPC) and PPβ layer facing MC cells (PPC-PP-PPβ) to evaluate surface–material effects. Membrane properties and structures were evaluated. Antibacterial properties against Streptococcus mutans and Staphylococcus aureus were determined. Scanning electron microscope demonstrated smaller interfiber spaces of PPC and PPβ-PP-PPC compared to PPβ, PPC-PP-PPβ, and PP. PPC and PPβ-PP-PPC exhibited hydrophilic property. The three-layer membranes (PPC-PP-PPβ and PPβ-PP-PPC) demonstrated significantly higher Young’s modulus (94.99 ± 4.03 MPa and 92.88 ± 4.03 MPa) compared to PP (48.76 ± 18.15 MPa) or PPC (7.92 ± 3.97 MPa) (p < 0.05). No significant difference of cell proliferation was found among any groups at any time point (p > 0.05). Higher expression of integrins were detected at 12 h of cultures on PPC-PP-PPβ compared to the controls. Promoted osteoconductive effects of PPC-PP-PPβ were revealed by alkaline phosphatase assays and Western blot compared with the controls at 7 and 14 days. PPC, PPC-PP-PPβ and PPβ-PP-PPC exhibited a significantly wider antibacterial zone against the tested bacteria compared to PP and PPβ (p < 0.05). These results suggested that the three-layer electrospun membranes demonstrated superior properties: higher strength, better cell adhesion, and promoted osteoconductive properties compared to single-layer membrane: however, antibacterial properties were exhibited in three-layer electrospun membranes and chlorhexidine-doped single-layer membrane. We concluded that the novel three-layer membranes could be used as a biocompatible scaffold for intraoral bone regeneration due to its enhanced osteoconductive activity and antibacterial effect.
研究领域:
生物材料
·
组织工程
·
牙科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）