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Bioinspired Construction of Annulus Fibrosus Implants with a Negative Poisson’s Ratio for Intervertebral Disc Repair and Restraining Disc Herniation

Yulin Jiang,Juehan Wang,Ruibang Wu,Lin Qi,Leizheng Huang,Jing Wang,Meixuan Du,Zheng Liu,Yubao Li,Limin Liu,Ganjun Feng,Li Zhang

Inspired by the negative Poisson’s ratio (NPR) effects of the annulus fibrosus (AF) in intervertebral discs (IVDs), we designed a re-entrant honeycomb model and then 3D printed it into a poly(ε-caprolactone) (PCL) scaffold with NPR effects, which was followed by in situ polymerization of polypyrrole (PPy), thus constructing a PPy-coated NPR-structured PCL scaffold (−vPCL-PPy) to be used as the AF implant for the treatment of lumbar herniated discs. Mechanical testing and finite element (FE) simulation indicated that the NPR composite implant could sustain axial spine loading and resist nucleus pulposus (NP) swelling while displaying uniform stress diffusion under NP swelling and contraction. More interestingly, the NPR-structured composite scaffold could also apply a reacting force to restrain NP herniation owing to the NPR effect. In addition, the in vitro biological assessment and in vivo implantation demonstrated that the NPR composite scaffold exhibited good biocompatibility and exerted the ability to restore the physiological function of the disc segments.