Journal of Materials Chemistry C
·
2013
·Vol. 2
·期 2
·240-244
·
IF 0
Yong-Qiang Liu,Meng Zhang,Feng-Xia Wang,Ge-Bo Pan
A facile and rapid microwave-assisted method was developed to synthesize uniform single-crystalline Sb2Se3 nanowires in high yields. The as-prepared Sb2Se3 nanowires were directly used for fabricating prototype photodetectors. The device displayed a remarkable response to light intensity with an on/off ratio larger than 150, short response/recovery times (0.2/1.2 s), and long-term durability. The high sensitivity and robust environmental stability of the devices demonstrate the bright prospects for Sb2Se3 nanowires in highly efficient photodetectors for practical use.
研究领域:
材料科学
·
纳米技术
·
光电材料
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DOI
ACS Omega
·
2023
·
IF 4.1
Rong Yang,Zhen Zhang,Naiqian Miao,Weichen Fang,Zuo Xiao,Xiaodong Shen,Wenbo Xin
Recently, carbon nanomaterial-supported plasmonic nanocrystals used as high-performance surface-enhanced Raman scattering (SERS) substrates have attracted increasing attention due to their ultra-high sensitivity of detection. However, most of the work focuses on the design of 2-D planar substrates with traditional plasmonic structures, such as nanoparticles, nanorods, nanowires, and so forth. Here, we report a novel strategy for the preparation of high-yield Au nanohydrangeas on three-dimensional porous polydopamine (PDA)/polyvinyl alcohol (PVA)/carbon nanotube (CNT) foams. The structures and growth mechanisms of these specific Au nanocrystals are systematically investigated. PDA plays the role of both a reducing agent as well as an anchoring site for Au nanohydrangeas’ growth. We also show that the ratio of surfactant KBr to the gold precursor (HAuCl4) is key to obtain these structures in a manner of high production. Moreover, the substrate of the CNT foam–Au nanohydrangea hybrid can be employed as SERS sensors and can detect the analytes down to 10–9 M.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AIP Advances
·
2018
·Vol. 8
·期 8
·
IF 1.653
Zhu Ziming,Xu Guojie,Chen Rouxi,Wang Zhifeng,Huang Jiaxu,Chen Xindu,Zeng Jun,Liang Feng,Fang Feiyu,Wang Han,Wu Peixuan,He Yunbo,Zhao Yixiang,Li Yang
The electrospinning electric field is the main factor responsible for the jet stretching force. Previous studies showed that nonhomogeneous electric field would affect the jets formed during the multi-needles electrospinning. Therefore, a multitude of methods were explored to optimize the electric field in multi-needles electrospinning, such as adjusting the supplied voltage on each needle, varying the space of the needles and spatial distribution of the needles. In this paper, three categories of needles distribution were explored for a homogeneous electric field and the design of a higher needles density of electrospinning head. The theoretical and experimental results showed that the homogeneous electric field formed with the trapezoidal head at 15mm distance while the others’ head required over 30mm. Hence, the trapezoidal arrangement is a better multi-needles distribution for electrospinning head, and has much more significance for high yield of electrospinning nanofibers.
研究领域:
材料科学
·
静电纺丝技术
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
PROTEIN EXPRESSION AND PURIFICATION
·
2024
·
IF 1.4
Dezheng Peng,Yang Li,Linlin Si,Bo Zhu,Peng Wu,Yibang Li,Dongfang Tang,Yu Liu,Yunxiao Zhang
Semaglutide is currently the most promising antidiabetic drug, especially for the treatment of type 2 diabetes mellitus, due to its excellent efficacy in glycemic control and weight loss. However, the production of semaglutide remains high cost, and high yield, low cost, and high purity still remains a challenge. Herein, we reported a convenient and high-yield strategy for the preparation of semaglutide through fragmented condensation coupling, involving solid-phase peptide synthesis of tetrapeptide and on-column refolding and on-column enzyme cleavage based inclusion body expression of Lys 26 Arg 34 GLP-1 (11–37) with fused protein tags in an X-Y-D4K-G pattern. The optimized N-terminal protein tag significantly boosts inclusion body expression level, while on-column refolding and on-column enzyme cleavage avoid precipitation, enhancing efficiency and yield together with one-step purification. The successful preparation of semaglutide is expected to achieve large-scale industrial production with low cost, high yield and high purity.
研究领域:
药学
·
生物技术
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Synthetic and Systems Biotechnology
·
2025
·
IF 4.4
Wei Li,Di Liu,Linbo Gou,Shengfang Wu,Xiuwen Zhou,Tai-Ping Fan,Long Wang,Yujie Cai
(-)-α-Bisabolol, a valuable monocyclic sesquiterpene alcohol, has garnered significant attention in the pharmaceutical and cosmetic industries due to its remarkable anti-inflammatory, antibacterial, and skin-care properties. In this study, Serratia marcescens HBQA7 ( S. marcescens HBQA7), a non-model strain resistant to terpenoid toxicity, was used as the production host, and the expression intensities of different integration sites were screened. The complete (-)-α-bisabolol synthesis pathway was integrated into these sites, achieving a production titer of 3.5 g L −1 . On this basis, by knocking out competitive pathway genes (such as slaB and adhE ) and global regulatory factors ( arcA and iclR ), and introducing efficient glucose transport and activation ( glf and glk ), the shake flask fermentation titer was increased to 7.21 g L −1 . Through optimization of fermentation culture by orthogonal experiments and others, the titer was further increased to 9.90 g L −1 . Finally, through the fed-batch fermentation process conducted in a 50 L bioreactor, a titer of 102.3 g L −1 was achieved after 110 h of cultivation. The productivity reached 0.93 g L −1 h −1 . This study not only establishes the most efficient microbial production system for (-)-α-bisabolol reported to date, but also demonstrates the outstanding potential of S. marcescens as a chassis for terpenoid biosynthesis. It provides a novel strategy for the industrial production of high-value terpenoids.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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