Journal of Environmental Sciences
·
2020
·
IF 4.302
Zhao-Feng Yuan,Williamson Gustave,Raju Sekar,Jonathan Bridge,Jia-Yue Wang,Wei-Jia Feng,Bin Guo,Zheng Chen
The redox-sensitive elements, such as iron, manganese, sulfur, phosphorus, and arsenic, shift their speciation every millimeter (mm) across the soil-water interface in the flooded soil environments. Monitoring of element speciation at this high-resolution (HR) within the SWI is still difficult. The key challenge lies in obtaining sufficient porewater samples at specific locations along the soil gradient for downstream analysis. Here with an optimized inductively coupled plasma mass spectrometry (ICP-MS) method and a HR porewater sampler, we demonstrate mm-scale element profiles mapping across the SWI in paddy soils. High-concentrations of iron and manganese (> 10 mg/L) were measured by ICP-MS in an extended dynamic range mode to avoid signal overflow. The iron profile along the SWI generated by the ICP-MS method showed no significant difference ( p < 0.05) compared to that measured independently using a colorimetric method. Furthermore, four arsenic (arsenite, arsenate, monomethylarsonic and dimethylarsinic acid), two phosphorus (phosphite and phosphate) and two sulfur (sulfide and sulfate) species were separated in 10 min by ion chromatography -ICP-MS with the NH 4 HCO 3 mobile phase. We verified the technique using paddy soils collected from the field, and present the mm-scale profiles of iron, manganese, and arsenic, phosphorus, sulfur species (relative standard deviation < 8%). The technique developed in this study will significantly promote the measurement throughput in limited samples (e.g. 100 μL) collected by HR samplers, which would greatly facilitate redox-sensitive elements biogeochemical cycling in saturated soils.
研究领域:
土壤学
·
环境科学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Fang Tan,Bin Lu,Zengze Liu,Guangyu Chen,Yanqun Liu,Feifei Cheng,Yikai Zhou
Tetrabromobisphenol A (TBBPA) is extensively used as brominated flame retardant. TBBPA and some of its metabolites had been identified as endocrine disrupter with potential health risk. Understanding the distribution characters of TBBPA and its metabolites in fish is essential to evaluate the potential impacts of TBBPA on aqueous ecosystem. This study developed a simple method to identify and quantify TBBPA and its metabolites simultaneously in tissues of alult zebrafish by ultra-high performance liquid chromatography couple with Orbitrap high resolution mass spectrometry(UHPLC-Orbitrap-HRMS). Six TBBPA metabolites were identified in liver, kidney, gill and muscle of adult zebrafish exposed to water containing different TBBPA levels, two of them, 1,3-dibromo-2‑methoxy‑5-vinylbenzene and 2,6-dibromo-4-nitrophenol were first detected. TBBPA and its metabolites were mainly distributed in the livers and kidneys of zebrafish. The levels of TBBPA and metabolites reached maximum on exposed day 3, then decreased gradually in liver and kidney. TBBPA oxidative cleavage products and TBBPA-monosulfate were the dominant metabolites. UHPLC-Orbitrap-HRMS provided an effective solution to study the distribution and metabolite characters of TBBPA in aquatic organisms.
研究领域:
环境科学
·
分析化学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 415
·期 3
·493-507
·
IF 4.478
Li Zhuoya,Huang Xinyi,Wang Xuan,Ren Jianwei,Xu Buyi,Luo Chunying,Wang Yanjun,Wang Lian,Harada Kouji H.,Zou Xiaoli
A rapid and sensitive high-performance liquid chromatography–high-resolution orbitrap mass spectrometry method was developed for the simultaneous screening of 354 organic poisons and metabolites in blood and urine, including drugs, medications, pesticides, rodenticides, veterinary drugs, alkaloids, and mycotoxins with a multi-toxicant chromatography-mass spectrometry information library. The method and library showed good prospects in clinical poisoning screening and forensic toxicological identification. Blood and urine samples were extracted successively with ethyl acetate in acidic and alkaline conditions; then, the extract was blown to nearly dry by nitrogen gas and redissolved with methanol-aqueous solution (v:v, 50:50), and the dissolved solution was analyzed by LC-MS/MS after filtering. Precursor ions’ m / z was set for identification, retention time, fragment ions, and isotopic pattern which were used for confirmation. No interference peaks were found in the blank samples, showing good specificity. The LODs of toxicants in urine and blood were 1.00×10 −3 –50.0 ng/mL and 2.07×10 −3 –50.0 ng/mL, respectively, while the LOQs were 3.30×10 −3 –1.67×10 2 ng/mL and 6.91×10 −3 –1.67×10 2 ng/mL. The intra-day precision and inter-day precision of urine samples were 2.31–9.13% and 4.75–12.3%, respectively, which were 1.92–10.8% and 2.01–12.1% in blood samples. The established method was applied to analyze 9 cases of clinical poisoning patients, and bromadiolone, carbofuran, and amanitins were detected, respectively. A total of 382 biospecimens from drug abusers were analyzed with the proposed method, which indicated that some drugs were detected in 62 cases, mainly including methamphetamine, heroin, and MDMA. The results were consistent with the information from traditional liquid chromatography-triple quadrupole mass spectrometry. Graphical abstract
研究领域:
临床医学
·
法医学
✓ 已验证
DOI
PubMed
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Bingjie Li,Jinbin Pan,Ruijie Zhang,Bing Han,Yujie Zhao,Guijun Liu,Yujie Tong,Yujing He,Guangchao Xie,Ruxia Liu,Ting Zhou,Quan Zhang,Shao-Kai Sun
High-resolution vascular imaging at tens of micrometers in deep tissues in vivo remains a critical challenge. Ultrahigh field susceptibility-weighted imaging (SWI) holds promise but lacking compatible high-sensitivity imaging probes. Herein, we show a holmium (Ho)-based nanoprobes-enhanced SWI strategy for ultrahigh-resolution imaging of cerebral microvessels at 9.4 T. The polyethylene glycol (PEG)-NaHoF 4 nanoprobes (NPs) fabricated via coprecipitation synthesis combined with PEG modification possess uniform size, appropriate hydrodynamic size (20 nm), good biocompatibility, and long circulation half-life (710 min). Notably, the PEG-NaHoF 4 NPs exhibit high r 2 / r 1 742.7) and T 2 * relaxivity ( r 2 *, 73.16 s -1 mM -1 ) under 9.4 T due to the large magnetic moment (∼10.6 μ B ) and short electronic relaxation time (∼10 -13 s) of Ho 3+ . The high susceptibility of PEG-NaHoF 4 NPs in blood vessels induces a significant blooming effect, resulting in a magnified vascular appearance on SWI. In vivo high-resolution imaging of cerebral microvessels with diameters as small as 10 μm is achieved using PEG-NaHoF 4 NPs-enhanced SWI under 9.4 T. In two representative brain disease models, glioma and stroke, this nanoprobe enables high-resolution visualization of tumor vasculature and post-stroke collateral circulation, respectively. Our study offers a new paradigm for precise diagnosis of vascular-related diseases, providing a robust tool for their diagnosis, treatment, and prognosis assessment.
研究领域:
医学影像学
·
神经科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Dacheng Xia,Jianping Li,Qiuyi Zhang,Shuwen Shen,Chenxu Sheng,Chunxiao Cong,Zhi-Jun Qiu,Laigui Hu,Ran Liu
With tunable and exceptional optical properties, quantum dots (QDs) have shown promise as valuable luminescent materials for various visual applications. However, achieving the economical and facile manufacturing of QD patterns still remains a challenge for high-resolution applications. QD arrays with pixel sizes down to micrometers are difficult to achieve with conventional techniques. In this work, a low-cost dewetting-assisted self-assembly approach for patterning QDs was demonstrated using oleophilic/oleophobic patterns on different substrates treated by lithography and surface modification. High-resolution ordered droplet arrays of UV-curable QD ink were formed on prepatterned templates. Resultant large-area QD arrays with a pixel size down to 5 μm exhibited a high resolution of 2540 pixels per inch (PPI). Furthermore, dual-color microarrays with a resolution exceeding 4 kPPI were achieved by transfer-printing red and green QD microdot patterns onto a receiving substrate. High-resolution fluorescent anticounterfeiting labels were then successfully demonstrated, implying an avenue for low-cost high-resolution QD patterns for luminescent applications, such as optical anticounterfeiting, information encryption, and displays.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2024
·
IF 2.8
Yuqi Yin,Weiyang Sun,Xuan Wang,Jiayue Chen,Hongyan Zeng,Sifan Hao,Lin Ren,Li Yong,Chunying Luo,Xiaoli Zou
Background Poisonings caused by plant toxins and mycotoxins occur frequently, which do great harm to human health and social public health safety. When a poisoning incident occurs, biological samples are commonly be used to conduct the detection of toxic substances and their metabolites for targeted clinical treatment and incident analysis. Objective To establish an efficient and accurate analysis method of 39 phytotoxins and mycotoxins in blood and urine by high performance liquid chromatography quadrupole tandem orbitrap mass spectrometry (HPLC-Orbitrap MS). Method After 3 mL of methanol being added to 1 mL blood and urine respectively for extraction and protein precipitation, the supernatant was injected into HPLC-Orbitrap MS for analysis. The phytotoxins and mycotoxins were separated by Hypersil GOLD PFP column with gradient elution using methanol-5 mmol/L ammonium acetate as mobile phase. The data were collected in ESI positive ion mode using Full MS/dd-MS 2 for mass spectrometry detection. Result The mass database of 39 phytotoxins and mycotoxins was developed, and accurate qualitative analysis can be obtained by matching with the database using the proposed identification criteria. Limit of detections (LODs) were 1.34 × 10 −4 ∼ 1.92 ng/mL and 1.92 × 10 −4 ∼ 9.80 ng/mL for blood and urine samples, respectively. Limits of quantification (LOQ) of toxins in blood and urine ranged from 4.47 × 10 −4 ∼ 6.32 ng/mL and 6.39 × 10 −4 ∼ 32.67 ng/mL, respectively. Intra-day relative standard deviations (RSDs) were 0.79 % ∼ 10.90 %, and inter-day RSDs were 1.08 % ∼ 18.93 %. The recoveries can reach 90 % ∼ 110 % with matrix matching calibration curves. Conclusion The established method is simple and rapid to operate, which can complete the sample analysis within 30 min, providing technical support for clinical poisoning treatment and public health poisoning analysis.
研究领域:
毒理学
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分析化学
·
临床医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 113
·112534-112543
·
IF 3.289
Qiqi Zhao,Aihua Zhang,Wenjing Zong,Na An,Huamin Zhang,Yihan Luan,Hongxin Cao,Hui Sun,Xijun Wang
Hyperlipidemia (HLP) is a metabolic disorder which is characterized by a disturbance in lipid metabolism and is a primary risk factor for cardiovascular disease and atherosclerosis. Patients who were diagnosed with hyperlipidemia are usually with a serious dyslipidemia, which can be evaluated by current clinical markers such as triglyceride, total cholesterol, low density lipoprotein cholesterol, and high-density lipoprotein. Metabolic profiling has great potential to help the diagnosis and prognosis of hyperlipidemia patients in an earlier stage. To explore the metabolic profiling, we used ultraperformance liquid chromatography mass spectrometry, monitored the metabolites' alterations and impaired pathways in HLP patients. Of note, a total of 37 serum metabolites from HLP patients were tentatively identified. Furthermore, they were involved in 11 pathways such as linoleic acid metabolism, glycerophospholipid metabolism, terpenoid backbone biosynthesis, sphingolipid metabolism, glycosylphosphatidylinositol-anchor biosynthesis, steroid hormone biosynthesis, arachidonic acid metabolism, pentose and glucuronate interconversions, starch and sucrose metabolism, glycerolipid metabolism and purine metabolism. These results provide potential biomarkers for early risk assessment of HLP and offer further insights into the complex metabolic pathway changes in HLP. They also suggest the distinction of utilizing UPLC-Q-TOF-MS for exploring metabolic characterization of HLP patients.
研究领域:
生物化学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Jinmei Song,Yuhong He,Haijing Hu,Mingbian Li,Chenglong Li,Bai Yang,Haotong Wei
Computed tomography (CT) imaging has emerge as an effective medical diagnostic technique due to its rapid and 3D imaging capabilities, often employing indirect imaging methods through scintillator materials. Arraying scintillators that can confine light scattering to enable high-resolution CT imaging remains an area of ongoing exploration for emerging perovskite scintillators. Here an anti-scattering cesium lead bromide (CsPbBr 3 ) scintillator array embedded within a polyurethane acrylate matrix for CT imaging using a cost-effective solution-processed method is reported. Due to the large refractive index contrast between the scintillator and matrix, photon propagation can be well confined within the CsPbBr 3 scintillator array to significantly suppress the light scattering and enhance the light collection efficiency by nearly two times compared to the monolithic film. Furthermore, the scintillator array exhibits low-dosage and high-resolution CT imaging capability by reconstructing a 3D tooth image with a good spatial resolution of 20.1 lp cm −1 at a low effective dose of 0.22 mSv. This work highlights that the CsPbBr 3 scintillator array is a highly promising candidate for CT imaging.
研究领域:
医学影像
·
材料科学
·
放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2022
·Vol. 11
·期 3
·2202059
·
IF 10.05
Zhicheng Wang,Jiale Guo,Qi-Sheng Lin,Guanghui Rao,Jingtai Zhao,Chengzhang Yang,Weixiang He,Chujie Wang,Zhijun Zhang
Copper-based metal halide scintillators have received increasing attention due to their high light yield and nontoxicity. However, the synthetic methods are still not feasible for actual commercialization for the difficulty in scaling up and the absence of green chemical footprint. Herein, we report a new, simple, aqueous synthetic method for the mass production of highly purified and crystallized Cs 3 Cu 2 Cl 5 powder by a room-temperature reaction between a saturated aqueous solution of CsCl and a saturated hydrochloric acid solution of CuCl. The product exhibits a photoluminence peak centering at 527 nm (FWHM = 106.7 nm) and a quantum yield (PLQY) of 97%. A prototype X-ray imaging detector is fabricated by coupling a large area scintillation screen prepared by blade coating of Cs 3 Cu 2 Cl 5 powder and a commercial thin-film transistor (TFT) panel (16 cm × 13 cm, 125 µm pixel size) with readout circuit. The device exhibits a high spatial resolution of 4 lp mm −1 , exceeding the theoretical limit of the TFT panel, and an excellent dynamic imaging ability. In short, this work demonstrates an efficient novel synthetic method of Cs 3 Cu 2 Cl 5 and its application as X-ray imaging device, providing an applicable solution for its future commercialization.
研究领域:
材料科学
·
医学影像
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2023
·Vol. 37
·期 13
·e9518
·
IF 2
Lihua Qu,Xiaoyu Qi,Li Zhao,Yu Zhang,Ronghua Zhuge,Zhihui Hao,Congmin Liu
Rationale The residues of fipronil and its metabolites in chicken eggs pose a threat to human health, so regular monitoring is necessary. However, the pretreatments of the existing detection methods are complex and time-consuming. A simple and streamlined pretreatment method is needed to improve the detection efficiency. Method A rapid, efficient, and facile approach employing the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method with online solid-phase extraction liquid chromatography tandem Q Exactive Orbitrap high-resolution mass spectrometry (online-SPE-LC-HRMS) was established and evaluated for the determination of fipronil, fipronil-desulfinyl, fipronil-sulfone, and fipronil-sulfide in chicken eggs. An improved sample preparation technique combining QuEChERS and online-SPE was developed. Negative targeted ion fragmentation scanning and targeted-selected ion monitoring of HRMS were adopted to identify and quantify the target analytes. Results The proposed pretreatment method took a few steps in <13 min to achieve excellent recoveries and negligible interference. High selectivity was acquired with the adoption of Q/Orbitrap HRMS. The limit of quantification (LOQ) of the analytes was 2.5 μg kg −1 , meeting the detection requirements of the maximum residue level enacted by the Codex Alimentarius Commission, Japan, and the United States for the sum of fipronil and its metabolites. Extraction recoveries at three spiked concentration levels were within 84.56% to 93.84%, with relative standard deviation ≤5.87%. Conclusion The established method is efficient and easy to operate and displays satisfactory LOQs, recoveries, accuracy, and precision. This approach serves as a reference method for monitoring eggs while providing potential solutions for fipronil determination in more complicated matrices.
研究领域:
食品安全
·
分析化学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Zhi-Zhong Zhang,Jun-Hua Wei,Jian-Bin Luo,Xu-Dong Wang,Zi-Lin He,Dai-Bin Kuang
Current X-ray imaging scintillators are dominated by inorganic scintillators grown through a high-temperature process. Exploring new types of scintillators with mild growth conditions, high light yields, and eco-friendly chemical compositions is essential and challenging. Herein, the zero-dimensional large-area laminar organic–inorganic hybrid metal halide TEA2MnI4 (TEA = tetraethylammonium) single crystal with dimensions of 50 mm × 60 mm × 0.82 mm is grown via a local-heating solvent evaporation method. Compared with its Cl- and Br-based counterparts, the incorporation of the iodine component enhances the X-ray attenuation ability and significantly accelerates the decay of the photoluminescence of TEA2MnI4. Interestingly, the prepared TEA2MnI4 exhibits a high transmittance of >90% over the range of 515–765 nm and exhibits a high light yield of 26288 photons/MeV, which provides the prerequisite for high-resolution X-ray imaging. The TEA2MnI4 single-crystal scintillator displays an astonishing spatial resolution exceeding 25 line pairs per millimeter, which provides a design concept for a Mn–I-based single crystal for high-performance scintillator applications.
研究领域:
材料科学
·
医学影像学
✓ 已验证
DOI
PubMed
高影响因子
Nanoscale
·
2020
·Vol. 12
·期 17
·9727-9732
·
IF 6.895
Qiang Xu,Juan Wang,Wenyi Shao,Xiao Ouyang,Xiang Wang,Xinlei Zhang,Yong Guo,Xiaoping Ouyang
Low dimensional scintillators have been successfully and widely applied in the radiation-detection community for home security, scientific research, and imaging. We have grown zero-dimensional Cs4PbBr6 materials with CsPbBr3 nanocrystals embedded by using a solution-growth method at low temperature. We have demonstrated the scintillation properties of these 0D nanoscintillators with high luminescence quantum efficiency for green light. In addition, we have successfully achieved pulse height spectra with this 0D perovskite material, which has been demonstrated with fast decay time (<10 ns), high energy resolution (3.0 ± 0.1%, 59.5 keV from 241Am), high light yield (64 000 photons per MeV) and long term stability under various atmospheres (moisture, radiation). These results are much better than those of the most widely used commercial products such as NaI(Tl). It also demonstrates that this 0D all-inorganic material can be employed as a scintillator for ionization radiation applications such as X-ray imaging and spectroscopy applications.
研究领域:
材料科学
·
辐射探测技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）